Home Carboxes 66898-62-2
66898-62-2,MFCD00866135
Catalog No.:AA00IMHQ

66898-62-2 | [(1R)-3-oxo-1H-2-benzofuran-1-yl] 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥95%
in stock  
$55.00   $38.00
- +
100mg
95%
in stock  
$67.00   $47.00
- +
250mg
95%
in stock  
$112.00   $78.00
- +
1g
95%
in stock  
$299.00   $209.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00IMHQ
Chemical Name:
[(1R)-3-oxo-1H-2-benzofuran-1-yl] 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylate
CAS Number:
66898-62-2
Molecular Formula:
C21H13F3N2O4
Molecular Weight:
414.3341
MDL Number:
MFCD00866135
SMILES:
O=C(c1cccnc1Nc1cccc(c1)C(F)(F)F)OC1OC(=O)c2c1cccc2
Properties
Properties
 
Form:
Solid  
MP:
164-166°C  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
644  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  
XLogP3:
5.3  

Downstream Synthesis Route

[1]Farmaco,EdizionePratica,1981,vol.36,p.372-385

[2]Patent:US4168313,1979,A

[1]Los,M.;Boned,J.E.;Piccinali,C.[Farmaco,EdizionePratica,1981,vol.36,#5,p.372-385]

[1]Los,M.;Boned,J.E.;Piccinali,C.[Farmaco,EdizionePratica,1981,vol.36,#5,p.372-385]

[1]Los,M.;Boned,J.E.;Piccinali,C.[Farmaco,EdizionePratica,1981,vol.36,#5,p.372-385]

Literature

Title: Contribution of pH to systemic exposure of niflumic acid following oral administration of talniflumate.

Journal: European journal of clinical pharmacology 20110401

Title: Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20091201

Title: Determination of talniflumate and niflumic acid in human plasma by liquid chromatography-tandem mass spectrometry.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20090401

Title: Liquid chromatography-mass spectrometric method for the sensitive determination of niflumic acid in human plasma and its application to pharmacokinetic study of talniflumate tablet.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081215

Title: Effect of food on systemic exposure to niflumic acid following postprandial administration of talniflumate.

Journal: European journal of clinical pharmacology 20081001

Title: Talniflumate increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.

Journal: The Journal of pharmacology and experimental therapeutics 20060401

Title: Quantitation of niflumic acid in human plasma by high-performance liquid chromatography with ultraviolet absorbance detection and its application to a bioequivalence study of talniflumate tablets.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050725

Title: Simultaneous determination of niflumic acid and its prodrug, talniflumate in human plasma by high performance liquid chromatography.

Journal: Biomedical chromatography : BMC 20050101

Title: Talniflumate (Genaera).

Journal: Current opinion in investigational drugs (London, England : 2000) 20040501

Title: Hyun-Ji Kim, et al. Pharmacokinetics of talniflumate, a prodrug of niflumic acid, following oral administration to man. Archives of Pharmacal Research volume 19, Article number: 297 (1996)

Title: Mollereau, et al. Agonist and Antagonist Activities on Human NPFF(2) Receptors of the NPY Ligands GR231118 and BIBP3226. Br J Pharmacol.2001 May;133(1):1-4.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 66898-62-2
Tags:66898-62-2 Molecular Formula|66898-62-2 MDL|66898-62-2 SMILES|66898-62-2 [(1R)-3-oxo-1H-2-benzofuran-1-yl] 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylate