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6452-73-9,MFCD00058008
Catalog No.:AA00E8LG

6452-73-9 | OXPRENOLOL HYDROCHLORIDE

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100mg
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250mg
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500mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00E8LG
Chemical Name:
OXPRENOLOL HYDROCHLORIDE
CAS Number:
6452-73-9
Molecular Formula:
C15H24ClNO3
Molecular Weight:
301.8090
MDL Number:
MFCD00058008
SMILES:
C=CCOc1ccccc1OCC(CNC(C)C)O.Cl
Properties
Properties
 
Form:
Solid  
MP:
91-93°C  
Storage:
-20 ℃;Inert atmosphere;  

Computed Properties
 
Complexity:
246  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
9  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Simultaneous and sensitive capillary electrophoretic enantioseparation of three β-blockers with the combination of achiral ionic liquid and dual CD derivatives.

Journal: Talanta 20120130

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: The interactivities with lipid membranes differentially characterize selective and nonselective beta1-blockers.

Journal: European journal of anaesthesiology 20100901

Title: Quantitative determination of propranolol by ultraviolet HPLC in human plasma.

Journal: Toxicology mechanisms and methods 20100301

Title: High frequency controlled capsules with integrated gas producing cells.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20090501

Title: Determination of selected beta-receptor antagonists in biological samples by solid-phase extraction with cholesterolic phase and LC/MS.

Journal: Analytical and bioanalytical chemistry 20090101

Title: Quantitative determination of salbutamol in tablets by multiple-injection capillary zone electrophoresis.

Journal: Journal of chromatography. A 20081017

Title: Principles for different modes of multiple-injection CZE.

Journal: Electrophoresis 20081001

Title: Optimization of 12 chiral analytes with 8 polymeric surfactants.

Journal: Journal of chromatographic science 20081001

Title: Enantiomeric separation by using nano-liquid chromatography with on-column focusing.

Journal: Journal of separation science 20080801

Title: Study on chiral resolution of three beta-blockers by affinity electrokinetic chromatography.

Journal: Talanta 20080315

Title: Drug treatment during pregnancy and isolated orofacial clefts in hungary.

Journal: The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 20070301

Title: High sensitivity analysis of oxprenolol in urine by capillary electrophoresis with C18 packed on-line preconcentrator.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060724

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Changes in butyrylcholinesterase activity and serum lipids after oxprenolol and glibenclamide treatments in non-diabetic rats.

Journal: Arzneimittel-Forschung 20060101

Title: Multivariate optimization approach for chiral resolution of drugs using human serum albumin in affinity electrokinetic chromatography-partial filling technique.

Journal: Electrophoresis 20051101

Title: Chiral separation of oxprenolol by affinity electrokinetic chromatography-partial filling technique using human serum albumin as chiral selector.

Journal: Journal of pharmaceutical and biomedical analysis 20050901

Title: [Medium sized rings from alprenolol and oxprenolol].

Journal: Die Pharmazie 20041001

Title: [Bromometric assay of alprenolol and oxprenolol].

Journal: Die Pharmazie 20040901

Title: Iontophoretic in vivo transdermal delivery of beta-blockers in hairless rats and reduced skin irritation by liposomal formulation.

Journal: Pharmaceutical research 20030901

Title: Oxprenolol-loaded bioadhesive microspheres: preparation and in vitro/in vivo characterization.

Journal: Journal of microencapsulation 20030101

Title: [Toxicologic analysis of some adrenergic-beta blockers in the diagnosis of intoxications].

Journal: Archiwum medycyny sadowej i kryminologii 20030101

Title: Quantitative determination of oxprenolol and timolol in urine by capillary zone electrophoresis.

Journal: Journal of chromatography. A 20020308

Title: Complexation of the antihypertensive drug oxprenolol with copper(II).

Journal: Journal of inorganic biochemistry 20010101

Title: Role of sympathetic nervous system in experimental hypertension and diabetes mellitus.

Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 19990101

Title: Atypical beta-adrenergic receptor in 3T3-F442A adipocytes. Pharmacological and molecular relationship with the human beta 3-adrenergic receptor.

Journal: The Journal of biological chemistry 19911025

Title: Cardioprotection by beta-blockers: molecular and structural aspects in experimental hypertension.

Journal: Drugs under experimental and clinical research 19900101

Title: A nonsteady-state agonist antagonist interaction model using plasma potassium concentrations to quantify the beta-2 selectivity of beta blockers.

Journal: The Journal of pharmacology and experimental therapeutics 19890401

Title: Beta-2-adrenoceptor-mediated hypokalemia and its abolishment by oxprenolol.

Journal: Clinical pharmacology and therapeutics 19871201

Title: Haemodynamic, metabolic, and lymphocyte beta 2-adrenoceptor changes following chronic beta-adrenoceptor antagonism.

Journal: European journal of clinical pharmacology 19870101

Title: Interference by sulphinpyrazone with the antihypertensive effects of oxprenolol.

