675-21-8,MFCD06658278
Catalog No.:AA00600Z

675-21-8 | 5-Fluoropyrimidine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
96%
in stock  
$162.00   $114.00
- +
1g
96%
in stock  
$385.00   $269.00
- +
5g
96%
in stock  
$1,147.00   $803.00
- +
25g
96%
in stock  
$3,951.00 $2,766.00
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00600Z
Chemical Name:
5-Fluoropyrimidine
CAS Number:
675-21-8
Molecular Formula:
C4H3FN2
Molecular Weight:
98.0784
MDL Number:
MFCD06658278
SMILES:
Fc1cncnc1
Properties
Properties
 
BP:
129°C at 760 mmHg  
Form:
Liquid  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
51.7  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
7  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
0  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
0  

Literature

Title: Resected pancreatic neuroendocrine tumors: patterns of failure and disease-related outcomes with or without radiotherapy.

Journal: International journal of radiation oncology, biology, physics 20120715

Title: Antifungal resistance and new strategies to control fungal infections.

Journal: International journal of microbiology 20120101

Title: Targeting the human EGFR family in esophagogastric cancer.

Journal: Nature reviews. Clinical oncology 20110405

Title: Changing management and survival in patients with stage IV colorectal cancer.

Journal: Diseases of the colon and rectum 20110201

Title: Phase II study of FOLFIRI regimen in patients with advanced colorectal cancer refractory to fluoropyrimidine and oxaliplatin.

Journal: Cancer chemotherapy and pharmacology 20110101

Title: HER2 Testing in Gastric/Gastroesophageal Junction Adenocarcinomas: Unique Features of a Familiar Test.

Journal: Gastrointestinal cancer research : GCR 20110101

Title: Early alpha-fetoprotein response predicts treatment efficacy of antiangiogenic systemic therapy in patients with advanced hepatocellular carcinoma.

Journal: Cancer 20101001

Title: [The role of oral fluoropyrimidines in colorectal cancer treatment--a review].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20100701

Title: A case with synchronous multiple liver metastases from gastric carcinoma: postoperative long-term disease-free survival.

Journal: Langenbeck's archives of surgery 20090701

Title: Commentary 2008: 25 or 50 years later?

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20081020

Title: Is there an optimal chemotherapy regimen for the treatment of advanced gastric cancer that will provide a platform for the introduction of new biological agents?

Journal: The oncologist 20080701

Title: [Genetic polymorphisms related to fluoropyrimidine sensitivity and toxicity].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20080701

Title: Key labeling technologies to tackle sizeable problems in RNA structural biology.

Journal: International journal of molecular sciences 20080601

Title: A phase II study to determine the ability of gefitinib to reverse fluoropyrimidine resistance in metastatic colorectal cancer (the INFORM study).

Journal: British journal of cancer 20080226

Title: [Pharmacogenetics in fluoropyrimidine chemotherapy].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20080201

Title: Synthesis of 5-fluoropyrimidine nucleotides as sensitive NMR probes of RNA structure.

Journal: Journal of the American Chemical Society 20071205

Title: Tumor quantification of several fluoropyrimidines resistance gene expression with a unique quantitative RT-PCR method. Implications for pretherapeutic determination of tumor resistance phenotype.

Journal: Cancer letters 20061028

Title: [Multicenter phase II study of modified FOLFIRI regimen in the advanced colorectal cancer patient refractory to fluoropyrimidine and oxaliplatin].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20061001

Title: Coexpression of the uracil phosphoribosyltransferase gene with a chimeric human nerve growth factor receptor/cytosine deaminase fusion gene, using a single retroviral vector, augments cytotoxicity of transduced human T cells exposed to 5-fluorocytosine.

Journal: Human gene therapy 20060501

Title: Analysis of pyrimidine catabolism in Drosophila melanogaster using epistatic interactions with mutations of pyrimidine biosynthesis and beta-alanine metabolism.

Journal: Genetics 20060301

Title: [5 -fluoropyrimidines for treatment of biliary tract cancers].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20060101

Title: Interest of fluorine-19 nuclear magnetic resonance spectroscopy in the detection, identification and quantification of metabolites of anticancer and antifungal fluoropyrimidine drugs in human biofluids.

Journal: Chemotherapy 20060101

Title: Advances and challenges in fluoropyrimidine pharmacogenomics and pharmacogenetics.

Journal: Pharmacogenomics 20051201

Title: A randomized phase III trial of post-operative adjuvant oral fluoropyrimidine versus sequential paclitaxel/oral fluoropyrimidine; and UFT versus S1 for T3/T4 gastric carcinoma: the Stomach Cancer Adjuvant Multi-institutional Trial Group (Samit) Trial.

Journal: Japanese journal of clinical oncology 20051101

Title: Development of a stereological method to measure levels of fluoropyrimidine metabolizing enzymes in tumor sections using laser scanning cytometry.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20050401

Title: DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.

Journal: The Journal of biological chemistry 20050218

Title: Pathways of pyrimidine salvage in Streptomyces.

