Home Amines 640290-67-1
640290-67-1,MFCD28502109
Catalog No.:AA003AI0

640290-67-1 | 2-Hydroxy-5-[[[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]methyl]amino]benzoic acid

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Price(USD)
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1mg
99%
1 week  
$177.00   $124.00
- +
5mg
99%
1 week  
$447.00   $313.00
- +
10mg
99%
1 week  
$765.00   $535.00
- +
50mg
99%
1 week  
$2,035.00   $1,424.00
- +
100mg
99%
1 week  
$2,987.00   $2,091.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003AI0
Chemical Name:
2-Hydroxy-5-[[[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]methyl]amino]benzoic acid
CAS Number:
640290-67-1
Molecular Formula:
C15H8F7NO3
Molecular Weight:
383.2177
MDL Number:
MFCD28502109
SMILES:
Fc1c(CNc2ccc(c(c2)C(=O)O)O)c(F)c(c(c1F)C(F)(F)F)F
Properties
Computed Properties
 
Complexity:
490  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
4  
XLogP3:
4.4  

Literature

Title: Attenuated effects of Neu2000 on hypoxia-induced synaptic activities in a rat hippocampus.

Journal: Archives of pharmacal research 20140201

Title: Neu2000, an NR2B-selective, moderate NMDA receptor antagonist and potent spin trapping molecule for stroke.

Journal: Drug news & perspectives 20101101

Title: The functional and neuroprotective actions of Neu2000, a dual-acting pharmacological agent, in the treatment of acute spinal cord injury.

Journal: Journal of neurotrauma 20100101

Title: The novel NMDA receptor antagonist, 2-hydroxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-benzylamino)-benzoic acid, is a gating modifier in cultured mouse cortical neurons.

Journal: Journal of neurochemistry 20090601

Title: Marked prevention of ischemic brain injury by Neu2000, an NMDA antagonist and antioxidant derived from aspirin and sulfasalazine.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20070601

Title: Concurrent administration of Neu2000 and lithium produces marked improvement of motor neuron survival, motor function, and mortality in a mouse model of amyotrophic lateral sclerosis.

Journal: Molecular pharmacology 20070401

Title: Gwag BJ, et al. Marked prevention of ischemic brain injury by Neu2000, an NMDA antagonist and antioxidant derived from aspirin and sulfasalazine. J Cereb Blood Flow Metab. 2007 Jun;27(6):1142-51.

Title: Sung IC, et, al. Neu2000, an NR2B-selective, Moderate NMDA Receptor Antagonist and Potent Spin Trapping Molecule for Stroke. Drug News Perspect. 2010 Nov; 23(9): 549-56.

Title: Nishant PV, et, al. Antioxidant Properties of Neu2000 on Mitochondrial Free Radicals and Oxidative Damage. Toxicol In Vitro. 2013 Mar; 27(2): 788-97.

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Tags:640290-67-1 Molecular Formula|640290-67-1 MDL|640290-67-1 SMILES|640290-67-1 2-Hydroxy-5-[[[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]methyl]amino]benzoic acid