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6640-24-0,MFCD00040732
Catalog No.:AA0033LO

6640-24-0 | 1-(3-chlorophenyl)piperazine

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1g
97%
in stock  
$103.00   $73.00
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5g
97%
in stock  
$311.00   $218.00
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10g
97%
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$560.00   $392.00
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25g
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0033LO
Chemical Name:
1-(3-chlorophenyl)piperazine
CAS Number:
6640-24-0
Molecular Formula:
C10H13ClN2
Molecular Weight:
196.6766
MDL Number:
MFCD00040732
SMILES:
Clc1cccc(c1)N1CCNCC1
NSC Number:
49307
Properties
Properties
 
BP:
336.4 °C at 760 mmHg  
Form:
Solid  
MP:
210-214 °C  
Refractive Index:
1,598-1,600  
Storage:
Room Temperature;  

Computed Properties
 
Complexity:
157  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
1.7  

Literature

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Title: Additive inhibition of human α1β2γ2 GABAA receptors by mixtures of commonly used drugs of abuse.

Journal: Neurotoxicology 20130301

Title: Activation of 5-HT(2C) receptors in the dorsal periaqueductal gray increases antinociception in mice exposed to the elevated plus-maze.

Journal: Behavioural brain research 20121101

Title: Binding of the amphetamine-like 1-phenyl-piperazine to monoamine transporters.

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Title: Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.

Journal: Journal of medicinal chemistry 20120726

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Title: Estradiol increases the anorexia associated with increased 5-HT(2C) receptor activation in ovariectomized rats.

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Title: Mirtazapine antagonises the subjective, hormonal and neuronal effects of m-chlorophenylpiperazine (mCPP) infusion: a pharmacological-challenge fMRI (phMRI) study.

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Title: Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels.

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Title: Chemical profile of meta-chlorophenylpiperazine (m-CPP) in ecstasy tablets by easy ambient sonic-spray ionization, X-ray fluorescence, ion mobility mass spectrometry and NMR.

Journal: Analytical and bioanalytical chemistry 20110701

Title: Hypophagic and hypolocomotive effects of metachloro phenyl piperazine in rats treated with theophylline and caffeine.

Journal: Pakistan journal of pharmaceutical sciences 20110701

Title: The trazodone metabolite meta-chlorophenylpiperazine can cause false-positive urine amphetamine immunoassay results.

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Title: Participation of cyclooxygenase pathway in the vasoconstriction induced by 5-HT in the in situ autoperfused kidney of long-term diabetic rats.

Journal: European journal of pharmacology 20110520

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Journal: Physiology & behavior 20110110

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Journal: Journal of psychopharmacology (Oxford, England) 20101201

Title: Dose proportionality of once-daily trazodone extended-release caplets under fasting conditions.

Journal: Journal of clinical pharmacology 20101201

Title: 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver.

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Title: Blockade of 5-HT2A/2C-type receptors impairs learning in female rats in the course of estrous cycle.

Journal: Bulletin of experimental biology and medicine 20101201

Title: Neuro-psychopharmacogenetics and Neurological Antecedents of Posttraumatic Stress Disorder: Unlocking the Mysteries of Resilience and Vulnerability.

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Title: Constitutive activity of serotonin 2C receptors at G protein-independent signaling: modulation by RNA editing and antidepressants.

Journal: Molecular pharmacology 20101101

Title: Trazodone, meta-chlorophenylpiperazine (an hallucinogenic drug and trazodone metabolite), and the hallucinogen trifluoromethylphenylpiperazine cross-react with the EMIT®II ecstasy immunoassay in urine.

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Title: Hypothalamic orexin and pro-opiomelanocortin activities are essential for the anorexic effects of m-chlorophenylpiperazine in mice.

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Title: Multiple anxiogenic drugs recruit a parvalbumin-containing subpopulation of GABAergic interneurons in the basolateral amygdala.

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Title: 5-HT2C receptor activation prevents stress-induced enhancement of brain 5-HT turnover and extracellular levels in the mouse brain: modulation by chronic paroxetine treatment.

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Title: Analysis of phenylpiperazine-like stimulants in human hair as trimethylsilyl derivatives by gas chromatography-mass spectrometry.

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Title: Detection of 1-benzylpiperazine, 1-(3-trifluoromethylphenyl)-piperazine, and 1-(3-chlorophenyl)-piperazine in 3,4-methylenedioxymethamphetamine-positive urine samples.

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Title: Comprehensive identification of active compounds in tablets by flow-injection data-dependent tandem mass spectrometry combined with library search.

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Title: Acute SSRI-induced anxiogenic and brain metabolic effects are attenuated 6 months after initial MDMA-induced depletion.

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Title: Fluvoxamine exerts anorexic effect in 5-HT2C receptor mutant mice with heterozygous mutation of beta-endorphin gene.

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Journal: Psychopharmacology 20080901

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Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080801

Title: Exercise is associated with reduction in the anxiogenic effect of mCPP on acoustic startle.

Journal: Behavioral neuroscience 20080801

Title: 5-HT(2C) receptor activation is a common mechanism on proerectile effects of apomorphine, oxytocin and melanotan-II in rats.

Journal: European journal of pharmacology 20080728

Title: Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice.

Journal: Biochemical and biophysical research communications 20080718

Title: Behavioral effects of 1-(m-chlorophenyl)piperazine (m-CPP) in a rat model of tardive dyskinesia.

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Title: 5HT2 receptor activation facilitates P2X receptor mediated excitatory neurotransmission to cardiac vagal neurons in the nucleus ambiguus.

Journal: Neuropharmacology 20080601

Title: Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism.

Journal: Gastroenterology 20080601

Title: Acute chlorophenylpiperazine overdose: a case report and review of the literature.

Journal: Therapeutic drug monitoring 20080601

Title: Detection of novel reactive metabolites of trazodone: evidence for CYP2D6-mediated bioactivation of m-chlorophenylpiperazine.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080501

Title: Effects of a Cannabinoid1 receptor antagonist and Serotonin2C receptor agonist alone and in combination on motivation for palatable food: a dose-addition analysis study in mice.

Journal: The Journal of pharmacology and experimental therapeutics 20080501

Title: Behavioral characterization of serotonergic activation in the flatworm Planaria.

