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Title: Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice.
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Title: Pharmacokinetics of oltipraz and its major metabolite (RM) in patients with liver fibrosis or cirrhosis: relationship with suppression of circulating TGF-beta1.
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Title: Inactivation of protein tyrosine phosphatases by oltipraz and other cancer chemopreventive 1,2-dithiole-3-thiones.
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Title: Comparison of microscopy and Alamar blue reduction in a larval based assay for schistosome drug screening.
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Title: Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice.
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Title: Radioprotectors and mitigators of radiation-induced normal tissue injury.
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Title: Involvement of pregnane X receptor in the regulation of CYP2B6 gene expression by oltipraz in human hepatocytes.
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Title: Quantitative morphometry of respiratory tract epithelial cells as a tool for testing chemopreventive agent efficacy.
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Title: Antioxidant and mitochondrial protective effects of oxidized metabolites of oltipraz.
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Title: Chemoprevention of cigarette smoke-induced alterations of MicroRNA expression in rat lungs.
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Title: Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene.
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Title: Effects of tert-butylhydroquinone on intestinal inflammatory response and apoptosis following traumatic brain injury in mice.
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Title: Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expression.
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Title: Therapeutic potential of dithiolethiones for hepatic diseases.
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Title: Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect.
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Title: Hydrogen peroxide is a second messenger in phase 2 enzyme induction by cancer chemopreventive dithiolethiones.
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Title: Parasitological and histo-pathological studies on schistosomiasis mansoni infected mice and treated with praziquatel and/or oltipraz.
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Title: Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.
Journal: Toxicology letters 20090710
Title: Oxidized metabolites of oltipraz exert cytoprotective effects against arachidonic acid through AMP-activated protein kinase-dependent cellular antioxidant effect and mitochondrial protection.
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Title: Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones.
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Title: Inhibition of colon carcinogenesis by post-initiation induction of NQO1 in Sprague-Dawley rats.
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Title: Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat.
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Title: Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear factor erythroid 2-related factor 2.
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Title: ANIT-induced intrahepatic cholestasis alters hepatobiliary transporter expression via Nrf2-dependent and independent signaling.
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Title: This month in APR.
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Title: Oltipraz promotion of liver regeneration after partial hepatectomy: The role of PI3-kinase-dependent C/EBPbeta and cyclin E regulation.
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Title: Comparison of citrus coumarins on carcinogen-detoxifying enzymes in Nrf2 knockout mice.
Journal: Toxicology letters 20090328
Title: Chemical genomics of cancer chemopreventive dithiolethiones.
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Title: Pharmacokinetics of oltipraz in diabetic rats with liver cirrhosis.
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Title: Phytochemicals as potential chemopreventive and chemotherapeutic agents in hepatocarcinogenesis.
Journal: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20090201
Title: Role of hepatitis B virus X repression of C/EBPbeta activity in the down-regulation of glutathione S-transferase A2 gene: implications in other phase II detoxifying enzyme expression.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20090201
Title: Inhibition of arachidonic acid and iron-induced mitochondrial dysfunction and apoptosis by oltipraz and novel 1,2-dithiole-3-thione congeners.
Journal: Molecular pharmacology 20090101
Title: Pharmacokinetic interaction between oltipraz and silymarin in rats.
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Title: LAS0811: from combinatorial chemistry to activation of antioxidant response element.
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Title: Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes.
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Title: Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis.
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Title: Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers.
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Title: Dithiolethiones for cancer chemoprevention: where do we stand?
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Title: Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response.
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Title: The Nrf2 activator oltipraz also activates the constitutive androstane receptor.
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Title: A Bayesian approach estimating treatment effects on biomarkers containing zeros with detection limits.
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Title: Abrogation of hyperosmotic impairment of insulin signaling by a novel class of 1,2-dithiole-3-thiones through the inhibition of S6K1 activation.
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Title: Minimal role of hepatic transporters in the hepatoprotection against LCA-induced intrahepatic cholestasis.
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Title: Dietary berries and ellagic acid prevent oxidative DNA damage and modulate expression of DNA repair genes.
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Title: Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice.
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Title: Induction of drug metabolism enzymes and transporters by oltipraz in rats.
