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Home Amines 677297-51-7
677297-51-7,MFCD16038873
Catalog No.:AA006JXR

677297-51-7 | 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$29.00   $21.00
- +
5mg
98%
in stock  
$101.00   $71.00
- +
10mg
98%
in stock  
$150.00   $105.00
- +
250mg
96%
in stock  
$577.00   $404.00
- +
1g
96%
in stock  
$1,424.00   $997.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA006JXR
Chemical Name:
3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol
CAS Number:
677297-51-7
Molecular Formula:
C18H14N6O2
Molecular Weight:
346.3428
MDL Number:
MFCD16038873
SMILES:
Oc1cccc(c1)c1nc2nc(N)nc(c2nc1c1cccc(c1)O)N
Properties
Properties
 
Form:
Solid  
MP:
>174ºC (dec.)  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
483  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
2  
XLogP3:
1.7  

Downstream Synthesis Route

[1]Patent:US2005/282814,2005,A1

677297-51-7   
3-2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-ylphenoldihydrochloride 

[1]Patent:US2007/259876,2007,A1.Locationinpatent:Page/Pagecolumn17

677297-51-7    75-75-2   
3-2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-ylphenolmethanesulfonate 

[1]Patent:US2007/259876,2007,A1.Locationinpatent:Page/Pagecolumn17

[1]JournalofMedicinalChemistry,2007,vol.50,p.4279-4294

123-00-2    677297-51-7   
C25H27N7O3 

[1]JournalofMedicinalChemistry,2007,vol.50,p.4279-4294

Literature

Title: PI3Kδ and PI3Kγ as targets for autoimmune and inflammatory diseases.

Journal: Journal of medicinal chemistry 20121025

Title: Comprehensive analysis of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111030

Title: Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.

Journal: Chemistry & biology 20101124

Title: Aerosolized phosphoinositide 3-kinase gamma/delta inhibitor TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease.

Journal: The Journal of pharmacology and experimental therapeutics 20090301

Title: Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction.

Journal: Journal of medicinal chemistry 20070906

Title: Doukas J, et al. Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19866-71.

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SDS
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Tags:677297-51-7 Molecular Formula|677297-51-7 MDL|677297-51-7 SMILES|677297-51-7 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol