Home Amines 66981-73-5
66981-73-5,MFCD00865376
Catalog No.:AA01CP2C

66981-73-5 | 7-[[(11R)-3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl]amino]heptanoic acid

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5mg
≥98%
in stock  
$147.00   $103.00
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50mg
≥98%
in stock  
$815.00   $570.00
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250mg
≥98%
in stock  
$1,840.00   $1,288.00
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  • Technical Information
  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01CP2C
Chemical Name:
7-[[(11R)-3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl]amino]heptanoic acid
CAS Number:
66981-73-5
Molecular Formula:
C21H25ClN2O4S
Molecular Weight:
436.9522
MDL Number:
MFCD00865376
SMILES:
CN1C2=CC=CC=C2C(C3=C(S1(=O)=O)C=C(C=C3)Cl)NCCCCCCC(=O)O
Properties
Computed Properties
 
Complexity:
654  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
1  
XLogP3:
1.2  

Literature

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Title: A simple transcriptomic signature able to predict drug-induced hepatic steatosis.

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Title: The same antidepressant elicits contrasting patterns of synaptic changes in the amygdala vs hippocampus.

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Title: Anxiety- rather than depression-like behavior is associated with adult neurogenesis in a female mouse model of higher trait anxiety- and comorbid depression-like behavior.

Journal: Translational psychiatry 20121001

Title: In vitro inhibition of mitochondrial respiratory rate by antidepressants.

Journal: Toxicology letters 20120918

Title: Outpatient treatment of children and adolescents with antidepressants in Croatia.

Journal: International journal of psychiatry in clinical practice 20120901

Title: Tianeptine vs amitriptyline for the treatment of irritable bowel syndrome with diarrhea: a multicenter, open-label, non-inferiority, randomized controlled study.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20120901

Title: Sildenafil, a phosphodiesterase type 5 inhibitor, enhances the activity of two atypical antidepressant drugs, mianserin and tianeptine, in the forced swim test in mice.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20120807

Title: The effect of pH on polymorph formation of the pharmaceutically active compound tianeptine.

Journal: International journal of pharmaceutics 20120801

Title: Tianeptine treatment induces antidepressive-like effects and alters BDNF and energy metabolism in the brain of rats.

Journal: Behavioural brain research 20120801

Title: Tianeptine's effects on spontaneous and Ca2+-induced uterine smooth muscle contraction.

Journal: Acta physiologica Hungarica 20120601

Title: Tianeptine: more cases of dependence.

Journal: Prescrire international 20120501

Title: The antinociceptive effects of intravenous tianeptine in colorectal distension-induced visceral pain in rats: the role of 5-HT₃ receptors.

Journal: European journal of pharmacology 20120415

Title: Assessment of abuse of tianeptine from a reimbursement database using 'doctor-shopping' as an indicator.

Journal: Fundamental & clinical pharmacology 20120401

Title: Factors influencing the choice of antidepressants: a study of antidepressant prescribing practice at University Psychiatric Clinic in Belgrade.

Journal: Vojnosanitetski pregled 20120401

Title: Tricyclic antidepressants for autism spectrum disorders (ASD) in children and adolescents.

Journal: The Cochrane database of systematic reviews 20120314

Title: The analgesic activity of intrathecal tianeptine, an atypical antidepressant, in a rat model of inflammatory pain.

Journal: Anesthesia and analgesia 20120301

Title: Usefulness of LDAEP to predict tolerability to SSRIs in major depressive disorder: a case report.

Journal: Psychiatry investigation 20120301

Title: Emotional memory impairments in a genetic rat model of depression: involvement of 5-HT/MEK/Arc signaling in restoration.

Journal: Molecular psychiatry 20120201

Title: Chronic fluoxetine treatment in middle-aged rats induces changes in the expression of plasticity-related molecules and in neurogenesis.

Journal: BMC neuroscience 20120101

Title: Stress leads to contrasting effects on the levels of brain derived neurotrophic factor in the hippocampus and amygdala.

Journal: PloS one 20120101

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Journal: Frontiers in cellular neuroscience 20120101

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Journal: PloS one 20120101

Title: Preclinical and clinical evidence of antioxidant effects of antidepressant agents: implications for the pathophysiology of major depressive disorder.

Journal: Oxidative medicine and cellular longevity 20120101

Title: Tianeptine in combination with monoamine oxidase inhibitors for major depressive disorder.

Journal: BMJ case reports 20120101

Title: Tianeptine reverses stress-induced asymmetrical hippocampal volume and N-acetylaspartate loss in rats: an in vivo study.

Journal: Psychiatry research 20111230

Title: Tianeptine potentiates AMPA receptors by activating CaMKII and PKA via the p38, p42/44 MAPK and JNK pathways.

Journal: Neurochemistry international 20111201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

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Journal: The Journal of clinical psychiatry 20111201

Title: Neurotrophins role in depression neurobiology: a review of basic and clinical evidence.

Journal: Current neuropharmacology 20111201

Title: cGMP Signaling, Phosphodiesterases and Major Depressive Disorder.

Journal: Current neuropharmacology 20111201

Title: The protective effect of tianeptine on Gp120-induced apoptosis in astroglial cells: role of GS and NOS, and NF-κB suppression.

Journal: British journal of pharmacology 20111101

Title: Epidemiological characterization of drug overconsumption: the example of antidepressants.

Journal: Journal of addictive diseases 20111001

Title: [Depressive disorder, treatment and sexual dysfunction--part II].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20111001

Title: Effect of tianeptine on cognitive functions in patients with depressive disorders during a 3-month observation.