Journal: Current microbiology 20050101

Title: Thymidylate synthase and dihydropyrimidine dehydrogenase in non-small cell lung cancer: relationship between mRNA expression and activity.

Journal: Anticancer research 20050101

Title: Combination of oral fluoropyrimidine and docetaxel: reappraisal of synergistic effect against gastric carcinoma xenografts.

Journal: In vivo (Athens, Greece) 20050101

Title: Tumor dihydropyrimidine dehydrogenase expression is a useful marker in adjuvant therapy with oral fluoropyrimidines after curative resection of colorectal cancer.

Journal: Cancer chemotherapy and pharmacology 20041201

Title: [Postoperative changes in serum lipid levels of breast cancer and adjuvant chemotherapy].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20041001

Title: Phase I and pharmacokinetic study of the oral fluoropyrimidine S-1 on a once-daily-for-28-day schedule in patients with advanced malignancies.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040801

Title: Potential for predicting toxicity and response of fluoropyrimidines in patients.

Journal: Current drug targets 20040501

Title: Significance of postoperative adjuvant immunochemotherapy after curative resection of colorectal cancers: identification of responders incorporating the age factor.

Journal: Oncology reports 20040301

Title: The modulated oral fluoropyrimidine prodrug S-1, and its use in gastrointestinal cancer and other solid tumors.

Journal: Anti-cancer drugs 20040201

Title: [The clinical importance of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the 5-fluoropyrimidine-based therapy of metastatic colorectal tumours].

Journal: Magyar onkologia 20040101

Title: A role for DNA mismatch repair in sensing and responding to fluoropyrimidine damage.

Journal: Oncogene 20031020

Title: ZD1839 (Iressa) modifies the activity of key enzymes linked to fluoropyrimidine activity: rational basis for a new combination therapy with capecitabine.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20031015

Title: Is the measurement of thymidylate synthase to determine suitability for treatment with 5-fluoropyrimidines ready for prime time?

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030401

Title: [The antitumor activity of DPD inhibitory-fluoropyrimidine (DIF) and non-DIF alone or in combination with paclitaxel against orthotopically implanted human breast cancer].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20020501

Title: Significance of postoperative adjuvant immunochemotherapy after curative resection of colorectal cancers: Association between host or tumor factors and survival.

Journal: International journal of oncology 20020201

Title: Tumor dihydropyrimidine dehydrogenase activity in advanced cervical carcinoma.

Journal: Oncology reports 20020101

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Related Products of 675-21-8
Tags:675-21-8 Molecular Formula|675-21-8 MDL|675-21-8 SMILES|675-21-8 5-Fluoropyrimidine
Catalog No.: AA00600Z
675-21-8,MFCD06658278
675-21-8 | 5-Fluoropyrimidine
Pack Size: 250mg
Purity: 96%
in stock
$162.00 $114.00
Pack Size: 1g
Purity: 96%
in stock
$385.00 $269.00
Pack Size: 5g
Purity: 96%
in stock
$1,147.00 $803.00
Pack Size: 25g
Purity: 96%
in stock
$3,951.00 $2,766.00
Quantity
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Technical Information
Catalog Number: AA00600Z
Chemical Name: 5-Fluoropyrimidine
CAS Number: 675-21-8
Molecular Formula: C4H3FN2
Molecular Weight: 98.0784
MDL Number: MFCD06658278
SMILES: Fc1cncnc1
Properties
BP: 129°C at 760 mmHg  
Form: Liquid  
Storage: Keep in dry area;-20 ℃;  
Complexity: 51.7  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 7  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 0  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 0  
Literature fold

Title: Resected pancreatic neuroendocrine tumors: patterns of failure and disease-related outcomes with or without radiotherapy.

Journal: International journal of radiation oncology, biology, physics20120715

Title: Antifungal resistance and new strategies to control fungal infections.

Journal: International journal of microbiology20120101

Title: Targeting the human EGFR family in esophagogastric cancer.

Journal: Nature reviews. Clinical oncology20110405

Title: Changing management and survival in patients with stage IV colorectal cancer.

Journal: Diseases of the colon and rectum20110201

Title: Phase II study of FOLFIRI regimen in patients with advanced colorectal cancer refractory to fluoropyrimidine and oxaliplatin.

Journal: Cancer chemotherapy and pharmacology20110101

Title: HER2 Testing in Gastric/Gastroesophageal Junction Adenocarcinomas: Unique Features of a Familiar Test.

Journal: Gastrointestinal cancer research : GCR20110101

Title: Early alpha-fetoprotein response predicts treatment efficacy of antiangiogenic systemic therapy in patients with advanced hepatocellular carcinoma.

Journal: Cancer20101001

Title: [The role of oral fluoropyrimidines in colorectal cancer treatment--a review].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy20100701

Title: A case with synchronous multiple liver metastases from gastric carcinoma: postoperative long-term disease-free survival.

Journal: Langenbeck's archives of surgery20090701

Title: Commentary 2008: 25 or 50 years later?

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20081020

Title: Is there an optimal chemotherapy regimen for the treatment of advanced gastric cancer that will provide a platform for the introduction of new biological agents?