Journal: European journal of clinical pharmacology 19860101

Title: Predictors of blood pressure increases after withdrawal of antihypertensive therapy.

Journal: Journal of hypertension. Supplement : official journal of the International Society of Hypertension 19851201

Title: Effect of oxprenolol on ventricular arrhythmias: the European Infarction Study experience.

Journal: Journal of the American College of Cardiology 19851101

Title: Cardiovascular risk and risk factors in a randomized trial of treatment based on the beta-blocker oxprenolol: the International Prospective Primary Prevention Study in Hypertension (IPPPSH). The IPPPSH Collaborative Group.

Journal: Journal of hypertension 19850801

Title: Increased plasma vasopressin and serum uric acid in the low renin type of essential hypertension.

Journal: Acta medica Scandinavica 19840101

Title: Leucine-induced hypoglycemia in a family: effect of diphenylhydantoin, oxprenolol, and diazoxide.

Journal: Hormone research 19840101

Title: Clinical responses to oxprenolol in the elderly.

Journal: The American journal of cardiology 19831110

Title: Some functional changes in experimentally induced cardiac overload.

Journal: Acta physiologica et pharmacologica Bulgarica 19830101

Title: Oxprenolol hydrochloride: pharmacology, pharmacokinetics, adverse effects and clinical efficacy.

Journal: Pharmacotherapy 19830101

Title: The acute and chronic effect of oxprenolol and propranolol on peripheral blood flow in hypertensive patients.

Journal: British journal of clinical pharmacology 19821101

Title: Beta-adrenoreceptor antagonists and diplopia.

Journal: Lancet (London, England) 19821009

Title: Interaction between oxprenolol and indomethacin on blood pressure in essential hypertensive patients.

Journal: European journal of clinical pharmacology 19820101

Title: Slow release oxprenolol in angina pectoris: study comparing oxprenolol, once daily, with propranolol, four times daily.

Journal: The American journal of cardiology 19810501

Title: Effect of prazosin and oxprenolol on plasma renin activity and blood pressure in patients with essential hypertension.

Journal: Cardiology 19810101

Title: Atenolol, sustained-release oxprenolol, and long-acting propranolol in hypertension.

Journal: British medical journal 19800628

Title: Comparison of the activity and plasma levels of oxprenolol, slow release oxprenolol, long acting propranolol and sotalol.

Journal: European journal of clinical pharmacology 19800601

Title: Two patients with schizophrenic-like psychosis after treatment with beta-adrenergic blockers.

Journal: British medical journal 19790324

Title: Antiarrhythmic effect of oxprenolol on halothane-epinephrine and coronary ligation induced ventricular arrhythmias in beagle dogs.

Journal: Japanese journal of pharmacology 19780801

Title: Therapy of extrapyramidal side effects, with particular reference to persistent dyskinesia and lithium tremor.

Journal: International pharmacopsychiatry 19780101

Title: [The role of reduction of the heart rate in the favorable effect of the beta blockers on myocardial ischemia due to isoprenalin in patients with angina pectoris].

Journal: Schweizerische medizinische Wochenschrift 19771105

Title: Lack of carcinogenicity of oxprenolol, a beta-adrenergic blocking agent.

Journal: Toxicology and applied pharmacology 19770901

Title: Inappropriate antihypertensive therapy in the elderly.

Journal: Lancet (London, England) 19761218

Title: Effect of beta-blockade during bowling competitions.

Journal: Annals of clinical research 19761201

Title: Severe hypertension produced by interaction of phenylpropanolamine with methyldopa and oxprenolol.

Journal: British medical journal 19760731

Title: Raynaud's phenomenon as side effect of beta-blockers in hypertension.

Journal: British medical journal 19760619

Title: Prevention of isoproterenol-induced cardiac hypertrophy by beta-blocking agents in the rat.

Journal: Acta physiologica Academiae Scientiarum Hungaricae 19760101

Title: Effect of beta receptor blockade on the initiation and perpetuation of ouabain-induced ventricular tachyarrhythmia.

Journal: The Journal of pharmacology and experimental therapeutics 19750501

Title: Influence of oxprenolol on adrenaline-induced reflex bradycardia in dogs.

Journal: Revue canadienne de biologie 19720301

Title: Use of oxprenolol in cardiac arrhythmias associated with acute myocardial ischaemia.

Journal: British medical journal 19710130

Title: T Nagatomo, et al. Binding Characteristics of 3H-dihydroalprenolol to Beta-Adrenoceptors of Rat Heart Treated With Neuraminidase. Jpn J Pharmacol. 1983 Aug;33(4):851-7.

Title: A S Manning, et al. Abrupt Withdrawal of Chronic Beta-Blockade: Adaptive Changes in Cyclic AMP and Contractility. J Mol Cell Cardiol. 1981 Nov;13(11):999-1009.

Title: Modamio P, et al. A comparative in vitro study of percutaneous penetration of β-blockers in human skin. International journal of pharmaceutics, 2000, 194(2): 249-259.

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