Journal: Psychiatria Danubina 20110901

Title: Tianeptine in the combined treatment of combat related posttraumatic stress disorder.

Journal: Psychiatria Danubina 20110901

Title: Antidepressant prescribing patterns in Korea: results from the clinical research center for depression study.

Journal: Psychiatry investigation 20110901

Title: Absence of psychostimulant effects of a supratherapeutic dose of tianeptine: a placebo-controlled study versus methylphenidate in young healthy volunteers.

Journal: Journal of clinical psychopharmacology 20110801

Title: [Evaluation of the influence of tianeptine on the psychosomatic status of patients with ulcerative colitis in remission].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20110801

Title: Collapsin response mediator protein-2: an emerging pathologic feature and therapeutic target for neurodisease indications.

Journal: Molecular neurobiology 20110601

Title: Effects of tryptophan depletion and tryptophan loading on the affective response to high-dose CO2 challenge in healthy volunteers.

Journal: Psychopharmacology 20110601

Title: Baseline lipid levels and acute treatment response to paroxetine and tianeptine in depressed women.

Journal: Journal of clinical psychopharmacology 20110601

Title: Biomarkers in development of psychotropic drugs.

Journal: Dialogues in clinical neuroscience 20110601

Title: Fluoxetine Up-Regulates Bcl-xL Expression in Rat C6 Glioma Cells.

Journal: Psychiatry investigation 20110601

Title: Efficacy of antidepressants for dysthymia: a meta-analysis of placebo-controlled randomized trials.

Journal: The Journal of clinical psychiatry 20110401

Title: Importance of neuroplasticity changes in mood disorder.

Journal: The Journal of the American Osteopathic Association 20110401

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Journal: Indian journal of pharmacology 20110401

Title: Duloxetine-related panic attacks.

Journal: Psychiatria Danubina 20110301

Title: Tablet potency of Tianeptine in coated tablets by near infrared spectroscopy: model optimisation, calibration transfer and confidence intervals.

Journal: Journal of pharmaceutical and biomedical analysis 20110220

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Journal: PloS one 20110101

Title: NMDA and AMPA receptors are involved in the antidepressant-like activity of tianeptine in the forced swim test in mice.

Journal: Pharmacological reports : PR 20110101

Title: Neurosteroids reduce social isolation-induced behavioral deficits: a proposed link with neurosteroid-mediated upregulation of BDNF expression.

Journal: Frontiers in endocrinology 20110101

Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201

Title: Amitriptyline and tianeptine poisoning treated by naloxone.

Journal: Human & experimental toxicology 20100901

Title: Formulation of a novel tianeptine sodium orodispersible film.

Journal: AAPS PharmSciTech 20100901

Title: Tianeptine reduces morphine antinociceptive tolerance and physical dependence.

Journal: Behavioural pharmacology 20100901

Title: Acute effects of serotonergic antidepressants on tryptophan metabolism and corticosterone levels in rats.

Journal: Pakistan journal of pharmaceutical sciences 20100701

Title: Computational analysis of the impact of chronic stress on intrinsic and synaptic excitability in the hippocampus.

Journal: Journal of neurophysiology 20100601

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Title: The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation.

Journal: Molecular psychiatry 20100301

Title: Tianeptine may be a therapeutic option for Tourette's syndrome.

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Title: [Effects of amitriptyline, fluoxetine, and tianeptine on the content of monoamines and their metabolites in Wistar rat brain structures].

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Title: Neurotrophic effects of tianeptine on hippocampal neurons: a proteomic approach.

Journal: Journal of proteome research 20100205

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Journal: Molecular psychiatry 20100101

Title: Interaction of the human plasma membrane monoamine transporter (hPMAT) with antidepressants and antipsychotics.

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Title: Antidepressants are a rational complementary therapy for the treatment of Alzheimer's disease.

Journal: Molecular neurodegeneration 20100101

Title: Effect of venlafaxine on bone loss associated with ligature-induced periodontitis in Wistar rats.

Journal: Journal of negative results in biomedicine 20100101

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Title: Neural pathways in allergic inflammation.

Journal: Journal of allergy 20100101

Title: [Affective disorders in acute myocardial infarction and possibilities of their correction with tianeptin].

Journal: Terapevticheskii arkhiv 20100101

Title: [Antiviral therapy in a patient with chronic hepatitis C, metabolic syndrome and interferon-induced depression].

Journal: Klinicheskaia meditsina 20100101

Title: Chronic stress effects on hippocampal structure and synaptic function: relevance for depression and normalization by anti-glucocorticoid treatment.

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Journal: Diabetes, metabolic syndrome and obesity : targets and therapy 20100101

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Journal: Indian journal of psychiatry 20100101

Title: Addictive potential of Tianeptine - the threatening reality.

Journal: Georgian medical news 20090901

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Journal: Dialogues in clinical neuroscience 20090901

Title: Re-exposure to endotoxin induces differential cytokine gene expression in the rat hypothalamus and spleen.

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Title: Comparative study on the gastroprotective potential of some antidepressants in indomethacin-induced ulcer in rats.

Journal: Chemico-biological interactions 20090715

Title: The effect of antidepressant drugs on the HPA axis activity, glucocorticoid receptor level and FKBP51 concentration in prenatally stressed rats.

Journal: Psychoneuroendocrinology 20090701

Title: Comparison of antidepressant effects of azafan, tianeptine, and paroxetine.

Journal: Bulletin of experimental biology and medicine 20090701

Title: Effect of a single dose of citalopram on amygdala response to emotional faces.

