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68475-42-3,MFCD00866794
Catalog No.:AA00IBRG

68475-42-3 | Anagrelide

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10mg
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50mg
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  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00IBRG
Chemical Name:
Anagrelide
CAS Number:
68475-42-3
Molecular Formula:
C10H7Cl2N3O
Molecular Weight:
256.0881
MDL Number:
MFCD00866794
SMILES:
O=C1N=C2N(C1)Cc1c(N2)ccc(c1Cl)Cl
Properties
Computed Properties
 
Complexity:
360  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
XLogP3:
1.6  

Literature

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Journal: Medical oncology (Northwood, London, England) 20121201

Title: Pharmacokinetics and tolerability of anagrelide hydrochloride in young (18 - 50 years) and elderly (≥ 65 years) patients with essential thrombocythemia.

Journal: International journal of clinical pharmacology and therapeutics 20121101

Title: Inverted takotsubo cardiomyopathy in a patient with essential thrombocythemia exposed to anagrelide and phentermine.

Journal: International journal of cardiology 20121004

Title: Front-line therapy in polycythemia vera and essential thrombocythemia.

Journal: Blood reviews 20120901

Title: Platelet-lowering therapy with anagrelide as an adjuvant therapy for treatment of primary pulmonary neoplasm-associated extreme thrombocytosis.

Journal: Japanese journal of clinical oncology 20120801

Title: Current treatment practices for essential thrombocythemia: survey results from European hematologists/oncologists.

Journal: Hematology (Amsterdam, Netherlands) 20120701

Title: How to manage essential thrombocythemia.

Journal: Leukemia 20120501

Title: Ruxolitinib for the treatment of myelofibrosis: its clinical potential.

Journal: Therapeutics and clinical risk management 20120101

Title: Sequential occurrence of thrombotic thrombocytopenic purpura, essential thrombocythemia, and idiopathic thrombocytopenic purpura in a 42-year-old African-American woman: a case report and review of the literature.

Journal: Journal of medical case reports 20120101

Title: Low impact of cardiovascular adverse events on anagrelide treatment discontinuation in a cohort of 232 patients with essential thrombocythemia.

Journal: Leukemia research 20111201

Title: Anagrelide and cardiovascular events. Much ado about nothing?

Journal: Leukemia research 20111201

Title: cGMP Signaling, Phosphodiesterases and Major Depressive Disorder.

Journal: Current neuropharmacology 20111201

Title: Epigenetic abnormalities in myeloproliferative neoplasms: a target for novel therapeutic strategies.

Journal: Clinical epigenetics 20110801

Title: Very Late Stent Thrombosis in a Drug-Eluting Stent due to Interruption of Anti-Platelet Agents in Patients With Acute Myocardial Infarction and Thrombocytosis.

Journal: Korean circulation journal 20110701

Title: Stress cardiomyopathy complicated by left ventricular thrombi and cerebral infarctions in a patient with essential thrombocythemia.

Journal: Journal of cardiovascular ultrasound 20110601

Title: [Differential diagnosis of clinical relevance].

Journal: Therapeutische Umschau. Revue therapeutique 20110301

Title: [Diagnosis and treatment of BCR/ABL-negative myeloproliferative diseases--principles and rationale of CZEMP recommendations].

Journal: Vnitrni lekarstvi 20110201

Title: Refined cytogenetic-risk categorization for overall and leukemia-free survival in primary myelofibrosis: a single center study of 433 patients.

Journal: Leukemia 20110101

Title: Critical appraisal of nilotinib in frontline treatment of chronic myeloid leukemia.

Journal: Cancer management and research 20110101

Title: Estimating the budget impact of orphan medicines in Europe: 2010 - 2020.

Journal: Orphanet journal of rare diseases 20110101

Title: Thrombocytosis: diagnostic evaluation, thrombotic risk stratification, and risk-based management strategies.

Journal: Thrombosis 20110101

Title: Gender and Vascular Complications in the JAK2 V617F-Positive Myeloproliferative Neoplasms.

Journal: Thrombosis 20110101

Title: Management of essential thrombocythemia.

Journal: Hematology. American Society of Hematology. Education Program 20110101

Title: Emerging treatments for essential thrombocythemia.

