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635728-49-3,MFCD18251642
Catalog No.:AA00E8KK

635728-49-3 | Darunavir ethanolate

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10mg
98%(HPLC)
in stock  
$24.00   $17.00
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50mg
98%(HPLC)
in stock  
$56.00   $39.00
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250mg
98%(HPLC)
in stock  
$154.00   $108.00
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5g
98+%
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00E8KK
Chemical Name:
Darunavir ethanolate
CAS Number:
635728-49-3
Molecular Formula:
C29H43N3O8S
Molecular Weight:
593.7320
MDL Number:
MFCD18251642
SMILES:
CC(CN(S(=O)(=O)c1ccc(cc1)N)C[C@H]([C@H](Cc1ccccc1)NC(=O)O[C@H]1CO[C@@H]2[C@H]1CCO2)O)C.CCO
Properties
Computed Properties
 
Complexity:
856  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
12  

Literature

Title: Design, Synthesis, Biological Evaluation, and X-ray Studies of HIV-1 Protease Inhibitors with Modified P2' Ligands of Darunavir.

Journal: ChemMedChem 20171207

Title: GRL-04810 and GRL-05010, difluoride-containing nonpeptidic HIV-1 protease inhibitors (PIs) that inhibit the replication of multi-PI-resistant HIV-1 in vitro and possess favorable lipophilicity that may allow blood-brain barrier penetration.

Journal: Antimicrobial agents and chemotherapy 20131201

Title: GRL-0519, a novel oxatricyclic ligand-containing nonpeptidic HIV-1 protease inhibitor (PI), potently suppresses replication of a wide spectrum of multi-PI-resistant HIV-1 variants in vitro.

Journal: Antimicrobial agents and chemotherapy 20130501

Title: Influence of SLCO1B1 polymorphisms on the drug-drug interaction between darunavir/ritonavir and pravastatin.

Journal: Journal of clinical pharmacology 20121101

Title: Metabolic effects of darunavir/ritonavir versus atazanavir/ritonavir in treatment-naive, HIV type 1-infected subjects over 48 weeks.

Journal: AIDS research and human retroviruses 20121001

Title: Single- and multiple-dose pharmacokinetics of darunavir plus ritonavir and etravirine in semen and rectal tissue of HIV-negative men.

Journal: Journal of acquired immune deficiency syndromes (1999) 20121001

Title: Liquid chromatographic separation and thermodynamic investigation of stereoisomers of darunavir on Chiralpak AD-H column.

Journal: Journal of separation science 20121001

Title: Long-term glucose tolerance in highly experienced HIV-infected patients receiving nucleoside analogue-sparing regimens.

Journal: AIDS (London, England) 20120910

Title: Short communication: Phenotypic protease inhibitor resistance and cross-resistance in the clinic from 2006 to 2008 and mutational prevalences in HIV from patients with discordant tipranavir and darunavir susceptibility phenotypes.

Journal: AIDS research and human retroviruses 20120901

Title: Body fat distribution in HIV-infected patients treated for 96 weeks with darunavir/ritonavir monotherapy versus darunavir/ritonavir plus nucleoside reverse transcriptase inhibitors: the MONOI-ANRS136 substudy.

Journal: HIV medicine 20120901

Title: Virological response to darunavir in patients infected with HIV is linked to darunavir resistance-associated mutations corrected by the count of mutations with positive impact and is not associated with pharmacological and combined virological/pharmacological parameters.

Journal: Fundamental & clinical pharmacology 20120801

Title: Minimal effects of Darunavir on adipocyte differentiation and metabolism in 3T3-L1 cells.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20120801

Title: Drug interaction profile for GSK2248761, a next generation non-nucleoside reverse transcriptase inhibitor.

Journal: British journal of clinical pharmacology 20120801

Title: The MONET trial: week 144 analysis of the efficacy of darunavir/ritonavir (DRV/r) monotherapy versus DRV/r plus two nucleoside reverse transcriptase inhibitors, for patients with viral load < 50 HIV-1 RNA copies/mL at baseline.

Journal: HIV medicine 20120801

Title: Enamino-oxindole HIV protease inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20120801

Title: Determinants of darunavir cerebrospinal fluid concentrations: impact of once-daily dosing and pharmacogenetics.

Journal: AIDS (London, England) 20120731

Title: Interleukin-6 and C-reactive protein levels after 3 years of treatment with darunavir/ritonavir monotherapy or darunavir/ritonavir + two nucleoside reverse transcriptase inhibitors in the MONET trial.

Journal: The Journal of antimicrobial chemotherapy 20120701

Title: Activity of human immunodeficiency virus type 1 protease inhibitors against the initial autocleavage in Gag-Pol polyprotein processing.

Journal: Antimicrobial agents and chemotherapy 20120701

Title: Computational studies of darunavir into HIV-1 protease and DMPC bilayer: necessary conditions for effective binding and the role of the flaps.

Journal: Journal of chemical information and modeling 20120625

Title: Steady-state pharmacokinetic interactions of darunavir/ritonavir with lipid-lowering agent rosuvastatin.

Journal: Journal of clinical pharmacology 20120601

Title: Efficacy and safety outcomes among treatment-experienced women and men treated with etravirine in gender, race and clinical experience.

Journal: AIDS research and human retroviruses 20120601

Title: Genotypic resistance profiles associated with virological failure to darunavir-containing regimens: a cross-sectional analysis.

Journal: Infection 20120601

Title: Resistant minority species are rarely observed in patients on darunavir/ritonavir monotherapy.

Journal: The Journal of antimicrobial chemotherapy 20120601

Title: High dose of darunavir in treatment-experienced HIV-infected adolescent results in virologic suppression and improved CD4 cell count.

Journal: Therapeutic drug monitoring 20120601

Title: Darunavir : a nonpeptidic protease inhibitor for antiretroviral-naive and treatment-experienced adults with HIV infection.

Journal: Expert opinion on pharmacotherapy 20120601

Title: A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS model.

Journal: PLoS pathogens 20120601

Title: Long-term efficacy and safety of raltegravir, etravirine, and darunavir/ritonavir in treatment-experienced patients: week 96 results from the ANRS 139 TRIO trial.

Journal: Journal of acquired immune deficiency syndromes (1999) 20120415

Title: [Leucoencephalopathy in a patient with type I human immunodeficiency virus (HIV-1) infection and symptoms of a hypertensive emergency].

Journal: Enfermedades infecciosas y microbiologia clinica 20120401

Title: Viremia and HIV-1 drug resistance mutations among patients receiving second-line highly active antiretroviral therapy in Chennai, Southern India.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20120401

Title: Substituent effects on P2-cyclopentyltetrahydrofuranyl urethanes: design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20120315

Title: Efficacy and safety of once-daily ritonavir-boosted darunavir and abacavir/lamivudine for treatment-naïve patients: a pilot study.

Journal: AIDS (London, England) 20120313

Title: Long-term efficacy of darunavir/ritonavir monotherapy in patients with HIV-1 viral suppression: week 96 results from the MONOI ANRS 136 study.

Journal: The Journal of antimicrobial chemotherapy 20120301

Title: Once daily maraviroc 300 mg or 150 mg in combination with ritonavir-boosted darunavir 800/100 mg.

Journal: The Journal of antimicrobial chemotherapy 20120301

Title: Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors.

Journal: Protein science : a publication of the Protein Society 20120301

Title: Origin of decrease in potency of darunavir and two related antiviral inhibitors against HIV-2 compared to HIV-1 protease.

