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Title: N-desmethyl-loperamide is selective for P-glycoprotein among three ATP-binding cassette transporters at the blood-brain barrier.
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Title: P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide.
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Title: Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20090501
Title: P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20090101
Title: Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function.
Journal: Journal of medicinal chemistry 20081009
Title: Itraconazole, gemfibrozil and their combination markedly raise the plasma concentrations of loperamide.
Journal: European journal of clinical pharmacology 20060601
Title: Tissue distribution of loperamide and N-desmethylloperamide following a fatal overdose.
Journal: Journal of analytical toxicology 20051001
Title: Identification of an N-methyl-4-phenylpyridinium-like metabolite of the antidiarrheal agent loperamide in human liver microsomes: underlying reason(s) for the lack of neurotoxicity despite the bioactivation event.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040901