Journal: Behavioural pharmacology 20080501

Title: m-CPP induced hypolocomotion does not interfere in the assessment of memory functions in rats.

Journal: Pakistan journal of pharmaceutical sciences 20080401

Title: Inverse agonist and neutral antagonist actions of antidepressants at recombinant and native 5-hydroxytryptamine2C receptors: differential modulation of cell surface expression and signal transduction.

Journal: Molecular pharmacology 20080301

Title: Single-blind and Double-blind Randomized Controlled Trials of Palmtherapy(R), an Alternative Medical Approach, for Anxiety before Cardiac Catheterization.

Journal: Evidence-based complementary and alternative medicine : eCAM 20080301

Title: Investigation of the first deaths in the United Kingdom involving the detection and quantitation of the piperazines BZP and 3-TFMPP.

Journal: Journal of analytical toxicology 20080301

Title: Stereotypic behaviour in the deer mouse: pharmacological validation and relevance for obsessive compulsive disorder.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20080215

Title: 5-HT2 receptor activation in the midbrain periaqueductal grey (PAG) reduces anxiety-like behaviour in mice.

Journal: Behavioural brain research 20080211

Title: Ejaculatory response induced by a 5-HT2 receptor agonist m-CPP in rats: differential roles of 5-HT2 receptor subtypes.

Journal: Pharmacology, biochemistry, and behavior 20080201

Title: Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.

Journal: Journal of medicinal chemistry 20080124

Title: 5-HT(2C) antagonism blocks blood oxygen level-dependent pharmacological-challenge magnetic resonance imaging signal in rat brain areas related to feeding.

Journal: The European journal of neuroscience 20080101

Title: Comparison of electron and chemical ionization modes by validation of a quantitative gas chromatographic-mass spectrometric assay of new generation antidepressants and their active metabolites in plasma.

Journal: Journal of chromatography. A 20071228

Title: An antidepressant that extends lifespan in adult Caenorhabditis elegans.

Journal: Nature 20071122

Title: Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways.

Journal: Cell metabolism 20071107

Title: MDMA-like behavioral effects of N-substituted piperazines in the mouse.

Journal: Pharmacology, biochemistry, and behavior 20071101

Title: Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT2C receptor inactivation induce appetite-suppressing effects in mice via 5-HT1B receptors.

Journal: The international journal of neuropsychopharmacology 20071001

Title: Behavioural effects of rapid intravenous administration of meta-chlorophenylpiperazine (m-CPP) in patients with generalized social anxiety disorder, panic disorder and healthy controls.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20071001

Title: Adrenergic and serotoninergic regulation of myocardial contractility in patients with various morphofunctional changes in the heart resulting from chronic heart failure.

Journal: Bulletin of experimental biology and medicine 20071001

Title: Increase of plasma brain-derived neurotrophic factor levels in two psychotic depressed patients responding to lithium addition to paroxetine treatment.

Journal: Neuropsychiatric disease and treatment 20071001

Title: Stimulation of growth hormone release by 5-hydroxytryptamine (5-HT) in cultured rat anterior pituitary cell aggregates: evidence for mediation by 5-HT2B, 5-HT7, 5-HT1B, and ketanserin-sensitive receptors.

Journal: Endocrinology 20070901

Title: The chronobiology and neurobiology of winter seasonal affective disorder.

Journal: Dialogues in clinical neuroscience 20070901

Title: Proof of a 1-(3-chlorophenyl)piperazine (mCPP) intake: use as adulterant of cocaine resulting in drug-drug interactions?

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070815

Title: Trazodone inhibits T-type calcium channels.

Journal: Neuropharmacology 20070801

Title: Possible involvement of spinal noradrenergic mechanisms in the antiallodynic effect of intrathecally administered 5-HT2C receptor agonists in the rats with peripheral nerve injury.

Journal: European journal of pharmacology 20070712

Title: Amygdala-prefrontal disconnection in borderline personality disorder.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070701

Title: Neurochemical and behavioral effects of m-CPP in a rat model of tardive dyskinesia.

Journal: Pakistan journal of pharmaceutical sciences 20070701

Title: 5-HT2 modulation of AY-9944 induced atypical absence seizures.

Journal: Neuroscience letters 20070511

Title: Identification of an immune-responsive mesolimbocortical serotonergic system: potential role in regulation of emotional behavior.

Journal: Neuroscience 20070511

Title: Novel class of arylpiperazines containing N-acylated amino acids: their synthesis, 5-HT1A, 5-HT2A receptor affinity, and in vivo pharmacological evaluation.

Journal: Bioorganic & medicinal chemistry 20070415

Title: High-throughput quantitation of nefazodone and its metabolites in human plasma by high flow direct-injection LC-MS/MS.

Journal: Journal of pharmaceutical and biomedical analysis 20070411

Title: Role of pregabalin in the treatment of generalized anxiety disorder.

Journal: Neuropsychiatric disease and treatment 20070401

Title: The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain.

Journal: European journal of pharmacology 20070322

Title: Discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a selective, orally active agonist of the 5-HT(2C) receptor.

Journal: Journal of medicinal chemistry 20070322

Title: Anxiogenic-like effects of mCPP microinfusions into the amygdala (but not dorsal or ventral hippocampus) in mice exposed to elevated plus-maze.

Journal: Behavioural brain research 20070312

Title: 5-Hydroxytryptamine2C receptor contribution to m-chlorophenylpiperazine and N-methyl-beta-carboline-3-carboxamide-induced anxiety-like behavior and limbic brain activation.

Journal: The Journal of pharmacology and experimental therapeutics 20070301

Title: Effect of meta-chlorophenylpiperazine and cholecystokinin on food intake of Osborne-Mendel and S5B/P1 rats.

Journal: Obesity (Silver Spring, Md.) 20070301

Title: Selective activation of 5-HT(2C) receptors stimulates GABA-ergic function in the rat substantia nigra pars reticulata: a combined in vivo electrophysiological and neurochemical study.

Journal: Neuroscience 20070223

Title: Influence of diltiazem on the behavior of zolpidem-treated mice in the elevated-plus maze test.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20070201

Title: Amphetamine and mCPP effects on dopamine and serotonin striatal in vivo microdialysates in an animal model of hyperactivity.

Journal: Neurotoxicity research 20070201

Title: 3,4-Methylenedioxymethamphetamine (MDMA) neurotoxicity in rats: a reappraisal of past and present findings.

Journal: Psychopharmacology 20070101

Title: Carbon dioxide inhalation induces dose-dependent and age-related negative affectivity.

Journal: PloS one 20070101

Title: Salicylate-induced tinnitus: molecular mechanisms and modulation by anxiety.

Journal: Progress in brain research 20070101

Title: Anxiolytic activity of a novel potent serotonin 5-HT2C receptor antagonist FR260010: a comparison with diazepam and buspirone.

Journal: European journal of pharmacology 20061228

Title: Hyperphagia alters expression of hypothalamic 5-HT2C and 5-HT1B receptor genes and plasma des-acyl ghrelin levels in Ay mice.

Journal: Endocrinology 20061201

Title: Serotonin dysfunction in pathological gamblers: increased prolactin response to oral m-CPP versus placebo.

Journal: CNS spectrums 20061201

Title: Polymorphism in the serotonin transporter gene and moderators of prolactin response to meta-chlorophenylpiperazine in African-American cocaine abusers and controls.

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Title: [Role of the serotonergic nervous system in anxiety disorders and the anxiolytic mechanism of selective serotonin reuptake inhibitors].

Journal: Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20061101

Title: Role of the 5-HT2C receptor in improving weight-supported stepping in adult rats spinalized as neonates.

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Title: The genetic studies of obsessive-compulsive disorder and its future directions.

Journal: Yonsei medical journal 20060831

Title: Relationship of prolactin response to meta-chlorophenylpiperazine with severity of drug use in cocaine dependence.

Journal: Human psychopharmacology 20060801

Title: Functional magnetic resonance imaging and c-Fos mapping in rats following an anorectic dose of m-chlorophenylpiperazine.

Journal: NeuroImage 20060701

Title: Effects of soybean food pellets on m-CPP-induced anxiety model of mice.

Journal: Biological & pharmaceutical bulletin 20060701

Title: Pharmacological evidence for a functional serotonin-2B receptor in a human uterine smooth muscle cell line.

Journal: The Journal of pharmacology and experimental therapeutics 20060601

Title: Pharmacological characterization of 5-hydroxytryptamine-induced contraction in the chicken gastrointestinal tract.

Journal: Autonomic & autacoid pharmacology 20060401

Title: Pharmacological evaluation of the stress-induced social avoidance model of anxiety.

Journal: Brain research bulletin 20060331

Title: Childhood sexual abuse in relation to neurobiological challenge tests in patients with borderline personality disorder and normal controls.

Journal: Psychiatry research 20060330

Title: A negative feedback system between brain serotonin systems and plasma active ghrelin levels in mice.

Journal: Biochemical and biophysical research communications 20060317

Title: Relationship of disinhibition and aggression to blunted prolactin response to meta-chlorophenylpiperazine in cocaine-dependent patients.

Journal: Psychopharmacology 20060301

Title: Serotonin 1B and 2C receptor interactions in the modulation of feeding behaviour in the mouse.

Journal: Psychopharmacology 20060301

Title: 5-HT2c receptor activation induces grooming behaviour in rats: possible correlations with obsessive-compulsive disorder.

Journal: Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20060301

Title: Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists.

Journal: Bioorganic & medicinal chemistry letters 20060201

Title: Does meta-chlorophenylpiperazine (mCPP) activate human platelets?

Journal: Platelets 20060201

Title: gamma-Aminobutyric acid-serotonin interactions in healthy men: implications for network models of psychosis and dissociation.

Journal: Biological psychiatry 20060115

Title: Medial parabrachial nucleus neurons modulate d-fenfluramine-induced anorexia through 5HT2C receptors.

Journal: Brain research 20060105

Title: Desensitization of 5-HT2A receptor function by chronic administration of selective serotonin reuptake inhibitors.

Journal: Brain research 20060105

Title: Discriminative stimulus effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans trained to discriminate among d-amphetamine, meta-chlorophenylpiperazine and placebo.

Journal: Drug and alcohol dependence 20060104

Title: Effects of mu-CPP and mesulergine on dietary choices in deprived rats: possible mechanisms of their action.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20060101

Title: Pharmacologic analysis of non-synonymous coding h5-HT2A SNPs reveals alterations in atypical antipsychotic and agonist efficacies.

Journal: The pharmacogenomics journal 20060101

Title: The C(-1019)G 5-HT1A promoter polymorphism and personality traits: no evidence for significant association in alcoholic patients.

Journal: Behavioral and brain functions : BBF 20060101

Title: [Metachlorophenylpiperazine (mCPP): a new designer drug].

Journal: Therapie 20060101

Title: Development of a solid phase extraction for 13 'new' generation antidepressants and their active metabolites for gas chromatographic-mass spectrometric analysis.

Journal: Journal of chromatography. A 20051209

Title: Estradiol supplementation modulates neuroendocrine response to M-chlorophenylpiperazine in menstrual status migrainosus triggered by oral contraception-free interval.

Journal: Human reproduction (Oxford, England) 20051201

Title: Selective and nonselective serotonin antagonists block the aversive stimulus properties of MK212 and m-chlorophenylpiperazine (mCPP) in mice.

Journal: Neuropharmacology 20051201

Title: Methylone and mCPP, two new drugs of abuse?

Journal: Addiction biology 20051201

Title: Ethanol substitutes for the discriminative stimulus effects of m-chlorophenylpiperazine.

Journal: Brain research 20051116

Title: m-Chlorophenylpiperazine exacerbates perception of salicylate-induced tinnitus in rats.

Journal: The European journal of neuroscience 20051101

Title: Enhanced 5-HT2C receptor signaling is associated with haloperidol-induced 'early onset' vacuous chewing in rats: implications for antipsychotic drug therapy.

Journal: Psychopharmacology 20051001

Title: Chronic treatment with duloxetine is necessary for an anxiolytic-like response in the mouse zero maze: the role of the serotonin transporter.

Journal: Psychopharmacology 20051001

Title: Effect of 5-hydroxytryptamine on neurogenic vasoconstriction in the isolated, autoperfused hindquarters of the rat.