Journal: The British journal of psychiatry : the journal of mental science 20090601

Title: Efficacy, tolerability and safety of tianeptine in special populations of depressive patients.

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Title: Antidepressant action of tianeptine is connected with acceleration of serotonin turnover in the synapse: a hypothesis.

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Title: Different effects of tianeptine pretreatment in rats exposed to acute stress and repeated severe stress.

Journal: Methods and findings in experimental and clinical pharmacology 20090401

Title: Protective effects of melatonin against oxidative stress in Fmr1 knockout mice: a therapeutic research model for the fragile X syndrome.

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Title: Antidepressants reverse the attenuation of the neurotrophic MEK/MAPK cascade in frontal cortex by elevated platform stress; reversal of effects on LTP is associated with GluA1 phosphorylation.

Journal: Neuropharmacology 20090101

Title: Use of Coaxil (tianeptine) in elderly patients with combined mild cognitive and depressive-anxiety disorders.

Journal: Neuroscience and behavioral physiology 20090101

Title: [Myocardial infarction and depression: clinical-functional relationships and possibilities of correction of left ventricular remodeling with antidepressant tianeptine].

Journal: Kardiologiia 20090101

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Journal: PloS one 20090101

Title: Stress and depression: preclinical research and clinical implications.

Journal: PloS one 20090101

Title: [Experience of application of tianeptine in anxiety-depressive disorders comorbid with climacteric syndrome].

Journal: Kardiologiia 20090101

Title: Impaired interleukin-1beta and c-Fos expression in the hippocampus is associated with a spatial memory deficit in P2X(7) receptor-deficient mice.

Journal: PloS one 20090101

Title: 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo.

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Journal: Kardiologiia 20090101

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Journal: Przeglad lekarski 20090101

Title: Prenatal stress decreases glycogen synthase kinase-3 phosphorylation in the rat frontal cortex.

Journal: Pharmacological reports : PR 20090101

Title: [Dynamics of depressive disorders, endothelial dysfunction, and phagocytic activity of neutrophils in patients with chronic inflammation under influence of treatment with tianeptine].

Journal: Kardiologiia 20090101

Title: Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation.

Journal: The International journal of neuroscience 20090101

Title: [Current views on the pathogenesis of depression and approaches to antidepressive therapy (in case of coaxil)].

Journal: Terapevticheskii arkhiv 20090101

Title: Possible Role of Platelet GluR1 Receptors in Comorbid Depression and Cardiovascular Disease.

Journal: Cardiovascular psychiatry and neurology 20090101

Title: Tianeptine treating narcolepsy. Case report.

Journal: Neuro endocrinology letters 20090101

Title: [Peptic ulcer in patients with neurotic and affective disorders: comorbidity, clinicoendoscopic and psychopathological features, approaches to therapy].

Journal: Terapevticheskii arkhiv 20090101

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Journal: Advances in pharmacology (San Diego, Calif.) 20090101

Title: [The clinical picture and treatment of depression spectrum disorders in patients with cardiovascular disease].

Journal: Terapevticheskii arkhiv 20090101

Title: Amantadine reduces glucagon and enhances insulin secretion throughout the oral glucose tolerance test: central plus peripheral nervous system mechanisms.

Journal: Diabetes, metabolic syndrome and obesity : targets and therapy 20090101

Title: Mind, brain and psychotherapy.

Journal: Indian journal of psychological medicine 20090101

Title: The effect of tianeptine in the prevention of radiation-induced neurocognitive impairment.

Journal: Medical hypotheses 20081201

Title: A new spectrophotometric method for the determination of tianeptine in tablets using ion-pair reagents.

Journal: Chemical & pharmaceutical bulletin 20081201

Title: Cellular and molecular mechanisms in the long-term action of antidepressants.

Journal: Dialogues in clinical neuroscience 20081201

Title: ['Atypical' antidepressive mechanisms: glutamatergic modulation and neuroplasticity in case of tianeptine].

Journal: Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20081201

Title: Tianeptine: an antidepressant with memory-protective properties.

Journal: Current neuropharmacology 20081201

Title: Stimulus properties of venlafaxine in a conditioned taste aversion procedure.

Journal: European journal of pharmacology 20081031

Title: Neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole augment the effects of antidepressants acting via serotonergic system in the forced swimming test in rats.

Journal: Pharmacology, biochemistry, and behavior 20081001

Title: Planned complex suicide: an unusual case.

Journal: Journal of forensic sciences 20080701

Title: Dimensional personality traits and treatment outcome in patients with major depressive disorder.

Journal: Journal of affective disorders 20080601

Title: Tianeptine: potential influences on neuroplasticity and novel pharmacological effects.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20080515

Title: The immobility produced by intermittent swim stress is not mediated by serotonin.

Journal: Pharmacology, biochemistry, and behavior 20080501

Title: Inhibition by tianeptine of neuronally mediated contractions in the rat isolated gastrointestinal tract.

Journal: Pharmacological research 20080501

Title: Psychopharmacology of aggression in children and adolescents with autism: a critical review of efficacy and tolerability.

Journal: Journal of child and adolescent psychopharmacology 20080401

Title: The enduring effects of an adolescent social stressor on synaptic density, part II: Poststress reversal of synaptic loss in the cortex by adinazolam and MK-801.

Journal: Synapse (New York, N.Y.) 20080301

Title: Effect of some antidepressants on the low corticosterone concentration-induced gene transcription in LMCAT fibroblast cells.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20080301

Title: Pre-training administration of tianeptine, but not propranolol, protects hippocampus-dependent memory from being impaired by predator stress.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20080201

Title: Association analysis between variants of the interleukin-1beta and the interleukin-1 receptor antagonist gene and antidepressant treatment response in major depression.

