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63132-39-8,MFCD00266681
Catalog No.:AA00EEON

63132-39-8 | Olpadronate Sodium

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100mg
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250mg
95%
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00EEON
Chemical Name:
Olpadronate Sodium
CAS Number:
63132-39-8
Molecular Formula:
C5H15NO7P2
Molecular Weight:
263.1226
MDL Number:
MFCD00266681
SMILES:
CN(CCC(P(=O)(O)O)(P(=O)(O)O)O)C
Properties
Computed Properties
 
Complexity:
283  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
5  
XLogP3:
-5.9  

Literature

Title: Protein phosphatases: possible bisphosphonate binding sites mediating stimulation of osteoblast proliferation.

Journal: Archives of biochemistry and biophysics 20110315

Title: Initial results of the treatment of diffuse sclerosing osteomyelitis of the mandible with bisphosphonates.

Journal: Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 20110101

Title: The bisphosphonate olpadronate inhibits skeletal prostate cancer progression in a green fluorescent protein nude mouse model.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060415

Title: A comparison of the gastrointestinal effects of the nitrogen-containing bisphosphonates pamidronate, alendronate, and olpadronate in humans.

Journal: Journal of clinical pharmacology 20060401

Title: Effect of topical administration of monosodium olpadronate on experimental periodontitis in rats.

Journal: Journal of periodontology 20060101

Title: Changes in bone volume and bone resorption by olpadronate treatment in an experimental model of uremic bone disease.

Journal: Journal of musculoskeletal & neuronal interactions 20050601

Title: The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds.

Journal: Bioorganic & medicinal chemistry letters 20040906

Title: Quantitative structure-activity relationships for gammadelta T cell activation by bisphosphonates.

Journal: Journal of medicinal chemistry 20040115

Title: Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo.

Journal: Journal of medicinal chemistry 20040101

Title: Modulation of cytosolic calcium levels in osteoblast-like osteosarcoma cells by olpadronate and its amino-derivative IG-9402.

Journal: Calcified tissue international 20030301

Title: Highly potent geminal bisphosphonates. From pamidronate disodium (Aredia) to zoledronic acid (Zometa).

Journal: Journal of medicinal chemistry 20020815

Title: Activity of bisphosphonates against Trypanosoma brucei rhodesiense.

Journal: Journal of medicinal chemistry 20020704

Title: Bisphosphonates suppress bone resorption by a direct effect on early osteoclast precursors without affecting the osteoclastogenic capacity of osteogenic cells: the role of protein geranylgeranylation in the action of nitrogen-containing bisphosphonates on osteoclast precursors.

Journal: Bone 20020101

Title: Extracellular signal-regulated kinases and calcium channels are involved in the proliferative effect of bisphosphonates on osteoblastic cells in vitro.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20011101

Title: Do different aminobisphosphonates have similar preventive effect on experimental thyroid hormone-induced osteopenia in rats?

Journal: Calcified tissue international 20011101

Title: Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy.

Journal: Journal of medicinal chemistry 20010315

Title: Ion exchange chromatographic determination of olpadronate, phosphate, phosphite, chloride and methanesulfonic acid.

Journal: Journal of pharmaceutical and biomedical analysis 20010301

Title: Bone mineral density response to long-term bisphosphonate therapy in fibrous dysplasia.

Journal: Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry 20010101

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Tags:63132-39-8 Molecular Formula|63132-39-8 MDL|63132-39-8 SMILES|63132-39-8 Olpadronate Sodium