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62013-04-1,MFCD00865041
Catalog No.:AA019FSU

62013-04-1 | Dirithromycin

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
≥95%
in stock  
$63.00   $44.00
- +
500mg
≥95%
in stock  
$112.00   $78.00
- +
1g
>98.0%(HPLC)(N)
in stock  
$142.00   $100.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA019FSU
Chemical Name:
Dirithromycin
CAS Number:
62013-04-1
Molecular Formula:
C42H78N2O14
Molecular Weight:
835.0737
MDL Number:
MFCD00865041
SMILES:
COCCOC[C@@H]1N[C@H]2[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@@H](C)[C@@H]([C@H](C(=O)O[C@@H]([C@@]([C@H](O1)[C@H]2C)(C)O)CC)C)O[C@@H]1O[C@@H](C)[C@@H]([C@](C1)(C)OC)O
Properties
Properties
 
BP:
871.8°C at 760 mmHg  
Form:
Solid  
MP:
186-189° (dec) (Counter)  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
1300  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
20  
Heavy Atom Count:
58  
Hydrogen Bond Acceptor Count:
16  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
12  
XLogP3:
4.2  

Literature

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Long-acting erythromycins: assessing their role in treating outpatient odontogenic infections.

Journal: Texas dental journal 20090401

Title: Quantitative determination of erythromycylamine in human plasma by liquid chromatography-mass spectrometry and its application in a bioequivalence study of dirithromycin.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080315

Title: Characterization of impurities in dirithromycin by liquid chromatography/ion trap mass spectrometry.

Journal: Journal of chromatography. A 20060825

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: In vitro activity of azithromycin and dirithromycin against axenic Entamoeba histolytica.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20041201

Title: A computational approach to the synthesis of dirithromycin.

Journal: Journal of molecular modeling 20040401

Title: Efficacy of oral levofloxacin and dirithromycin alone and in combination with rifampicin in the treatment of experimental murine Brucella abortus infection.

Journal: International journal of antimicrobial agents 20040201

Title: Actual therapeutic management of allergic and hyperreactive nasal disorders.

Journal: GMS current topics in otorhinolaryngology, head and neck surgery 20040101

Title: A comparison of 5-day courses of dirithromycin and azithromycin in the treatment of acute exacerbations of chronic obstructive pulmonary disease.

Journal: Clinical therapeutics 20030201

Title: Macrolides in dermatology.

Journal: Clinics in dermatology 20030101

Title: From the Centers for Disease Control and Prevention. Sudden death in a traveler following halofantrine administration--Togo, 2000.

Journal: JAMA 20010411

Title: Comparative study of dirithromycin and azithromycin in the treatment of acute bacterial exacerbations of chronic bronchitis.

Journal: Journal of chemotherapy (Florence, Italy) 19990401

Title: Dirithromycin: a new macrolide.

Journal: The Annals of pharmacotherapy 19961001

Title: [Extra and intracellular activity of dirithromycin against Mycobacterium avium].

Journal: Pathologie-biologie 19950401

Title: Dirithromycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic efficacy.

Journal: Drugs 19941001

Title: Pharmacokinetics of dirithromycin.

Journal: The Journal of antimicrobial chemotherapy 19930301

Title: Wasilewski MM, et, al. Five-day dirithromycin therapy is as effective as seven-day erythromycin therapy for acute exacerbations of chronic bronchitis. J Antimicrob Chemother. 1999 Apr;43(4):541-8.

Title: Counter FT, et, al. Synthesis and antimicrobial evaluation of dirithromycin (AS-E 136; LY237216), a new macrolide antibiotic derived from erythromycin. Antimicrob Agents Chemother. 1991 Jun;35(6):1116-26.

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