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627530-84-1,MFCD15146692
Catalog No.:AA00ECA6

627530-84-1 | Bms-564929

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5mg
≥96%
in stock  
$290.00   $203.00
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10mg
≥96%
in stock  
$438.00   $307.00
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50mg
≥96%
in stock  
$1,584.00   $1,109.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00ECA6
Chemical Name:
Bms-564929
CAS Number:
627530-84-1
Molecular Formula:
C14H12ClN3O3
Molecular Weight:
305.7164
MDL Number:
MFCD15146692
SMILES:
N#Cc1ccc(c(c1Cl)C)N1C(=O)[C@H]2N(C1=O)CC[C@H]2O
Properties
Computed Properties
 
Complexity:
531  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
1.1  

Downstream Synthesis Route

[1]BioorganicandMedicinalChemistryLetters,2007,vol.17,p.1860-1864

[1]Hamann,LawrenceG.;Manfredi,MarkC.;Sun,Chongqing;KrystekJr.,StanleyR.;Huang,Yanting;Bi,Yingzhi;Augeri,DavidJ.;Wang,Tammy;Zou,Yan;Betebenner,David.A.;Fura,Aberra;Seethala,Ramakrishna;Golla,Rajasree;Kuhns,JoyceE.;Lupisella,JohnA.;Darienzo,CeliaJ.;Custer,LauraL.;Price,JenniferL.;Johnson,JamesM.;Biller,ScottA.;Zahler,Robert;Ostrowski,Jacek[BioorganicandMedicinalChemistryLetters,2007,vol.17,#7,p.1860-1864]

Literature

Title: Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit.

Journal: Journal of medicinal chemistry 20090625

Title: N-aryl-oxazolidin-2-imine muscle selective androgen receptor modulators enhance potency through pharmacophore reorientation.

Journal: Journal of medicinal chemistry 20090514

Title: Synthesis and SAR of tetrahydropyrrolo[1,2-b][1,2,5]thiadiazol-2(3H)-one 1,1-dioxide analogues as highly potent selective androgen receptor modulators.

Journal: Bioorganic & medicinal chemistry letters 20070815

Title: Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators.

Journal: Bioorganic & medicinal chemistry letters 20070401

Title: Pharmacological and x-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats.

Journal: Endocrinology 20070101

Title: Ostrowski J, et al. Pharmacological and x-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats. Endocrinology. 2007 Jan;148(1):4-12.

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