[1]ChemischeBerichte,1888,vol.21,p.615
[2]JournaloftheAmericanChemicalSociety,2015,vol.137,#21,p.6920-6931
[1]Synthesis(Germany),2018,vol.50,#10,p.2033-2040
[1]Patent:CN102875344,2016,B,.Locationinpatent:Paragraph0010;0021;0023
[1]Patent:US5849732,1998,A,
[1]Patent:CN107382690,2017,A,.Locationinpatent:Paragraph0021;0022;0024;0026;0028
[1]JournaloftheAmericanChemicalSociety,1952,vol.74,p.2107
[1]JournaloftheAmericanChemicalSociety,1953,vol.75,p.1094,1096
[1]GazzettaChimicaItaliana,1930,vol.60,p.777,778
[1]Patent:US2683743,1950,
Title: Novel cyanocombretastatins as potent tubulin polymerisation inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20121101
Title: Inhibitory activity of Dodonaea viscosa var. angustifolia extract against Streptococcus mutans and its biofilm.
Journal: Journal of ethnopharmacology 20121031
Title: 5-Chloro-2-(3,4,5-trimeth-oxy-phen-yl)-1,3-benzothia-zole.
Journal: Acta crystallographica. Section E, Structure reports online 20121001
Title: Synthesis and cytotoxicity of 3,4-disubstituted-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazoles and novel 5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives bearing 3,4,5-trimethoxyphenyl moiety.
Journal: Bioorganic & medicinal chemistry letters 20120701
Title: Simple metal-free organic D-pi-A dyes with alkoxy- or fluorine substitutions: application in dye sensitized solar cells.
Journal: Journal of nanoscience and nanotechnology 20120601
Title: (2E)-1-(2,4-Dichloro-phen-yl)-3-(3,4,5-trimeth-oxy-phen-yl)prop-2-en-1-one.
Journal: Acta crystallographica. Section E, Structure reports online 20120501
Title: 7-Chloro-4-[(E)-2-(3,4,5-trimeth-oxy-benzyl-idene)hydrazin-1-yl]quinoline.
Journal: Acta crystallographica. Section E, Structure reports online 20120401
Title: Polygamain, a new microtubule depolymerizing agent that occupies a unique pharmacophore in the colchicine site.
Journal: Molecular pharmacology 20120301
Title: (E)-4-Meth-oxy-N'-(3,4,5-trimeth-oxy-benzyl-idene)benzohydrazide.
Journal: Acta crystallographica. Section E, Structure reports online 20120301
Title: 1,2,3-Trimeth-oxy-4,5,6-trinitro-benzene.
Journal: Acta crystallographica. Section E, Structure reports online 20120301
Title: (Z)-3-(1H-Indol-3-yl)-2-(3,4,5-tri-methoxy-phen-yl)acrylonitrile.
Journal: Acta crystallographica. Section E, Structure reports online 20120301
Title: (Z)-3-(1-Benzofuran-2-yl)-2-(3,4,5-tri-meth-oxy-phen-yl)acrylonitrile.
Journal: Acta crystallographica. Section E, Structure reports online 20120301
Title: Synthesis and evaluation of a series of 2-substituted-5-thiopropylpiperazine (piperidine)-1,3,4-oxadiazoles derivatives as atypical antipsychotics.
Journal: PloS one 20120101
Title: 5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2.
Journal: Journal of medicinal chemistry 20111222
Title: Structural and theoretical-experimental physicochemical study of trimethoprim/randomly methylated-β-cyclodextrin binary system.
Journal: Carbohydrate research 20111213
Title: 4-(3-Chloro-phen-yl)-3-[(2,6-difluoro-benz-yl)sulfan-yl]-5-(3,4,5-trimeth-oxy-phen-yl)-4H-1,2,4-triazole.
