[1]Tetrahedron,1959,vol.5,p.311,326
[1]Patent:EP1471052,2004,A1.Locationinpatent:Page17
[1]Patent:EP2759533,2014,A1.Locationinpatent:Paragraph0436;0437
[1]Patent:US2016/145227,2016,A1.Locationinpatent:Paragraph0095-0103
[1]CurrentPatentAssignee:CHISSOCORPORATION-JP2019/214542,2019,ALocationinpatent:Paragraph0045;0052-0054
Title: Interference in mevalonate pathway ameliorates homocysteine-induced endothelium-dysfunction.
Journal: European journal of pharmacology 20121005
Title: Production and characterization of antifungal compounds produced by Lactobacillus plantarum IMAU10014.
Journal: PloS one 20120101
Title: Biosynthesis of sesqui- and diterpenes by the gibberellin producer Fusarium fujikuroi.
Journal: Chembiochem : a European journal of chemical biology 20111125
Title: Molecular mechanism of vasorelaxant and antiatherogenic effects of the statins in the human saphenous vein graft.
Journal: European journal of pharmacology 20110901
Title: Liquid chromatography-tandem mass spectrometry method for the measurement of serum mevalonic acid: a novel marker of hydroxymethylglutaryl coenzyme A reductase inhibition by statins.
Journal: Annals of clinical biochemistry 20110501
Title: Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells.
Journal: Experimental biology and medicine (Maywood, N.J.) 20110501
Title: Camphene, a plant-derived monoterpene, reduces plasma cholesterol and triglycerides in hyperlipidemic rats independently of HMG-CoA reductase activity.
Journal: PloS one 20110101
Title: An essential farnesylated kinesin in Trypanosoma brucei.
Journal: PloS one 20110101
Title: Involvement of oxidative stress in simvastatin-induced apoptosis of murine CT26 colon carcinoma cells.
Journal: Toxicology letters 20101215
Title: Cloning and characterization of a novel gene that encodes (S)-beta-bisabolene synthase from ginger, Zingiber officinale.
Journal: Planta 20100601
Title: Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering.
Journal: Applied microbiology and biotechnology 20100201
Title: Involvement of the phospholipid sterol acyltransferase1 in plant sterol homeostasis and leaf senescence.
Journal: Plant physiology 20100101
Title: Functional annotation, genome organization and phylogeny of the grapevine (Vitis vinifera) terpene synthase gene family based on genome assembly, FLcDNA cloning, and enzyme assays.
Journal: BMC plant biology 20100101
Title: Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones.
Journal: Bioorganic & medicinal chemistry 20091201
Title: Effects of cholesterol and nuclear hormone receptor agonists on the production of transforming growth factor-beta in macrophages.
Journal: Bulletin of experimental biology and medicine 20090901
Title: Complete blockage of the mevalonate pathway results in male gametophyte lethality.
Journal: Journal of experimental botany 20090501
Title: Conjugated hyperbilirubinaemia as the first manifestation of mevalonic aciduria in a term newborn.
Journal: Neuro endocrinology letters 20090101
Title: Stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Journal: Journal of lipid research 20081201
Title: Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis.
Journal: Molecular pharmacology 20080501
Title: Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis.
Journal: Plant & cell physiology 20080401
Title: Statins induce lethal effects in acute myeloblastic leukemia [corrected] cells within 72 hours.
Journal: Leukemia & lymphoma 20080201
Title: Determination of key intermediates in cholesterol and bile acid biosynthesis by stable isotope dilution mass spectrometry.
Journal: Analytical chemistry insights 20080101
Title: Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells.
Journal: Neoplasia (New York, N.Y.) 20071201
Title: Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs.
Journal: Toxicology and applied pharmacology 20070815
Title: Modulation by simvastatin of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells.
Journal: British journal of pharmacology 20070801
Title: Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS.
Journal: Journal of lipid research 20070501
Title: Validation of the LC-MS/MS method for the quantification of mevalonic acid in human plasma and determination of the matrix effect.
Journal: Journal of lipid research 20061001
Title: Biosynthesis of mono- and sesquiterpenes in strawberry fruits and foliage: 2H labeling studies.
Journal: Journal of agricultural and food chemistry 20060222
Title: Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells.
Journal: Immunology and cell biology 20060201
Title: Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2.
Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 20060201
Title: Juvenile hormone titer versus juvenile hormone synthesis in female nymphs and adults of the German cockroach, Blattella germanica.
Journal: Journal of insect science (Online) 20060101
Title: Prenylation-defective human connexin32 mutants are normally localized and function equivalently to wild-type connexin32 in myelinating Schwann cells.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050803
Title: 4,8-Dimethyldecanal, the aggregation pheromone of Tribolium castaneum, is biosynthesized through the fatty acid pathway.
Journal: Journal of chemical ecology 20050601
Title: Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20050215
Title: Revised chirality of the acyl group of 8'-O-(3-hydroxy-3-methylglutaryl)-8'-hydroxyabscisic acid.
Journal: Phytochemistry 20040901
Title: Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20040801
Title: Cell-based screen of HMG-CoA reductase inhibitors and expression regulators using LC-MS.
Journal: Analytical biochemistry 20040601
Title: Calmodulin antagonist W-7 inhibits de novo synthesis of cholesterol and suppresses secretion of de novo synthesized and preformed lipids from cultured hepatocytes.
Journal: Biochimica et biophysica acta 20040601
Title: Leukaemia inhibitory factor or oncostatin M induction of Swiss 3T3 cells does not require mevalonic acid synthesis nor protein isoprenylation to initiate DNA replication.
Journal: Biochemical and biophysical research communications 20040123
Title: Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs.
Journal: Lipids in health and disease 20040101
Title: Methodology for synthesis and isolation of 5-phosphomevalonic acid.
Journal: Analytical biochemistry 20031015
Title: Frontalin: De novo biosynthesis of an aggregation pheromone component by Dendroctonus spp. bark beetles (Coleoptera: Scolytidae).
Journal: Insect biochemistry and molecular biology 20030801
Title: Lovastatin inhibits brain endothelial cell Rho-mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030501
Title: Regulation of isoprenoid/cholesterol biosynthesis in cells from mevalonate kinase-deficient patients.
Journal: The Journal of biological chemistry 20030221
Title: Effect of phytosterols on cholesterol metabolism and MAP kinase in MDA-MB-231 human breast cancer cells.
Journal: The Journal of nutritional biochemistry 20030201
Title: Biogenetic studies in Syringa vulgaris L.: synthesis and bioconversion of deuterium-labeled precursors into lilac aldehydes and lilac alcohols.
Journal: Journal of agricultural and food chemistry 20030115
Title: Anti-proliferative action of endogenous dehydroepiandrosterone metabolites on human cancer cell lines.
Journal: Steroids 20030101
Title: Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes.
Journal: Journal of lipid research 20030101
Title: HMG-CoA reductase inhibition aborts functional differentiation and triggers apoptosis in cultured primary human monocytes: a potential mechanism of statin-mediated vasculoprotection.
Journal: BMC cardiovascular disorders 20030101
Title: Pughiinin A, a sesquiterpene from the fungus Kionochaeta pughii BCC 3878.
Journal: Planta medica 20021101
Title: Simultaneous evaluation of HMG-CoA reductase and cholesterol 7alpha-hydroxylase activities by electrospray tandem MS.
Journal: Lipids 20021101
Title: [Mevalonolactone: a volatile compound produced by Psammotettix alienus (Dhb)].
Journal: Comptes rendus biologies 20020901
Title: Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects.
Journal: Journal of neuroscience research 20020601
Title: CD43 polarization in unprimed T cells can be dissociated from raft coalescence by inhibition of HMG CoA reductase.
Journal: Blood 20020401
Title: Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor.
Journal: European journal of biochemistry 20020301
Title: Prolonged inhibition of cholesterol synthesis by atorvastatin inhibits apo B-100 and triglyceride secretion from HepG2 cells.
Journal: Atherosclerosis 20010701
Title: Progesterone inhibits apolipoprotein-mediated cellular lipid release: a putative mechanism for the decrease of high-density lipoprotein.
Journal: Biochimica et biophysica acta 20010629
Title: Biosynthesis of 2-methyl-3-buten-2-ol emitted from needles of Pinus ponderosa via the non-mevalonate DOXP/MEP pathway of isoprenoid formation.
Journal: Planta 20010601
Title: Isoprenoid biosynthesis is not compromised in a Zellweger syndrome mouse model.
Journal: Biochimica et biophysica acta 20010531
Title: Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography-electrospray mass spectrometry.
Journal: Journal of chromatography. B, Biomedical sciences and applications 20010425
Title: Synthetic applications of epoxide hydrolases.
Journal: Current opinion in chemical biology 20010401
Title: Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated.
Journal: The Biochemical journal 19930115
Title: The gamma subunit of transducin is farnesylated.
Journal: Proceedings of the National Academy of Sciences of the United States of America 19901001
Title: Lipid and lipoprotein metabolism in Hep G2 cells.
Journal: Biochimica et biophysica acta 19880812
Title: Domingos SR, et al. On the structural intricacies of a metabolic precursor: Direct spectroscopic detection of water-induced conformational reshaping of mevalonolactone. J Chem Phys. 2017 Sep 28;147(12):124310.
Title: Cecatto C, et al. Mevalonolactone disrupts mitochondrial functions and induces permeability transition pore opening in rat brain mitochondria: Implications for the pathogenesis of mevalonic aciduria. Neurochem Int. 2017 Sep;108:133-145.