Journal: Neuropsychiatric disease and treatment 20080201

Title: Serotonergic anti-depressants and ethanol withdrawal syndrome: a review.

Journal: Alcohol and alcoholism (Oxford, Oxfordshire) 20080101

Title: Neurobiological and clinical effects of the antidepressant tianeptine.

Journal: CNS drugs 20080101

Title: Post-traumatic stress disorder in different types of stress (clinical features and treatment).

Journal: Neuroscience and behavioral physiology 20080101

Title: Diverse antidepressants increase CDP-diacylglycerol production and phosphatidylinositide resynthesis in depression-relevant regions of the rat brain.

Journal: BMC neuroscience 20080101

Title: [Dynamics of biochemical parameters in patients with anxious depression treated with serotonergic antidepressants with different mechanisms of action].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101

Title: [The use of coaxil (tianeptine) in the treatment of aged people with combined mild cognitive impairment and depressive-anxiety disorders].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101

Title: Neurotrophins and cytokines in neuronal plasticity.

Journal: Novartis Foundation symposium 20080101

Title: [Tianeptin (coaxil) in therapy of depression in cardiovascular patients].

Journal: Terapevticheskii arkhiv 20080101

Title: Antidepressant treatments-induced modifications of glutamatergic transmission in rat frontal cortex.

Journal: Pharmacological reports : PR 20080101

Title: Effects of co-administration of fluoxetine or tianeptine with metyrapone on immobility time and plasma corticosterone concentration in rats subjected to the forced swim test.

Journal: Pharmacological reports : PR 20080101

Title: Effect of two behavioral tests on corticosterone level in plasma of mice lacking the noradrenaline transporter.

Journal: Pharmacological reports : PR 20080101

Title: Information Processing Bias in Post-traumatic Stress Disorder.

Journal: The open neuroimaging journal 20080101

Title: Cough up for just a cup of coffee: Pharmacoeconomics of depression.

Journal: Indian journal of psychiatry 20080101

Title: Psychological factors in asthma.

Journal: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20080101

Title: Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine.

Journal: The European journal of neuroscience 20071201

Title: Acute selective serotonin reuptake inhibitors increase conditioned fear expression: blockade with a 5-HT(2C) receptor antagonist.

Journal: Biological psychiatry 20071115

Title: Tianeptine abuse: yet again.

Journal: Prescrire international 20071001

Title: Modulation of antidepressant-like activity of magnesium by serotonergic system.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20070901

Title: Fatal intoxication with tianeptine (Stablon).

Journal: Forensic science international 20070806

Title: High-performance liquid chromatographic stability indicating assay method of tianeptine sodium with simultaneous fluorescence and UV detection.

Journal: Journal of chromatographic science 20070701

Title: Tianeptine increases brain-derived neurotrophic factor expression in the rat amygdala.

Journal: European journal of pharmacology 20070622

Title: The effects of antidepressants on cyclic AMP-response element-driven gene transcription in a model cell system.

Journal: Biochemical pharmacology 20070615

Title: Coaxil (tianeptine) in the treatment of depression in Parkinson's disease.

Journal: Neuroscience and behavioral physiology 20070501

Title: Polycystic ovary syndrome and hyperprolactinemia are distinct entities.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20070501

Title: Acute stress-mediated increases in extracellular glutamate levels in the rat amygdala: differential effects of antidepressant treatment.

Journal: The European journal of neuroscience 20070501

Title: Is it possible to be dependent to Tianeptine, an antidepressant? A case report.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20070413

Title: Effects of tianeptine on onset time of pentylenetetrazole-induced seizures in mice: possible role of adenosine A1 receptors.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070201

Title: Is hippocampal atrophy a future drug target?

Journal: Medical hypotheses 20070101

Title: [Comparative study of the effects of amitriptyline, fluoxetine, and tianeptine on the amplitude of transcallosal evoked potentials].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20070101

Title: Anti-inflammatory properties of desipramine and fluoxetine.

Journal: Respiratory research 20070101

Title: Determination of tianeptine in tablets by high-performance liquid chromatography with fluorescence detection.

Journal: Journal of AOAC International 20070101

Title: The temporal dynamics model of emotional memory processing: a synthesis on the neurobiological basis of stress-induced amnesia, flashbulb and traumatic memories, and the Yerkes-Dodson law.

Journal: Neural plasticity 20070101

Title: Hippocampal neurogenesis, depressive disorders, and antidepressant therapy.

Journal: Neural plasticity 20070101

Title: Stress and memory: behavioral effects and neurobiological mechanisms.

Journal: Neural plasticity 20070101

Title: [Clinico-epidemiological characteristics of elderly patients with cardiovascular diseases comorbid with depression (results of a multicenter prospective trial COORDINATA)].

Journal: Terapevticheskii arkhiv 20070101

Title: Effects of repetitive administration of tianeptine, zinc hydroaspartate and electroconvulsive shock on the reactivity of 5-HT(7) receptors in rat hippocampus.

Journal: Pharmacological reports : PR 20070101

Title: [Pharmacologic correction of psycho-emotive disorders in the rehabilitation of patients after removal of brain tumors].

Journal: Voprosy onkologii 20070101

Title: Long-term voluntary exercise and the mouse hypothalamic-pituitary-adrenocortical axis: impact of concurrent treatment with the antidepressant drug tianeptine.

Journal: Journal of neuroendocrinology 20061201

Title: Common efficacy of psychotropic drugs in restoring stress-induced impairment of prefrontal plasticity.

