Home Other Building Blocks 61281-37-6
61281-37-6,MFCD00887634
Catalog No.:AA00IKGZ

61281-37-6 | Schisandrin B

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$68.00   $47.00
- +
5mg
≥98%
in stock  
$165.00   $115.00
- +
25mg
analytical standard,>98%
in stock  
$243.00   $170.00
- +
100mg
analytical standard,>98%
in stock  
$611.00   $428.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00IKGZ
Chemical Name:
Schisandrin B
CAS Number:
61281-37-6
Molecular Formula:
C23H28O6
Molecular Weight:
400.4648
MDL Number:
MFCD00887634
SMILES:
COc1cc2C[C@H](C)[C@H](C)Cc3c(c2c(c1OC)OC)c(OC)c1c(c3)OCO1
Properties
Computed Properties
 
Complexity:
544  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
2  
XLogP3:
5.1  

Literature

Title: The Nrf2-ARE pathway is associated with Schisandrin b attenuating benzo(a)pyrene-Induced HTR cells damages in vitro.

Journal: Environmental toxicology 20161101

Title: Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation.

Journal: Chemico-biological interactions 20150425

Title: Neuroprotective effects of Schisandrin B against transient focal cerebral ischemia in Sprague-Dawley rats.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20121201

Title: Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-κB signaling pathway in lipopolysaccharide-induced microglia.

Journal: European journal of pharmacology 20121005

Title: Schisandrin B exhibits anti-inflammatory activity through modulation of the redox-sensitive transcription factors Nrf2 and NF-κB.

Journal: Free radical biology & medicine 20121001

Title: Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family.

Journal: Bioorganic & medicinal chemistry letters 20120901

Title: Gomisin N enhances TRAIL-induced apoptosis via reactive oxygen species-mediated up-regulation of death receptors 4 and 5.

Journal: International journal of oncology 20120401

Title: Enrichment and purification of deoxyschizandrin and γ-schizandrin from the extract of Schisandra chinensis fruit by macroporous resins.

Journal: Molecules (Basel, Switzerland) 20120319

Title: Cytochrome P450-catalysed reactive oxygen species production mediates the (-)schisandrin B-induced glutathione and heat shock responses in AML12 hepatocytes.

Journal: Cell biology international 20120301

Title: Schisandrin B, attenuates cisplatin-induced oxidative stress, genotoxicity and neurotoxicity through modulating NF-κB pathway in mice.

Journal: Free radical research 20120101

Title: Prooxidant-induced glutathione antioxidant response in vitro and in vivo: a comparative study between schisandrin B and curcumin.

Journal: Biological & pharmaceutical bulletin 20120101

Title: Beneficial effect of (-)schisandrin B against 3-nitropropionic acid-induced cell death in PC12 cells.

Journal: BioFactors (Oxford, England) 20120101

Title: Schisandrin B as a hormetic agent for preventing age-related neurodegenerative diseases.

Journal: Oxidative medicine and cellular longevity 20120101

Title: Protective effect of schisandrin B against cyclosporine A-induced nephrotoxicity in vitro and in vivo.

Journal: The American journal of Chinese medicine 20120101

Title: The protective effects of tea polyphenols and schisandrin B on nephrotoxicity of mercury.

Journal: Biological trace element research 20111201

Title: Gomisin N has anti-allergic effect and inhibits inflammatory cytokine expression in mouse bone marrow-derived mast cells.

Journal: Immunopharmacology and immunotoxicology 20111201

Title: Prevention and treatment of doxorubicin-induced cardiotoxicity by dexrazoxane and schisandrin B in rabbits.

Journal: International journal of toxicology 20111201

Title: Different role of Schisandrin B on mercury-induced renal damage in vivo and in vitro.

Journal: Toxicology 20110815

Title: Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice.

Journal: Free radical research 20110801

Title: Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts.

Journal: Fitoterapia 20110601

Title: Effective kinetics of schisandrin B on serum/hepatic triglyceride and total cholesterol levels in mice with and without the influence of fenofibrate.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20110601

Title: Inhibitory effect of schisandrin B on free fatty acid-induced steatosis in L-02 cells.