Journal: Acta crystallographica. Section E, Structure reports online 20111201
Title: Substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonamides as antimitotics. Antiproliferative, antiangiogenic and antitumoral activity, and quantitative structure-activity relationships.
Journal: European journal of medicinal chemistry 20111101
Title: (E)-4-Hy-droxy-N'-(3,4,5-trimeth-oxy-benzyl-idene)benzohydrazide.
Journal: Acta crystallographica. Section E, Structure reports online 20111101
Title: Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase.
Journal: Journal of structural biology 20111001
Title: Synthesis and structure-activity relationships of constrained heterocyclic analogues of combretastatin A4.
Journal: ChemMedChem 20110905
Title: (E)-1-(Pyridin-2-yl)-3-(3,4,5-trimeth-oxy-phen-yl)prop-2-en-1-one.
Journal: Acta crystallographica. Section E, Structure reports online 20110901
Title: (E)-1-(2-Amino-phen-yl)-3-(3,4,5-trimeth-oxy-phen-yl)prop-2-en-1-one.
Journal: Acta crystallographica. Section E, Structure reports online 20110901
Title: (2E)-1-(5-Chloro-thio-phen-2-yl)-3-(2,4,5-trimeth-oxy-phen-yl)prop-2-en-1-one.
Journal: Acta crystallographica. Section E, Structure reports online 20110801
Title: Trimethoxybenzene complexes of pentafluorophenylchlorocarbene.
Journal: The journal of physical chemistry. A 20110721
Title: Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4.
Journal: Journal of medicinal chemistry 20110714
Title: [(E)-N'-(5-Chloro-2-oxidobenzyl-idene-κO)-3,4,5-trimeth-oxy-benzohydrazidato-κN',O](pyridine-κN)copper(II).
Journal: Acta crystallographica. Section E, Structure reports online 20110501
Title: One-pot synthesis and anticancer studies of 2-arylamino-5-aryl-1,3,4-thiadiazoles.
Journal: Bioorganic & medicinal chemistry letters 20110415
Title: Hammett analysis of a family of carbene-carbene complex equilibria.
Journal: Organic letters 20110304
Title: Synthesis of novel indolyl-1,2,4-triazoles as potent and selective anticancer agents.
Journal: Chemical biology & drug design 20110301
Title: Domino approach to 2-aroyltrimethoxyindoles as novel heterocyclic combretastatin A4 analogues.
Journal: European journal of medicinal chemistry 20110101
Title: Inorganic base-catalyzed formation of antivirally active N-substituted benzamides from α-amido sulfones and N-nucleophile.
Journal: Chemistry Central journal 20110101
Title: Solvolyses of benzoyl chlorides in weakly nucleophilic media.
Journal: International journal of molecular sciences 20110101
Title: Novel quinolines bearing a biologically active trimethoxyphenyl moiety as a new class of antitumor agents.
Journal: Arzneimittel-Forschung 20110101
Title: Design, synthesis, and biological evaluation of the first podophyllotoxin analogues as potential vascular-disrupting agents.
Journal: ChemMedChem 20101203
Title: N-(X-Methylphenyl)-2-{(Z)-[(2,3,4-trimethoxyphenyl)methylidene]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, where X = 2 and 3.
Journal: Acta crystallographica. Section C, Crystal structure communications 20101201
Title: (E)-1-(2-Fur-yl)-3-(3,4,5-trimeth-oxy-phen-yl)prop-2-en-1-one.
Journal: Acta crystallographica. Section E, Structure reports online 20101201
Title: 1-(4-Hy-droxy-phen-yl)-3-(3,4,5-tri-methoxy-phen-yl)thio-urea.
Journal: Acta crystallographica. Section E, Structure reports online 20101201
Title: Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization.
Journal: Journal of medicinal chemistry 20101111
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Copper-catalyzed thiolation of the di- or trimethoxybenzene arene C-H bond with disulfides.
Journal: The Journal of organic chemistry 20101001
Title: Synthesis and in vitro antitumor activity of new 4,5-dihydropyrazole derivatives.
Journal: Bioorganic & medicinal chemistry 20100901
Title: Ethyl 2-methyl-5-oxo-4-(3,4,5-trimeth-oxy-phen-yl)-1,4,5,6,7,8-hexa-hydro-quinoline-3-carboxyl-ate.
Journal: Acta crystallographica. Section E, Structure reports online 20100901
Title: (2E)-1-(2-Bromo-phen-yl)-3-(3,4,5-trimeth-oxy-phen-yl)prop-2-en-1-one.
Journal: Acta crystallographica. Section E, Structure reports online 20100701
Title: 5-Meth-oxy-1-(3,4,5-trimethoxy-phen-yl)-1H-indole.
Journal: Acta crystallographica. Section E, Structure reports online 20100701
Title: (Z)-2-Amino-5-[2,4-dimeth-oxy-6-(4-methoxy-styr-yl)benzyl-idene]-1,3-thia-zol-4(5H)-one methanol solvate.
Journal: Acta crystallographica. Section E, Structure reports online 20100701
Title: Characterization of the colchicine binding site on avian tubulin isotype betaVI.
Journal: Biochemistry 20100406
Title: Design, synthesis, and biological evaluation of 3,4,5-trimethoxyphenyl acrylamides as antinarcotic agents.
Journal: Journal of enzyme inhibition and medicinal chemistry 20100201
Title: Exploring the effect of 2,3,4-trimethoxy-phenyl moiety as a component of indolephenstatins.
Journal: European journal of medicinal chemistry 20100201
Title: A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent.
Journal: Bioorganic & medicinal chemistry 20100115
Title: Lipophilic aroylhydrazone chelator HNTMB and its multiple effects on ovarian cancer cells.
Journal: BMC cancer 20100101
Title: On the chiroptical behavior of conjugated multichromophoric compounds of a new pseudoaromatic class: bicolchicides and biisocolchicides.
Journal: PloS one 20100101
Title: Synthesis and antimicrobial activity of 3-(1,3,4-Oxadiazol-2-yl)quinazolin-4(3H)-ones.
Journal: Scientia pharmaceutica 20100101
Title: Synthesis and biological evaluation of 2-amino-7,7-dimethyl 4-substituted-5-oxo-1-(3,4,5-trimethoxy)-1,4,5,6,7,8-hexahydro-quinoline-3-carbonitrile derivatives as potential cytotoxic agents.
Journal: Bioorganic & medicinal chemistry letters 20091215
Title: Apoptosis of human Burkitt's lymphoma cells induced by 2-N,N-diethylaminocarbonyloxymethyl-1-diphenylmethyl-4-(3,4,5-trimethoxybenzoyl) piperazine hydrochloride (PMS-1077).
Journal: Archives of pharmacal research 20091201
Title: 2-(3,4,5-Trimethoxy-phen-yl)-1H-pyrrolo[2,3-b]pyridine.
Journal: Acta crystallographica. Section E, Structure reports online 20091201
Title: 1-Phenyl-3-(2,4,6-trimethoxy-phen-yl)prop-2-en-1-one.
Journal: Acta crystallographica. Section E, Structure reports online 20091101
Title: Isocombretastatins A: 1,1-diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds.
Journal: Bioorganic & medicinal chemistry 20090901
Title: 3,4,5-Trimeth-oxy-N-(2-methoxy-phen-yl)benzamide.
Journal: Acta crystallographica. Section E, Structure reports online 20090801
Title: A second polymorph of (2E)-1-(4-fluoro-phen-yl)-3-(3,4,5-trimethoxy-phen-yl)prop-2-en-1-one.