Journal: The journal of physical chemistry. B 20120301

Title: Budget impact analysis of switching to darunavir/ritonavir monotherapy for HIV-infected people in Spain.

Journal: Applied health economics and health policy 20120301

Title: Week 96 efficacy, virology and safety of darunavir/r versus lopinavir/r in treatment-experienced patients in TITAN.

Journal: Current HIV research 20120301

Title: Three-year evaluation of neuropsychiatric adverse events in the MONET trial of darunavir/ritonavir, with or without nucleoside analogues.

Journal: International journal of STD & AIDS 20120301

Title: Interaction of I50V mutant and I50L/A71V double mutant HIV-protease with inhibitor TMC114 (darunavir): molecular dynamics simulation and binding free energy studies.

Journal: The journal of physical chemistry. B 20120216

Title: Co-administration of raltegravir reduces daily darunavir exposure in HIV-1 infected patients.

Journal: Pharmacological research 20120201

Title: Interpretation of genotypic resistance to predict darunavir/ritonavir failure in antiretroviral experienced patients.

Journal: Journal of acquired immune deficiency syndromes (1999) 20120201

Title: Interactions between buprenorphine and the protease inhibitors darunavir-ritonavir and fosamprenavir-ritonavir.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20120201

Title: Cost-effectiveness of combination therapy with etravirine in treatment-experienced adults with HIV-1 infection.

Journal: AIDS (London, England) 20120128

Title: Decomposing the energetic impact of drug-resistant mutations: the example of HIV-1 protease-DRV binding.

Journal: Methods in molecular biology (Clifton, N.J.) 20120101

Title: Pharmacokinetics of abacavir and its anabolite carbovir triphosphate without and with darunavir/ritonavir or raltegravir in HIV-infected subjects.

Journal: Antiviral therapy 20120101

Title: Effects of ritonavir-boosted darunavir, atazanavir and lopinavir on adipose functions and insulin sensitivity in murine and human adipocytes.

Journal: Antiviral therapy 20120101

Title: The prevalence of darunavir-associated mutations in HIV-1-infected children in the UK.

Journal: Antiviral therapy 20120101

Title: Impact of hepatitis C co-infection on response to antiretroviral treatment.

Journal: AIDS reviews 20120101

Title: Antiretroviral simplification with darunavir/ritonavir monotherapy in routine clinical practice: safety, effectiveness, and impact on lipid profile.

Journal: PloS one 20120101

Title: Darunavir: a critical review of its properties, use and drug interactions.

Journal: Pharmacology 20120101

Title: Assessing darunavir/ritonavir-based therapy in a racially diverse population: 48-week outcomes from GRACE.

Journal: Journal of the National Medical Association 20120101

Title: Plasma and intracellular pharmacokinetics of darunavir/ritonavir once daily and raltegravir once and twice daily in HIV-infected individuals.

Journal: Journal of acquired immune deficiency syndromes (1999) 20111215

Title: TMC310911, a novel human immunodeficiency virus type 1 protease inhibitor, shows in vitro an improved resistance profile and higher genetic barrier to resistance compared with current protease inhibitors.

Journal: Antimicrobial agents and chemotherapy 20111201

Title: Boosted tipranavir versus darunavir in treatment-experienced patients: observational data from the randomized POTENT trial.

Journal: Drugs in R&D 20111201

Title: Efficacy of a nucleoside-sparing regimen of darunavir/ritonavir plus raltegravir in treatment-naive HIV-1-infected patients (ACTG A5262).

Journal: AIDS (London, England) 20111113

Title: In vitro activity of antiretroviral drugs against Plasmodium falciparum.

Journal: Antimicrobial agents and chemotherapy 20111101

Title: Emerging HIV-1 resistance to tipranavir and darunavir in patients with virological failure to first-generation protease inhibitors in Taiwan.

Journal: International journal of STD & AIDS 20111101

Title: Factors associated with virological failure in HIV-1-infected patients receiving darunavir/ritonavir monotherapy.

Journal: The Journal of infectious diseases 20111015

Title: The higher barrier of darunavir and tipranavir resistance for HIV-1 protease.

Journal: Biochemical and biophysical research communications 20110909

Title: [Immune reconstitution syndrome related to a Mycobacterium avium complex infection, revealed by a mono-adenitis].

Journal: Medecine et maladies infectieuses 20110901

Title: Ritonavir-boosted atazanavir exposure is associated with an increased rate of renal stones compared with efavirenz, ritonavir-boosted lopinavir and ritonavir-boosted darunavir.

Journal: AIDS (London, England) 20110824

Title: Application of a validated ultra performance liquid chromatography-tandem mass spectrometry method for the quantification of darunavir in human plasma for a bioequivalence study in Indian subjects.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110815

Title: 96 week results from the MONET trial: a randomized comparison of darunavir/ritonavir with versus without nucleoside analogues, for patients with HIV RNA <50 copies/mL at baseline.

Journal: The Journal of antimicrobial chemotherapy 20110801

Title: Studies on adaptability of binding residues and flap region of TMC-114 resistance HIV-1 protease mutants.

Journal: Journal of biomolecular structure & dynamics 20110801

Title: Short communication: high effectiveness of etravirine in routine clinical practice in treatment-experienced HIV type 1-infected patients.

Journal: AIDS research and human retroviruses 20110701

Title: Changes in cerebral function parameters in HIV type 1-infected subjects switching to darunavir/ritonavir either as monotherapy or with nucleoside analogues.

Journal: AIDS research and human retroviruses 20110701

Title: Effect of continuous venovenous hemodiafiltration on darunavir and raltegravir exposure after administration via a gastroduodenal tube.

Journal: AIDS (London, England) 20110619

Title: Design and synthesis of potent HIV-1 protease inhibitors incorporating hydroxyprolinamides as novel P2 ligands.

Journal: Bioorganic & medicinal chemistry letters 20110615

Title: Effects of darunavir/ritonavir-based therapy on metabolic and anthropometric parameters in women and men over 48 weeks.

Journal: AIDS patient care and STDs 20110601

Title: Effects of tipranavir, darunavir, and ritonavir on platelet function, coagulation, and fibrinolysis in healthy volunteers.

Journal: Current HIV research 20110601

Title: Darunavir: an effective protease inhibitor for HIV-infected patients.

Journal: Expert review of anti-infective therapy 20110601

Title: Efficacy, tolerability and risk factors for virological failure of darunavir-based therapy for treatment-experienced HIV-infected patients: the Swiss HIV Cohort Study.

Journal: HIV medicine 20110501

Title: Clinical evaluation of the determination of plasma concentrations of darunavir, etravirine, raltegravir and ritonavir in dried blood spot samples.

Journal: Bioanalysis 20110501

Title: Impact of adding enfuvirtide to the predictive value of the darunavir genotypic resistance score.

Journal: Journal of acquired immune deficiency syndromes (1999) 20110501

Title: Week 48 analysis of once-daily vs. twice-daily darunavir/ritonavir in treatment-experienced HIV-1-infected patients.

Journal: AIDS (London, England) 20110424

Title: Reply to 'Pharmacokinetics of etravirine, raltegravir and darunavir/ritonavir in treatment experienced patients'.

Journal: AIDS (London, England) 20110424

Title: Darunavir/ritonavir and raltegravir coadministered in routine clinical practice: potential role for an unexpected drug interaction.

Journal: Pharmacological research 20110301

Title: Pharmacokinetic interactions between darunavir/ritonavir and opioid maintenance therapy using methadone or buprenorphine/naloxone.

Journal: Journal of clinical pharmacology 20110201

Title: The effect of lopinavir/ritonavir and darunavir/ritonavir on the HIV integrase inhibitor S/GSK1349572 in healthy participants.

