[1]Synthesis,1993,#1,p.125-128
[1]SyntheticCommunications,1989,vol.19,#5and6,p.843-850
[1]Synthesis,1993,#1,p.125-128
[1]JournaloftheChemicalSociety,1945,p.751,757
[1]Xenobiotica,1995,vol.25,#6,p.563-573
[1]JournaloftheChemicalSociety,1950,p.1884,1886
[1]ChemischeBerichte,1962,vol.95,p.1812-1819
[1]RecueildesTravauxChimiquesdesPays-Bas,1938,vol.57,p.248,263
[1]MeditsinskayaPromyshlennostSSSR,1958,vol.12,p.16,20 Chem.Abstr.,1959,p.16146
[1]JournaloftheChemicalSociety,1945,p.751,757
Title: Effect of decursin on the pharmacokinetics of theophylline and its metabolites in rats.
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Journal: Journal of bacteriology 20090701
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Journal: European journal of clinical pharmacology 20090401
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Journal: International journal of radiation biology 20090201
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Journal: Journal of pharmacological sciences 20080401
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Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20080301
Title: [Recommended treatment of apnea in premature infants. A review based on literature and own experience].
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Journal: Bioorganic & medicinal chemistry 20070515
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Title: Urinary biomarkers for assessing dietary exposure to caffeine.
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Title: Xanthine oxidase activity and blood glutathione redox ratio in infants and children with septic shock syndrome.
Journal: Intensive care medicine 20010101
Title: [The acetylator polymorphism in a Khmer population: clinical consequences].
Journal: Therapie 20010101
Title: Neurotoxic convulsions induced by theophylline and its metabolites in mice.
Journal: Biological & pharmaceutical bulletin 19960601
Title: Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii.
Journal: Biochemical pharmacology 19951109
Title: Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists.
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Journal: Toxicologic pathology 19940101
Title: Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors.
Journal: Journal of medicinal chemistry 19931029
Title: Algharrawi KH, et al. Direct conversion of theophylline to 3-methylxanthine by metabolically engineered E. coli. Microb Cell Fact. 2015 Dec 21;14:203.
Title: Youn H, et al. 1-Methylxanthine enhances the radiosensitivity of tumor cells. Int J Radiat Biol. 2009 Feb;85(2):167-74.