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Title: Gender divergent expression of Nqo1 in Sprague Dawley and August Copenhagen x Irish rats.
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Title: Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration.
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Title: Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes.
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Title: Progress curve analysis of CYP1A2 inhibition: a more informative approach to the assessment of mechanism-based inactivation?
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Title: Pharmacokinetic interaction between oltipraz and omeprazole in rats: Competitive inhibition of metabolism of oltipraz by omeprazole via CYP1A1 and 3A2, and of omeprazole by oltipraz via CYP1A1/2, 2D1/2, and 3A1/2.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20071201
Title: Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway.
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Title: Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transport.
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Title: Interactions of the major metabolite of the cancer chemopreventive drug oltipraz with cytochrome c: a novel pathway for cancer chemoprevention.
Journal: Free radical biology & medicine 20071001
Title: Identification of a novel class of dithiolethiones that prevent hepatic insulin resistance via the adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway.
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Title: Keap1 eye on the target: chemoprevention of liver cancer.
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Title: Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines.
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Title: Oltipraz may be useful in the prevention or treatment of Alzheimer's disease.
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Title: Chemopreventive agents alters global gene expression pattern: predicting their mode of action and targets.
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Title: Workgroup report: public health strategies for reducing aflatoxin exposure in developing countries.
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Title: cis-Terpenones as an effective chemopreventive agent against aflatoxin B1-induced cytotoxicity and TCDD-induced P450 1A/B activity in HepG2 cells.
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Title: The induction of CYP1A1 by oltipraz is mediated through calcium-dependent-calpain.
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Title: A general approach for sample size and statistical power calculations assessing of interventions using a mixture model in the presence of detection limits.
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Title: Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes.
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Title: Heme oxygenase-1 as a potential therapeutic target for hepatoprotection.
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Title: Oltipraz chemoprevention trial in Qidong, People's Republic of China: unaltered oxidative biomarkers.
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Title: Inhibition of TGFbeta1-mediated PAI-1 induction by oltipraz through selective interruption of Smad 3 activation.
Journal: Cytokine 20060901
Title: Sample size and statistical power assessing the effect of interventions in the context of mixture distributions with detection limits.
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Title: The chemopreventive efficacy of inhaled oltipraz particulates in the B[a]P-induced A/J mouse lung adenoma model.
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Title: Differential effects of the oxidized metabolites of oltipraz on the activation of CCAAT/enhancer binding protein-beta and NF-E2-related factor-2 for GSTA2 gene induction.
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Title: Pharmacokinetics of oltipraz in mutant Nagase analbuminemic rats.
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Title: Pharmacokinetics and therapeutic effects of oltipraz after consecutive or intermittent oral administration in rats with liver cirrhosis induced by dimethylnitrosamine.
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Title: Pharmacokinetics of oltipraz in rat models of diabetes mellitus induced by alloxan or streptozotocin.
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Title: Early loss of Fhit in the respiratory tract of rodents exposed to environmental cigarette smoke.
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Title: Structure-activity relationships in the induction of Phase II enzymes by derivatives of 3H-1,2-dithiole-3-thione in rats.
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Title: Effect of selenium-containing compounds on hepatic chemoprotective enzymes in mice.
Journal: Toxicology 20060315
Title: The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells.
Journal: The Journal of pharmacology and experimental therapeutics 20060301
Title: Antioxidant agents transiently inhibit aneuploidy progression in Li-Fraumeni cell strains.
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Title: Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole.
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Title: Role of p90 ribosomal S6-kinase-1 in oltipraz-induced specific phosphorylation of CCAAT/enhancer binding protein-beta for GSTA2 gene transactivation.
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Title: Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats.
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Title: Modest induction of phase 2 enzyme activity in the F-344 rat prostate.
Journal: BMC cancer 20060101
Title: Cyanobacterial lipopolysaccharides and human health - a review.
Journal: Environmental health : a global access science source 20060101
Title: Induction of antioxidant genes in the brain as a therapeutic target in bipolar disorder: potential role of oltipraz.
Journal: Medical hypotheses 20060101
Title: Pretreatment of human epidermal keratinocytes with D,L-sulforaphane protects against sulfur mustard cytotoxicity.
Journal: Cutaneous and ocular toxicology 20060101
Title: Modulation of multigene expression and proteome profiles by chemopreventive agents.