Journal: World journal of gastroenterology 20110521

Title: Simultaneous and rapid determination of main lignans in different parts of Schisandra sphenanthera by micellar electrokinetic capillary chromatography.

Journal: Molecules (Basel, Switzerland) 20110503

Title: Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.

Journal: Journal of medicinal chemistry 20110414

Title: Schisandrin B protects against solar irradiation-induced oxidative stress in rat skin tissue.

Journal: Fitoterapia 20110401

Title: Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in H9c2 cells.

Journal: Molecular and cellular biochemistry 20110401

Title: Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in AML12 hepatocytes.

Journal: Free radical research 20110401

Title: Protective effects of dibenzocyclooctadiene lignans from Schisandra chinensis against beta-amyloid and homocysteine neurotoxicity in PC12 cells.

Journal: Phytotherapy research : PTR 20110301

Title: A proteomic approach in investigating the hepatoprotective mechanism of Schisandrin B: role of raf kinase inhibitor protein.

Journal: Journal of proteome research 20110107

Title: Quantitative analysis of major dibenzocyclooctane lignans in Schisandrae fructus by online TLC-DART-MS.

Journal: Phytochemical analysis : PCA 20110101

Title: (-)Schisandrin B ameliorates paraquat-induced oxidative stress by suppressing glutathione depletion and enhancing glutathione recovery in differentiated PC12 cells.

Journal: BioFactors (Oxford, England) 20110101

Title: Schisandrin B enhances the glutathione redox cycling and protects against oxidant injury in different types of cultured cells.

Journal: BioFactors (Oxford, England) 20110101

Title: Schisandrin B prevents doxorubicin-induced chronic cardiotoxicity and enhances its anticancer activity in vivo.

Journal: PloS one 20110101

Title: Schisandrin B co-treatment ameliorates the impairment on mitochondrial antioxidant status in various tissues of long-term ethanol treated rats.

Journal: Fitoterapia 20101201

Title: Enhanced oral bioavailability of Wurenchun (Fructus Schisandrae Chinensis extracts) by self-emulsifying drug delivery systems.

Journal: Drug development and industrial pharmacy 20101101

Title: A new 3,4-seco-lupane-type triterpenoid from the pulp of Acanthopanax senticosus (Rupr. et Maxim) Harms.

Journal: Natural product research 20101001

Title: Highly sensitive determination of Schisandrin and Schisandrin B in plasma of rats after administration of Wurenchun (Fructus Schisandrae Chinensis Extracts) preparations by LC-ESI-MS/MS.

Journal: Biomedical chromatography : BMC 20100601

Title: [Intestinal absorption of the effective components of Schisandra chinensis Baill by rats single-pass perfusion in situ].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100501

Title: Inhibitory effects of schisandrin A and schisandrin B on CYP3A activity.

Journal: Methods and findings in experimental and clinical pharmacology 20100401

Title: A simple and sensitive HPLC method for the simultaneous determination of eight bioactive components and fingerprint analysis of Schisandra sphenanthera.

Journal: Analytica chimica acta 20100303

Title: [Research on liposoluble ingredients of Quchiling].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100101

Title: [Schisandrin B prevents doxorubicin-induced cardiotoxicity in rabbits].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20100101

Title: Schisandrin B-induced glutathione antioxidant response and cardioprotection are mediated by reactive oxidant species production in rat hearts.

Journal: Biological & pharmaceutical bulletin 20100101

Title: [Changes of lignans' content in stems of Schisandra chinensis].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091201

Title: Schisandrin B stereoisomers protect against hypoxia/reoxygenation-induced apoptosis and associated changes in the Ca(2+)-induced mitochondrial permeability transition and mitochondrial membrane potential in AML12 hepatocytes.

Journal: Phytotherapy research : PTR 20091101

Title: Schisandrin B stimulates a cytoprotective response in rat liver exposed to mercuric chloride.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20091101

Title: Schisandrin B protects rat cortical neurons against Abeta1-42-induced neurotoxicity.

Journal: Die Pharmazie 20090701

Title: [Selection of mobile phases for the determination of gamma-schisandrin and multi-active constituents in Schisandra chinensis and its preparations by high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20090501

Title: Optimization of extraction and purification of active fractions from Schisandra chinensis (Turcz.) and its osteoblastic proliferation stimulating activity.

Journal: Phytotherapy research : PTR 20090201

Title: Effect of schisandrin B and sesamin mixture on CCl(4)-induced hepatic oxidative stress in rats.

Journal: Phytotherapy research : PTR 20090201

Title: Non-thermal extraction of effective ingredients from Schisandra chinensis Baill and the antioxidant activity of its extract.

Journal: Natural product research 20090101

Title: Schisandrin B enhances cerebral mitochondrial antioxidant status and structural integrity, and protects against cerebral ischemia/reperfusion injury in rats.

Journal: Biological & pharmaceutical bulletin 20080701

Title: [Lignans from different processed products of Schisandra chinensis fruits].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20080601

Title: Schisandrin B stereoisomers protect against hypoxia/reoxygenation-induced apoptosis and inhibit associated changes in Ca2+-induced mitochondrial permeability transition and mitochondrial membrane potential in H9c2 cardiomyocytes.

Journal: Life sciences 20080523

Title: Schisandrin B Enhances Renal Mitochondrial Antioxidant Status, Functional and Structural Integrity, and Protects against Gentamicin-Induced Nephrotoxicity in Rats.

Journal: Biological & pharmaceutical bulletin 20080401

Title: Schisandrin B from Schisandra chinensis reduces hepatic lipid contents in hypercholesterolaemic mice.

Journal: The Journal of pharmacy and pharmacology 20080301

Title: Long-term schisandrin B treatment mitigates age-related impairments in mitochondrial antioxidant status and functional ability in various tissues, and improves the survival of aging C57BL/6J mice.

Journal: BioFactors (Oxford, England) 20080101

Title: Inhibitory effect of schisandrin B on gastric cancer cells in vitro.

Journal: World journal of gastroenterology 20071228

Title: Schisandrin B prevents doxorubicin-induced cardiotoxicity via enhancing glutathione redox cycling.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20071115

Title: Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against carbon tetrachloride toxicity in mouse livers.

Journal: Biological & pharmaceutical bulletin 20070601

Title: Schisandrin B: a dual inhibitor of P-glycoprotein and multidrug resistance-associated protein 1.

Journal: Cancer letters 20070208

Title: Schisandrin B induced antioxidant response is partly mediated by cytochrome P-4502E1 catalyzed reaction in mouse liver.

Journal: Molecular and cellular biochemistry 20061201

Title: (-)Schisandrin B is more potent than its enantiomer in enhancing cellular glutathione and heat shock protein production as well as protecting against oxidant injury in H9c2 cardiomyocytes.

Journal: Molecular and cellular biochemistry 20060901

Title: Chronic schisandrin B treatment improves mitochondrial antioxidant status and tissue heat shock protein production in various tissues of young adult and middle-aged rats.

Journal: Biogerontology 20060801

Title: Dibenzocyclooctadiene lingnans: a class of novel inhibitors of P-glycoprotein.

Journal: Cancer chemotherapy and pharmacology 20060701

Title: A novel experimental model of acute hypertriglyceridemia induced by schisandrin B.

Journal: European journal of pharmacology 20060510

Title: Schisandrin B enhances doxorubicin-induced apoptosis of cancer cells but not normal cells.

Journal: Biochemical pharmacology 20060227

Title: Effects of schisandrin B enantiomers on cellular glutathione and menadione toxicity in AML12 hepatocytes.

Journal: Pharmacology 20060101

Title: Schisandrin B-induced increase in cellular glutathione level and protection against oxidant injury are mediated by the enhancement of glutathione synthesis and regeneration in AML12 and H9c2 cells.

Journal: BioFactors (Oxford, England) 20060101

Title: Role of cytochrome P-450 in schisandrin B-induced antioxidant and heat shock responses in mouse liver.

Journal: Life sciences 20051021

Title: Schisandrin B--a novel inhibitor of P-glycoprotein.