Journal: The oncologist20080701

Title: [Genetic polymorphisms related to fluoropyrimidine sensitivity and toxicity].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy20080701

Title: Key labeling technologies to tackle sizeable problems in RNA structural biology.

Journal: International journal of molecular sciences20080601

Title: A phase II study to determine the ability of gefitinib to reverse fluoropyrimidine resistance in metastatic colorectal cancer (the INFORM study).

Journal: British journal of cancer20080226

Title: [Pharmacogenetics in fluoropyrimidine chemotherapy].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy20080201

Title: Synthesis of 5-fluoropyrimidine nucleotides as sensitive NMR probes of RNA structure.

Journal: Journal of the American Chemical Society20071205

Title: Tumor quantification of several fluoropyrimidines resistance gene expression with a unique quantitative RT-PCR method. Implications for pretherapeutic determination of tumor resistance phenotype.

Journal: Cancer letters20061028

Title: [Multicenter phase II study of modified FOLFIRI regimen in the advanced colorectal cancer patient refractory to fluoropyrimidine and oxaliplatin].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology]20061001

Title: Coexpression of the uracil phosphoribosyltransferase gene with a chimeric human nerve growth factor receptor/cytosine deaminase fusion gene, using a single retroviral vector, augments cytotoxicity of transduced human T cells exposed to 5-fluorocytosine.

Journal: Human gene therapy20060501

Title: Analysis of pyrimidine catabolism in Drosophila melanogaster using epistatic interactions with mutations of pyrimidine biosynthesis and beta-alanine metabolism.

Journal: Genetics20060301

Title: [5 -fluoropyrimidines for treatment of biliary tract cancers].

Journal: Nihon rinsho. Japanese journal of clinical medicine20060101

Title: Interest of fluorine-19 nuclear magnetic resonance spectroscopy in the detection, identification and quantification of metabolites of anticancer and antifungal fluoropyrimidine drugs in human biofluids.

Journal: Chemotherapy20060101

Title: Advances and challenges in fluoropyrimidine pharmacogenomics and pharmacogenetics.

Journal: Pharmacogenomics20051201

Title: A randomized phase III trial of post-operative adjuvant oral fluoropyrimidine versus sequential paclitaxel/oral fluoropyrimidine; and UFT versus S1 for T3/T4 gastric carcinoma: the Stomach Cancer Adjuvant Multi-institutional Trial Group (Samit) Trial.

Journal: Japanese journal of clinical oncology20051101

Title: Development of a stereological method to measure levels of fluoropyrimidine metabolizing enzymes in tumor sections using laser scanning cytometry.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20050401

Title: DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.

Journal: The Journal of biological chemistry20050218

Title: Pathways of pyrimidine salvage in Streptomyces.

Journal: Current microbiology20050101

Title: Thymidylate synthase and dihydropyrimidine dehydrogenase in non-small cell lung cancer: relationship between mRNA expression and activity.

Journal: Anticancer research20050101

Title: Combination of oral fluoropyrimidine and docetaxel: reappraisal of synergistic effect against gastric carcinoma xenografts.

Journal: In vivo (Athens, Greece)20050101

Title: Tumor dihydropyrimidine dehydrogenase expression is a useful marker in adjuvant therapy with oral fluoropyrimidines after curative resection of colorectal cancer.

Journal: Cancer chemotherapy and pharmacology20041201

Title: [Postoperative changes in serum lipid levels of breast cancer and adjuvant chemotherapy].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy20041001

Title: Phase I and pharmacokinetic study of the oral fluoropyrimidine S-1 on a once-daily-for-28-day schedule in patients with advanced malignancies.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20040801

Title: Potential for predicting toxicity and response of fluoropyrimidines in patients.

Journal: Current drug targets20040501

Title: Significance of postoperative adjuvant immunochemotherapy after curative resection of colorectal cancers: identification of responders incorporating the age factor.

Journal: Oncology reports20040301

Title: The modulated oral fluoropyrimidine prodrug S-1, and its use in gastrointestinal cancer and other solid tumors.

Journal: Anti-cancer drugs20040201

Title: [The clinical importance of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the 5-fluoropyrimidine-based therapy of metastatic colorectal tumours].

Journal: Magyar onkologia20040101

Title: A role for DNA mismatch repair in sensing and responding to fluoropyrimidine damage.

Journal: Oncogene20031020

Title: ZD1839 (Iressa) modifies the activity of key enzymes linked to fluoropyrimidine activity: rational basis for a new combination therapy with capecitabine.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20031015

Title: Is the measurement of thymidylate synthase to determine suitability for treatment with 5-fluoropyrimidines ready for prime time?

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20030401

Title: [The antitumor activity of DPD inhibitory-fluoropyrimidine (DIF) and non-DIF alone or in combination with paclitaxel against orthotopically implanted human breast cancer].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy20020501

Title: Significance of postoperative adjuvant immunochemotherapy after curative resection of colorectal cancers: Association between host or tumor factors and survival.

Journal: International journal of oncology20020201

Title: Tumor dihydropyrimidine dehydrogenase activity in advanced cervical carcinoma.

Journal: Oncology reports20020101

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