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62952-06-1,MFCD00864299
Catalog No.:AA01CC3Q

62952-06-1 | DL-Lysine Acetylsalicylate

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1g
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$181.00   $127.00
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5g
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25g
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100g
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01CC3Q
Chemical Name:
DL-Lysine Acetylsalicylate
CAS Number:
62952-06-1
Molecular Formula:
C15H22N2O6
Molecular Weight:
326.3450
MDL Number:
MFCD00864299
SMILES:
CC(=O)Oc1ccccc1C(=O)[O-].[NH3+]CCCCC(C(=O)O)N
Properties
Properties
 
Form:
Solid  
MP:
124-129°C  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
318  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
1  

Literature

Title: High glucose inhibits the aspirin-induced activation of the nitric oxide/cGMP/cGMP-dependent protein kinase pathway and does not affect the aspirin-induced inhibition of thromboxane synthesis in human platelets.

Journal: Diabetes 20121101

Title: Prevention by daily soluble aspirin of colorectal adenoma recurrence: 4-year results of the APACC randomised trial.

Journal: Gut 20120201

Title: Is a positive nasal lysine-aspirin challenge test associated with a more severe phenotype of chronic rhinosinusitis and asthma?

Journal: American journal of rhinology & allergy 20120101

Title: Lysine acetylsalicylate ameliorates lung injury in rats acutely exposed to paraquat.

Journal: Chinese medical journal 20110801

Title: The nose as a target organ in the diagnosis of severe aspirin-exacerbated respiratory disease.

Journal: American journal of rhinology & allergy 20110101

Title: Rapid desensitisation of patients with aspirin allergy who undergo coronary angioplasty.

Journal: Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20110101

Title: [Addition of antithrombosis in situ in the case of digital replantation: preliminary prospective study of 13 cases].

Journal: Chirurgie de la main 20101001

Title: Evaluation of nasal mucosal swelling and microcirculation throughout nasal and bronchial provocation tests with lysine-aspirin in asthmatics with nasal polyposis.

Journal: Rhinology 20100601

Title: COX-2 expression in adenoma: an imperfect marker for chemoprevention.

Journal: Gut 20100501

Title: Endoscopic application of hemostatic thrombin-gelatin matrix (FloSeal) in anticoagulated pigs.

Journal: Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy 20100101

Title: [Acoustic rhinometry in the evaluation of intranasal aspirin challenge].

Journal: Pneumonologia i alergologia polska 20100101

Title: Lipoxin A4 generation is decreased in aspirin-sensitive patients in lysine-aspirin nasal challenge in vivo model.

Journal: Allergy 20091201

Title: An effective antidote for paraquat poisonings: the treatment with lysine acetylsalicylate.

Journal: Toxicology 20090131

Title: Cellular allergen stimulation test with acetylsalicylic acid-lysine is not a useful test to discriminate between asthmatic patients with and without acetylsalicylic acid sensitivity.

Journal: International archives of allergy and immunology 20090101

Title: [Treatment of aneurysms of the infrapopliteal arteries. Case report and literature review].

Journal: Il Giornale di chirurgia 20090101

Title: Diagnosis of aspirin-induced asthma combining the bronchial and the oral challenge tests: a pilot study.

Journal: Journal of investigational allergology & clinical immunology 20090101

Title: Aspisol inhibits tumor growth and induces apoptosis in breast cancer.

Journal: Experimental oncology 20081201

Title: Effect of aspirin and heparin on random skin flap survival in rats.

Journal: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20080601

Title: Nitric oxide inhibition and consecutive Aspisol application show a prolonged survival of orthotopic transplanted livers in a rat model.

Journal: Transplantation proceedings 20080501

Title: Study of non-opioid analgesics tolerance in young and adult rats.

Journal: Georgian medical news 20080501

Title: The clinical effectiveness of aspirin desensitization in chronic rhinosinusitis.

Journal: Current allergy and asthma reports 20080501

Title: Systemic responses after bronchial aspirin challenge in sensitive patients with asthma.

Journal: The Journal of allergy and clinical immunology 20080201

Title: Intranasal lysine-aspirin administration decreases polyp volume in patients with aspirin-intolerant asthma.

Journal: The Journal of laryngology and otology 20071201

Title: Urinary LTE4 is higher after nasal provocation test with L-ASA in bronchial than in only nasal responders.

Journal: European annals of allergy and clinical immunology 20070501

Title: The local antinociceptive actions of nonsteroidal antiinflammatory drugs in the mouse radiant heat tail-flick test.

Journal: Anesthesia and analgesia 20070401

Title: [The management of stroke in Phnom Penh, Cambodia].

Journal: Bulletin de la Societe de pathologie exotique (1990) 20070201

Title: [Inhibitory effects of Aspisol on growth of transplanted breast cancer in C3H mice].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20061201

Title: [Kawasaki adult disease: case report].

Journal: La Revue de medecine interne 20060801

Title: Effect of combined administration of clopidogrel and lysine acetylsalicylate versus clopidogrel and aspirin on platelet aggregation and activated GPIIb/IIIa expression in healthy volunteers.

Journal: Platelets 20060301

Title: Amphotericin B and lysine acetylsalicylate in the combined treatment of nasal polyposis associated with mycotic infection.

Journal: Journal of investigational allergology & clinical immunology 20060101

Title: [Nasal provocation test with lysine-aspirin in diagnosis of nonallergic rhinitis with eosinophilia].

Journal: Otolaryngologia polska = The Polish otolaryngology 20060101

Title: Aspirin augments the concentration of endogenous hydrogen sulfide in mouse brain and liver.

Journal: Folia medica Cracoviensia 20060101

Title: Intranasal lysine-aspirin in aspirin-sensitive nasal polyposis: a controlled trial.

Journal: The Laryngoscope 20050801

Title: Effects of symptomatic treatments on cutaneous hyperalgesia and laser evoked potentials during migraine attack.

Journal: Cephalalgia : an international journal of headache 20050501

Title: Comparison of intravenous valproate with intravenous lysine-acetylsalicylic acid in acute migraine attacks.

Journal: Headache 20050101

Title: [Assessment of efficacy of migraine attack treatment with lysine acetylsalicylate and metoclopramide].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20041201

Title: Induction of opioid tolerance by lysine-acetylsalicylate in rats.

Journal: Pain 20040901

Title: Reproducibility of response to nasal lysine-aspirin challenge in patients with aspirin-induced asthma.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20040801

Title: Montelukast protects against nasal lysine-aspirin challenge in patients with aspirin-induced asthma.

Journal: The European respiratory journal 20040801

Title: Nitroglycerin-induced nNOS increase in rat trigeminal nucleus caudalis is inhibited by systemic administration of lysine acetylsalicylate but not of sumatriptan.

Journal: Cephalalgia : an international journal of headache 20040601

Title: [Comparison of the effectiveness of lysine acetylsalicylate and metoclopramide combination with ergotamine plus caffeine in the treatment of migraine attacks].

Journal: Wiadomosci lekarskie (Warsaw, Poland : 1960) 20040101

Title: [Risk of gastric bleeding after intake of D,L-mono-lysinacetylsalicylate and acetylsalicylic acid].

Journal: Therapie 20040101

Title: Subclinical aspirin sensitivity in subjects with nasal polyposis.

Journal: Clinical otolaryngology and allied sciences 20031201

Title: Abnormal habituation of 'nociceptive' blink reflex in migraine--evidence for increased excitability of trigeminal nociception.

Journal: Cephalalgia : an international journal of headache 20031001

Title: Selective cyclo-oxygenase-2 inhibition with parecoxib acutely impairs endothelium-dependent vasodilatation in patients with essential hypertension.

Journal: Journal of hypertension 20030901

Title: The heritability of antinociception II: pharmacogenetic mediation of three over-the-counter analgesics in mice.

Journal: The Journal of pharmacology and experimental therapeutics 20030501

Title: Comparative pharmacokinetics of salicylate in camels, sheep and goats.

Journal: European journal of drug metabolism and pharmacokinetics 20030101

Title: General adverse reaction to aspirin administered by transdermal iontophoresis.

Journal: European journal of clinical pharmacology 20021201

Title: Treatment of migraine.

Journal: The New England journal of medicine 20020905

Title: Strategies in the treatment of migraine.

Journal: Mayo Clinic proceedings 20020801

Title: Regulation of the 24h body temperature rhythm of women in luteal phase: role of gonadal steroids and prostaglandins.

Journal: Chronobiology international 20020701

Title: [Determination of aspirin and free salicylic acid in lysinipirine injection by high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20020501

Title: Anthropometric data and acetylsalicylic acid pharmacokinetics.

Journal: International journal of clinical pharmacology and therapeutics 20020101

Title: Lysine acetylsalicylate decreases proliferation and extracellular matrix gene expression rate in keloid fibroblasts in vitro.

Journal: European journal of dermatology : EJD 20020101

Title: Inhibition of prostaglandin synthesis reduces hyperthermic reactions induced by hypocretin-1/orexin A.

Journal: Brain research 20010803

Title: [Otorhinolaryngologic pain in the adult. A comparison of the analgesic efficacy of lysine acetylsalicylate and paracetamol].

Journal: Presse medicale (Paris, France : 1983) 20010519

Title: Antithrombotic drugs for older subjects. Guidelines formulated jointly by the Italian Societies of Haemostasis and Thrombosis (SISET) and of Gerontology and Geriatrics (SIGG).

Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD 20010201

Title: [Pharmacokinetics after oral and intravenous administration of d,l-monolysine acetylsalicylate and an oral dose of acetylsalicylic acid in healthy volunteers].

Journal: Therapie 20010101

Title: Patient-controlled analgesia with morphine plus lysine acetyl salicylate.

Journal: Anesthesia and analgesia 19991001

Title: Epileptogenic activity induced by combined treatment with antiinflammatory drugs and enoxacin and its inhibition by a calcium antagonist, nicardipine.

Journal: Methods and findings in experimental and clinical pharmacology 19961101

Title: [Liver cirrhosis and granulomatous hepatitis after prolonged ingestion of lysine acetylsalicylate].

Journal: Gastroenterologie clinique et biologique 19951101

Title: Aspirin-induced asthma and bronchial hyperresponsiveness.

Journal: Allergie et immunologie 19911201

Title: Contribution of prostacyclin to D-tubocurarine-induced hypotension in humans.

Journal: Anesthesiology 19900101

Title: Protection against pulmonary oxygen toxicity by interleukin-1 and tumor necrosis factor: role of antioxidant enzymes and effect of cyclooxygenase inhibitors.

Journal: Biotherapy (Dordrecht, Netherlands) 19890101

Title: Effect of pre-treatment with lysine acetyl salicylate on suxamethonium-induced myalgia.

Journal: British journal of anaesthesia 19870501

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