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Home Other Building Blocks 622370-35-8
622370-35-8,MFCD28127604
Catalog No.:AA00EK3Q

622370-35-8 | Tradipitant

Pack Size
Purity
Availability
Price(USD)
Quantity
  
2mg
98%
in stock  
$132.00   $93.00
- +
5mg
98%
in stock  
$212.00   $148.00
- +
50mg
99%
in stock  
$240.00   $168.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00EK3Q
Chemical Name:
Tradipitant
CAS Number:
622370-35-8
Molecular Formula:
C28H16ClF6N5O
Molecular Weight:
587.9030
MDL Number:
MFCD28127604
SMILES:
Clc1ccccc1C(=O)c1cccnc1c1nnn(c1c1ccncc1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Properties
Computed Properties
 
Complexity:
865  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
11  
Rotatable Bond Count:
6  
XLogP3:
6.2  

Downstream Synthesis Route
620533-92-8   
C19H13ClN2O2*H3O4P 
  622370-35-8 

[1]CurrentPatentAssignee:ELILILLY&CO-WO2005/42515,2005,A1Locationinpatent:Page/Pagecolumn15-16

[1]CurrentPatentAssignee:ELILILLY&CO-WO2005/42515,2005,A1Locationinpatent:Page/Pagecolumn15-16

[2]CurrentPatentAssignee:ELILILLY&CO-WO2005/42515,2005,A1Locationinpatent:Page/Pagecolumn22-23

[1]CurrentPatentAssignee:ELILILLY&CO-WO2003/91226,2003,A1Locationinpatent:Page/Pagecolumn124

622370-35-8   
{2-1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-1,2,3triazol-4-yl-pyridin-3-yl}-(2-chloro-phenyl)-methanol 

[1]CurrentPatentAssignee:ELILILLY&CO-WO2003/91226,2003,A1Locationinpatent:Page/Pagecolumn112

620533-92-8   
(2-chlorophenyl)-2-(2-hydroxy-2-pyridin-4-yl-vinyl)pyridin-3-ylmethanonebenzoate 
  622370-35-8 

[1]CurrentPatentAssignee:VANDAPHARMACEUTICALSINC;ELILILLY&CO-WO2008/79600,2008,A1Locationinpatent:Page/Pagecolumn3-4

Literature

Title: In vitro and ex vivo autoradiography of the NK-1 antagonist [³H]-LY686017 in Guinea pig brain.

Journal: Neuropeptides 20110401

Title: Development of the 2nd generation neurokinin-1 receptor antagonist LY686017 for social anxiety disorder.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20100201

Title: Findings on alcohol dependence point to promising avenues for targeted therapies.

Journal: JAMA 20090422

Title: Psychopharmacology. Tackling alcoholism with drugs.

Journal: Science (New York, N.Y.) 20080411

Title: Neurokinin 1 receptor antagonism as a possible therapy for alcoholism.

Journal: Science (New York, N.Y.) 20080314

Title: [A new pharmacological treatment option for alcohol dependence discovered in transnational study: neurokinin-1 receptor antagonist as a possible therapy for alcoholism?].

Journal: Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater 20080101

Title: Gackenheimer SL, et al. In vitro and ex vivo autoradiography of the NK-1 antagonist H-LY686017 in Guinea pig brain. Neuropeptides. 2011 Apr;45(2):157-64.

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