Journal: Journal of blood medicine 20110101

Title: Compensatory thrombopoietin production from the liver and bone marrow stimulates thrombopoiesis of living rat megakaryocytes in chronic renal failure.

Journal: Nephron extra 20110101

Title: [Two clinical cases of essential thrombocythemia complicated by thrombosis in parturients].

Journal: Likars'ka sprava 20110101

Title: Anagrelide represses GATA-1 and FOG-1 expression without interfering with thrombopoietin receptor signal transduction.

Journal: Journal of thrombosis and haemostasis : JTH 20101001

Title: Plasma levels of angiogenic factors and circulating endothelial cells in essential thrombocythemia: correlation with cytoreductive therapy and JAK2-V617F mutational status.

Journal: Leukemia & lymphoma 20100901

Title: Development of acute myocardial infarction in a young female patient with essential thrombocythemia treated with anagrelide: a case report.

Journal: The Korean journal of hematology 20100601

Title: Anagrelide for the treatment of thrombocythaemia in daily clinical practice: a post-marketing observational survey on efficacy and safety performed in Germany.

Journal: Onkologie 20100101

Title: JAK2 mutation and thrombosis in the myeloproliferative neoplasms.

Journal: Current hematologic malignancy reports 20100101

Title: Postpartal recurrent non-ST elevation myocardial infarction in essential thrombocythaemia: case report and review of the literature.

Journal: Thrombosis journal 20100101

Title: [Diagnosis and therapy for patients with essential thrombocythemia. Guidelines of Croatian Cooperative Group for hematologic disorders--KROHEM].

Journal: Lijecnicki vjesnik 20100101

Title: JAK2 Negative Polycythemia Vera.

Journal: Journal of laboratory physicians 20100101

Title: Chronic myeloproliferative neoplasms: a collaborative approach.

Journal: Mediterranean journal of hematology and infectious diseases 20100101

Title: Essential thrombocythemia: aeromedical considerations.

Journal: Aviation, space, and environmental medicine 20091101

Title: [The results of patients with essentials thrombocythemia and other myeloproliferation-related thrombocythemia--a report of patients treated with Thromboreductin].

Journal: Vnitrni lekarstvi 20091101

Title: Management of refractory essential thrombocythemia with anagrelide in a patient undergoing hemodialysis.

Journal: Clinical therapeutics 20091101

Title: Essential thrombocythemia: past and present.

Journal: Internal and emergency medicine 20091001

Title: Myelofibrosis involving lymph node: a novel cytogenetic abnormality in a mimicker of mesenchymal neoplasm.

Journal: Journal of hematopathology 20090901

Title: Atypical Takotsubo syndrome during anagrelide therapy.

Journal: Journal of cardiovascular medicine (Hagerstown, Md.) 20090701

Title: Reticulin accumulation in essential thrombocythemia: prognostic significance and relationship to therapy.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090620

Title: [Retrospective analysis of the efficacy and tolerability of anagrelide in patients with essential thrombocytemia: Spanish registry of essential thrombocytemia].

Journal: Medicina clinica 20090620

Title: Role of platelet counts in the management of essential thrombocythemia: experience with anagrelide.

Journal: Expert review of hematology 20090601

Title: Anagrelide for the treatment of essential thrombocythemia: a survey among European hematologists/oncologists.

Journal: Hematology (Amsterdam, Netherlands) 20090201

Title: Limited efficacy of hydroxyurea in lowering of the JAK2 V617F allele burden.

Journal: Hematology (Amsterdam, Netherlands) 20090201

Title: Pharmacokinetics, bioequivalence, tolerability, and effects on platelet counts of two formulations of anagrelide in healthy volunteers and patients with thrombocythemia associated with chronic myeloproliferation.

Journal: Clinical therapeutics 20090201

Title: Long-term management of thrombocytosis in essential thrombocythaemia.

Journal: Annals of hematology 20090101

Title: Myelofibrosis with myeloid metaplasia: the advanced phase of an untreated disseminated hematological cancer. Time to change our therapeutic attitude with early upfront treatment?

Journal: Leukemia research 20090101

Title: Anagrelide: 20 years later.

Journal: Expert review of anticancer therapy 20090101

Title: Wild-type JAK2 secondary acute erythroleukemia developing after JAK2-V617F-mutated primary myelofibrosis.

