Home Other Building Blocks 6665-83-4
6665-83-4,MFCD03840496
Catalog No.:AA003N5X

6665-83-4 | 6-Hydroxyflavone

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1g
>98.0%(HPLC)
in stock  
$55.00   $39.00
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5g
>98.0%(HPLC)
in stock  
$134.00   $94.00
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10g
95%
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$262.00   $184.00
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25g
95%
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$596.00   $417.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003N5X
Chemical Name:
6-Hydroxyflavone
CAS Number:
6665-83-4
Molecular Formula:
C15H10O3
Molecular Weight:
238.2381
MDL Number:
MFCD03840496
SMILES:
Oc1ccc2c(c1)c(=O)cc(o2)c1ccccc1
NSC Number:
26744
Properties
Properties
 
BP:
450.1°C at 760 mmHg  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
355  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
3.6  

Literature

Title: In vitro effects of some flavones on human pyruvate kinase isoenzyme M2.

Journal: Journal of biochemical and molecular toxicology 20150301

Title: Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20150201

Title: A new strategy to rapidly evaluate kinetics of glucuronide efflux by breast cancer resistance protein (BCRP/ABCG2).

Journal: Pharmaceutical research 20121101

Title: Interference of selected flavonoid aglycons in platelet aggregation assays.

Journal: Clinical chemistry and laboratory medicine 20120227

Title: Antioxidant properties of 4-quinolones and structurally related flavones.

Journal: Bioorganic & medicinal chemistry 20120115

Title: Microbial transformations of 7-hydroxyflavanone.

Journal: TheScientificWorldJournal 20120101

Title: Non-covalent interaction of dietary polyphenols with total plasma proteins of type II diabetes: molecular structure/property-affinity relationships.

Journal: Integrative biology : quantitative biosciences from nano to macro 20111101

Title: Noncovalent interaction of dietary polyphenols with common human plasma proteins.

Journal: Journal of agricultural and food chemistry 20111012

Title: Sulfation of selected mono-hydroxyflavones by sulfotransferases in vitro: a species and gender comparison.

Journal: The Journal of pharmacy and pharmacology 20110701

Title: Multivariate QSAR study on the antimutagenic activity of flavonoids against 3-NFA on Salmonella typhimurium TA98.

Journal: European journal of medicinal chemistry 20101001

Title: Integrated ligand and structure based studies of flavonoids as fatty acid biosynthesis inhibitors of Plasmodium falciparum.

Journal: Bioorganic & medicinal chemistry letters 20100815

Title: A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition.

Journal: European journal of medicinal chemistry 20100601

Title: GABA(A) receptor subtype selectivity underlying anxiolytic effect of 6-hydroxyflavone.

Journal: Biochemical pharmacology 20100501

Title: [Effect of seven kinds of flavonoids on recombinant human protein tyrosine phosphatase].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100501

Title: 2-(4-Bromo-phen-yl)-6-methyl-4H-1-benzopyran-4-one (4'-bromo-6-methyl-flavone).

Journal: Acta crystallographica. Section E, Structure reports online 20100401

Title: Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids.

Journal: Bioorganic & medicinal chemistry 20100101

Title: Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay.

Journal: Bioorganic & medicinal chemistry letters 20090815

Title: Mechanism of CYP2C9 inhibition by flavones and flavonols.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090301

Title: Secretion of cortisol and aldosterone as a vulnerable target for adrenal endocrine disruption - screening of 30 selected chemicals in the human H295R cell model.

Journal: Journal of applied toxicology : JAT 20081101

Title: QSAR modeling of the interaction of flavonoids with GABA(A) receptor.

Journal: European journal of medicinal chemistry 20080801

Title: Microbial metabolism part 9. Structure and antioxidant significance of the metabolites of 5,7-dihydroxyflavone (chrysin), and 5- and 6-hydroxyflavones.

Journal: Chemical & pharmaceutical bulletin 20080401

Title: Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2.

Journal: Bioorganic & medicinal chemistry 20071201

Title: [Effects of flavonoids with different structures on proliferation of leukemia cell line HL-60].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20071201

Title: Analysis of flavonoids by CE using capacitively coupled contactless conductivity detection.

Journal: Electrophoresis 20070301

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling 20061101

Title: Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.

Journal: Journal of medicinal chemistry 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.

Journal: Journal of medicinal chemistry 20050908

Title: Flavonoid inhibition of overexpressed human 3beta-hydroxysteroid dehydrogenase type II.

Journal: The Journal of steroid biochemistry and molecular biology 20040201

Title: Relaxant effects of flavonoids in isolated guinea pig trachea and their structure-activity relationships.

Journal: Planta medica 20031201

Title: Insect antifeedant activity of flavones and chromones against Spodoptera litura.

Journal: Journal of agricultural and food chemistry 20030115

Title: Effects of flavonoid phytochemicals on cortisol production and on activities of steroidogenic enzymes in human adrenocortical H295R cells.

Journal: The Journal of steroid biochemistry and molecular biology 20020301

Title: Covalent alteration of the CYP3A4 active site: evidence for multiple substrate binding domains.

Journal: Archives of biochemistry and biophysics 20010701

Title: Structure-activity relationships and molecular modeling analysis of flavonoids binding to the benzodiazepine site of the rat brain GABA(A) receptor complex.

Journal: Journal of medicinal chemistry 19991021

Title: Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases.

Journal: European journal of biochemistry 19900705

Title: Das S, et al. Characterization of non-covalent binding of 6-hydroxyflavone and 5,7-dihydroxyflavone with bovine hemoglobin: Multi-spectroscopic and molecular docking analyses. J Photochem Photobiol B. 2018 Jan;178:40-52.

Title: Lai CH, et al. Effects of 6-Hydroxyflavone on Osteoblast Differentiation in MC3T3-E1 Cells. Evid Based Complement Alternat Med. 2014;2014:924560.

Title: Wang X, et al. 6-Hydroxyflavone and derivatives exhibit potent anti-inflammatory activity among mono-, di- and polyhydroxylated flavones in kidney mesangial cells. PLoS One. 2015 Mar 19;10(3):e0116409.

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