Journal: Biochemical and biophysical research communications 20050923

Title: Separation and determination of active components in Schisandra chinensis Baill. and its medicinal preparations by non-aqueous capillary electrophoresis.

Journal: Biomedical chromatography : BMC 20050901

Title: Structural determinants of schisandrin B which enhance mitochondrial functional ability and glutathione status as well as heat shock protein expression in rat hearts and H9c2 cells.

Journal: Molecular and cellular biochemistry 20050801

Title: [Effects of schisandrin B on reversing multidrug resistance in human breast cancer cells transfected with mdr1 gene].

Journal: Zhonghua yi xue za zhi 20050622

Title: Preparative separation and purification of deoxyschisandrin and gamma-schisandrin from Schisandra chinensis (Turcz.) Baill by high-speed counter-current chromatography.

Journal: Journal of chromatography. A 20050225

Title: Schisandrin B protects myocardial ischemia-reperfusion injury partly by inducing Hsp25 and Hsp70 expression in rats.

Journal: Molecular and cellular biochemistry 20041101

Title: Antioxidative effect of schisanhenol on human low density lipoprotein and its quantum chemical calculation.

Journal: Acta pharmacologica Sinica 20040801

Title: Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity.

Journal: Journal of neuroscience research 20040501

Title: Determination of specific receptor sites for platelet activating factor in bovine neutrophils.

Journal: American journal of veterinary research 20040501

Title: Hepatoprotective mechanism of schisandrin B: role of mitochondrial glutathione antioxidant status and heat shock proteins.

Journal: Free radical biology & medicine 20030815

Title: Hepatoprotective action of schisandrin B against carbon tetrachloride toxicity was mediated by both enhancement of mitochondrial glutathione status and induction of heat shock proteins in mice.

Journal: BioFactors (Oxford, England) 20030101

Title: Time-dependent enhancement in mitochondrial glutathione status and ATP generation capacity by schisandrin B treatment decreases the susceptibility of rat hearts to ischemia-reperfusion injury.

Journal: BioFactors (Oxford, England) 20030101

Title: In vivo antioxidant action of a lignan-enriched extract of Schisandra fruit and an anthraquinone-containing extract of Polygonum root in comparison with schisandrin B and emodin.

Journal: Planta medica 20021101

Title: Schisandrin B protects against tert-butylhydroperoxide induced cerebral toxicity by enhancing glutathione antioxidant status in mouse brain.

Journal: Molecular and cellular biochemistry 20020901

Title: Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice.

Journal: Planta medica 20020301

Title: [Study on supercritical CO2 fluid extraction and separation of components from fruits of Schisandra sphenanthera].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20011101

Title: Schisandrin B modulates the ischemia-reperfusion induced changes in non-enzymatic antioxidant levels in isolated-perfused rat hearts.

Journal: Molecular and cellular biochemistry 20010401

Title: Effects of schisandrin B pretreatment on tumor necrosis factor-alpha induced apoptosis and Hsp70 expression in mouse liver.

Journal: Cell stress & chaperones 20010101

Title: Checker R, et al. Schisandrin B exhibits anti-inflammatory activity through modulation of the redox-sensitive transcription factors Nrf2 and NF-κB. Free Radic Biol Med. 2012 Oct 1;53(7):1421-30.

Title: Lam PY, et al. Schisandrin B as a hormetic agent for preventing age-related neurodegenerative diseases. Oxid Med Cell Longev. 2012;2012:250825.

Title: Zeng KW, et al. Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-κB signaling pathway in lipopolysaccharide-induced microglia. Eur J Pharmacol. 2012 Oct 5;692(1-3):29-37.

Title: Liu Z, et al. Schisandrin B attenuates cancer invasion and metastasis via inhibiting epithelial-mesenchymal transition. PLoS One. 2012;7(7):e40480.

Title: Zhu S, et al. Protective effect of schisandrin B against cyclosporine A-induced nephrotoxicity in vitro and in vivo. Am J Chin Med. 2012;40(3):551-66.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:61281-37-6 Molecular Formula|61281-37-6 MDL|61281-37-6 SMILES|61281-37-6 Schisandrin B