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Title: Modulation of apoptosis by cancer chemopreventive agents.
Journal: Mutation research 20051211
Title: Case-control study of an acute aflatoxicosis outbreak, Kenya, 2004.
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Title: Oltipraz-induced phase 2 enzyme response conserved in cells lacking mitochondrial DNA.
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Title: Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists.
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Title: Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
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Title: Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050901
Title: Enhanced CCAAT/enhancer-binding protein beta-liver-enriched inhibitory protein production by Oltipraz, which accompanies CUG repeat-binding protein-1 (CUGBP1) RNA-binding protein activation, leads to inhibition of preadipocyte differentiation.
Journal: Molecular pharmacology 20050901
Title: Induction of phase-1 metabolizing enzymes by oltipraz, flavone and indole-3-carbinol enhance the formation and transport of benzo[a]pyrene sulfate conjugates in intestinal Caco-2 cells.
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Title: Assessing the effect of interventions in the context of mixture distributions with detection limits.
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Title: Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver.
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Title: Effects of cysteine on the pharmacokinetics of oltipraz in rats with protein-calorie malnutrition.
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Title: Nrf2 as a novel molecular target for chemoprevention.
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Title: Glutathione-mediated formation of oxygen free radicals by the major metabolite of oltipraz.
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Title: Hepatic and intestinal first-pass effects of oltipraz in rats.
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Title: Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression.
Journal: Molecular and cellular biology 20050501
Title: Interspecies pharmacokinetic scaling of oltipraz in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics.
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Title: Safety and efficacy of weekly oral oltipraz in chronic smokers.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20050401
Title: Effect of enzyme inducers and inhibitors on the pharmacokinetics of oltipraz in rats.
Journal: The Journal of pharmacy and pharmacology 20050401
Title: Pharmacokinetics of oltipraz after intravenous and oral administration in rats with dehydration for 72 hours.
Journal: Biopharmaceutics & drug disposition 20050301
Title: Cancer chemopreventive oltipraz generates superoxide anion radical.
Journal: Archives of biochemistry and biophysics 20050301
Title: QSAR studies on 1,2-dithiole-3-thiones: modeling of lipophilicity, quinone reductase specific activity, and production of growth hormone.
Journal: Bioorganic & medicinal chemistry letters 20050215
Title: Oltipraz regulates different categories of genes relevant to chemoprevention in human hepatocytes.
Journal: Carcinogenesis 20050201
Title: Oltipraz, 3H-1,2-dithiole-3-thione, and sulforaphane induce overlapping and protective antioxidant responses in murine microglial cells.
Journal: Toxicology letters 20041128
Title: Chemoprevention of hepatocellular carcinoma in aflatoxin endemic areas.
Journal: Gastroenterology 20041101
Title: Dietary induction of NQO1 increases the antitumour activity of mitomycin C in human colon tumours in vivo.
Journal: British journal of cancer 20041018
Title: Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis.
Journal: Cancer research 20040915
Title: Effects of acute renal failure on the pharmacokinetics of oltipraz in rats.
Journal: Journal of pharmaceutical sciences 20040901
Title: Ceramide, an apoptotic rheostat, inhibits CCAAT/enhancer binding protein-beta and NF-E2-related factor-2 activation: the role in glutathione S-transferase A2 gene repression.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040901
Title: NF-kappaB activation by the chemopreventive dithiolethione oltipraz is exerted through stimulation of MEKK3 signaling.
Journal: The Journal of biological chemistry 20040618
Title: Ceramide negatively regulates glutathione S-transferase gene transactivation via repression of hepatic nuclear factor-1 that is degraded by the ubiquitin proteasome system.
Journal: Molecular pharmacology 20040601
Title: Prostate intraepithelial neoplasia in Noble rats, a potential intermediate endpoint for chemoprevention studies.
Journal: European journal of cancer (Oxford, England : 1990) 20040601
Title: Pharmacokinetic changes of oltipraz after intravenous and oral administration to rats with liver cirrhosis induced by dimethylnitrosamine.
Journal: International journal of pharmaceutics 20040504
Title: Oltipraz inhibits inducible nitric oxide synthase in vitro and inhibits nitric oxide production in activated microglial cells.