Journal: Journal of clinical pharmacology 20110201

Title: Long-term successful control of super-multidrug-resistant human immunodeficiency virus type 1 infection by a novel combination therapy of raltegravir, etravirine, and boosted-darunavir.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20110201

Title: Protease inhibitor monotherapy.

Journal: Current opinion in infectious diseases 20110201

Title: Pharmacoeconomics of darunavir.

Journal: Expert review of pharmacoeconomics & outcomes research 20110201

Title: Darunavir/ritonavir monotherapy in clinical practice.

Journal: AIDS (London, England) 20110102

Title: 800 mg Darunavir tablets prepared by hot melt extrusion.

Journal: Pharmaceutical development and technology 20110101

Title: Comparative evaluation of seven resistance interpretation algorithms and their derived genotypic inhibitory quotients for the prediction of 48 week virological response to darunavir-based salvage regimens.

Journal: The Journal of antimicrobial chemotherapy 20110101

Title: Transwell-grown HepG2 cell monolayers as in vitro permeability model to study drug-drug or drug-food interactions.

Journal: Journal of medicinal food 20110101

Title: Indications for the use of next-generation antiretroviral drugs in current clinical practice.

Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20110101

Title: Analysis of drug resistance during HIV RNA viraemia in the MONET trial of darunavir/ritonavir monotherapy.

Journal: Antiviral therapy 20110101

Title: Virological characterization of patients failing darunavir/ritonavir or lopinavir/ritonavir treatment in the ARTEMIS study: 96-week analysis.

Journal: Antiviral therapy 20110101

Title: Added value of deep sequencing relative to population sequencing in heavily pre-treated HIV-1-infected subjects.

Journal: PloS one 20110101

Title: Prevalence and factors associated with darunavir resistance mutations in multi-experienced HIV-1-infected patients failing other protease inhibitors in a referral teaching center in Brazil.

Journal: The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20110101

Title: Interpretation of genotypic HIV-1 resistance to darunavir and virological response: validation of available systems and of a new score.

Journal: Antiviral therapy 20110101

Title: Selection of an M184V mutation in the cerebrospinal fluid of a treatment-naive HIV-infected individual starting darunavir-based therapy.

Journal: Antiviral therapy 20110101

Title: Protease inhibitors as preferred initial regimen for antiretroviral-naive HIV patients.

Journal: AIDS reviews 20110101

Title: Pre-steady-state kinetics of interaction of wild-type and multiple drug-resistant HIV protease with first and second generation inhibitory drugs.

Journal: Doklady. Biochemistry and biophysics 20110101

Title: Effect of baseline characteristics on the efficacy and safety of once-daily darunavir/ ritonavir in HIV-1-infected, treatment-naïve ARTEMIS patients at week 96.

Journal: HIV clinical trials 20110101

Title: A reduced dose of darunavir/ritonavir is effective in PI-experienced HIV-infected patients.

Journal: The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20110101

Title: Darunavir outcomes study: comparative effectiveness of virologic suppression, regimen durability, and discontinuation reasons for three-class experienced patients at 48 weeks.

Journal: AIDS research and human retroviruses 20101201

Title: Resistance analyses in highly experienced patients failing raltegravir, etravirine and darunavir/ritonavir regimen.

Journal: AIDS (London, England) 20101113

Title: Probing multidrug-resistance and protein-ligand interactions with oxatricyclic designed ligands in HIV-1 protease inhibitors.

Journal: ChemMedChem 20101108

Title: Impact of drug transporters on cellular resistance towards saquinavir and darunavir.

Journal: The Journal of antimicrobial chemotherapy 20101101

Title: Characterization of genotypic and phenotypic changes in HIV-1-infected patients with virologic failure on an etravirine-containing regimen in the DUET-1 and DUET-2 clinical studies.

Journal: AIDS research and human retroviruses 20101101

Title: Pharmacokinetics and pharmacodynamics of the non-nucleoside reverse-transcriptase inhibitor etravirine in treatment-experienced HIV-1-infected patients.

Journal: Clinical pharmacology and therapeutics 20101101

Title: Increased aripiprazole concentrations in an HIV-positive male concurrently taking duloxetine, darunavir, and ritonavir.

Journal: The Annals of pharmacotherapy 20101101

Title: A 48-week pilot study switching suppressed patients to darunavir/ritonavir and etravirine from enfuvirtide, protease inhibitor(s), and non-nucleoside reverse transcriptase inhibitor(s).

Journal: AIDS research and human retroviruses 20101101

Title: HIV protease inhibitors: garlic supplements and first-pass intestinal metabolism impact on the therapeutic efficacy.

Journal: Biopharmaceutics & drug disposition 20101101

Title: Virological response with fully active etravirine: pooled results from the DUET-1 and DUET-2 trials.

Journal: International journal of STD & AIDS 20101101

Title: Darunavir concentrations exceed the protein-corrected EC₅₀ for wild-type HIV in the semen of HIV-1-infected men.

Journal: AIDS (London, England) 20101023

Title: Pharmacokinetics of etravirine, raltegravir and darunavir/ritonavir in treatment experienced patients.

Journal: AIDS (London, England) 20101023

Title: Co-administration of darunavir and a new pharmacokinetic booster: formulation strategies and evaluation in dogs.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20101009

Title: First antiretroviral patent in global drug pool puts pressure on companies to follow suit.

Journal: BMJ (Clinical research ed.) 20101005

Title: Efficacy, safety and pharmacokinetics of 900/100 mg of darunavir/ritonavir once daily in treatment-experienced patients.

Journal: The Journal of antimicrobial chemotherapy 20101001

Title: Efficacy of darunavir/ritonavir maintenance monotherapy in patients with HIV-1 viral suppression: a randomized open-label, noninferiority trial, MONOI-ANRS 136.

Journal: AIDS (London, England) 20100924

Title: Sex-based outcomes of darunavir-ritonavir therapy: a single-group trial.

Journal: Annals of internal medicine 20100921

Title: In situ intestinal perfusion in knockout mice demonstrates inhibition of intestinal p-glycoprotein by ritonavir causing increased darunavir absorption.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20100901

Title: Neither ritonavir nor darunavir affect cell surface expression of tetherin or Vpu-mediated tetherin down-modulation.

Journal: AIDS (London, England) 20100731

Title: Suboptimal adherence to darunavir/ritonavir has minimal effect on efficacy compared with lopinavir/ritonavir in treatment-naive, HIV-infected patients: 96 week ARTEMIS data.

Journal: The Journal of antimicrobial chemotherapy 20100701

Title: Analysis of resistance testing in South Trinidad.

Journal: The West Indian medical journal 20100701

Title: Species-specific interaction of HIV protease inhibitors with accumulation of cholyl-glycylamido-fluorescein (CGamF) in sandwich-cultured hepatocytes.

Journal: Journal of pharmaceutical sciences 20100601

Title: Etravirine in combination with darunavir/ritonavir and optimized background regimen results in suppression of HIV replication in treatment-experienced patients. Evaluation of Katlama C, Haubrich R, Lalezari J, et al. Efficacy and safety of etravirine in treatment-experienced HIV-1 patients: pooled 48-week analysis of two randomized, controlled trials. AIDS 2009; 23: 2289-300.

Journal: Expert opinion on pharmacotherapy 20100601

Title: HIV-protease inhibitors suppress skeletal muscle fatty acid oxidation by reducing CD36 and CPT1 fatty acid transporters.