Journal: Neurotoxicity research 20061201

Title: Protective and damaging effects of stress mediators: central role of the brain.

Journal: Dialogues in clinical neuroscience 20061201

Title: Traumatic stress: effects on the brain.

Journal: Dialogues in clinical neuroscience 20061201

Title: Sertraline, escitalopram and tianeptine related abnormal movements but not with bupropion: a case report.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20060930

Title: Tianeptine can be effective in men with depression and erectile dysfunction.

Journal: The journal of sexual medicine 20060901

Title: New directions for drug discovery.

Journal: Dialogues in clinical neuroscience 20060901

Title: [Tianeptine-induced weight gain in adolescents suffering from autism].

Journal: Minerva pediatrica 20060801

Title: Enhanced susceptibility to periodontitis in an animal model of depression: reversed by chronic treatment with the anti-depressant tianeptine.

Journal: Journal of clinical periodontology 20060701

Title: Differential pulse, square wave and adsorptive stripping voltammetric quantification of tianeptine in tablets.

Journal: Journal of pharmaceutical and biomedical analysis 20060616

Title: Effects of repeated tianeptine treatment on CRF mRNA expression in non-stressed and chronic mild stress-exposed rats.

Journal: Neuropharmacology 20060601

Title: Antidepressants: general practitioners' opinions and clinical practice.

Journal: Acta psychiatrica Scandinavica 20060601

Title: Treatments in depression.

Journal: Dialogues in clinical neuroscience 20060601

Title: Acute and chronic tianeptine treatments attenuate ethanol withdrawal syndrome in rats.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20060501

Title: Determination of tianeptine in human plasma using high-performance liquid chromatography with fluorescence detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060413

Title: A comparative study of fluoxetine, moclobemide, and tianeptine in the treatment of posttraumatic stress disorder following an earthquake.

Journal: European psychiatry : the journal of the Association of European Psychiatrists 20060401

Title: Acute effects of tianeptine on circulating neurotransmitters and cardiovascular parameters.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20060301

Title: Biochemical profile in patients with anxious depression under the treatment with serotonergic antidepressants with different mechanisms of action.

Journal: Human psychopharmacology 20060301

Title: Benefit of tianeptine and morphine in a transgenic model of familial amyotrophic lateral sclerosis.

Journal: Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 20060301

Title: Differential effects of predator stress and the antidepressant tianeptine on physiological plasticity in the hippocampus and basolateral amygdala.

Journal: Stress (Amsterdam, Netherlands) 20060301

Title: Regulation of hippocampal gene expression is conserved in two species subjected to different stressors and antidepressant treatments.

Journal: Biological psychiatry 20060201

Title: Neonatal dexamethasone and chronic tianeptine treatment inhibit ligature-induced periodontitis in adult rats.

Journal: Journal of periodontal research 20060201

Title: Evident exception in clinical practice not sufficient to break traditional hypothesis.

Journal: PLoS medicine 20060201

Title: Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants.

Journal: The Journal of biological chemistry 20060127

Title: Discriminative stimulus properties of tianeptine.

Journal: Psychopharmacology 20060101

Title: Evidence that serotonin reuptake modulators increase the density of serotonin innervation in the forebrain.

Journal: Journal of neurochemistry 20060101

Title: [A case of tianeptine abuse].

Journal: Turk psikiyatri dergisi = Turkish journal of psychiatry 20060101

Title: [Coaxil (tianeptine) in the treatment of depression in Parkinson's disease].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101

Title: [Depression in cardiological practice: pilot results from a multicenter clinico-epidemiological trial in hypertensive patients with ischemic heart disease (koordinata)].

Journal: Terapevticheskii arkhiv 20060101

Title: [Treatment of depression in patients with myocardial infarction with tianeptine].

Journal: Kardiologiia 20060101

Title: [Effects of antidepressants in models of brain self-stimulation and place preference after prolong social isolation and alcoholization].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20060101

Title: [Trends in heart rate variability in patients with ischemic heart disease and depression treated with antidepressant tianeptine].

Journal: Terapevticheskii arkhiv 20060101

Title: [A double-blind controlled study of the efficacy and acceptability of tianeptine in comparison with fluvoxamine in the treatment of depressed alcoholic patients].

Journal: Psychiatria polska 20060101

Title: [Anabolic-catabolic balance in depression: an effect of coaxil].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101

Title: [A comparative study of efficacy and tolerability of antidepressants from different classes in mild and moderate depression].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101

Title: [Effect of depressive state on parameters of heart rate variability in patients with ischemic heart disease and correction of revealed disturbances with antidepressant tianeptine].

Journal: Kardiologiia 20060101

Title: [Experience in application of various antidepressants in gerontology].

Journal: Klinicheskaia meditsina 20060101

Title: Tianeptine: a novel atypical antidepressant that may provide new insights into the biomolecular basis of depression.

Journal: Recent patents on CNS drug discovery 20060101

Title: Control of ACTH secretion by excitatory amino acids: functional significance and clinical implications.

Journal: Endocrine 20051201

Title: Contribution of sleep research to the development of new antidepressants.

Journal: Dialogues in clinical neuroscience 20051201

Title: Sleep disturbances, psychiatric disorders, and psychotropic drugs.

Journal: Dialogues in clinical neuroscience 20051201

Title: [Trends in pharmacotherapy of unipolar depression at the beginning of the century in Hungary].

Journal: Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20051201

Title: [Attention deficit hyperactivity: tianeptine open trial].

Journal: Minerva pediatrica 20051001

Title: The pharmacological management of depression.

Journal: Dialogues in clinical neuroscience 20050901

Title: Neuroendocrine predictors of the evolution of depression.