Journal: Acta crystallographica. Section E, Structure reports online 20090801
Title: Conformational and configurational disorder in 6-(3,4,5-trimethoxyphenyl)-6,7-dihydro-5H-1,3-dioxolo[4,5-g]quinolin-8(5H)-one and 6-(1,3-benzodioxol-5-yl)-6,7-dihydro-5H-1,3-dioxolo[4,5-g]quinolin-8-one: a hydrogen-bonded chain of rings and pi-stacked hydrogen-bonded chains.
Journal: Acta crystallographica. Section C, Crystal structure communications 20090701
Title: (E)-1-(2-Thien-yl)-3-(3,4,5-trimethoxy-phen-yl)prop-2-en-1-one.
Journal: Acta crystallographica. Section E, Structure reports online 20090701
Title: An isotropic chemical shift-chemical shift anisotropic correlation experiment using discrete magic angle turning.
Journal: Journal of magnetic resonance (San Diego, Calif. : 1997) 20090501
Title: Integration of ligand and structure-based virtual screening for the identification of the first dual targeting agent for heat shock protein 90 (Hsp90) and tubulin.
Journal: Journal of medicinal chemistry 20090423
Title: N-[(E)-2-Chloro-benzyl-idene]-3-(4-methyl-benzyl-sulfan-yl)-5-(3,4,5-trimethoxy-phen-yl)-4H-1,2,4-triazol-4-amine.
Journal: Acta crystallographica. Section E, Structure reports online 20090401
Title: (E)-1-(4-Bromo-phen-yl)-3-(2,4,6-trimethoxy-phen-yl)prop-2-en-1-one.
Journal: Acta crystallographica. Section E, Structure reports online 20090401
Title: (E)-3-Allyl-sulfanyl-N-(4-methoxy-benzyl-idene)-5-(3,4,5-trimethoxy-phen-yl)-4H-1,2,4-triazol-4-amine.
Journal: Acta crystallographica. Section E, Structure reports online 20090301
Title: Synthesis and in vitro cytotoxic evaluation of novel 3,4,5-trimethoxyphenyl substituted beta-carboline derivatives.
Journal: European journal of medicinal chemistry 20090201
Title: Synthesis and activity evaluation of benzoylurea derivatives as potential antiproliferative agents.
Journal: Bioorganic & medicinal chemistry letters 20090201
Title: Simultaneous Distillation Extraction of Some Volatile Flavor Components from Pu-erh Tea Samples-Comparison with Steam Distillation-Liquid/Liquid Extraction and Soxhlet Extraction.
Journal: International journal of analytical chemistry 20090101
Title: Novel, unifying mechanism for mescaline in the central nervous system: electrochemistry, catechol redox metabolite, receptor, cell signaling and structure activity relationships.
Journal: Oxidative medicine and cellular longevity 20090101
Title: (E)-1-(4-Bromo-phen-yl)-3-(3,4,5-trimethoxy-phen-yl)prop-2-en-1-one.
Journal: Acta crystallographica. Section E, Structure reports online 20090101
Title: 3,4,5-Trimethoxy-benzohydrazidium chloride.
Journal: Acta crystallographica. Section E, Structure reports online 20081201
Title: 4-Des-oxy-4β-[(5-meth-oxy-1H-indol-3-yl)oxalylamino]podophyllotoxin methanol solvate.
Journal: Acta crystallographica. Section E, Structure reports online 20081201
Title: Ethyl 3-hydr-oxy-13-methyl-4'-phenyl-2'-(3,4,5-trimethoxy-phen-yl)-6,7,8,9,11,12,13,14,15,16-deca-hydro-spiro-[cyclo-penta-[a]phenanthrene-16,3'-pyrrolidine]-5'-carboxyl-ate.
Journal: Acta crystallographica. Section E, Structure reports online 20081101
Title: Naphthylphenstatins as tubulin ligands: synthesis and biological evaluation.
Journal: Bioorganic & medicinal chemistry 20081001
Title: Triphenyl(3,4,5-trimethoxy-benzyl)-phospho-nium chloride monohydrate.