Journal: Clinical and experimental pharmacology & physiology 20051001

Title: Inhibition of serotonin transporters by cocaine and meprylcaine through 5-TH2C receptor stimulation facilitates their seizure activities.

Journal: Brain research 20050928

Title: Does the panic attack activate the hypothalamic-pituitary-adrenal axis?

Journal: Anais da Academia Brasileira de Ciencias 20050901

Title: The AGNP-TDM Expert Group Consensus Guidelines: focus on therapeutic monitoring of antidepressants.

Journal: Dialogues in clinical neuroscience 20050901

Title: Updated overview of the putative role of the serotoninergic system in obsessive-compulsive disorder.

Journal: Neuropsychiatric disease and treatment 20050901

Title: Association of the promoter polymorphism -1438G/A of the 5-HT2A receptor gene with behavioral impulsiveness and serotonin function in women with bulimia nervosa.

Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20050805

Title: Serotonergic/glutamatergic interactions: potentiation of phencyclidine-induced stimulus control by citalopram.

Journal: Pharmacology, biochemistry, and behavior 20050701

Title: Analgesic therapy in postherpetic neuralgia: a quantitative systematic review.

Journal: PLoS medicine 20050701

Title: Responsiveness of 5-HT(1A) and 5-HT2 receptors in the rat orbitofrontal cortex after long-term serotonin reuptake inhibition.

Journal: Journal of psychiatry & neuroscience : JPN 20050701

Title: Brain angiotensin and anxiety-related behavior: the transgenic rat TGR(ASrAOGEN)680.

Journal: Brain research 20050607

Title: The use of sudden darkness in mice: a behavioural and pharmacological approach.

Journal: Psychopharmacology 20050601

Title: Metabolism of designer drugs of abuse.

Journal: Current drug metabolism 20050601

Title: Endophenotypes in the personality disorders.

Journal: Dialogues in clinical neuroscience 20050601

Title: Effects of 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus on ethanol discrimination in the rat.

Journal: Alcohol (Fayetteville, N.Y.) 20050601

Title: Reinforced spatial alternation as an animal model of obsessive-compulsive disorder (OCD): investigation of 5-HT2C and 5-HT1D receptor involvement in OCD pathophysiology.

Journal: Biological psychiatry 20050515

Title: Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTPgammaS binding.

Journal: Journal of psychopharmacology (Oxford, England) 20050501

Title: Effects of serotonin and serotonergic agonists and antagonists on the production of tumor necrosis factor alpha and interleukin-6.

Journal: Psychiatry research 20050430

Title: Effect of the activation of central 5-HT2C receptors by the 5-HT2C agonist mCPP on blood pressure and heart rate in rats.

Journal: Brain research 20050408

Title: Measurement and characterization of energy intake in the mouse.

Journal: Current protocols in pharmacology 20050401

Title: Agonist diversity in 5-HT(2C) receptor-mediated weight control in rats.

Journal: Psychopharmacology 20050301

Title: m-CPP, a 5-HT2C receptor agonist that modifies the perfusion pressure of the hindquarter vascular bed of anesthetized rat.

Journal: Pharmacology 20050201

Title: Anxiogenic treatments do not increase fear-potentiated startle in mice.

Journal: Biological psychiatry 20050101

Title: Serotonergic 5-HT2C receptors as a potential therapeutic target for the design antiepileptic drugs.

Journal: Current topics in medicinal chemistry 20050101

Title: Serotonergic systems associated with arousal and vigilance behaviors following administration of anxiogenic drugs.

Journal: Neuroscience 20050101

Title: Pharmacological challenge with a serotonin 1D agonist in alcohol dependence.

Journal: BMC psychiatry 20050101

Title: Effects of the 5-HT7 receptor antagonists SB-269970 and DR 4004 in autoshaping Pavlovian/instrumental learning task.

Journal: Behavioural brain research 20041206

Title: Thermogenic effect of YM348, a novel 5-HT2C-receptor agonist, in rats.

Journal: The Journal of pharmacy and pharmacology 20041201

Title: Anxiety-like state associates with taste to produce conditioned taste aversion.

Journal: Biological psychiatry 20041201

Title: Behavioral effects of serotonin and serotonin agonists in two crayfish species, Procambarus clarkii and Orconectes rusticus.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20041201

Title: Behavioral phenotype of pre-proenkephalin-deficient mice on diverse congenic backgrounds.

Journal: Psychopharmacology 20041101

Title: Neuroimaging and 5-HT2C receptor polymorphism: a HMPAO-SPECT study in healthy male probands using mCPP-challenge of the 5-HT2C receptor.

Journal: Pharmacopsychiatry 20041101

Title: Reduced hypophagic effects of d-fenfluramine and the 5-HT2C receptor agonist mCPP in 5-HT1B receptor knockout mice.

Journal: Psychopharmacology 20041001

Title: Behavioural effects of rapid intravenous administration of meta-chlorophenylpiperazine in patients with panic disorder and controls.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20041001

Title: Increased repetitive behaviours and prolactin responsivity to oral m-chlorophenylpiperazine in adults with autism spectrum disorders.

Journal: The international journal of neuropsychopharmacology 20040901

Title: Differential effects of 5-HT1 and 5-HT2 receptor agonists on hindlimb movements in paraplegic mice.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20040901

Title: A 5-HT2C agonist elicits hyperactivity and oral dyskinesia with hypophagia in rabbits.

Journal: Physiology & behavior 20040801

Title: Chronic treatment with fluvoxamine desensitizes 5-HT2C receptor-mediated hypolocomotion in rats.

Journal: Pharmacology, biochemistry, and behavior 20040801

Title: Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20040801

Title: Pharmacokinetics of m-chlorophenylpiperazine after intravenous and oral administration in healthy male volunteers: implication for the pharmacodynamic profile.

Journal: Pharmacopsychiatry 20040701

Title: Vasoconstrictor responses to 5-hydroxytryptamine in the autoperfused hindquarters of spontaneously hypertensive rats.

Journal: Pharmacology 20040601

Title: Serotonin function, personality-trait variations, and childhood abuse in women with bulimia-spectrum eating disorders.