Journal: Acta haematologica 20090101

Title: Drugs associated with more suicidal ideations are also associated with more suicide attempts.

Journal: PloS one 20090101

Title: Anagrelide treatment in early pregnancy in a patient with JAK2V617F-positive essential thrombocythemia: case report and literature review.

Journal: Acta haematologica 20090101

Title: Pathogenesis and management of essential thrombocythemia.

Journal: Hematology. American Society of Hematology. Education Program 20090101

Title: The combined use of hydroxyurea and anagrelide allows satisfactory hematologic control in patients with chronic myeloproliferative disorders and thrombocytosis: a report on 13 patients with poor tolerance to hydroxyurea monotherapy.

Journal: Leukemia & lymphoma 20081101

Title: Successful rechallenge with anagrelide in a patient with anagrelide-associated cardiomyopathy.

Journal: Annals of hematology 20080801

Title: Evidence and expertise in the management of polycythemia vera and essential thrombocythemia.

Journal: Leukemia 20080801

Title: Bone marrow pathology in essential thrombocythemia: interobserver reliability and utility for identifying disease subtypes.

Journal: Blood 20080101

Title: Essential thrombocytemia and acute coronary syndrome: clinical profile and association with other thromboembolic events.

Journal: Acute cardiac care 20080101

Title: Aortic valve replacement in a young patient with essential thrombocytosis.

Journal: Journal of cardiothoracic surgery 20080101

Title: TPO, but not soluble-IL-6 receptor, levels increase after anagrelide treatment of thrombocythemia in chronic myeloproliferative disorders.

Journal: International journal of medical sciences 20080101

Title: [What is the current treatment of patients with essential thrombocytopenia and other myeloproliferations accompanied with thrombocythemia [corrected] and what can be the predictive sign of the risk of thrombosis in such patients--a report from the registry of patients treated by Thromboreductine].

Journal: Vnitrni lekarstvi 20080101

Title: [Anagrelide for treatment of patients with essential thrombocythaemia].

Journal: Lijecnicki vjesnik 20080101

Title: Hydroxyurea and anagrelide combination therapy in patients with chronic myeloproliferative diseases resistant or intolerant to monotherapy.

Journal: Acta haematologica 20080101

Title: Myelofibrosis: biology and treatment options.

Journal: European journal of haematology. Supplementum 20071001

Title: Essential thrombocythaemia treatment options: addressing patient-specific needs.

Journal: European journal of haematology. Supplementum 20071001

Title: Options in the management of essential thrombocythaemia.

Journal: European journal of haematology. Supplementum 20071001

Title: Practical approach to treating essential thrombocythaemia: case studies.

Journal: European journal of haematology. Supplementum 20071001

Title: Essential versus reactive thrombocythemia in children: retrospective analyses of 12 cases.

Journal: Pediatric blood & cancer 20070701

Title: Chronic myeloid leukemia evolving after idiopathic myelofibrosis.

Journal: The Israel Medical Association journal : IMAJ 20070701

Title: Therapy for polycythemia vera and essential thrombocythemia is driven by the cardiovascular risk.

Journal: Seminars in thrombosis and hemostasis 20070601

Title: [Essential thrombocytemia and other myeloproliferations with thrombocytemia in the data of the register of patients treated with Thromboreductin till the end of 2006].

Journal: Vnitrni lekarstvi 20070601

Title: Imatinib and tyrosine kinase inhibition, in the management of BCR-ABL negative myeloproliferative disorders.

Journal: Biologics : targets & therapy 20070601

Title: Acute coronary syndromes and Anagrelide.

Journal: International journal of cardiology 20070412

Title: Myelofibrosis with a novel translocation, t(1;3)(q31;q23), and response to imatinib mesylate.

Journal: Leukemia 20070301

Title: Examination of platelet function in whole blood under dynamic flow conditions with the cone and plate(let) analyzer: effect of erythrocytosis and thrombocytosis.

Journal: American journal of clinical pathology 20070301

Title: [Appearance of leg ulcers associated with intake of anagrelide].

Journal: Deutsche medizinische Wochenschrift (1946) 20070216

Title: Essential thrombocythemia.

Journal: Orphanet journal of rare diseases 20070101

Title: A novel unconventional antigen MPD5 elicits anti-tumor humoral immune responses in a subset of patients with polycythemia vera.

