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612847-09-3,MFCD09026909
Catalog No.:AA00EC9W

612847-09-3 | AKTI-1/2

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Purity
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1mg
≥98%
in stock  
$79.00   $55.00
- +
5mg
≥98%
in stock  
$183.00   $128.00
- +
10mg
≥98%
in stock  
$282.00   $197.00
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100mg
≥97%
in stock  
$1,574.00   $1,102.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00EC9W
Chemical Name:
AKTI-1/2
CAS Number:
612847-09-3
Molecular Formula:
C34H29N7O
Molecular Weight:
551.6404
MDL Number:
MFCD09026909
SMILES:
O=c1[nH]c2c(n1C1CCN(CC1)Cc1ccc(cc1)c1nc3cc4[nH]cnc4cc3nc1c1ccccc1)cccc2
Properties
Computed Properties
 
Complexity:
1270  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
42  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
4.3  

Literature

Title: PI3K/Akt/GSK3β induced CREB activation ameliorates arsenic mediated alterations in NMDA receptors and associated signaling in rat hippocampus: Neuroprotective role of curcumin.

Journal: Neurotoxicology 20180701

Title: DJ-1 regulating PI3K-Nrf2 signaling plays a significant role in bibenzyl compound 20C-mediated neuroprotection against rotenone-induced oxidative insult.

Journal: Toxicology letters 20170405

Title: Effects of Chrysotile Exposure in Human Bronchial Epithelial Cells: Insights into the Pathogenic Mechanisms of Asbestos-Related Diseases.

Journal: Environmental health perspectives 20160601

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Pseudomonas aeruginosa pyocyanin activates NRF2-ARE-mediated transcriptional response via the ROS-EGFR-PI3K-AKT/MEK-ERK MAP kinase signaling in pulmonary epithelial cells.

Journal: PloS one 20130101

Title: A selective Akt inhibitor produces hypotension and bradycardia in conscious rats due to inhibition of the autonomic nervous system.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20120201

Title: Inhibition of Akt signaling in hepatoma cells induces apoptotic cell death independent of Akt activation status.

Journal: Investigational new drugs 20111201

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Acylated and unacylated ghrelin attenuate isoproterenol-induced lipolysis in isolated rat visceral adipocytes through activation of phosphoinositide 3-kinase γ and phosphodiesterase 3B.

Journal: Biochimica et biophysica acta 20110601

Title: Akti-1/2, an allosteric inhibitor of Akt 1 and 2, efficiently inhibits CaMKIα activity and aryl hydrocarbon receptor pathway.

Journal: Chemico-biological interactions 20101205

Title: A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells.

Journal: European journal of medicinal chemistry 20100201

Title: The efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine.

Journal: Bioorganic & medicinal chemistry 20080901

Title: Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20050201

Title: Lindsley, et al. Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors. Bioorg. Med. Chem. Lett. (2005), 15(3), 761-764.

Title: Zhong Z, et al. Furanodiene, a Natural Product, Inhibits Breast Cancer Growth Both in vitro and in vivo. Cell Physiol Biochem. 2012;30(3):778-90. Epub 2012 Aug 2.

Title: Leonardo Romorini, et al. AKT/GSK3β signaling pathway is critically involved in human pluripotent stem cell survival. Sci Rep. 2016; 6: 35660

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