Journal: The Journal of clinical psychiatry 20040601

Title: New arylpiperazine 5-HT(1A) receptor ligands containing the pyrimido[2,1-f]purine fragment: synthesis, in vitro, and in vivo pharmacological evaluation.

Journal: Journal of medicinal chemistry 20040506

Title: Indoline derivatives as 5-HT(2C) receptor agonists.

Journal: Bioorganic & medicinal chemistry letters 20040503

Title: mCPP-induced hyperactivity in 5-HT2C receptor mutant mice is mediated by activation of multiple 5-HT receptor subtypes.

Journal: Neuropharmacology 20040401

Title: Relationship between anorexia and loss of serotonin uptake sites in brain of mice and rats receiving d-norfenfluramine or d-fenfluramine.

Journal: Pharmacology, biochemistry, and behavior 20040301

Title: The application of the principles of clinical drug development to pharmacological challenge tests of the serotonergic system.

Journal: Journal of psychopharmacology (Oxford, England) 20040301

Title: Antiallodynic effects of intrathecally administered 5-HT(2C) receptor agonists in rats with nerve injury.

Journal: Pain 20040301

Title: m-Chlorophenylpiperazine (mCPP) modulates the discriminative stimulus effects of cocaine through actions at the 5-HT2C receptor.

Journal: Behavioral neuroscience 20040201

Title: Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor.

Journal: European journal of pharmacology 20040126

Title: Neurobiological correlates of diagnosis and underlying traits in patients with borderline personality disorder compared with normal controls.

Journal: Psychiatry research 20040101

Title: Modification of human 5-HT(2C) receptor function by Cys23Ser, an abundant, naturally occurring amino-acid substitution.

Journal: Molecular psychiatry 20040101

Title: Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist.

Journal: European journal of pharmacology 20040101

Title: Bulimia nervosa with co-morbid avoidant personality disorder: behavioural characteristics and serotonergic function.

Journal: Psychological medicine 20040101

Title: Serotonergic dissection of obsessive compulsive symptoms: a challenge study with m-chlorophenylpiperazine and sumatriptan.

Journal: Neuropsychobiology 20040101

Title: Serotoninergics attenuate hyperlocomotor activity in rats. Potential new therapeutic strategy for hyperactivity.

Journal: Neurotoxicity research 20040101

Title: Substitution profiles of N-methyl-D-aspartate antagonists in ethanol-discriminating inbred mice.

Journal: Alcohol (Fayetteville, N.Y.) 20040101

Title: 5-HT2C receptors inhibit and 5-HT1A receptors activate the generation of spike-wave discharges in a genetic rat model of absence epilepsy.

Journal: Experimental neurology 20031201

Title: Depression of mGluR-mediated IPSCs by 5-HT in dopamine neurons of the rat substantia nigra pars compacta.

Journal: The European journal of neuroscience 20031101

Title: Implications of compulsive and impulsive traits for serotonin status in women with bulimia nervosa.

Journal: Psychiatry research 20031015

Title: A PET study after treatment with an anxiety-provoking agent, m-chlorophenyl-piperazine, in conscious rhesus monkeys.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20030901

Title: Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy.

Journal: British journal of pharmacology 20030901

Title: Involvement of 5-HT(2) receptor in imipramine-induced hyperglycemia in mice.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20030901

Title: Central 5-HT2B/2C and 5-HT3 receptor stimulation decreases salt intake in sodium-depleted rats.

Journal: Brain research 20030815

Title: Regulation of septo-hippocampal activity by 5-hydroxytryptamine(2C) receptors.

Journal: The Journal of pharmacology and experimental therapeutics 20030801

Title: Discriminative stimulus effects of m-chlorophenylpiperazine as a model of the role of serotonin receptors in anxiety.

Journal: Life sciences 20030801

Title: MDMA exposure alters cognitive and electrophysiological sensitivity to rapid tryptophan depletion in rhesus monkeys.

Journal: Pharmacology, biochemistry, and behavior 20030801

Title: Serotonin in the dorsal periaqueductal gray modulates inhibitory avoidance and one-way escape behaviors in the elevated T-maze.

Journal: European journal of pharmacology 20030725

Title: Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).

Journal: Journal of medicinal chemistry 20030703

Title: Neuroendocrine response to the serotonin agonist M-chlorophenylpiperazine in women with menstrual status migrainosus.

Journal: Neuroendocrinology 20030701

Title: m-CPP-induced self-grooming is mediated by 5-HT2C receptors.

Journal: Behavioural brain research 20030616

Title: Effects of single and repeated electroconvulsive shock on the social and agonistic behaviour of resident rats.

Journal: Neuropharmacology 20030601

Title: Screening for and validated quantification of amphetamines and of amphetamine- and piperazine-derived designer drugs in human blood plasma by gas chromatography/mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20030601

Title: Oral administration of the 5-HT2Creceptor agonist, mCPP, reduces body weight gain in rats over 28 days as a result of maintained hypophagia.

Journal: Psychopharmacology 20030501

Title: Experimental anxiety and antiepileptics: the effects of valproate and vigabatrin in the mirrored chamber test.

Journal: Methods and findings in experimental and clinical pharmacology 20030501

Title: Effects of m-CPP in altering neuronal function: blocking depolarization in invertebrate motor and sensory neurons but exciting rat dorsal horn neurons.

Journal: Brain research 20030418

Title: Serotonin induces tonic firing in layer V pyramidal neurons of rat prefrontal cortex during postnatal development.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030415

Title: Neurogenic dural protein extravasation induced by meta-chlorophenylpiperazine (mCPP) involves nitric oxide and 5-HT2B receptor activation.

Journal: Cephalalgia : an international journal of headache 20030301

Title: Reduced social interaction following 3,4-methylenedioxymethamphetamine is not associated with enhanced 5-HT 2C receptor responsivity.

Journal: Neuropharmacology 20030301

Title: The glycine transporter-1 inhibitors NFPS and Org 24461: a pharmacological study.

Journal: Pharmacology, biochemistry, and behavior 20030301

Title: Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs.

Journal: Biological psychiatry 20030215

Title: Differential regulation of somatodendritic and nerve terminal dopamine release by serotonergic innervation of substantia nigra.

