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652-78-8,MFCD00017429
Catalog No.:AA003QQM

652-78-8 | Gossypin

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10mg
≥95%
in stock  
$53.00   $37.00
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50mg
≥95%
in stock  
$140.00   $98.00
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100mg
≥95%
in stock  
$255.00   $178.00
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250mg
≥95%
in stock  
$505.00   $353.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003QQM
Chemical Name:
Gossypin
CAS Number:
652-78-8
Molecular Formula:
C21H20O13
Molecular Weight:
480.3757
MDL Number:
MFCD00017429
SMILES:
OC[C@H]1O[C@@H](Oc2c(O)cc(c3c2oc(c2ccc(c(c2)O)O)c(c3=O)O)O)[C@@H]([C@H]([C@@H]1O)O)O
Properties
Properties
 
Form:
Solid  
MP:
>250°C (dec.)  
Storage:
2-8℃;Inert atmosphere;  

Computed Properties
 
Complexity:
789  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
13  
Hydrogen Bond Donor Count:
9  
Rotatable Bond Count:
4  

Literature

Title: Antidiabetic activity of gossypin, a pentahydroxyflavone glucoside, in streptozotocin-induced experimental diabetes in rats.

Journal: Journal of diabetes 20120301

Title: Gossypin induces G2/M arrest in human malignant glioma U251 cells by the activation of Chk1/Cdc25C pathway.

Journal: Cellular and molecular neurobiology 20120301

Title: Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities.

Journal: Bioorganic & medicinal chemistry letters 20111015

Title: Oral supplementation of gossypin during lead exposure protects alteration in heme synthesis pathway and brain oxidative stress in rats.

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20100501

Title: [Effect of seven kinds of flavonoids on recombinant human protein tyrosine phosphatase].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100501

Title: Evaluation of anti-allergic activity of gossypin and suramin in mast cell-mediated allergy model.

Journal: Indian journal of biochemistry & biophysics 20100401

Title: The flavonoid glycosides, myricitrin, gossypin and naringin exert anxiolytic action in mice.

Journal: Neurochemical research 20091001

Title: Antiinflammatory and antinociceptive activities of gossypin and procumbentin--cyclooxygenase-2 (COX-2) inhibition studies.

Journal: Phytotherapy research : PTR 20090601

Title: Gossypin up-regulates LDL receptor through activation of ERK pathway: a signaling mechanism for the hypocholesterolemic effect.

Journal: Journal of agricultural and food chemistry 20081210

Title: Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis.

Journal: Blood 20070615

Title: Prophylactic effect of gossypin against percutaneously administered sulfur mustard.

Journal: Biomedical and environmental sciences : BES 20070601

Title: Gossypin protects primary cultured rat cortical cells from oxidative stress- and beta-amyloid-induced toxicity.

Journal: Archives of pharmacal research 20040401

Title: Inhibitory activity of flavonoids and tannins against HIV-1 protease.

Journal: Biological & pharmaceutical bulletin 20000901

Title: Application of the electrotopological state index to QSAR analysis of flavone derivatives as HIV-1 integrase inhibitors.

Journal: Pharmaceutical research 19961201

Title: Inhibition of HIV activation in latently infected cells by flavonoid compounds.

Journal: AIDS research and human retroviruses 19960101

Title: Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds.

Journal: Biochemical pharmacology 19940803

Title: Ajaikumar B Kunnumakkara, et al.  Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis. Blood. 2007 Jun 15;109(12):5112-21.

Title: Kanika Patel, et al. Gossypin: A phytochemical of multispectrum potential. the Journal of Coastal Life Medicine.

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