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648903-57-5,MFCD08276916
Catalog No.:AA00ECA1

648903-57-5 | BAY 61-3606 dihydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
1 week  
$118.00   $83.00
- +
2mg
95%
1 week  
$143.00   $100.00
- +
5mg
95%
1 week  
$202.00   $141.00
- +
10mg
95%
1 week  
$283.00   $198.00
- +
25mg
95%
1 week  
$432.00   $303.00
- +
50mg
95%
1 week  
$616.00   $432.00
- +
100mg
95%
1 week  
$872.00   $611.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ECA1
Chemical Name:
BAY 61-3606 dihydrochloride
CAS Number:
648903-57-5
Molecular Formula:
C20H20Cl2N6O3
Molecular Weight:
463.3172
MDL Number:
MFCD08276916
SMILES:
COc1cc(ccc1OC)c1nc(Nc2ncccc2C(=O)N)n2c(c1)ncc2.Cl.Cl
Properties
Computed Properties
 
Complexity:
566  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
6  

Literature

Title: Inhibition of IKKα by BAY61-3606 Reveals IKKα-Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected Cells.

Journal: PloS one 20160101

Title: Jedi-1 and MEGF10 signal engulfment of apoptotic neurons through the tyrosine kinase Syk.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120919

Title: Spleen tyrosine kinase mediates high glucose-induced transforming growth factor-β1 up-regulation in proximal tubular epithelial cells.

Journal: Experimental cell research 20120910

Title: ITAM receptor-mediated generation of reactive oxygen species in human platelets occurs via Syk-dependent and Syk-independent pathways.

Journal: Journal of thrombosis and haemostasis : JTH 20120601

Title: BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner.

Journal: PloS one 20120101

Title: Comparison of the anti-allergic activity of Syk inhibitors with optimized Syk siRNAs in FcepsilonRI-activated RBL-2H3 basophilic cells.

Journal: Cellular immunology 20100101

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218

Title: The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents.

Journal: The Journal of pharmacology and experimental therapeutics 20030901

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