Home Other Building Blocks 648449-76-7
648449-76-7,MFCD09265247
Catalog No.:AA006SFW

648449-76-7 | AS-604850

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$7.00   $5.00
- +
5mg
98+%
in stock  
$15.00   $11.00
- +
10mg
98+%
in stock  
$22.00   $15.00
- +
25mg
98+%
in stock  
$35.00   $25.00
- +
50mg
98+%
in stock  
$57.00   $40.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006SFW
Chemical Name:
AS-604850
CAS Number:
648449-76-7
Molecular Formula:
C11H5F2NO4S
Molecular Weight:
285.2235
MDL Number:
MFCD09265247
SMILES:
O=C1NC(=O)/C(=C/c2ccc3c(c2)OC(O3)(F)F)/S1
Properties
Properties
 
Form:
Solid  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
468  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
2.8  

Literature

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Different PI 3-kinase inhibitors have distinct effects on endothelial permeability and leukocyte transmigration.

Journal: The international journal of biochemistry & cell biology 20121101

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Phosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells.

Journal: Journal of hepatology 20101101

Title: Phosphoinositide 3-kinase gamma mediates chemotactic responses of human eosinophils to platelet-activating factor.

Journal: International immunopharmacology 20100901

Title: Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells.

Journal: Blood 20060115

Title: Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

Journal: Nature medicine 20050901

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

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SDS
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