Journal: International journal of immunopathology and pharmacology 20070101

Title: Progression of bone marrow fibrosis in patients with essential thrombocythemia and polycythemia vera during anagrelide treatment.

Journal: Medical oncology (Northwood, London, England) 20070101

Title: Impact of imatinib on the pharmacokinetics and in vivo efficacy of etoposide and/or ifosfamide.

Journal: BMC pharmacology 20070101

Title: Expertise-based management in essential thrombocythemia and polycythemia vera.

Journal: Cancer journal (Sudbury, Mass.) 20070101

Title: Effect of anagrelide on platelet coagulant function in patients with essential thrombocythemia.

Journal: Acta haematologica 20070101

Title: Platelet-mediated erythromelalgic, cerebral, ocular and coronary microvascular ischemic and thrombotic manifestations in patients with essential thrombocythemia and polycythemia vera: a distinct aspirin-responsive and coumadin-resistant arterial thrombophilia.

Journal: Platelets 20061201

Title: Hematoma of a congenitally bicuspid aortic valve in a patient with polycythemia vera and the antiphospholipid antibody syndrome.

Journal: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 20061201

Title: Long-term use of anagrelide in the treatment of children with essential thrombocythemia.

Journal: European journal of haematology 20061001

Title: Advances in the therapy of chronic idiopathic myelofibrosis.

Journal: The oncologist 20060901

Title: [Combination of imatinib and anagrelide in treatment of chronic myeloid leukemia in blastic phase].

Journal: Vnitrni lekarstvi 20060901

Title: [Primary thrombocythemia: diagnosis and therapy].

Journal: Medizinische Klinik (Munich, Germany : 1983) 20060815

Title: Acute biphenotypic leukemia arising in a patient with essential thrombocythemia.

Journal: American journal of hematology 20060801

Title: Current management of the myeloproliferative disorders: a case-based review.

Journal: Archives of pathology & laboratory medicine 20060801

Title: Molecular basis of the diagnosis and treatment of polycythemia vera and essential thrombocythemia.

Journal: Blood 20060601

Title: Comparison between anagrelide and hydroxycarbamide in their activities against haematopoietic progenitor cell growth and differentiation: selectivity of anagrelide for the megakaryocytic lineage.

Journal: Leukemia 20060601

Title: Anagrelide: new drug. Essential thrombocythaemia: further evaluation needed for this last-resort treatment.

Journal: Prescrire international 20060601

Title: Effects of anagrelide on megakaryopoiesis and platelet production.

Journal: Seminars in thrombosis and hemostasis 20060601

Title: Anagrelide: what was new in 2004 and 2005?

Journal: Seminars in thrombosis and hemostasis 20060601

Title: Pegylated interferon therapy for patients with Philadelphia chromosome-negative myeloproliferative disorders.

Journal: Seminars in thrombosis and hemostasis 20060601

Title: Long-term incidence of hematological evolution in three French prospective studies of hydroxyurea and pipobroman in polycythemia vera and essential thrombocythemia.

Journal: Seminars in thrombosis and hemostasis 20060601

Title: Update on diagnosis and management of essential thrombocythemia.

Journal: Seminars in thrombosis and hemostasis 20060601

Title: Coronary artery intervention after cytostatics treatment in unstable angina patient with essential thrombocythemia. A case report and literature review.

Journal: The Korean journal of internal medicine 20060601

Title: Emergence of chronic myelogenous leukemia in a patient with primary thrombocythemia and absence of BCR/ABL rearrangement.

Journal: Cancer genetics and cytogenetics 20060501

Title: JAK2 V617F: a single mutation in the myeloproliferative group of disorders.

Journal: The Ulster medical journal 20060501

Title: [Anagrelide in the treatment of essential thrombocythemia (ET) and other myeloproliferative disorders with thrombocythemia based on data from patient register in the CR].

Journal: Vnitrni lekarstvi 20060501

Title: Analysis of risk factors: the rationale of the guidelines of the Czech Hematological Society for diagnosis and treatment of chronic myeloproliferative disorders with thrombocythemia.

Journal: Seminars in thrombosis and hemostasis 20060401

Title: Anagrelide treatment in myeloproliferative disorders.

