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67287-95-0,MFCD03792727
Catalog No.:AA01E4XV

67287-95-0 | SKF83959

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1mg
≥98%
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$36.00   $25.00
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5mg
≥98%
in stock  
$135.00   $94.00
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10mg
≥98%
in stock  
$250.00   $175.00
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25mg
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$580.00   $406.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01E4XV
Chemical Name:
SKF83959
CAS Number:
67287-95-0
Molecular Formula:
C18H21BrClNO2
Molecular Weight:
398.7218
MDL Number:
MFCD03792727
SMILES:
CN1CCc2c([C@H](C1)c1cccc(c1)C)cc(c(c2Cl)O)O.Br
Properties
Computed Properties
 
Complexity:
380  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Reduced striatal dopamine D1-D2 receptor heteromer expression and behavioural subsensitivity in juvenile rats.

Journal: Neuroscience 20121206

Title: Dopamine D1 receptors regulate type 1 inositol 1,4,5-trisphosphate receptor expression via both AP-1- and NFATc4-mediated transcriptional processes.

Journal: Journal of neurochemistry 20120801

Title: Phenotypic disruption to orofacial movement topography in conditional mutants with generalized CamKIIa/Cre D1Tox versus striatal-specific DARPP-32/Cre D1Tox ablation of D1 dopamine receptor-expressing cells.

Journal: Synapse (New York, N.Y.) 20110901

Title: SKF83959 suppresses excitatory synaptic transmission in rat hippocampus via a dopamine receptor-independent mechanism.

Journal: Journal of neuroscience research 20110801

Title: Calcium-related signaling pathways contributed to dopamine-induced cortical neuron apoptosis.

Journal: Neurochemistry international 20110201

Title: Dopamine D1-D2 receptor Heteromer-mediated calcium release is desensitized by D1 receptor occupancy with or without signal activation: dual functional regulation by G protein-coupled receptor kinase 2.

Journal: The Journal of biological chemistry 20101105

Title: Orofacial movements in phospholipase C-related catalytically inactive protein-1/2 double knockout mice: Effect of the GABAergic agent diazepam and the D(1) dopamine receptor agonist SKF 83959.

Journal: Synapse (New York, N.Y.) 20100901

Title: Activation of phosphatidylinositol-linked D1-like receptors increases spontaneous glutamate release in rat somatosensory cortical neurons in vitro.

Journal: Brain research 20100709

Title: Assessment of jaw movements by magnetic sensor in relation to topographies of orofacial behaviour in freely moving rats: Studies with the dopamine D(1)-like receptor agonists SKF 83822 vs SKF 83959.

Journal: European journal of pharmacology 20100425

Title: Electrophysiological effects of SKF83959 on hippocampal CA1 pyramidal neurons: potential mechanisms for the drug's neuroprotective effects.

Journal: PloS one 20100101

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Phosphatidylinositol-linked novel D(1) dopamine receptor facilitates long-term depression in rat hippocampal CA1 synapses.

Journal: Neuropharmacology 20090801

Title: Activation of phosphatidylinositol-linked D1-like receptor modulates FGF-2 expression in astrocytes via IP3-dependent Ca2+ signaling.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090617

Title: Activation of phosphatidylinositol-linked novel D1 dopamine receptor contributes to the calcium mobilization in cultured rat prefrontal cortical astrocytes.

Journal: Cellular and molecular neurobiology 20090501

Title: Activation of phosphatidylinositol-linked novel D1 dopamine receptors inhibits high-voltage-activated Ca2+ currents in primary cultured striatal neurons.

Journal: Journal of neurophysiology 20090501

Title: Phenotype of spontaneous orofacial dyskinesia in neuregulin-1 'knockout' mice.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20090317

Title: Perinatal n-3 fatty acid deficiency selectively reduces myo-inositol levels in the adult rat PFC: an in vivo (1)H-MRS study.

Journal: Journal of lipid research 20090301

Title: Regulation of DARPP-32 phosphorylation by three distinct dopamine D1-like receptor signaling pathways in the neostriatum.

Journal: Journal of neurochemistry 20081101

Title: Synthesis of 6-substituted 1-phenylbenzazepines and their dopamine D(1) receptor activities.

Journal: Bioorganic & medicinal chemistry 20081101

Title: Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling.