Journal: Archives of biochemistry and biophysics 20040415
Title: Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: potential mechanisms of action.
Journal: Breast cancer research : BCR 20040101
Title: In vitro effect of low concentrations of oltipraz on the antioxidant defence of mouse hepatocytes and Schistosoma mansoni worms.
Journal: British journal of biomedical science 20040101
Title: Effects of dietary anticarcinogens and nonsteroidal anti-inflammatory drugs on rat gastrointestinal UDP-glucuronosyltransferases.
Journal: Anticancer research 20040101
Title: Pretreatment of human epidermal keratinocytes in vitro with ethacrynic Acid reduces sulfur mustard cytotoxicity.
Journal: Toxicology mechanisms and methods 20040101
Title: Evaluation of the cancer chemopreventive potency of dithiolethione analogs of oltipraz.
Journal: Carcinogenesis 20031201
Title: Oltipraz inhibits 3-methylcholanthrene induction of CYP1A1 by CCAAT/enhancer-binding protein activation.
Journal: The Journal of biological chemistry 20031107
Title: Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20031101
Title: Phase 2 enzyme induction by the major metabolite of oltipraz.
Journal: Chemical research in toxicology 20031101
Title: Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030901
Title: Pharmacokinetic interaction between oltipraz and dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB) after single intravenous and oral administration to rats.
Journal: The Journal of pharmacy and pharmacology 20030901
Title: Oltipraz is a bifunctional inducer activating both phase I and phase II drug-metabolizing enzymes via the xenobiotic responsive element.
Journal: Molecular pharmacology 20030801
Title: Role of the AP-1 element and redox factor-1 (Ref-1) in mediating transcriptional induction of DT-diaphorase gene expression by oltipraz: a target for chemoprevention.
Journal: Biochemical pharmacology 20030701
Title: Induction of NAD(P)H quinone: oxidoreductase1 inhibits carcinogen-induced aberrant crypt foci in colons of Sprague-Dawley rats.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20030601
Title: Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice.
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Journal: Wei sheng yan jiu = Journal of hygiene research 20030301
Title: Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones.
Journal: The Journal of biological chemistry 20030124
Title: Mechanism of rat UDP-glucuronosyltransferase 1A6 induction by oltipraz: evidence for a contribution of the Aryl hydrocarbon receptor pathway.
Journal: Molecular pharmacology 20030101
Title: Essential role of phosphatidylinositol 3-kinase-dependent CCAAT/enhancer binding protein beta activation in the induction of glutathione S-transferase by oltipraz.
Journal: Journal of the National Cancer Institute 20030101
Title: Modulation of cigarette smoke-related end-points in mutagenesis and carcinogenesis.
Journal: Mutation research 20030101
Title: Dietary aflatoxin exposure and chemoprevention of cancer: a clinical review.
Journal: Journal of toxicology. Clinical toxicology 20030101
Title: In vitro evaluation of chemopreventive agents using cultured human prostate epithelial cells.
Journal: Oncology reports 20030101
Title: Thiolytic chemistry of alternative precursors to the major metabolite of the cancer chemopreventive oltipraz.
Journal: The Journal of organic chemistry 20021227
Title: Oltipraz regenerates cirrhotic liver through CCAAT/enhancer binding protein-mediated stellate cell inactivation.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021201
Title: Prevention of liver cancer.
Journal: Current oncology reports 20021101
Title: Protection of retinal pigment epithelial cells from oxidative damage by oltipraz, a cancer chemopreventive agent.
Journal: Investigative ophthalmology & visual science 20021101
Title: The anti-fibrogenic effect of a pharmaceutical composition of [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] (oltipraz) and dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB).
Journal: Archives of pharmacal research 20021001
Title: Inhibition of mitogen-activated protein kinase activity of human lymphocytes after oral administration of Oltipraz.
Journal: Molecular cancer therapeutics 20021001
Title: Strategies for chemoprevention of liver cancer.
Journal: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20020801
Title: Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent.
Journal: The Journal of biological chemistry 20020705
Title: Tissue distribution and chemical induction of multiple drug resistance genes in rats.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020701
Title: Induction of human UDP-glucuronosyltransferase UGT1A1 by flavonoids-structural requirements.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020501
Title: Oltipraz protects the passive smoke induced changes in renal glyoxalase system of rats.