Journal: Journal of neurochemistry 20030201

Title: Effect of repeated administration of dexfenfluramine on feeding and brain Fos in mice.

Journal: Physiology & behavior 20030201

Title: Central serotonergic effects of m-chlorophenylpiperazine (mCPP) among normal control adolescents.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030101

Title: Pharmacological characterization of 5-HT(1B) receptor-mediated inhibition of local excitatory synaptic transmission in the CA1 region of rat hippocampus.

Journal: British journal of pharmacology 20030101

Title: 5-HT1B receptor knockout mice show a compensatory reduction in 5-HT2C receptor function.

Journal: The European journal of neuroscience 20030101

Title: 5-HT2C receptor agonists as potential drugs for the treatment of obesity.

Journal: Current topics in medicinal chemistry 20030101

Title: Piperazine-derived designer drug 1-(3-chlorophenyl)piperazine (mCPP): GC-MS studies on its metabolism and its toxicological detection in rat urine including analytical differentiation from its precursor drugs trazodone and nefazodone.

Journal: Journal of analytical toxicology 20030101

Title: Anxiolytic-like profile of propofol, a general anesthetic, in the plus-maze test in mice.

Journal: Polish journal of pharmacology 20030101

Title: Neuroendocrine response to meta-chlorophenylpiperazine and ipsapirone in relation to anxiety and aggression.

Journal: Psychiatry research 20021215

Title: Synthesis and pharmacological evaluation of new arylpiperazines. 3-[4-[4-(3-chlorophenyl)-1-piperazinyl]butyl]-quinazolidin-4-one - a dual serotonin 5-HT(1A)/5-HT(2A) receptor ligand with an anxiolytic-like activity.

Journal: Bioorganic & medicinal chemistry 20021201

Title: Cognitive performance of MDMA-treated rhesus monkeys: sensitivity to serotonergic challenge.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20021201

Title: Serotonergic dysregulation in bipolar disorders: a literature review of serotonergic challenge studies.

Journal: Bipolar disorders 20021201

Title: Antidepressants reduce phosphoinositide-specific phospholipase C (PI-PLC) activity and the mRNA and protein expression of selective PLC beta 1 isozyme in rat brain.

Journal: Neuropharmacology 20021201

Title: Involvement of 5-HT(2A/2B/2C) receptors on memory formation: simple agonism, antagonism, or inverse agonism?

Journal: Cellular and molecular neurobiology 20021201

Title: Neurogenetics of emotional reactivity to stress in animals.

Journal: Dialogues in clinical neuroscience 20021201

Title: Sleep-wake effects of meta-chlorophenyl piperazine and mianserin in the behaviorally depressed rat.

Journal: European journal of pharmacology 20021122

Title: 2'-NH(2)-MPTP [1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine] depletes serotonin and norepinephrine in rats: a comparison with 2'-CH(3)-MPTP [1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine].

Journal: The Journal of pharmacology and experimental therapeutics 20021101

Title: 5-HT2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus maze.

Journal: Psychopharmacology 20021101

Title: The effects of gender and gonadal steroids on the neuroendocrine and temperature response to m-chlorophenylpiperazine in leuprolide-induced hypogonadism in women and men.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20021101

Title: In vitro identification of metabolic pathways and cytochrome P450 enzymes involved in the metabolism of etoperidone.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20021101

Title: Allelic variants of the serotonin(2C) receptor and neuroendocrinological responses to the serotonin(2C) receptor agonist m-chlorophenylpiperazine in healthy male volunteers.

Journal: Pharmacopsychiatry 20021101

Title: Effects of GABA(A) compounds on mCPP drug discrimination in rats.

Journal: Life sciences 20021018

Title: mCPP-induced hypophagia in rats is unaffected by the profile of dietary unsaturated fatty acids.

Journal: Pharmacology, biochemistry, and behavior 20021001

Title: p-Methylthioamphetamine and 1-(m-chlorophenyl)piperazine, two non-neurotoxic 5-HT releasers in vivo, differ from neurotoxic amphetamine derivatives in their mode of action at 5-HT nerve endings in vitro.

Journal: Journal of neurochemistry 20020901

Title: Are there anxious genes?

Journal: Dialogues in clinical neuroscience 20020901

Title: 5-HT(2C) receptor activation by m-chlorophenylpiperazine detected in humans with fMRI.

Journal: Neuroreport 20020827

Title: Relationship between plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine, and its clinical effect in depressed patients.

Journal: Therapeutic drug monitoring 20020801

Title: Metachlorophenylpiperazine (m-CPP) induced intracavernous pressure responses in anaesthetized rats.

Journal: International journal of impotence research 20020801

Title: The effects of serotonin agonists on the hypothalamic regulation of sexual receptivity in Syrian hamsters.

Journal: Hormones and behavior 20020801

Title: Central administration of mCPP, a serotonin 5-HT(2B/2C) agonist, decreases water intake in rats.

Journal: Pharmacology, biochemistry, and behavior 20020701

Title: Blunted prefrontal cortical 18fluorodeoxyglucose positron emission tomography response to meta-chlorophenylpiperazine in impulsive aggression.

Journal: Archives of general psychiatry 20020701

Title: Therapeutic and adverse actions of serotonin transporter substrates.

Journal: Pharmacology & therapeutics 20020701

Title: Ritanserin antagonism of m-chlorophenylpiperazine effects in neuroleptic-free schizophrenics patients: support for serotonin-2 receptor modulation of schizophrenia symptoms.

Journal: Psychopharmacology 20020601

Title: Treatment of depression associated with the menstrual cycle: premenstrual dysphoria, postpartum depression, and the perimenopause.

Journal: Dialogues in clinical neuroscience 20020601

Title: Gonadal steroids, brain, and behavior: role of context.

Journal: Dialogues in clinical neuroscience 20020601

Title: Ethopharmacological analysis of the unstable elevated exposed plus maze, a novel model of extreme anxiety: predictive validity and sensitivity to anxiogenic agents.

Journal: Psychopharmacology 20020501

Title: Antinociceptive role of 5-HT1A receptors in rat spinal cord.

Journal: British journal of anaesthesia 20020501

Title: Altered prolactin response to M-chlorophenylpiperazine in monkeys previously treated with 3,4-methylenedioxymethamphetamine (MDMA) or fenfluramine.

