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627536-09-8,MFCD11519969
Catalog No.:AA00ECBV

627536-09-8 | SD-208

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$12.00   $8.00
- +
10mg
98%
in stock  
$35.00   $25.00
- +
100mg
98%
in stock  
$130.00   $91.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00ECBV
Chemical Name:
SD-208
CAS Number:
627536-09-8
Molecular Formula:
C17H10ClFN6
Molecular Weight:
352.7529
MDL Number:
MFCD11519969
SMILES:
Clc1ccc(c(c1)c1nc(Nc2ccncc2)c2c(n1)nccn2)F
Properties
Computed Properties
 
Complexity:
437  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
3  

Downstream Synthesis Route
Literature

Title: Didecyldimethylammonium chloride induces pulmonary fibrosis in association with TGF-β signaling in mice.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20131101

Title: Hypoxia influences stem cell-like properties in multidrug resistant K562 leukemic cells.

Journal: Blood cells, molecules & diseases 20131001

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: TGF-β regulates sclerostin expression via the ECR5 enhancer.

Journal: Bone 20120301

Title: TGF-β1 mediates sirolimus and cyclosporine A-induced alteration of barrier function in renal epithelial cells via a noncanonical ERK1/2 signaling pathway.

Journal: American journal of physiology. Renal physiology 20111201

Title: Differential TGF-{beta} signaling in retinal vascular cells: a role in diabetic retinopathy?

Journal: Investigative ophthalmology & visual science 20100401

Title: Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness.

Journal: Molecular pharmacology 20070701

Title: Evaluation of the anti-hepatitis C virus effect of novel potent, selective, and orally bioavailable JNK and VEGFR kinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20070401

Title: Potential involvement of BMP receptor type IB activation in a synergistic effect of chondrogenic promotion between rhTGFbeta3 and rhGDF5 or rhBMP7 in human mesenchymal stem cells.

Journal: Growth factors (Chur, Switzerland) 20061201

Title: Effect of transforming growth factor-beta receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling.

Journal: The Journal of pharmacology and experimental therapeutics 20061101

Title: Transforming growth factor-beta receptor type 1 (TGFbetaRI) kinase activity but not p38 activation is required for TGFbetaRI-induced myofibroblast differentiation and profibrotic gene expression.

Journal: Molecular pharmacology 20060801

Title: Progressive transforming growth factor beta1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor.

Journal: American journal of respiratory and critical care medicine 20050415

Title: Uhl M, et al. SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo. Cancer Res. 2004 Nov 1;64(21):7954-61.

Title: Ge R, et al. Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-beta type I receptor kinase in vivo. Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4315-30.

Title: Sun Y, et al. Inhibition of intimal hyperplasia in murine aortic allografts by the oral administration of the transforming growth factor-beta receptor I kinase inhibitor SD-208. J Heart Lung Transplant. 2014 Jun;33(6):654-61.

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