Journal: Molecular and cellular biochemistry 20020401
Title: Glucuronidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyltransferases.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020301
Title: Investigations on the effects of oltipraz on the nucleotide excision repair in the liver.
Journal: Biochemical pharmacology 20020215
Title: Inhibition of dimethylnitrosamine-induced liver fibrosis by [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] (oltipraz) in rats: suppression of transforming growth factor-beta1 and tumor necrosis factor-alpha expression.
Journal: Chemico-biological interactions 20020122
Title: The chemopreventive agent oltipraz possesses potent antiangiogenic activity in vitro, ex vivo, and in vivo and inhibits tumor xenograft growth.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020101
Title: Enhancing effects of oltipraz on the development of spontaneous hepatic lesions in LEC rats.
Journal: Toxicologic pathology 20020101
Title: The drug efflux pump MRP2: regulation of expression in physiopathological situations and by endogenous and exogenous compounds.
Journal: Cell biology and toxicology 20020101
Title: Cell-based studies reveal differences in glutathione S-transferase induction between oltipraz and tert-butylhydroquinone.
Journal: Journal of biochemical and molecular toxicology 20020101
Title: The glutathione system in alkylator resistance.
Journal: Cancer treatment and research 20020101
Title: Regulation of biliary drug efflux pump expression by hormones and xenobiotics.
Journal: Toxicology 20011005
Title: Multiple points of intervention in the prevention of cancer and other mutation-related diseases.
Journal: Mutation research 20010901
Title: Effect of chemopreventive agents on DNA adduction induced by the potent mammary carcinogen dibenzo[a,l]pyrene in the human breast cells MCF-7.
Journal: Mutation research 20010901
Title: Role of phase 2 enzyme induction in chemoprotection by dithiolethiones.
Journal: Mutation research 20010901
Title: A review of cancer chemopreventive agents.
Journal: Current medicinal chemistry 20010901
Title: Kinetic constraints for the thiolysis of 4-methyl-5-(pyrazin-2-yl)-1,2-dithiole-3-thione (oltipraz) and related dithiole-3-thiones in aqueous solution.
Journal: Chemical research in toxicology 20010801
Title: Formation of DNA adducts in the aorta of smoke-exposed rats, and modulation by chemopreventive agents.
Journal: Mutation research 20010725
Title: An alternative promoter contributes to tissue- and inducer-specific expression of the rat UDP-glucuronosyltransferase 1A6 gene.
Journal: Toxicology and applied pharmacology 20010701
Title: Oltipraz chemoprevention trial in Qidong, People's Republic of China: results of urine genotoxicity assays as related to smoking habits.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20010701
Title: Liquid chromatography electrospray-mass spectrometry of urinary aflatoxin biomarkers: characterization and application to dosimetry and chemoprevention in rats.
Journal: Chemical research in toxicology 20010701
Title: In vivo inhibition of human CYP1A2 activity by oltipraz.
Journal: Cancer chemotherapy and pharmacology 20010601
Title: The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.
Journal: Cancer research 20010415
Title: Modulation of biomarkers by chemopreventive agents in smoke-exposed rats.
Journal: Cancer research 20010315
Title: Modulation of apoptosis by cigarette smoke and cancer chemopreventive agents in the respiratory tract of rats.
Journal: Carcinogenesis 20010301
Title: Oltipraz concentrations in plasma, buccal mucosa cells, and lipids: pharmacological studies.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20010301
Title: Phase I/pharmacodynamic study of N-acetylcysteine/oltipraz in smokers: early termination due to excessive toxicity.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20010301
Title: Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione.
Journal: Molecular medicine (Cambridge, Mass.) 20010201
Title: Effects of chemopreventive and antitelomerase agents on the spontaneous immortalization of breast epithelial cells.
Journal: Journal of the National Cancer Institute 20010103
Title: 1,2-dithiole-3-thione and its structural analogue oltipraz are potent inhibitors of dibenz.
Journal: International journal of cancer 20010101
Title: Differential effects of oltipraz on CYP1A and CYP2B in rat lung.