Journal: Synapse (New York, N.Y.) 20020401

Title: Human CYP3A4 and the metabolism of nefazodone and hydroxynefazodone by human liver microsomes and heterologously expressed enzymes.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20020401

Title: Serotonin 2C receptor agonists and the behavioural satiety sequence in mice.

Journal: Pharmacology, biochemistry, and behavior 20020401

Title: Alteration in 5-hydroxytryptamine agonist-induced behaviour following a corticosterone implant in adult rats.

Journal: Pharmacology, biochemistry, and behavior 20020401

Title: Serotonin releasing agents. Neurochemical, therapeutic and adverse effects.

Journal: Pharmacology, biochemistry, and behavior 20020401

Title: The nature of the acetylcholine and 5-hydroxytryptamine receptors in buccal smooth muscle of the pest slug Deroceras reticulatum.

Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20020401

Title: Role of 5-hT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20020401

Title: The atypical 5-HT2 receptor mediating tachycardia in pithed rats: pharmacological correlation with the 5-HT2A receptor subtype.

Journal: British journal of pharmacology 20020301

Title: Saccadic peak velocity and EEG as end-points for a serotonergic challenge test.

Journal: Human psychopharmacology 20020301

Title: Comparison of the potency of MDL 100,907 and SB 242084 in blocking the serotonin (5-HT)(2) receptor agonist-induced increases in rat serum corticosterone concentrations: evidence for 5-HT(2A) receptor mediation of the HPA axis.

Journal: Neuropharmacology 20020201

Title: Effects of fenfluramine, m-CPP and triazolam on repeated-acquisition in squirrel monkeys before and after neurotoxic MDMA administration.

Journal: Psychopharmacology 20020201

Title: Evaluation of isotryptamine derivatives at 5-HT(2) serotonin receptors.

Journal: Bioorganic & medicinal chemistry letters 20020121

Title: Perturbations of plasma cortisol and DHEA-S following discontinuation of cocaine use in cocaine addicts.

Journal: Psychoneuroendocrinology 20020101

Title: Psychomotor slowing, neuroendocrine responses, and behavioral changes after oral administration of meta-chlorophenylpiperazine in normal volunteers.

Journal: Psychiatry research 20011231

Title: The subjective effects of MDMA and mCPP in moderate MDMA users.

Journal: Drug and alcohol dependence 20011201

Title: The effect of olanzapine treatment on m-chlorophenylpiperazine-induced hormone release in schizophrenia.

Journal: Journal of clinical psychopharmacology 20011201

Title: The 5-HT2C/2B receptor agonist m-chlorophenylpiperazine (mCPP) inhibits 2-deoxy-D-glucose (2-DG)-induced hyperphagia in rats.

Journal: Biological & pharmaceutical bulletin 20011201

Title: Effects of serotonin and serotonin analogs on posture and agonistic behavior in crayfish.

Journal: Journal of comparative physiology. A, Sensory, neural, and behavioral physiology 20011201

Title: Anxiety-like effects induced by acute fluoxetine, sertraline or m-CPP treatment are reversed by pretreatment with the 5-HT2C receptor antagonist SB-242084 but not the 5-HT1A receptor antagonist WAY-100635.

Journal: The international journal of neuropsychopharmacology 20011201

Title: m-CPP hypolocomotion is selectively antagonized by compounds with high affinity for 5-HT(2C) receptors but not 5-HT(2A) or 5-HT(2B) receptors.

Journal: Behavioural pharmacology 20011201

Title: Evaluation of the absorption, excretion and metabolism of [14C] etoperidone in man.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20011101

Title: Altered responsiveness to 5-HT at the crayfish neuromuscular junction due to chronic p-CPA and m-CPP treatment.

Journal: Brain research 20011019

Title: Association of serotonin and cortisol indices with childhood abuse in bulimia nervosa.

Journal: Archives of general psychiatry 20010901

Title: Mapping of brain activation in response to pharmacological agents using fMRI in the rat.

Journal: Magnetic resonance imaging 20010901

Title: Agonist-induced functional desensitization of recombinant human 5-HT2 receptors expressed in CHO-K1 cells.

Journal: Biochemical pharmacology 20010815

Title: Self-destructiveness and serotonin function in bulimia nervosa.

Journal: Psychiatry research 20010805

Title: Pedophilia is accompanied by increased plasma concentrations of catecholamines, in particular epinephrine.

Journal: Psychiatry research 20010805

Title: Tryptophan hydroxylase gene and major psychoses.

Journal: Psychiatry research 20010805

Title: SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety.

Journal: Neuropharmacology 20010801

Title: Altered response to meta-chlorophenylpiperazine in anorexia nervosa: support for a persistent alteration of serotonin activity after short-term weight restoration.

Journal: The International journal of eating disorders 20010701

Title: Effect of a low tryptophan diet on the prolactin responses to the 5-HT2A agonist DOI in the rat.

Journal: Pharmacopsychiatry 20010701

Title: The serotonergic 5-HT(2C) agonist m-chlorophenylpiperazine increases weight-supported locomotion without development of tolerance in rats with spinal transections.

Journal: Experimental neurology 20010601

Title: A neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) to rats results in a long-term defect in thermoregulation.

Journal: Psychopharmacology 20010601

Title: 1-(m-chlorophenyl)piperazine (mCPP) dissociates in vivo serotonin release from long-term serotonin depletion in rat brain.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010501

Title: Dissociation of systemic and hippocampal modulation of rat locomotor activity by 5-HT(2C) receptors.

Journal: Neuroscience research 20010501

Title: Strain-dependent effects of diazepam and the 5-HT2B/2C receptor antagonist SB 206553 in spontaneously hypertensive and Lewis rats tested in the elevated plus-maze.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20010501

Title: Decreased tryptophan availability but normal post-synaptic 5-HT2c receptor sensitivity in chronic fatigue syndrome.

Journal: Psychological medicine 20010501

Title: Effects of genetic polymorphism of CYP1A2 inducibility on the steady-state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine in depressed Japanese patients.