Journal: Dialogues in clinical neuroscience 20050901

Title: Neurobiology of mood, anxiety, and emotions as revealed by studies of a unique antidepressant: tianeptine.

Journal: Molecular psychiatry 20050601

Title: Investigation of the effects of tianeptine and fluoxetine on pentylenetetrazole-induced seizures in rats.

Journal: Journal of psychiatric research 20050301

Title: Social stress in tree shrews as an animal model of depression: an example of a behavioral model of a CNS disorder.

Journal: CNS spectrums 20050301

Title: Treatment of depression with the serotonin reuptake enhancer tianeptine in the primary care setting of India.

Journal: Journal of the Indian Medical Association 20050201

Title: [Synaptic plasticity and neuropathology: new approaches in drug discovery].

Journal: Medecine sciences : M/S 20050101

Title: [Coaxil treatment of primary headaches comorbid with depression].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20050101

Title: [Coaxil therapy of affective disorders in brain vascular pathology].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20050101

Title: [Comparative study of the antidepressant and anxiolytic activity of fluoxetine and tianeptine].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20050101

Title: [Depressive disorders in general medical practice in KOMPAS study: outlook of a cardiologist].

Journal: Kardiologiia 20050101

Title: [Evaluation of antidepressant activity in a model of depressionlike state due to social isolation in rats].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20050101

Title: [Depression in patients with chronic dermatoses and its treatment with coaxil].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20050101

Title: [Efficacy and tolerability of coaxil (tianeptine) in the therapy of posttraumatic stress disorder].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20050101

Title: [Correction of anxiety depressive disorders with tianeptine in patients with heart failure in early period after myocardial infarction].

Journal: Kardiologiia 20050101

Title: [Clinico-epidemiological program of the study of depression in cardiological practice in patients with hypertension and ischemic heart disease: first results of a multicenter study].

Journal: Kardiologiia 20050101

Title: Our experience with antidepressant treatment in the obese and type 2 diabetics.

Journal: Prague medical report 20050101

Title: Alterations of neuroplasticity in depression: the hippocampus and beyond.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20041201

Title: Preclinical research on stress, memory, and the brain in the development of pharmacotherapy for depression.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20041201

Title: Molecular mechanisms of neuroplasticity and pharmacological implications: the example of tianeptine.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20041201

Title: From restoration of neuroplasticity to the treatment of depression: clinical experience.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20041201

Title: The effects of tianeptine or paroxetine on 35% CO2 provoked panic in panic disorder.

Journal: Journal of psychopharmacology (Oxford, England) 20041201

Title: Treatment of bronchial asthma with tianeptine.

Journal: Methods and findings in experimental and clinical pharmacology 20041101

Title: Differential regulation of variant glucocorticoid receptor mRNAs in the rat hippocampus by the antidepressant fluoxetine.

Journal: Brain research. Molecular brain research 20041022

Title: Tianeptine: a facilitator of the reuptake of serotonin and norepinephrine as an antidepressant?

Journal: Journal of psychiatric practice 20040901

Title: Chronic administration of tianeptine balances lipopolysaccharide-induced expression of cytokines in the spleen and hypothalamus of rats.

Journal: Psychoneuroendocrinology 20040701

Title: Untreated depression and hippocampal volume loss.

Journal: The American journal of psychiatry 20040701

Title: The selective serotonin reuptake inhibitor citalopram increases fear after acute treatment but reduces fear with chronic treatment: a comparison with tianeptine.

Journal: Biological psychiatry 20040615

Title: Behavioral and neuroendocrine changes during mental stress and repeated treatment with antidepressants in healthy men.

Journal: Annals of the New York Academy of Sciences 20040601

Title: Cellular consequences of stress and depression.

Journal: Dialogues in clinical neuroscience 20040601

Title: Structural plasticity of the adult brain: how animal models help us understand brain changes in depression and systemic disorders related to depression.

Journal: Dialogues in clinical neuroscience 20040601

Title: Neural plasticity: consequences of stress and actions of antidepressant treatment.

Journal: Dialogues in clinical neuroscience 20040601

Title: Structural plasticity of the adult brain.

Journal: Dialogues in clinical neuroscience 20040601

Title: Antidepressant treatment with tianeptine reduces apoptosis in the hippocampal dentate gyrus and temporal cortex.

Journal: Biological psychiatry 20040415

Title: Regulation of the human corticotropin-releasing-hormone gene promoter activity by antidepressant drugs in Neuro-2A and AtT-20 cells.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040401

Title: Trends in the development of new antidepressants. Is there a light at the end of the tunnel?

Journal: Current medicinal chemistry 20040401

Title: Refractory pain-depression syndrome treated with tianeptine: a case report.

Journal: The Australian and New Zealand journal of psychiatry 20040301

Title: Current perspectives in the management of treatment-resistant depression.

Journal: Dialogues in clinical neuroscience 20040301

Title: Acute stress-induced changes in hippocampal/prefrontal circuits in rats: effects of antidepressants.

Journal: Cerebral cortex (New York, N.Y. : 1991) 20040201

Title: Tianeptine: a new exploratory therapy for asthma.

Journal: Chest 20040101

Title: Tianeptine as a slightly effective therapeutic option for attention-deficit hyperactivity disorder.

Journal: Neuropsychobiology 20040101

Title: [Detection of new antidepressive agents using thin-layer chromatography].

Journal: Soudni lekarstvi 20040101

Title: [Depressions and disorders of depressive spectrum in general medical practice. Results of the COMPAS program].