Journal: Carcinogenesis 20010101
Title: Chronic dosing of oltipraz in people at increased risk for colorectal cancer.
Journal: Cancer detection and prevention 20010101
Title: Interindividual differences in response to chemoprotection against aflatoxin-induced hepatocarcinogenesis: implications for human biotransformation enzyme polymorphisms.
Journal: Advances in experimental medicine and biology 20010101
Title: Comparative tissue-specific toxicities of 20 cancer preventive agents using cultured cells from 8 different normal human epithelia.
Journal: In vitro & molecular toxicology 20010101
Title: Determination of a chemopreventive agent, Oltipraz, in rat plasma and urine by high-performance liquid chromatography.
Journal: Research communications in molecular pathology and pharmacology 20010101
Title: Stability, blood partition and protein binding of an antifibrotic agent, oltipraz.
Journal: Research communications in molecular pathology and pharmacology 20010101
Title: Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane.
Journal: Chemical research in toxicology 20000401
Title: Correlation of chemopreventive efficacy data from the human epidermal cell assay with in vivo data.
Journal: Anticancer research 20000101
Title: Role of glutamate 144 and glutamate 164 in the catalytic mechanism of enoyl-CoA hydratase.
Journal: Biochemistry 19990720
Title: Oltipraz, a novel inhibitor of hepatitis B virus transcription through elevation of p53 protein.
Journal: Carcinogenesis 19981201
Title: Increased bioactivation of dihaloalkanes in rat liver due to induction of class theta glutathione S-transferase T1-1.
Journal: The Biochemical journal 19981101
Title: Effects of dietary anticarcinogens on rat gastrointestinal glutathione S-transferase theta 1-1 levels.
Journal: Carcinogenesis 19981101
Title: Oltipraz stimulates the transcription of the manganese superoxide dismutase gene in rat hepatocytes.
Journal: Carcinogenesis 19971101
Title: Mechanism of action of dietary chemoprotective agents in rat liver: induction of phase I and II drug metabolizing enzymes and aflatoxin B1 metabolism.
Journal: Carcinogenesis 19970901
Title: Enhancement of radiation-inducible hepatic glutathione-S-transferases Ya, Yb1, Yb2, Yc1, and Yc2 gene expression by oltipraz: possible role in radioprotection.
Journal: Molecular pharmacology 19970201
Title: Oltipraz-mediated changes in aflatoxin B(1) biotransformation in rat liver: implications for human chemointervention.
Journal: Cancer research 19960515
Title: Inhibition of human immunodeficiency virus type 1 long terminal repeat-driven transcription by an in vivo metabolite of oltipraz: implications for antiretroviral therapy.
Journal: Biochemical and biophysical research communications 19960425
Title: Inactivation of human immunodeficiency virus type 1 reverse transcriptase by oltipraz: evidence for the formation of a stable adduct.
Journal: Archives of biochemistry and biophysics 19951201
Title: Inhibition of human immunodeficiency virus type 1 replication by 7-methyl-6,8-bis(methylthio)pyrrolo[1,2-a]pyrazine, an in vivo metabolite of oltipraz.
Journal: Molecular pharmacology 19950701
Title: Cloning of cDNAs from fetal rat liver encoding glutathione S-transferase Yc polypeptides. The Yc2 subunit is expressed in adult rat liver resistant to the hepatocarcinogen aflatoxin B1.
Journal: The Journal of biological chemistry 19940812
Title: Oltipraz, an inhibitor of human immunodeficiency virus type 1 replication.
Journal: Proceedings of the National Academy of Sciences of the United States of America 19930501
Title: Chemoprotective effects of two dithiolthiones and of butylhydroxyanisole against carbon tetrachloride and acetaminophen toxicity.
Journal: Hepatology (Baltimore, Md.) 19830101
Title: Lee WH, et al. Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect. Mol Cancer Ther. 2009 Oct;8(10):2791-802.
Title: Lv S, et al. Glucagon-induced extracellular cAMP regulates hepatic lipid metabolism. J Endocrinol. 2017 Aug;234(2):73-87.
Title: Ramos-Gomez M, et al. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3410-5.
Title: Eba S, et al.The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice.Am J Respir Cell Mol Biol. 2013 Aug;49(2):324-33.