Journal: Pharmacology & toxicology 20010501

Title: Effect of aerobic exercise on behavioral and neuroendocrine responses to meta-chlorophenylpiperazine and to ipsapirone in untrained healthy subjects.

Journal: Psychopharmacology 20010501

Title: Discriminative stimulus properties of indorenate, a 5-HT1A, 5-HT1B and 5-HT2C agonist: a study in rats.

Journal: Journal of psychopharmacology (Oxford, England) 20010301

Title: Neuroendocrine and behavioral responses to mCPP in Obsessive-Compulsive Disorder.

Journal: Psychoneuroendocrinology 20010201

Title: Increased m-CPP-induced oral dyskinesia after lesion of serotonergic neurons.

Journal: Pharmacology, biochemistry, and behavior 20010201

Title: Investigations into migraine pathogenesis: time course for effects of m-CPP, BW723C86 or glyceryl trinitrate on appearance of Fos-like immunoreactivity in rat trigeminal nucleus caudalis (TNC).

Journal: Cephalalgia : an international journal of headache 20010201

Title: Low versus standard dose mCPP challenge in obsessive-compulsive patients.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010101

Title: Lower baseline plasma cortisol and prolactin together with increased body temperature and higher mCPP-induced cortisol responses in men with pedophilia.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010101

Title: Implications of impulsive and affective symptoms for serotonin function in bulimia nervosa.

Journal: Psychological medicine 20010101

Title: Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement.

Journal: Psychopharmacology 20010101

Title: m-Chlorophenylpiperazine excites non-dopaminergic neurons in the rat substantia nigra and ventral tegmental area by activating serotonin-2C receptors.

Journal: Neuroscience 20010101

Title: Inhibition of K(+)-evoked release of rat striatal 5-hydroxytryptamine by an atypical antidepressant: trazodone.

Journal: Neuropsychobiology 20010101

Title: Modulation of 5-HT(2A) receptor-mediated head-twitch behaviour in the rat by 5-HT(2C) receptor agonists.

Journal: Pharmacology, biochemistry, and behavior 20010101

Title: Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications.

Journal: Circulation 20001205

Title: Cloning, expression, and characterization of ferret 5-HT(3) receptor subunit.

Journal: European journal of pharmacology 20000707

Title: Agonist high and low affinity state ratios predict drug intrinsic activity and a revised ternary complex mechanism at serotonin 5-HT(2A) and 5-HT(2C) receptors.

Journal: Synapse (New York, N.Y.) 20000201

Title: Serotonin(2C) receptors appear to mediate genetic sensitivity to cocaine-induced convulsions.

Journal: Psychopharmacology 19991001

Title: Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions.

Journal: Psychopharmacology 19990701

Title: High-affinity agonist binding correlates with efficacy (intrinsic activity) at the human serotonin 5-HT2A and 5-HT2C receptors: evidence favoring the ternary complex and two-state models of agonist action.

Journal: Journal of neurochemistry 19990501

Title: Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, -HT(2B) and 5-HT2C receptors.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19990101

Title: Trazodone is metabolized to m-chlorophenylpiperazine by CYP3A4 from human sources.

Journal: Drug metabolism and disposition: the biological fate of chemicals 19980601

Title: [3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19980101

Title: Effect of fenfluramine challenge on cocaine craving in addicted male users.

Journal: The American journal on addictions 19980101

Title: The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons.

Journal: European journal of pharmacology 19970501

Title: SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist.

Journal: Neuropharmacology 19970101

Title: Bupropion plasma levels and CYP2D6 phenotype.

Journal: Therapeutic drug monitoring 19961001

Title: In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties.

Journal: British journal of pharmacology 19960201

Title: Radiolabelling of the human 5-HT2A receptor with an agonist, a partial agonist and an antagonist: effects on apparent agonist affinities.

Journal: Biochemical pharmacology 19960112

Title: Post-synaptic 5-HT1A receptor involvement in yawning and penile erections induced by apomorphine, physostigmine and mCPP in rats.

Journal: Psychopharmacology 19950801

Title: Trazodone treatment increases plasma prolactin concentrations in depressed patients.

Journal: International clinical psychopharmacology 19950601

Title: Penile erection and yawning induced by 5-HT1C receptor agonists in male rats: relationship with dopaminergic and oxytocinergic transmission.

Journal: European journal of pharmacology 19940811

Title: Central action of glaucine in rodents.

Journal: Acta poloniae pharmaceutica 19940101

Title: Prolonged penile erections induced by hydroxyzine: possible mechanism of action.

Journal: Neuropsychobiology 19940101

Title: d-Fenfluramine- and d-norfenfluramine-induced hypophagia: differential mechanisms and involvement of postsynaptic 5-HT receptors.

Journal: European journal of pharmacology 19930921

Title: Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.

Journal: The Journal of biological chemistry 19930825

Title: Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.

Journal: Molecular pharmacology 19930301

Title: Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.

Journal: Molecular pharmacology 19930301

Title: Trazodone induction of migraine headache through mCPP.

Journal: The American journal of psychiatry 19920501

Title: Basic central pharmacological properties of thiophosphoric acid alkaloid derivatives from Chelidonium majus L.

Journal: Polish journal of pharmacology and pharmacy 19920101

Title: Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.

Journal: Molecular pharmacology 19910801

Title: A pilot placebo-controlled study of chronic m-CPP administration in Alzheimer's disease.

Journal: Biological psychiatry 19910715

Title: Serotonergic responsivity in obsessive-compulsive disorder. Effects of chronic clomipramine treatment.

Journal: Archives of general psychiatry 19880201

Title: Central action of ipsapirone, a new anxiolytic drug, on serotoninergic, noradrenergic and dopaminergic functions.

Journal: Journal of neural transmission 19870101

Title: Central antiserotonergic and antidopaminergic action of pirenperone, a putative 5-HT2 receptor antagonist.

Journal: Polish journal of pharmacology and pharmacy 19850101

Title: 1-m-Chlorophenylpiperazine is an active metabolite common to the psychotropic drugs trazodone, etoperidone and mepiprazole.

Journal: The Journal of pharmacy and pharmacology 19821001

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Tags:6640-24-0 Molecular Formula|6640-24-0 MDL|6640-24-0 SMILES|6640-24-0 1-(3-chlorophenyl)piperazine