Journal: Kardiologiia 20040101

Title: Antidepressants in chronic unpredictable mild stress (CUMS)-induced deficit of fighting behavior.

Journal: Polish journal of pharmacology 20040101

Title: Plasticity at hippocampal to prefrontal cortex synapses is impaired by loss of dopamine and stress: importance for psychiatric diseases.

Journal: Neurotoxicity research 20040101

Title: Reboxetine: a norepinephrine selective reuptake pump inhibitor.

Journal: Journal of psychiatric practice 20040101

Title: Behavioural effects of thieno and pyrazolo [2,1] benzothiazepine derivatives in mice.

Journal: Arzneimittel-Forschung 20040101

Title: [Clinical efficacy of tianeptine in patients with ischemic heart disease and comorbid depression].

Journal: Kardiologiia 20040101

Title: [Preventive efficacy of tianeptine in recurrent depression with frequent exacerbations].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20040101

Title: [Coaxil efficacy in depression in patients with chronic cerebral ischemia].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20040101

Title: [A role of depression in chronic dorsalgia: approaches to therapeutic correction].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20040101

Title: [Extrapyramidal syndrome worsened by tianeptine].

Journal: Therapie 20040101

Title: [Comparison of two assessment tools of antidepressant side-effects: UKU scale versus spontaneous notification].

Journal: L'Encephale 20040101

Title: Thyroid hormones in the rat amygdala as common targets for antidepressant drugs, mood stabilizers, and sleep deprivation.

Journal: Biological psychiatry 20031115

Title: Prenatal stress in rats predicts immobility behavior in the forced swim test. Effects of a chronic treatment with tianeptine.

Journal: Brain research 20031107

Title: [Misuse of tianeptine: five cases of abuse].

Journal: Annales de medecine interne 20031101

Title: Evaluation of cognitive function of fluoxetine, sertraline and tianeptine in isolation and chronic unpredictable mild stress-induced depressive Wistar rats.

Journal: Indian journal of experimental biology 20031101

Title: Antidepressants: psychiatrists' opinions and clinical practice.

Journal: Acta psychiatrica Scandinavica 20030701

Title: Inhibition of microsomal triglyceride transfer protein: another mechanism for drug-induced steatosis in mice.

Journal: Hepatology (Baltimore, Md.) 20030701

Title: Tianeptine: a novel strategy of psychopharmacological treatment of children with autistic disorder.

Journal: Human psychopharmacology 20030701

Title: Switching to tianeptine in patients with antidepressant-induced sexual dysfunction.

Journal: Human psychopharmacology 20030601

Title: Alcohol, nicotine, caffeine, and mental disorders.

Journal: Dialogues in clinical neuroscience 20030601

Title: Broken heart: depression in cardiovascular disease.

Journal: Dialogues in clinical neuroscience 20030601

Title: Neuroprotective properties of tianeptine: interactions with cytokines.

Journal: Neuropharmacology 20030501

Title: [Therapy resistant major depression: improvement of symptomatology after combining antidepressants with Tianeptine (Stablon)].

Journal: Psychiatrische Praxis 20030501

Title: Clinical and neurobiological effects of tianeptine and paroxetine in major depression.

Journal: Journal of clinical psychopharmacology 20030401

Title: [Tianeptine induced acute hepatitis].

Journal: Gastroenterologie clinique et biologique 20030301

Title: Behavioral disturbances in dementia.

Journal: Dialogues in clinical neuroscience 20030301

Title: State markers of depression in sleep EEG: dependency on drug and gender in patients treated with tianeptine or paroxetine.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030201

Title: Treatment of major depression and anxiety with the selective serotonin re-uptake enhancer tianeptine in the outpatient psychiatric care setting of India.

Journal: Journal of the Indian Medical Association 20030201

Title: Tianeptine, plasma serotonin, and pulmonary hypertension.

Journal: Lancet (London, England) 20030104

Title: Local, but not systemic, administration of serotonergic antidepressants decreases hippocampal nitric oxide synthase activity.

Journal: Brain research 20030103

Title: Chronic treatment with the antidepressant tianeptine attenuates lipopolysaccharide-induced Fos expression in the rat paraventricular nucleus and HPA axis activation.

Journal: Psychoneuroendocrinology 20030101

Title: Tianeptine may be a useful adjunct in the treatment of alcohol dependence of adolescents.

Journal: Alcoholism, clinical and experimental research 20030101

Title: Neuropharmacological study of hetero[2,1]benzothiazepine derivatives analogues of tianeptine.

Journal: Farmaco (Societa chimica italiana : 1989) 20030101

Title: Psychopharmacological effects of tianeptine analogous hetero[2,1] benzothiazepine derivatives.

Journal: Arzneimittel-Forschung 20030101

Title: The ELIXIR study: evaluation of sexual dysfunction in 4557 depressed patients in France.

Journal: Current medical research and opinion 20030101

Title: Effect of antidepressants on the phospholipase A2 activity in plasma membranes of the rat brain cortex.

Journal: Polish journal of pharmacology 20030101

Title: [Therapy of affective disorders with tianeptine in patients with essential hypertension].

Journal: Kardiologiia 20030101

Title: [Clinical efficacy and tolerability of tianeptine in treatment of depression (Russian open multicenter trial)].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20030101

Title: [Does addiction to antidepressants exist? About a case of one addiction to tianeptine].

Journal: L'Encephale 20030101

Title: [A meta-analysis of randomized controlled trials of tianeptine versus SSRI in the short-term treatment of depression].

Journal: L'Encephale 20030101

Title: Mss4 gene is up-regulated in rat brain after chronic treatment with antidepressant and down-regulated when rats are anhedonic.

Journal: Molecular pharmacology 20021201

Title: The effects of paroxetine and tianeptine on peripheral biochemical markers in major depression.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20021201

Title: Sleep-wake mechanisms and drug discovery: sleep EEG as a tool for the development of CNS-acting drugs.

Journal: Dialogues in clinical neuroscience 20021201

Title: Modulation of tianeptine on ion currents induced by inhibitory neurotransmitters in acutely dissociated dorsal raphe neurons of Sprague-Dawley rats.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20021001

Title: Enhancement of stress-induced pituitary hormone release and cardiovascular activation by antidepressant treatment in healthy men.

Journal: Journal of psychopharmacology (Oxford, England) 20020901

Title: The antidepressant tianeptine persistently modulates glutamate receptor currents of the hippocampal CA3 commissural associational synapse in chronically stressed rats.

Journal: The European journal of neuroscience 20020901

Title: Psychopharmacology of anxiety disorders.

Journal: Dialogues in clinical neuroscience 20020901

Title: Tianeptine and fluoxetine in major depression: a 6-week randomised double-blind study.

Journal: Human psychopharmacology 20020801

Title: Synaptic plasticity and tianeptine: structural regulation.

Journal: European psychiatry : the journal of the Association of European Psychiatrists 20020701

Title: Structural plasticity and tianeptine: cellular and molecular targets.

Journal: European psychiatry : the journal of the Association of European Psychiatrists 20020701

Title: A meta-analysis of randomized controlled trials of tianeptine versus SSRI in the short-term treatment of depression.

Journal: European psychiatry : the journal of the Association of European Psychiatrists 20020701

Title: Overcoming the effects of stress on synaptic plasticity in the intact hippocampus: rapid actions of serotonergic and antidepressant agents.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020501

Title: Tianeptine: 5-HT uptake sites and 5-HT(1-7) receptors modulate memory formation in an autoshaping Pavlovian/instrumental task.

Journal: Neuroscience and biobehavioral reviews 20020501

Title: Effect of tianeptine and fluoxetine on the levels of Met-enkephalin and mRNA encoding proenkephalin in the rat.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20020301

Title: Effect of repeated treatment with tianeptine and fluoxetine on central dopamine D(2) /D(3) receptors.

Journal: Behavioural pharmacology 20020301

Title: Pathophysiology of depression and mechanisms of treatment.

Journal: Dialogues in clinical neuroscience 20020301

Title: The clinical pharmacology of depressive states.

Journal: Dialogues in clinical neuroscience 20020301

Title: Enhancing synaptic plasticity and cellular resilience to develop novel, improved treatments for mood disorders.

Journal: Dialogues in clinical neuroscience 20020301

Title: Efficacy and safety of tianeptine in major depression: evidence from a 3-month controlled clinical trial versus paroxetine.

Journal: CNS drugs 20020101

Title: [The level of 8-iso-prostaglandin F2 alpha, 4-hydroxynonenal and malondialdehyde in alcohol dependent men during combined therapy].

Journal: Psychiatria polska 20020101

Title: [Efficacy and acceptability of tianeptine and sertraline in the acute treatment phase of depression].

Journal: L'Encephale 20020101

Title: [The role of depressive disorders in hypertensive disease and possibilities of their correction: assessment of the effect of tianeptine].

Journal: Kardiologiia 20020101

Title: [The comparison of tianeptine and carbamazepine in benzodiazepines withdrawal symptoms].

Journal: Psychiatria polska 20020101

Title: Effect of antidepressant drugs on the human corticotropin-releasing-hormone gene promoter activity in neuro-2A cells.

Journal: Polish journal of pharmacology 20020101

Title: Asthma, asthma medication and autonomic nervous system dysfunction.

Journal: Clinical physiology (Oxford, England) 20011101

Title: Tianeptine versus fluoxetine in the treatment of depression complicating Alzheimer's disease.

Journal: International journal of geriatric psychiatry 20011101

Title: Effect of repeated treatment with tianeptine and fluoxetine on the central alpha(1)-adrenergic system.

Journal: Neuropharmacology 20010901

Title: Hormonal and behavioural abnormalities induced by stress in utero: an animal model for depression.

Journal: Stress (Amsterdam, Netherlands) 20010901

Title: Tianeptine and its enantiomers: effects on spatial memory in rats with medial septum lesions.

Journal: Neuropharmacology 20010801

Title: Effects of tianeptine and mianserin on car driving skills.

Journal: Psychopharmacology 20010401

Title: Current trends in the development of new antidepressants.

Journal: Current medicinal chemistry 20010201

Title: Chronic treatment with the atypical antidepressant tianeptine attenuates sickness behavior induced by peripheral but not central lipopolysaccharide and interleukin-1beta in the rat.

Journal: Psychopharmacology 20010201

Title: Tianeptine: a review of its use in depressive disorders.

Journal: CNS drugs 20010101

Title: Metyrapone reveals that previous chronic stress differentially impairs hippocampal-dependent memory.

Journal: Stress (Amsterdam, Netherlands) 20010101

Title: Although chemically related to amineptine, the antidepressant tianeptine is not a dopamine uptake inhibitor.

Journal: Pharmacology, biochemistry, and behavior 19990601

Title: Metabolic activation of the antidepressant tianeptine. II. In vivo covalent binding and toxicological studies at sublethal doses.

Journal: Biochemical pharmacology 19891001

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Tags:66981-73-5 Molecular Formula|66981-73-5 MDL|66981-73-5 SMILES|66981-73-5 7-[[(11R)-3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl]amino]heptanoic acid