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656820-32-5,MFCD07784513
Catalog No.:AA00FBFC

656820-32-5 | Reversine

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1mg
≥95%
in stock  
$52.00   $36.00
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5mg
≥97%(HPLC)
in stock  
$220.00   $154.00
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10mg
≥97%(HPLC)
in stock  
$266.00   $187.00
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25mg
in stock  
$593.00   $415.00
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50mg
≥97%(HPLC)
in stock  
$640.00   $448.00
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100mg
≥97%(HPLC)
in stock  
$1,107.00   $775.00
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250mg
≥97%(HPLC)
in stock  
$2,422.00   $1,695.00
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1000mg
98% by HPLC
in stock  
$9,618.00   $6,733.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00FBFC
Chemical Name:
Reversine
CAS Number:
656820-32-5
Molecular Formula:
C21H27N7O
Molecular Weight:
393.4854
MDL Number:
MFCD07784513
SMILES:
C1CCC(CC1)Nc1nc(Nc2ccc(cc2)N2CCOCC2)nc2c1nc[nH]2
Properties
Properties
 
BP:
736.4°C at 760 mmHg  
Form:
Solid  
MP:
305℃ (decomposition)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
503  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
XLogP3:
3.9  

Literature

Title: Reversine promotes porcine muscle derived stem cells (PMDSCs) differentiation into female germ-like cells.

Journal: Journal of cellular biochemistry 20121201

Title: The synthetic purine reversine selectively induces cell death of cancer cells.

Journal: Journal of cellular biochemistry 20121001

Title: Preliminary evidence for the dedifferentiation of RAW 264.7 cells into mesenchymal progenitor-like cells by a purine analog.

Journal: Tissue engineering. Part A 20120901

Title: [Research progress of cell dedifferentiation induced by reversine].

Journal: Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery 20120901

Title: Reversine, a 2,6-disubstituted purine, as an anti-cancer agent in differentiated and undifferentiated thyroid cancer cells.

Journal: Pharmaceutical research 20120701

Title: Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20120701

Title: Preferential killing of p53-deficient cancer cells by reversine.

Journal: Cell cycle (Georgetown, Tex.) 20120601

Title: Small molecules that recapitulate the early steps of urodele amphibian limb regeneration and confer multipotency.

Journal: ACS chemical biology 20120420

Title: Characterization of spindle checkpoint kinase Mps1 reveals domain with functional and structural similarities to tetratricopeptide repeat motifs of Bub1 and BubR1 checkpoint kinases.

Journal: The Journal of biological chemistry 20120217

Title: Reversine suppresses oral squamous cell carcinoma via cell cycle arrest and concomitantly apoptosis and autophagy.

Journal: Journal of biomedical science 20120101

Title: Reversin increase the plasticity of bone marrow-derived mesenchymal stem cell for generation of cardiomyocyte in vitro.

Journal: Acta medica Indonesiana 20120101

Title: APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment.

Journal: Nature cell biology 20110918

Title: Novel chemically defined approach to produce multipotent cells from terminally differentiated tissue syncytia.

Journal: ACS chemical biology 20110617

Title: Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis.

Journal: Nature communications 20110501

Title: Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction.

Journal: The EMBO journal 20110420

Title: Cardiogenol C can induce Mouse Hair Bulge Progenitor Cells to Transdifferentiate into Cardiomyocyte-like Cells.

Journal: Proteome science 20110101

Title: Proteomic definitions of mesenchymal stem cells.

Journal: Stem cells international 20110101

Title: Quantitative mass spectrometry analysis reveals similar substrate consensus motif for human Mps1 kinase and Plk1.

Journal: PloS one 20110101

Title: Uncoordinated loss of chromatid cohesion is a common outcome of extended metaphase arrest.

Journal: PloS one 20110101

Title: A simple guide screw method for intracranial xenograft studies in mice.

Journal: Journal of visualized experiments : JoVE 20110101

Title: Reversine increases multipotent human mesenchymal cells differentiation potential.

Journal: Journal of biological regulators and homeostatic agents 20110101

Title: Cell reprogramming: expectations and challenges for chemistry in stem cell biology and regenerative medicine.

Journal: Cell death and differentiation 20100801

Title: Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine.

Journal: The Journal of cell biology 20100712

Title: Reversine enhances generation of progenitor-like cells by dedifferentiation of annulus fibrosus cells.

Journal: Tissue engineering. Part A 20100401

Title: Beneficial effects of reversine on in vitro development of miniature pig somatic cell nuclear transfer embryos.

Journal: The Journal of reproduction and development 20100401

Title: Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity.

Journal: Nature medicine 20100401

Title: Ontology-based meta-analysis of global collections of high-throughput public data.

Journal: PloS one 20100101

Title: Proteomic signature of reversine-treated murine fibroblasts by 2-D difference gel electrophoresis and MS: possible associations with cell signalling networks.

Journal: Electrophoresis 20090601

Title: The Aurora B kinase activity is required for the maintenance of the differentiated state of murine myoblasts.

Journal: Cell death and differentiation 20090201

Title: Reversine increases the plasticity of lineage-committed cells toward neuroectodermal lineage.

Journal: The Journal of biological chemistry 20090130

Title: Proteomic analysis of blastema formation in regenerating axolotl limbs.

Journal: BMC biology 20090101

Title: Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells.

Journal: Molecular cancer therapeutics 20080501

Title: Induction of growth arrest and polycomb gene expression by reversine allows C2C12 cells to be reprogrammed to various differentiated cell types.

Journal: Proteomics 20071201

Title: The 2,6-disubstituted purine reversine induces growth arrest and polyploidy in human cancer cells.

Journal: International journal of oncology 20071201

Title: Reversine stimulates adipocyte differentiation and downregulates Akt and p70(s6k) signaling pathways in 3T3-L1 cells.

Journal: Biochemical and biophysical research communications 20070629

Title: Reversine inhibits spontaneous synaptic transmission in cultured rat hippocampal neurons.

Journal: Cell biology international 20070601

Title: Detection and functional characterization of Pgp1 (ABCB1) and MRP3 (ABCC3) efflux transporters in the PLHC-1 fish hepatoma cell line.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20070330

Title: Reversine-treated fibroblasts acquire myogenic competence in vitro and in regenerating skeletal muscle.

Journal: Cell death and differentiation 20061201

Title: Small molecules driving myotube fission.

Journal: Chemistry & biology 20051001

Title: 'Reversine' and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists.

Journal: Journal of medicinal chemistry 20050728

Title: Small molecules, big plans--can low-molecular-weight compounds control human regeneration?

Journal: Angewandte Chemie (International ed. in English) 20040806

Title: Unraveling the molecular basis for regenerative cellular plasticity.

Journal: PLoS biology 20040801

Title: Stem cells from differentiated cells.

Journal: Molecular interventions 20040401

Title: Dedifferentiation? What's next?

Journal: Molecular interventions 20040401

Title: Dedifferentiation of lineage-committed cells by a small molecule.

Journal: Journal of the American Chemical Society 20040121

Title: D'Alise AM, et al. Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells. Mol Cancer Ther. 2008 May;7(5):1140-9.

Title: Qin HX, et al. Synergistic antitumor activity of reversine combined with aspirin in cervical carcinoma in vitro and in vivo. Cytotechnology. 2013 Aug;65(4):643-53.

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Tags:656820-32-5 Molecular Formula|656820-32-5 MDL|656820-32-5 SMILES|656820-32-5 Reversine