Journal: Biochimica et biophysica acta 20100501

Title: Pharmacokinetics of multiple-dose darunavir in combination with low-dose ritonavir in individuals with mild-to-moderate hepatic impairment.

Journal: Clinical pharmacokinetics 20100501

Title: Intracellular and plasma steady-state pharmacokinetics of raltegravir, darunavir, etravirine and ritonavir in heavily pre-treated HIV-infected patients.

Journal: British journal of clinical pharmacology 20100501

Title: Use of darunavir/ritonavir once daily in treatment-naive pregnant woman: pharmacokinetics, compartmental exposure, efficacy and safety.

Journal: AIDS (London, England) 20100424

Title: Efficacy, safety, and tolerability of etravirine with and without darunavir/ritonavir or raltegravir in treatment-experienced patients: analysis of the etravirine early access program in the United States.

Journal: Journal of acquired immune deficiency syndromes (1999) 20100401

Title: Darunavir: in treatment-experienced pediatric patients with HIV-1 infection.

Journal: Paediatric drugs 20100401

Title: Report from the 17th Conference on Retroviruses and Opportunistic Infections. Randomized studies of once-daily darunavir and tenofovir/FTC + nevirapine.

Journal: Journal watch. AIDS clinical care 20100401

Title: Activity of elvitegravir, a once-daily integrase inhibitor, against resistant HIV Type 1: results of a phase 2, randomized, controlled, dose-ranging clinical trial.

Journal: The Journal of infectious diseases 20100315

Title: Insights into drug resistance of mutations D30N and I50V to HIV-1 protease inhibitor TMC-114: free energy calculation and molecular dynamic simulation.

Journal: Journal of molecular modeling 20100301

Title: Trends in uptake of recently approved antiretrovirals within a national healthcare system.

Journal: HIV medicine 20100301

Title: HIV RNA suppression rates after 24 weeks of treatment with etravirine, darunavir/ritonavir and raltegravir in the etravirine early access programme.

Journal: International journal of STD & AIDS 20100301

Title: Factors predictive of successful darunavir/ritonavir-based therapy in highly antiretroviral-experienced HIV-1-infected patients (the DARWEST study).

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20100301

Title: HIV type 1 antiretroviral resistance mutations in subtypes B, C, and F in the City of São Paulo, Brazil.

Journal: AIDS research and human retroviruses 20100301

Title: Short communication: evaluation of the effect of enfuvirtide in 11 HIV-1 vertically infected pediatric patients outside clinical trials.

Journal: AIDS research and human retroviruses 20100301

Title: FDA notifications. Labeling changed on Prezista.

Journal: AIDS alert 20100301

Title: Expanded postexposure prophylaxis for simultaneous multiple source HIV exposure in a health-care worker.

Journal: International journal of STD & AIDS 20100201

Title: Current drugs in clinical study.

Journal: Project Inform perspective 20100201

Title: The MONET trial: darunavir/ritonavir with or without nucleoside analogues, for patients with HIV RNA below 50 copies/ml.

Journal: AIDS (London, England) 20100116

Title: Analysis of CYP3A4-HIV-1 protease drugs interactions by computational methods for Highly Active Antiretroviral Therapy in HIV/AIDS.

Journal: Journal of molecular graphics & modelling 20100101

Title: Decreased plasma levels of darunavir/ritonavir in a vertically infected pregnant woman carrying multiclass-resistant HIV type-1.

Journal: Antiviral therapy 20100101

Title: Pharmacokinetic interaction between indinavir and darunavir with low-dose ritonavir in healthy volunteers.

Journal: Intervirology 20100101

Title: The effects of a nucleoside-sparing antiretroviral regimen on the pharmacokinetics of ritonavir-boosted darunavir in HIV type-1-infected patients.

Journal: Antiviral therapy 20100101

Title: Treatment simplification to once daily darunavir/ritonavir guided by the darunavir inhibitory quotient in heavily pretreated HIV-infected patients.

Journal: Antiviral therapy 20100101

Title: Darunavir/ritonavir and efavirenz exert differential effects on MRP1 transporter expression and function in healthy volunteers.

Journal: Antiviral therapy 20100101

Title: Use of newer antiretroviral agents, darunavir and etravirine with or without raltegravir, in pregnancy: a report of two cases.

Journal: Antiviral therapy 20100101

Title: The influence of aged garlic extract on the uptake of saquinavir and darunavir into HepG2 cells and rat liver slices.

Journal: Drug metabolism and pharmacokinetics 20100101

Title: Pharmacokinetics of once-daily etravirine without and with once-daily darunavir/ritonavir in antiretroviral-naive HIV type-1-infected adults.

Journal: Antiviral therapy 20100101

Title: Comparative cost-efficacy analysis of darunavir/ritonavir and other ritonavir-boosted protease inhibitors for first-line treatment of HIV-1 infection in the United States.

Journal: HIV clinical trials 20100101

Title: Neuropsychiatric adverse events with ritonavir-boosted darunavir monotherapy in HIV-infected individuals: a randomised prospective study.

Journal: HIV clinical trials 20100101

Title: Boosted protease inhibitor monotherapy. What have we learnt after seven years of research?

Journal: AIDS reviews 20100101

Title: Garlic flavonoids and organosulfur compounds: impact on the hepatic pharmacokinetics of saquinavir and darunavir.

Journal: Drug metabolism and pharmacokinetics 20100101

Title: Impact of the background regimen on virologic response to etravirine: pooled 48-week analysis of DUET-1 and -2.

Journal: HIV clinical trials 20100101

Title: Efficacy and safety of etravirine at week 96 in treatment-experienced HIV type-1-infected patients in the DUET-1 and DUET-2 trials.

Journal: Antiviral therapy 20100101

Title: Virologic and immunologic effectiveness of tipranavir/ritonavir (TPV/r)- versus darunavir/ritonavir (DRV/r)-based regimens in clinical practice.

Journal: Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20100101

Title: In vitro susceptibility and virological outcome to darunavir and lopinavir are independent of HIV type-1 subtype in treatment-naive patients.

Journal: Antiviral therapy 20100101

Title: A review of economic evaluations of darunavir boosted by low-dose ritonavir in treatment-experienced persons living with HIV infection.

Journal: PharmacoEconomics 20100101

Title: Costs to achieve undetectable HIV RNA with darunavir-containing highly active antiretroviral therapy in highly pretreated patients: the POWER experience.

Journal: PharmacoEconomics 20100101

Title: Cost effectiveness of darunavir/ritonavir in highly treatment-experienced, HIV-1-infected adults in the USA.

Journal: PharmacoEconomics 20100101

Title: Cost effectiveness of darunavir/ritonavir 600/100 mg bid in protease inhibitor-experienced, HIV-1-infected adults in Belgium, Italy, Sweden and the UK.

Journal: PharmacoEconomics 20100101

Title: US cost effectiveness of darunavir/ritonavir 600/100 mg bid in treatment-experienced, HIV-infected adults with evidence of protease inhibitor resistance included in the TITAN Trial.

Journal: PharmacoEconomics 20100101

Title: Cost effectiveness of darunavir/ritonavir 600/100 mg bid in treatment-experienced, lopinavir-naive, protease inhibitor-resistant, HIV-infected adults in Belgium, Italy, Sweden and the UK.

Journal: PharmacoEconomics 20100101

Title: Predicting direct costs of HIV care during the first year of darunavir-based highly active antiretroviral therapy using CD4 cell counts: evidence from POWER.

Journal: PharmacoEconomics 20100101

Title: Modelling the budget impact of darunavir in the treatment of highly treatment-experienced, HIV-infected adults in France.