Journal: Acta crystallographica. Section E, Structure reports online 20081001
Title: 6-(4-Methyl-phen-yl)-3-(3,4,5-trimethoxy-phen-yl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole.
Journal: Acta crystallographica. Section E, Structure reports online 20081001
Title: Design, synthesis and biological evaluation of dihydronaphthalene and benzosuberene analogs of the combretastatins as inhibitors of tubulin polymerization in cancer chemotherapy.
Journal: Bioorganic & medicinal chemistry 20080901
Title: Metabolism of (-)-grandisin from Piper solmsianum in Coleoptera and Lepidoptera species.
Journal: Phytochemistry 20080801
Title: 1-[2-(3,4-Dichloro-phen-yl)-5-(3,4,5-trimethoxy-phen-yl)-2,3-dihydro-1,3,4-oxadiazol-3-yl]ethanone.
Journal: Acta crystallographica. Section E, Structure reports online 20080801
Title: 6-(2-Methyl-phen-yl)-3-(3,4,5-trimethoxy-phen-yl)-1,2,4-triazolo[3,4-b][1,3,4]thia-diazole.
Journal: Acta crystallographica. Section E, Structure reports online 20080801
Title: 3,6-Bis(3,4,5-trimethoxy-phen-yl)-1,2,4-triazolo[3,4-b][1,3,4]thia-diazole.
Journal: Acta crystallographica. Section E, Structure reports online 20080801
Title: 3,3'-Bis(3,4,5-trimethoxy-benzo-yl)-1,1'-(o-phenyl-ene)dithio-urea ethanol solvate.
Journal: Acta crystallographica. Section E, Structure reports online 20080801
Title: 6-(4-Pyrid-yl)-3-(3,4,5-trimethoxy-phen-yl)-1,2,4-triazolo[3,4-b][1,3,4]thia-diazole.
Journal: Acta crystallographica. Section E, Structure reports online 20080801
Title: Synthesis and antifungal activity of novel sulfoxide derivatives containing trimethoxyphenyl substituted 1,3,4-thiadiazole and 1,3,4-oxadiazole moiety.
Journal: Bioorganic & medicinal chemistry 20080401
Title: Design, synthesis, and in vitro antitumor activity of new 1,4-diarylimidazole-2-ones and their 2-thione analogues.
Journal: Bioorganic & medicinal chemistry letters 20080201
Title: Synthesis and cytotoxicity studies of titanocene C analogues.
Journal: Metal-based drugs 20080101
Title: (E)-2-[4-tert-Butyl-5-(2,4,5-trimethoxy-benz-yl)thia-zol-2-ylimino-meth-yl]phenol.
Journal: Acta crystallographica. Section E, Structure reports online 20080101
Title: 4-(2-Methoxy-phenyl)-3-(3,4,5-tri-methoxy-phen-ethyl)-2H-1,2,4-triazole-5(4H)-thione.
Journal: Acta crystallographica. Section E, Structure reports online 20080101
Title: Luminescence studies of perturbation of tryptophan residues of tubulin in the complexes of tubulin with colchicine and colchicine analogues.
Journal: Biochemistry 20071218
Title: (Z)-3-(Benzo[b]thiophen-2-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile and (E)-3-(benzo[b]thiophen-2-yl)-2-(3,4-dimethoxyphenyl)acrylonitrile. [corrected].
Journal: Acta crystallographica. Section C, Crystal structure communications 20071201
Title: Identification and characterization of a new tubulin-binding tetrasubstituted brominated pyrrole.
Journal: Molecular pharmacology 20070701
Title: Synthesis and biological activity of naphthalene analogues of phenstatins: naphthylphenstatins.
Journal: Bioorganic & medicinal chemistry letters 20070615
Title: Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies.
Journal: Journal of medicinal chemistry 20070614
Title: Bimolecular hole transfer from the trimethoxybenzene radical cation in the excited state.