Journal: Neuropharmacology 20080601

Title: Neuroprotective effects of atypical D1 receptor agonist SKF83959 are mediated via D1 receptor-dependent inhibition of glycogen synthase kinase-3 beta and a receptor-independent anti-oxidative action.

Journal: Journal of neurochemistry 20080201

Title: Chronic SKF83959 induced less severe dyskinesia and attenuated L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease.

Journal: Neuropharmacology 20070701

Title: Behavioral effects of the R-(+)- and S-(-)-enantiomers of the dopamine D(1)-like partial receptor agonist SKF 83959 in monkeys.

Journal: European journal of pharmacology 20070308

Title: Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 receptor or DARPP-32 transduction 'knockout'.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20060801

Title: Modulation of Ca2+ signals by phosphatidylinositol-linked novel D1 dopamine receptor in hippocampal neurons.

Journal: Journal of neurochemistry 20060801

Title: Topographical resolution of jaw movements mediated by cyclase- vs. non-cyclase-coupled dopamine D(1)-like receptors: studies with SK&F 83822.

Journal: European journal of pharmacology 20060524

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: The atypical dopamine D1 receptor agonist SKF 83959 induces striatal Fos expression in rats.

Journal: European journal of pharmacology 20051228

Title: The paradoxical effects of SKF83959, a novel dopamine D1-like receptor agonist, in the rat acoustic startle reflex paradigm.

Journal: Neuroscience letters 20050701

Title: The role of the phosphatidyinositol-linked D1 dopamine receptor in the pharmacology of SKF83959.

Journal: Pharmacology, biochemistry, and behavior 20050401

Title: D1 dopamine receptor regulation of the levels of the cell-cycle-controlling proteins, cyclin D, P27 and Raf-1, in cerebral cortical precursor cells is mediated through cAMP-independent pathways.

Journal: Cerebral cortex (New York, N.Y. : 1991) 20050101

Title: SK&F 83822 distinguishes adenylyl cyclase from phospholipase C-coupled dopamine D1-like receptors: behavioural topography.

Journal: European journal of pharmacology 20040223

Title: Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines.

Journal: European journal of pharmacology 20030808

Title: Prefrontal, accumbal [shell] and ventral striatal mechanisms in jaw movements and non-cyclase-coupled dopamine D1-like receptors.

Journal: European journal of pharmacology 20030718

Title: SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain.

Journal: Journal of neurochemistry 20030401

Title: Congenic D1A dopamine receptor mutants: ethologically based resolution of behavioural topography indicates genetic background as a determinant of knockout phenotype.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030101

Title: Phenotypic, ethologically based resolution of spontaneous and D(2)-like vs D(1)-like agonist-induced behavioural topography in mice with congenic D(3) dopamine receptor 'knockout'.

Journal: Synapse (New York, N.Y.) 20021001

Title: Phenotypic resolution of spontaneous and D1-like agonist-induced orofacial movement topographies in congenic dopamine D1A receptor 'knockout' mice.

Journal: Neuropharmacology 20020401

Title: SKF 83959 is an antagonist of dopamine D1-like receptors in the prefrontal cortex and nucleus accumbens: a key to its antiparkinsonian effect in animals?

Journal: Neuropharmacology 20020201

Title: Aberrant behavioral effects of a dopamine D1 receptor antagonist and agonist in monkeys: evidence of uncharted dopamine D1 receptor actions.

Journal: Biological psychiatry 20011001

Title: Ventral striatal vs. accumbal (shell) mechanisms and non-cyclase-coupled dopamine D(1)-like receptors in jaw movements.

Journal: European journal of pharmacology 20010706

Title: SKF83959 exhibits biochemical agonism by stimulating [(35)S]GTP gamma S binding and phosphoinositide hydrolysis in rat and monkey brain.

Journal: Neuropharmacology 20010501

Title: Sheng G, et al. SKF83959 Has Protective Effects in the Scopolamine Model of Dementia. Biol Pharm Bull. 2018;41(3):427-434.

Title: Jin LQ, et al. SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain. J Neurochem. 2003;85(2):378-386.

Title: Neumeyer JL, et al. Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines. Eur J Pharmacol. 2003;474(2-3):137-140.

Title: Guo L, et al. SKF83959 is a potent allosteric modulator of sigma-1 receptor. Mol Pharmacol. 2013;83(3):577-586.

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