Journal: PharmacoEconomics 20100101

Title: Solid state characterization of the anti-HIV drug TMC114: interconversion of amorphous TMC114, TMC114 ethanolate and hydrate.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20091208

Title: Antiretroviral-induced toxic epidermal necrolysis in a patient positive for human immunodeficiency virus.

Journal: Clinical and experimental dermatology 20091201

Title: Revealing the dimer dissociation and existence of a folded monomer of the mature HIV-2 protease.

Journal: Protein science : a publication of the Protein Society 20091201

Title: [Safety and tolerability of etravirine].

Journal: Enfermedades infecciosas y microbiologia clinica 20091201

Title: Structural basis for the resilience of Darunavir (TMC114) resistance major flap mutations of HIV-1 protease.

Journal: Interdisciplinary sciences, computational life sciences 20091201

Title: Raltegravir, etravirine and r-darunavir combination in adolescents with multidrug-resistant virus.

Journal: AIDS (London, England) 20091113

Title: [Status of anti-HIV drug development and an overview of combined chemotherapy].

Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20091110

Title: Identification of new genotypic cut-off levels to predict the efficacy of lopinavir/ritonavir and darunavir/ritonavir in the TITAN trial.

Journal: HIV medicine 20091101

Title: High rate of virologic suppression with raltegravir plus etravirine and darunavir/ritonavir among treatment-experienced patients infected with multidrug-resistant HIV: results of the ANRS 139 TRIO trial.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20091101

Title: Drugs in traditional drug classes (nucleoside reverse transcriptase inhibitor/nonnucleoside reverse transcriptase inhibitor/protease inhibitors) with activity against drug-resistant virus (tipranavir, darunavir, etravirine).

Journal: Current opinion in HIV and AIDS 20091101

Title: A novel LC-ESI-MS method for the simultaneous determination of etravirine, darunavir and ritonavir in human blood plasma.

Journal: Talanta 20091015

Title: Influence of darunavir coadministration on nevirapine pharmacokinetics in HIV-infected patients: a population approach.

Journal: HIV medicine 20091001

Title: Pharmacokinetics, safety and efficacy of darunavir/ritonavir in treatment-experienced children and adolescents.

Journal: AIDS (London, England) 20090924

Title: Characterization of virologic failure patients on darunavir/ritonavir in treatment-experienced patients.

Journal: AIDS (London, England) 20090910

Title: Efficacy of darunavir despite low plasma trough levels during late pregnancy in an HIV-hepatitis C virus-infected patient.

Journal: AIDS (London, England) 20090910

Title: P-glycoprotein mediates efflux transport of darunavir in human intestinal Caco-2 and ABCB1 gene-transfected renal LLC-PK1 cell lines.

Journal: Biological & pharmaceutical bulletin 20090901

Title: Intracellular 'boosting' of darunavir using known transport inhibitors in primary PBMC.

Journal: British journal of clinical pharmacology 20090901

Title: [Immunorecovery after prolonged HIV-related immunosuppression: opportunities of the new antiretroviral classes].

Journal: Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20090901

Title: Once-daily darunavir/ritonavir vs. lopinavir/ritonavir in treatment-naive, HIV-1-infected patients: 96-week analysis.

Journal: AIDS (London, England) 20090824

Title: Improved bioavailability of darunavir by use of kappa-carrageenan versus microcrystalline cellulose as pelletisation aid.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20090801

Title: Early virologic suppression with three-class experienced patients: 24-week effectiveness in the darunavir outcomes study.

Journal: AIDS (London, England) 20090731

Title: Drug-drug interaction in a kidney transplant recipient receiving HIV salvage therapy and tacrolimus.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20090701

Title: HIV protease inhibitors: recent clinical trials and recommendations on use.

Journal: Expert opinion on pharmacotherapy 20090701

Title: Pharmacokinetic interaction between nevirapine and darunavir with low-dose ritonavir in HIV-1-infected patients.

Journal: British journal of clinical pharmacology 20090701

Title: Interactions of different inhibitors with active-site aspartyl residues of HIV-1 protease and possible relevance to pepsin.

Journal: Proteins 20090515

Title: Effects of ritonavir-boosted darunavir vs. ritonavir-boosted atazanavir on lipid and glucose parameters in HIV-negative, healthy volunteers.

Journal: HIV medicine 20090501

Title: Provider prescribing of 4 antiretroviral agents after implementation of drug use guidelines in the Department of Veterans Affairs.

Journal: Journal of managed care pharmacy : JMCP 20090501

Title: Harnessing nature's insight: design of aspartyl protease inhibitors from treatment of drug-resistant HIV to Alzheimer's disease.

Journal: Journal of medicinal chemistry 20090423

Title: Absorption, metabolism, and excretion of darunavir, a new protease inhibitor, administered alone and with low-dose ritonavir in healthy subjects.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090401

Title: Darunavir concentrations in cerebrospinal fluid and blood in HIV-1-infected individuals.

Journal: AIDS research and human retroviruses 20090401

Title: Predicting drug resistance of the HIV-1 protease using molecular interaction energy components.

Journal: Proteins 20090301

Title: Mutations associated with virological response to darunavir/ritonavir in HIV-1-infected protease inhibitor-experienced patients.

Journal: The Journal of antimicrobial chemotherapy 20090301

Title: Transplacental passage of ritonavir-boosted darunavir in two pregnant women.

Journal: International journal of STD & AIDS 20090301

Title: Prezista fares better than Kaletra in first line therapy.

Journal: Project Inform perspective 20090301

Title: Changes in darunavir/r resistance score after previous failure to tipranavir/r in HIV-1-infected multidrug-resistant patients.

Journal: Journal of acquired immune deficiency syndromes (1999) 20090201

Title: Pharmacologic aspects of new antiretroviral drugs.

Journal: Current HIV/AIDS reports 20090201

Title: Is dual therapy with raltegravir and protease inhibitors a feasible option in rescue strategy in HIV-1 infection?

Journal: Journal of acquired immune deficiency syndromes (1999) 20090201

Title: FDA notifications. FDA OKs new pediatric dosing for darunavir.

Journal: AIDS alert 20090201

Title: The use of darunavir/ritonavir as intensification in low viremic HIV-infected patients treated with boosted protease inhibitor-containing regimens.

Journal: Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20090101

Title: Darunavir: a review of its use in the management of HIV infection in adults.

Journal: Drugs 20090101

Title: Efficacy and safety of darunavir and etravirine in an antiretroviral multi-experienced youth with vertically HIV-1 infection.

Journal: European journal of medical research 20090101

Title: Hypersensitivity reaction to darunavir and desensitization protocol.

Journal: Journal of investigational allergology & clinical immunology 20090101

Title: Efficacy and safety of darunavir/ritonavir in treatment-experienced HIV type-1 patients in the POWER 1, 2 and 3 trials at week 96.

Journal: Antiviral therapy 20090101

Title: [Desensitization to tipranavir caused by toxicodermia].

Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20090101

Title: Influence of baseline protease inhibitor resistance on the efficacy of darunavir/ritonavir or lopinavir/ritonavir in the TITAN trial.

Journal: Journal of acquired immune deficiency syndromes (1999) 20081215

Title: Structural evidence for effectiveness of darunavir and two related antiviral inhibitors against HIV-2 protease.

Journal: Journal of molecular biology 20081205

Title: Safety and efficacy of enfuvirtide in combination with darunavir-ritonavir and an optimized background regimen in treatment-experienced human immunodeficiency virus-infected patients: the below the level of quantification study.

