Title: Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase.
Journal: Bioorganic & medicinal chemistry 20080101
Title: Exploring the active site of phenylethanolamine N-methyltransferase with 1,2,3,4-tetrahydrobenz[h]isoquinoline inhibitors.
Journal: Bioorganic & medicinal chemistry 20070201
Title: Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase.
Journal: Journal of medicinal chemistry 20060907
Title: Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase.
Journal: Journal of medicinal chemistry 20051117
Title: Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines.
Journal: Bioorganic & medicinal chemistry letters 20050215
Title: 3-hydroxymethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline inhibitors of phenylethanolamine N-methyltransferase that display remarkable potency and selectivity.
Journal: Journal of medicinal chemistry 20050113
Title: Phenylethanolamine N-methyltransferase inhibition: re-evaluation of kinetic data.
Journal: Bioorganic & medicinal chemistry letters 20040816
Title: Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase.
Journal: Journal of medicinal chemistry 20040101
Title: Synthesis and evaluation of 4-fluoro-8-substituted-2,3,4,5-tetrahydro-1H-2-benzazapines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
Journal: Journal of medicinal chemistry 20010816
Title: Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.
Journal: Bioorganic & medicinal chemistry letters 20010618
Title: The influence of SK & F 64139, a phenylethanolamine-N-methyltransferase inhibitor, on centrally mediated cardiovascular effects of alpha-methyldopa and clonidine.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 19821201
Title: Properties of 8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine, an inhibitor of norepinephrine N-methyltransferase.
Journal: Biochemical pharmacology 19810601
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