Home Amines 6312-73-8
6312-73-8,MFCD00830386
Catalog No.:AA00EG1F

6312-73-8 | 5-Bromo-6-aminouracil

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
95%
1 week  
$97.00   $68.00
- +
250mg
95%
1 week  
$164.00   $115.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00EG1F
Chemical Name:
5-Bromo-6-aminouracil
CAS Number:
6312-73-8
Molecular Formula:
C4H4BrN3O2
Molecular Weight:
205.9975
MDL Number:
MFCD00830386
SMILES:
Nc1[nH]c(=O)[nH]c(=O)c1Br
Properties
Properties
 
Form:
Solid  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
235  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
XLogP3:
-0.5  

Downstream Synthesis Route
6312-73-8    50-44-2   
6-amino-5-(7(9)<i>H</i>-purin-6-ylmercapto)-1<i>H</i>-pyrimidine-2,4-dione 

[1]JournaloftheChemicalSociety,1956,p.917,920

[1]BioorganicandMedicinalChemistryLetters,2004,vol.14,p.5247-5250

[2]EuropeanJournalofMedicinalChemistry,2008,vol.43,p.1248-1260

Literature

Title: Fluorophosphonylated nucleoside derivatives as new series of thymidine phosphorylase multisubstrate inhibitors.

Journal: Journal of medicinal chemistry 20120322

Title: The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism.

Journal: Bioorganic & medicinal chemistry letters 20100301

Title: Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule 'crystallization chaperone' 5'-O-tritylinosine (KIN59).

Journal: Biochemical pharmacology 20090801

Title: Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures.

Journal: Circulation research 20090102

Title: Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors.

Journal: European journal of medicinal chemistry 20080601

Title: Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs.

Journal: Journal of medicinal chemistry 20050127

Title: Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase.

Journal: Bioorganic & medicinal chemistry letters 20041101

Title: Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening.

Journal: Bioorganic & medicinal chemistry letters 20031103

Title: Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase.

Journal: Journal of medicinal chemistry 20030116

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:6312-73-8 Molecular Formula|6312-73-8 MDL|6312-73-8 SMILES|6312-73-8 5-Bromo-6-aminouracil