Journal: Antimicrobial agents and chemotherapy 20081201

Title: Use of darunavir and enfuvirtide in a pregnant woman.

Journal: International journal of STD & AIDS 20081201

Title: [Pharmacological and clinical profile of Darnavir (Prezista)].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20081201

Title: FDA approves darunavir.

Journal: AIDS patient care and STDs 20081201

Title: FDA notifications. Darunavir label has these changes.

Journal: AIDS alert 20081201

Title: US FDA expands approval for Johnson & Johnson HIV drug.

Journal: The AIDS reader 20081201

Title: Report from the 2008 joint ICAAC/IDSA meeting. Darunavir and atazanavir: 96-week data from ARTEMIS and CASTLE.

Journal: AIDS clinical care 20081201

Title: Darunavir now approved for use in treatment-naive patients.

Journal: AIDS clinical care 20081201

Title: Switching to darunavir/ritonavir achieves viral suppression in patients with persistent low replication on first-line lopinavir/ritonavir.

Journal: AIDS (London, England) 20081112

Title: Impact of gag mutations on selection of darunavir resistance mutations in HIV-1 protease.

Journal: The Journal of antimicrobial chemotherapy 20081101

Title: Darunavir-etravirine-raltegravir as salvage combination therapy in a heavily pretreated HIV-infected patient.

Journal: AIDS patient care and STDs 20081101

Title: [Role of the new molecules in antiretroviral therapy. Position of raltegravir].

Journal: Enfermedades infecciosas y microbiologia clinica 20081101

Title: Solution kinetics measurements suggest HIV-1 protease has two binding sites for darunavir and amprenavir.

Journal: Journal of medicinal chemistry 20081023

Title: Efficacy of once-daily darunavir/ritonavir 800/100 mg in HIV-infected, treatment-experienced patients with no baseline resistance-associated mutations to darunavir.

Journal: Journal of acquired immune deficiency syndromes (1999) 20081001

Title: Effect of ritonavir-boosted tipranavir or darunavir on the steady-state pharmacokinetics of elvitegravir.

Journal: Journal of acquired immune deficiency syndromes (1999) 20081001

Title: Effect of baseline viral susceptibility on response to darunavir/ritonavir versus control protease inhibitors in treatment-experienced HIV type 1-infected patients: POWER 1 and 2.

Journal: AIDS research and human retroviruses 20081001

Title: [Introduction. Darunavir].

Journal: Enfermedades infecciosas y microbiologia clinica 20081001

Title: [Chemical characteristics, mechanism of action and antiviral activity of darunavir].

Journal: Enfermedades infecciosas y microbiologia clinica 20081001

Title: [Darunavir in treatment-naïve patients. The ARTEMIS study].

Journal: Enfermedades infecciosas y microbiologia clinica 20081001

Title: [Darunavir as first-line therapy. The TITAN study].

Journal: Enfermedades infecciosas y microbiologia clinica 20081001

Title: [Darunavir in patients with advanced HIV and multiresistance. The POWER, DUET and BENCHMRK studies].

Journal: Enfermedades infecciosas y microbiologia clinica 20081001

Title: [Safety and tolerability of darunavir].

Journal: Enfermedades infecciosas y microbiologia clinica 20081001

Title: [Darunavir in HIV/HVC/HVB coinfection].

Journal: Enfermedades infecciosas y microbiologia clinica 20081001

Title: [Pharmacological interactions with darunavir].

Journal: Enfermedades infecciosas y microbiologia clinica 20081001

Title: [Resistance to darunavir].

Journal: Enfermedades infecciosas y microbiologia clinica 20081001

Title: [Position of darunavir in antiretroviral therapy].

Journal: Enfermedades infecciosas y microbiologia clinica 20081001

Title: Pattern and impact of emerging resistance mutations in treatment experienced patients failing darunavir-containing regimen.

Journal: AIDS (London, England) 20080912

Title: New therapeutic agents in the management of HIV: an overview of darunavir for clinicians.

Journal: Sexual health 20080901

Title: Pharmacokinetic interactions between ritonavir-boosted darunavir and NNRTIs: a report of 3 cases.

Journal: The AIDS reader 20080901

Title: Pharmacokinetics of darunavir/ritonavir and ketoconazole following co-administration in HIV-healthy volunteers.

Journal: British journal of clinical pharmacology 20080801

Title: Follow-up of a multi-drug resistant HIV-1 infected patient successfully treated with darunavir and etravirine.

Journal: Journal of medical virology 20080801

Title: Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir.

Journal: Journal of molecular biology 20080801

Title: Efficacy and safety of once-daily darunavir/ritonavir versus lopinavir/ritonavir in treatment-naive HIV-1-infected patients at week 48.

Journal: AIDS (London, England) 20080731

Title: New treatment options for HIV salvage patients: an overview of second generation PIs, NNRTIs, integrase inhibitors and CCR5 antagonists.

Journal: The Journal of infection 20080701

Title: Health Canada links darunavir to serious liver adverse effects.

Journal: The AIDS reader 20080701

Title: Quality control of protease inhibitors.

Journal: Journal of pharmaceutical sciences 20080601

Title: New protease inhibitors and non-nucleoside reverse transcriptase inhibitors.

Journal: Journal of HIV therapy 20080601

Title: Evaluating the potency of HIV-1 protease drugs to combat resistance.

Journal: Proteins 20080515

Title: HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants.

Journal: Journal of the American Chemical Society 20080514

Title: Dog model with implanted pump to test boosters for antiretroviral medication.

Journal: International journal of pharmaceutics 20080501

Title: Development of an implantable infusion pump for sustained anti-HIV drug administration.

Journal: International journal of pharmaceutics 20080501

Title: FDA alerts doctors to Prezista's possible link to liver damage, deaths.

Journal: The AIDS reader 20080501

Title: [Preserving future therapy options. Darunavir--the protease inhibitor for various patient groups].

Journal: MMW Fortschritte der Medizin 20080428

Title: [HIV therapy and adherence].

Journal: MMW Fortschritte der Medizin 20080428

Title: A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells.

Journal: The Journal of biological chemistry 20080411

Title: Inhibition of HIV-2 protease by HIV-1 protease inhibitors in clinical use.

Journal: Chemical biology & drug design 20080401

Title: Liver toxicity warning for darunavir.

Journal: AIDS patient care and STDs 20080401

Title: FDA notifications. New 600 mg tablet strength for darunavir is approved by FDA.

Journal: AIDS alert 20080401

Title: FDA notifications. Tibotec issues Dear Health Care Professional letter.

Journal: AIDS alert 20080401

Title: Evidence for different susceptibility to tipranavir and darunavir in patients infected with distinct HIV-1 subtypes.

Journal: AIDS (London, England) 20080312

Title: Experience with darunavir in HIV-infected adults enrolled in a US expanded access program: results from a single center.

Journal: Current medical research and opinion 20080301

Title: Resistance profile of darunavir: combined 24-week results from the POWER trials.

Journal: AIDS research and human retroviruses 20080301

Title: [New drugs for HIV infection].

Journal: Revue de l'infirmiere 20080301

Title: Different evidence of key amprenavir resistance mutations on the efficacy of darunavir.

Journal: AIDS (London, England) 20080130

Title: [New therapeutic options in protracted HIV-infected patients with virological failure].

Journal: Medicina clinica 20080126

Title: Response to 'key amprenavir resistance mutations counteract dramatic efficacy of darunavir in highly experienced patients'.

Journal: AIDS (London, England) 20080102

Title: Design of HIV protease inhibitors targeting protein backbone: an effective strategy for combating drug resistance.