Journal: The journal of physical chemistry. A 20070607
Title: N-Phenyl-N'-(2-chloroethyl)urea analogues of combretastatin A-4: Is the N-phenyl-N'-(2-chloroethyl)urea pharmacophore mimicking the trimethoxy phenyl moiety?
Journal: Bioorganic & medicinal chemistry letters 20070401
Title: Highly efficient ligands for dihydrofolate reductase from Cryptosporidium hominis and Toxoplasma gondii inspired by structural analysis.
Journal: Journal of medicinal chemistry 20070308
Title: Solvent-free iodination of organic molecules using the I(2)/urea-H(2)O(2) reagent system.
Journal: Organic & biomolecular chemistry 20070221
Title: The behavior of exciplex decay processes and interplay of radiationless transition and preliminary reorganization mechanisms of electron transfer in loose and tight pairs of reactants.
Journal: The journal of physical chemistry. A 20070118
Title: Quantitative 2D HSQC NMR determination of polymer structures by selecting suitable internal standard references.
Journal: Magnetic resonance in chemistry : MRC 20070101
Title: Lignan, phenolic and iridoid glycosides from Stereospermum cylindricum.
Journal: Phytochemistry 20060301
Title: Colchitaxel, a coupled compound made from microtubule inhibitors colchicine and paclitaxel.
Journal: Beilstein journal of organic chemistry 20060101
Title: Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design.
Journal: Journal of molecular biology 20050909
Title: Synthesis, structure, characterization, and photophysical studies of a new platinum terpyridyl-based triad with covalently linked donor and acceptor groups.
Journal: Inorganic chemistry 20050905
Title: Synthesis and magnetic properties comparison of M-Cu(II) and M-VO(II) Schiff base-porphyrazine complexes: what is the mechanism for spin-coupling?
Journal: Journal of the American Chemical Society 20050713
Title: New naphthylcombretastatins. Modifications on the ethylene bridge.
Journal: Bioorganic & medicinal chemistry 20050315
Title: Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety.
Journal: Journal of medicinal chemistry 20050127
Title: Photodynamic effects of porphyrin and chlorin photosensitizers in human colon adenocarcinoma cells.
Journal: Bioorganic & medicinal chemistry 20040915
Title: Synthesis and properties of dimetallic M1[Pz]-M2[Schiff base] complexes.
Journal: Inorganic chemistry 20040531
Title: An Au-catalyzed cyclialkylation of electron-rich arenes with epoxides to prepare 3-chromanols.
Journal: Journal of the American Chemical Society 20040519
Title: The intramolecular carboxyarylation approach to podophyllotoxin.
Journal: Journal of the American Chemical Society 20031008
Title: Synthesis, cytotoxicity and antiviral activity of podophyllotoxin analogues modified in the E-ring.
Journal: European journal of medicinal chemistry 20031001
Title: Sensitivity-enhanced phase-corrected ultra-slow magic angle turning using multiple-echo data acquisition.
Journal: Journal of magnetic resonance (San Diego, Calif. : 1997) 20030701
Title: Naphthalene analogues of lignans.
Journal: The Journal of organic chemistry 20030207
Title: Structural concept for fluorinated Y-enynes with solvatochromic properties.
Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20021201
Title: Water soluble molecular switches of fluorescence based on the Ni(III)/Ni(II) redox change.
Journal: Inorganic chemistry 20021118
Title: Synthesis of cyclophanetetrayne complexes from bis(propargyldicobalt) dication equivalents.
Journal: Chemical communications (Cambridge, England) 20020721
Title: Discovery of selective hydroxamic acid inhibitors of tumor necrosis factor-alpha converting enzyme.
Journal: Bioorganic & medicinal chemistry letters 20011119
Title: Zheng Li, et al. Cleavage of ethers and demethylation of lignin in acidic concentrated lithium bromide (ACLB) solution.