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63142-71-2,MFCD15071338
Catalog No.:AA003U1Z

63142-71-2 | Ribavirin 5’-Triphosphate Trisodium Salt

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003U1Z
Chemical Name:
Ribavirin 5’-Triphosphate Trisodium Salt
CAS Number:
63142-71-2
Molecular Formula:
C8H15N4O14P3
Molecular Weight:
484.1444
MDL Number:
MFCD15071338
SMILES:
C1=NC(=NN1C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)C(=O)N
Properties
Computed Properties
 
Complexity:
761  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
16  
Hydrogen Bond Donor Count:
7  
Rotatable Bond Count:
9  
XLogP3:
-5.7  

Literature

Title: Utility of high-resolution accurate MS to eliminate interferences in the bioanalysis of ribavirin and its phosphate metabolites.

Journal: Bioanalysis 20120801

Title: Synthesis of a 6-methyl-7-deaza analogue of adenosine that potently inhibits replication of polio and dengue viruses.

Journal: Journal of medicinal chemistry 20101125

Title: HPLC-MS/MS method for the intracellular determination of ribavirin monophosphate and ribavirin triphosphate in CEM ss cells.

Journal: Journal of pharmaceutical and biomedical analysis 20090712

Title: Effects of introduction of hydrophobic group on ribavirin base on mutation induction and anti-RNA viral activity.

Journal: Journal of medicinal chemistry 20080110

Title: Control of hepatitis C: a medicinal chemistry perspective.

Journal: Journal of medicinal chemistry 20050113

Title: A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate.

Journal: The Journal of biological chemistry 20040820

Title: Initial binding of the broad spectrum antiviral nucleoside ribavirin to the hepatitis C virus RNA polymerase.

Journal: The Journal of biological chemistry 20031226

Title: Structural analysis of the activation of ribavirin analogs by NDP kinase: comparison with other ribavirin targets.

Journal: Molecular pharmacology 20030301

Title: Nucleotide triphosphatase/helicase of hepatitis C virus as a target for antiviral therapy.

Journal: Antiviral research 20020901

Title: Mechanism of action of ribavirin in the combination treatment of chronic HCV infection.

Journal: Hepatology (Baltimore, Md.) 20020501

Title: Ribavirin is an inhibitor of human immunodeficiency virus reverse transcriptase.

Journal: Molecular pharmacology 19901201

Title: Effects of selenazofurin and ribavirin and their 5'-triphosphates on replicative functions of influenza A and B viruses.

Journal: Antimicrobial agents and chemotherapy 19860101

Title: Inhibition of rotaviruses by selected antiviral substances: mechanisms of viral inhibition and in vivo activity.

Journal: Antimicrobial agents and chemotherapy 19820101

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