Journal: Accounts of chemical research 20080101

Title: Darunavir/ritonavir pharmacokinetics following coadministration with clarithromycin in healthy volunteers.

Journal: Journal of clinical pharmacology 20080101

Title: Conformational analysis of TMC114, a novel HIV-1 protease inhibitor.

Journal: Journal of chemical information and modeling 20080101

Title: Darunavir: pharmacokinetics and drug interactions.

Journal: Antiviral therapy 20080101

Title: Warning on hepatotoxicity of darunavir.

Journal: AIDS reviews 20080101

Title: Successful use of a tipranavir/ritonavir-based antiretroviral regimen following development of viral resistance to darunavir.

Journal: HIV clinical trials 20080101

Title: Virological response to darunavir/ritonavir-based regimens in antiretroviral-experienced patients (PREDIZISTA study).

Journal: Antiviral therapy 20080101

Title: Effect of repeated doses of darunavir plus low-dose ritonavir on the pharmacokinetics of sildenafil in healthy male subjects: phase I randomized, open-label, two-way crossover study.

Journal: Clinical drug investigation 20080101

Title: Pharmacokinetic interaction between ethinyl estradiol, norethindrone and darunavir with low-dose ritonavir in healthy women.

Journal: Antiviral therapy 20080101

Title: Resilience to resistance of HIV-1 protease inhibitors: profile of darunavir.

Journal: AIDS reviews 20080101

Title: Successful rescue therapy with a darunavir/ritonavir and etravirine antiretroviral regimen in a child with vertically acquired multidrug-resistant HIV-1.

Journal: Antiviral therapy 20080101

Title: Pharmacokinetics, efficacy, and safety of darunavir/ritonavir 800/100 mg once-daily in treatment-naïve and -experienced patients.

Journal: HIV clinical trials 20080101

Title: Darunavir, a conceptually new HIV-1 protease inhibitor for the treatment of drug-resistant HIV.

Journal: Bioorganic & medicinal chemistry 20071215

Title: Impact of baseline protease genotype and phenotype on the response to darunavir outside clinical trials.

Journal: The Journal of antimicrobial chemotherapy 20071201

Title: Pharmacokinetic interaction between darunavir and saquinavir in HIV-negative volunteers.

Journal: Therapeutic drug monitoring 20071201

Title: HPLC-MS method for the simultaneous quantification of the new HIV protease inhibitor darunavir, and 11 other antiretroviral agents in plasma of HIV-infected patients.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071115

Title: Relative antiviral efficacy should not be inferred from cross-trial comparisons.

Journal: HIV medicine 20071101

Title: Determinants of HIV-1 genotypic resistance to darunavir (TMC114) in a large Italian resistance database (Antiretroviral Resistance Cohort Analysis).

Journal: Journal of acquired immune deficiency syndromes (1999) 20071101

Title: Defining HIV susceptibility to new antiretroviral agents--darunavir.

Journal: The Journal of infectious diseases 20071015

Title: Prevalence of darunavir resistance-associated mutations: patterns of occurrence and association with past treatment.

Journal: The Journal of infectious diseases 20071015

Title: Prevalence of darunavir resistance mutations in HIV-1-infected patients failing other protease inhibitors.

Journal: The Journal of antimicrobial chemotherapy 20071001

Title: Quantification of darunavir (TMC114) in human plasma by high-performance liquid chromatography with ultra-violet detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071001

Title: The validation of plasma darunavir concentrations determined by the HPLC method for protease inhibitors.

Journal: Biological & pharmaceutical bulletin 20071001

Title: Darunavir.

Journal: Drugs of today (Barcelona, Spain : 1998) 20071001

Title: Darunavir phase 3 study data released.

Journal: AIDS patient care and STDs 20071001

Title: Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization.

Journal: The Journal of biological chemistry 20070928

Title: Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease.

Journal: Journal of medicinal chemistry 20070906

Title: Safety and efficacy of darunavir (TMC114) with low-dose ritonavir in treatment-experienced patients: 24-week results of POWER 3.

Journal: Journal of acquired immune deficiency syndromes (1999) 20070901

Title: Lessons Learned From 2 Patients With Multidrug-Resistant HIV-1 Infection Successfully Treated With a Darunavir-Containing Antiretroviral Treatment Regimen.

Journal: Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20070901

Title: Predicting HIV care costs using CD4 counts from clinical trials.

Journal: The American journal of managed care 20070901

Title: Development of therapeutics for AIDS: structure-based molecular targeting.

Journal: Tuberculosis (Edinburgh, Scotland) 20070801

Title: Darunavir: a second-generation protease inhibitor.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070801

Title: Darunavir (TMC114): a new HIV-1 protease inhibitor.

Journal: Expert opinion on pharmacotherapy 20070801

Title: Trial of tipranavir versus darunavir in treatment-experienced patients enrolling.

Journal: AIDS patient care and STDs 20070801

Title: Darunavir: a nonpeptidic antiretroviral protease inhibitor.

Journal: Clinical therapeutics 20070801

Title: Pharmacokinetics and antiretroviral response to darunavir/ritonavir and etravirine combination in patients with high-level viral resistance.

Journal: AIDS (London, England) 20070711

Title: No patient left behind--better treatments for resistant HIV infection.

Journal: Lancet (London, England) 20070707

Title: Efficacy and safety of darunavir-ritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatment-experienced, HIV-infected patients in TITAN: a randomised controlled phase III trial.

Journal: Lancet (London, England) 20070707

Title: Key amprenavir resistance mutations counteract dramatic efficacy of darunavir in highly experienced patients.

Journal: AIDS (London, England) 20070531

Title: Prediction of clinical benefits of ritonavir-boosted TMC114 from treatment effects on CD4 counts and HIV RNA.

Journal: HIV medicine 20070501

Title: Relative antiviral efficacy of ritonavir-boosted darunavir and ritonavir-boosted tipranavir vs. control protease inhibitor in the POWER and RESIST trials.

Journal: HIV medicine 20070501

Title: Tibotec and Aspen collaborate on Prezista.

Journal: AIDS patient care and STDs 20070501

Title: Darunavir: promising initial results.

Journal: Lancet (London, England) 20070407

Title: Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: a pooled subgroup analysis of data from two randomised trials.

Journal: Lancet (London, England) 20070407

Title: The effect of different meal types on the pharmacokinetics of darunavir (TMC114)/ritonavir in HIV-negative healthy volunteers.

Journal: Journal of clinical pharmacology 20070401

Title: When and how to use tipranavir and darunavir.

Journal: The AIDS reader 20070401

Title: Darunavir: an overview of an HIV protease inhibitor developed to overcome drug resistance.

Journal: The AIDS reader 20070301

Title: Editorial comment: impact of darunavir for salvage therapy.

Journal: The AIDS reader 20070301

Title: Prezista gets EU approval.

Journal: AIDS patient care and STDs 20070301

Title: Efficacy and safety of TMC114/ritonavir in treatment-experienced HIV patients: 24-week results of POWER 1.

Journal: AIDS (London, England) 20070219

Title: Darunavir (TMC114) approved by the FDA.

Journal: AIDS alert 20070201

Title: Anti-HIV agents. Darunavir and some antidepressants.

Journal: TreatmentUpdate 20070101

Title: Darunavir offers potent new combo when used with enfuvirtide in ritonavir-boosted regimen.

Journal: HIV clinician 20070101

Title: 48-week study results show DRV's staying power.

Journal: IAPAC monthly 20070101

Title: Pharmacokinetics of darunavir (TMC114) and atazanavir during coadministration in HIV-negative, healthy volunteers.

Journal: Drugs in R&D 20070101

Title: Fast and simultaneous determination of darunavir and eleven other antiretroviral drugs for therapeutic drug monitoring: method development and validation for the determination of all currently approved HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in human plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20070101

Title: Analysis of treatment costs for HIV RNA reductions and CD4 increases for darunavir versus other antiretrovirals in treatment-experienced, HIV-infected patients.

Journal: HIV clinical trials 20070101

Title: Pharmacokinetic interaction between TMC114/r and efavirenz in healthy volunteers.

Journal: Antiviral therapy 20070101

Title: Pharmacokinetics of darunavir/ritonavir and TMC125 alone and coadministered in HIV-negative volunteers.

Journal: Antiviral therapy 20070101

Title: Clinical pharmacokinetics of darunavir.

Journal: Clinical pharmacokinetics 20070101

Title: Safety, tolerability, and efficacy of darunavir (TMC114) with low-dose ritonavir in treatment-experienced, hepatitis B or C co-infected patients in POWER 1 and 3.

Journal: HIV clinical trials 20070101

Title: Anti-HIV agents. Darunavir shows its strength.

Journal: TreatmentUpdate 20070101

Title: Analysis of costs by CD4 count category for the darunavir/r 600/100 mg bid and control protease inhibitor arms of the POWER 1 and 2 trials.

Journal: HIV clinical trials 20070101

Title: Darunavir: in the treatment of HIV-1 infection.

Journal: Drugs 20070101

Title: Darunavir in the treatment of HIV-1 infection: a viewpoint by Mark Holodniy.

Journal: Drugs 20070101

Title: Darunavir in the treatment of HIV-1 infection: a viewpoint by Renslow Sherer.

Journal: Drugs 20070101

Title: Enantioselective synthesis and selective monofunctionalization of (4R,6R)-4,6- dihydroxy-2,8-dioxabicyclo[3.3.0]octane.

Journal: Organic letters 20061207

Title: Screening and selecting for optimized antiretroviral drugs: rising to the challenge of drug resistance.

Journal: Current medical research and opinion 20061201

Title: British HIV Association (BHIVA) guidelines for the treatment of HIV-infected adults with antiretroviral therapy (2006).

Journal: HIV medicine 20061101

Title: XVI International AIDS Conference: Part 2.

Journal: The AIDS reader 20061101

Title: Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114.

Journal: Journal of molecular biology 20061013

Title: TMC114 approved for resistant patients.

Journal: AIDS patient care and STDs 20061001

Title: The latest in antiretroviral therapy.

Journal: Drug news & perspectives 20061001

Title: Darunavir (Prezista) for HIV infection.

Journal: The Medical letter on drugs and therapeutics 20060911

Title: Bis-tetrahydrofuran: a privileged ligand for darunavir and a new generation of hiv protease inhibitors that combat drug resistance.

Journal: ChemMedChem 20060901

Title: Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance.

Journal: Journal of medicinal chemistry 20060824

Title: FDA approval: darunavir.

Journal: AIDS clinical care 20060801

Title: FDA clears HIV drug for patients with resistant virus.

Journal: The AIDS reader 20060801

Title: Successful rescue therapy with darunabir (TMC114) in HIV-infected patients who have failed several ritonavir-boosted protease inhibitors.

Journal: AIDS (London, England) 20060713

Title: Tribulations and trials in HIV disease, Part 2.

Journal: The AIDS reader 20060601

Title: The clinical pharmacology of antiretrovirals in development.

Journal: Expert opinion on drug metabolism & toxicology 20060601

Title: FDA approves new PI.

Journal: IAPAC monthly 20060601

Title: Report from the 13th retrovirus conference. New data on TMC114 and TMC125.

Journal: AIDS clinical care 20060401

Title: Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M.

Journal: Journal of medicinal chemistry 20060223

Title: Prezista (darunavir, TMC-114) approved; may be important treatment advance.

Journal: AIDS treatment news 20060101

Title: New drugs: ranibizumab, posaconazole, and darunavir.

Journal: Journal of the American Pharmacists Association : JAPhA 20060101

Title: Anti-HIV agents. Darunavir shows its strength.

Journal: TreatmentUpdate 20060101

Title: Drug interactions. Interactions with TMC114 and TMC125.

Journal: TreatmentUpdate 20060101

Title: New HIV treatment.

Journal: FDA consumer 20060101

Title: Stereoselective and efficient synthesis of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol.

Journal: Organic letters 20051222

Title: [Protease inhibitors].

Journal: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20051201

Title: Protease inhibitors: the current status.

Journal: Journal of HIV therapy 20051201

Title: Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.

Journal: The FEBS journal 20051001

Title: HIV Pathogenesis and Treatment - Third International AIDS Society Conference.

Journal: IDrugs : the investigational drugs journal 20051001

Title: Meeting notes from the 3rd IAS Conference. New drugs.

Journal: AIDS clinical care 20051001

Title: New drugs.

Journal: HIV medicine 20050701

Title: TMC114/ritonavir substitution for protease inhibitor(s) in a non-suppressive antiretroviral regimen: a 14-day proof-of-principle trial.

Journal: AIDS (London, England) 20050610

Title: TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates.

Journal: Antimicrobial agents and chemotherapy 20050601

Title: New PI may offer hope to triple class patients.

Journal: AIDS patient care and STDs 20050501

Title: [New drugs--hope for salvage patients?].

Journal: MMW Fortschritte der Medizin 20050425

Title: Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor.

Journal: Journal of medicinal chemistry 20050324

Title: Development of a capillary electrophoretic method for the separation of diastereoisomers of a new human immunodeficiency virus protease inhibitor.

Journal: Electrophoresis 20050201

Title: New protease inhibitor TMC-114. Preliminary 24-week late breaker results of the phase II trial.

Journal: Positively aware : the monthly journal of the Test Positive Aware Network 20050101

Title: A lame duck, a dark horse, and a goat.

Journal: GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies 20050101

Title: Anti-HIV agents. TMC114--an overview.

Journal: TreatmentUpdate 20050101

Title: Anti-HIV agents. Interactions with TMC114.

Journal: TreatmentUpdate 20050101

Title: Anti-HIV agents. What the future holds for TMC114.

Journal: TreatmentUpdate 20050101

Title: Stereoselective photochemical 1,3-dioxolane addition to 5-alkoxymethyl-2(5H)-furanone: synthesis of bis-tetrahydrofuranyl ligand for HIV protease inhibitor UIC-94017 (TMC-114).

Journal: The Journal of organic chemistry 20041112

Title: TMC-114 (Tibotec).

Journal: Current opinion in investigational drugs (London, England : 2000) 20040801

Title: High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains.

Journal: Journal of molecular biology 20040423

Title: Strategies for overcoming resistance in HIV-1 infected patients receiving HAART.

Journal: AIDS reviews 20040101

Title: Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro.

Journal: Antimicrobial agents and chemotherapy 20031001

Title: Tie Y, et al. High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains. J Mol Biol. 2004 Apr 23;338(2):341-52.

Title: McKeage K, et al. Darunavir: a review of its use in the management of HIV infection in adults. Drugs. 2009;69(4):477-503.

Title: Bhalekar MR, et al. In-vivo bioavailability and lymphatic uptake evaluation of lipid nanoparticulates of darunavir. Drug Deliv. 2016 Sep;23(7):2581-2586.

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Tags:635728-49-3 Molecular Formula|635728-49-3 MDL|635728-49-3 SMILES|635728-49-3 Darunavir ethanolate