Journal: Seminars in thrombosis and hemostasis 20060401

Title: Management of essential thrombocythemia: implications of the medical research council primary thrombocythemia 1 trial.

Journal: Seminars in thrombosis and hemostasis 20060401

Title: Essential thrombocythemia: scientific advances and current practice.

Journal: Current opinion in hematology 20060301

Title: 'Double hit' from streptococcal pneumonia and hypersensitivity pneumonitis associated with anagrelide.

Journal: Clinical and laboratory haematology 20060201

Title: Bilateral adrenal hemorrhage associated with essential thrombocytosis.

Journal: American journal of hematology 20060201

Title: Anagrelide: a review of its use in the management of essential thrombocythaemia.

Journal: Drugs 20060101

Title: A preliminary investigation into the action of anagrelide: thrombopoietin-c-Mpl receptor interactions.

Journal: Experimental hematology 20060101

Title: [The use of anagrelide to treat thrombocytosis in connection with the chronic myeloproliferative disease].

Journal: Duodecim; laaketieteellinen aikakauskirja 20060101

Title: Polycythaemia vera and essential thrombocythaemia: current treatment strategies.

Journal: Drugs 20060101

Title: [Megakaryopoietic cytokine levels in patients with essential thrombocythemia and their relationship with clinical and biochemical features].

Journal: Medicina 20060101

Title: Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study.

Journal: Lancet (London, England) 20051203

Title: [Treatment of essential thrombocythemia].

Journal: La Revue de medecine interne 20051201

Title: Successful outcome with anagrelide in pregnancy.

Journal: Annals of hematology 20051001

Title: Comparison of the biological activities of anagrelide and its major metabolites in haematopoietic cell cultures.

Journal: British journal of pharmacology 20051001

Title: Anagrelide does not exert a myelodysplastic effect on megakaryopoiesis: a comparative immunohistochemical and morphometric study with hydroxyurea.

Journal: Histology and histopathology 20051001

Title: Essential thrombocythemia.

Journal: Seminars in hematology 20051001

Title: Anagrelide for control of thrombocytosis due to myeloproliferative disorders.

Journal: Future oncology (London, England) 20051001

Title: Risk-adapted therapy in essential thrombocythemia and polycythemia vera.

Journal: Blood reviews 20050901

Title: Treatment of symptomatic patients with essential thrombocythemia: effectiveness of anagrelide.

Journal: American journal of hematology 20050901

Title: High-output heart failure associated with anagrelide therapy for essential thrombocytosis.

Journal: Annals of internal medicine 20050816

Title: High-performance liquid chromatography-mass spectrometry method for determination of anagrelide in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050805

Title: Moyamoya syndrome in an adolescent with essential thrombocythemia: successful intracranial carotid stent placement.

Journal: Stroke 20050801

Title: Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia.

Journal: The New England journal of medicine 20050707

Title: When and how to treat essential thrombocythemia.

Journal: The New England journal of medicine 20050707

Title: Management of patients with polycythaemia vera: results of a survey among Swedish haematologists.

Journal: European journal of haematology 20050601

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology 20050601

Title: Renal tubular injury associated with anagrelide use.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20050501

Title: Anagrelide: analysis of long-term efficacy, safety and leukemogenic potential in myeloproliferative disorders.

Journal: Leukemia research 20050501

Title: A critical review of anagrelide therapy in essential thrombocythemia and related disorders.

Journal: Leukemia & lymphoma 20050501

Title: Primary and secondary thrombocytosis in childhood.

Journal: British journal of haematology 20050401

Title: Current treatment of myelofibrosis.

Journal: Clinical advances in hematology & oncology : H&O 20050401

Title: PDGF-A, PDGF-B, TGFbeta, and bFGF mRNA levels in patients with essential thrombocythemia treated with anagrelide.

Journal: American journal of hematology 20050201

Title: Anagrelide is effective in treating patients with hydroxyurea-resistant thrombocytosis in patients with chronic myeloid leukemia.

Journal: Leukemia 20050101

Title: Myeloproliferative disorders.

Journal: Clinical medicine (London, England) 20050101

Title: [Clinical application of anagrelide as a selective inhibitor of megakaryocyte system].

Journal: Wiadomosci lekarskie (Warsaw, Poland : 1960) 20050101

Title: [Anagrelide in the treatment of thrombocythemia essential (ET)].

Journal: Polskie Archiwum Medycyny Wewnetrznej 20041201

Title: Anagrelide for thrombocytosis in myeloproliferative disorders: a prospective study to assess efficacy and adverse event profile.

Journal: Cancer 20041115

Title: Anagrelide therapy in pregnancy: report of a case of essential thrombocythemia.

Journal: Annals of hematology 20041101

Title: [Unclear liver fibrosis in a 42-year-old patient with polycythemia vera].

Journal: Der Internist 20041101

Title: A long-term study of young patients with essential thrombocythemia treated with anagrelide.

Journal: Haematologica 20041101

Title: Anagrelide-associated cardiomyopathy in polycythemia vera and essential thrombocythemia.

Journal: Haematologica 20041101

Title: Anagrelide treatment in 52 patients with chronic myeloproliferative diseases.

Journal: Clinical and laboratory haematology 20041001

Title: Anagrelide-induced visual hallucinations in a patient with essential thrombocythemia.

Journal: European journal of haematology 20040901

Title: Effects of anagrelide on platelet factor 4 and vascular endothelial growth factor levels in patients with essential thrombocythemia.

Journal: British journal of haematology 20040901

Title: Anagrelide: a decade of clinical experience with its use for the treatment of primary thrombocythaemia.

Journal: Expert opinion on pharmacotherapy 20040801

Title: Anagrelide: an update on its mechanisms of action and therapeutic potential.

Journal: Expert review of anticancer therapy 20040801

Title: Thrombocytosis.

Journal: The New England journal of medicine 20040610

Title: Adverse effects and benefits of two years of anagrelide treatment for thrombocythemia in chronic myeloproliferative disorders.

Journal: Haematologica 20040501

Title: Essential thrombocythaemia in children: is a treatment needed?

Journal: Expert opinion on pharmacotherapy 20040501

Title: The leukemia controversy in myeloproliferative disorders: is it a natural progression of disease, a secondary sequela of therapy, or a combination of both?

Journal: Seminars in hematology 20040401

Title: Treatment paradigms in the management of myeloproliferative disorders.

Journal: Seminars in hematology 20040401

Title: Thrombocytosis.

Journal: The New England journal of medicine 20040318

Title: Thrombocytosis in an infant with high thrombopoietin concentrations.

Journal: Journal of pediatric hematology/oncology 20040201

Title: Thalidomide for the treatment of idiopathic myelofibrosis.

Journal: European journal of haematology 20040101

Title: Essential thrombocythemia-related acute ST-segment elevation myocardial infarction. A case report and literature review.

Journal: Angiology 20040101

Title: Management of the myeloproliferative disorders : distinguishing data from dogma.

Journal: The hematology journal : the official journal of the European Haematology Association 20040101

Title: [Retrospective analysis of the clinical course of 12 children given the diagnosis essential thrombocythemia].

Journal: Klinische Padiatrie 20040101

Title: [Diagnostic and therapeutic management of essential thrombocythemia in children].

Journal: Medycyna wieku rozwojowego 20040101

Title: [Recurring ischemic cerebral infarction caused by primary thrombocytosis in infancy].

Journal: Revista de neurologia 20031201

Title: Anagrelide-induced bone marrow changes during therapy of chronic myeloproliferative disorders with thrombocytosis. an immunohistochemical and morphometric study of sequential trephine biopsies.

Journal: Haematologica 20031001

Title: Anagrelide and imatinib mesylate combination therapy in patients with chronic myeloproliferative disorders.

Journal: Cancer chemotherapy and pharmacology 20030901

Title: Severe hypersensitivity pneumonitis associated with anagrelide.

Journal: The Annals of pharmacotherapy 20030901

Title: Pharmacotherapy of essential thrombocythaemia: economic considerations.

Journal: Expert opinion on pharmacotherapy 20030901

Title: Acute leukemia and myelodysplasia in patients with a Philadelphia chromosome negative chronic myeloproliferative disorder treated with hydroxyurea alone or with hydroxyurea after busulphan.

Journal: American journal of hematology 20030901

Title: [Ulcers on the legs and feet: a seldom recognised side effect of hydroxyurea].

Journal: Nederlands tijdschrift voor geneeskunde 20030802

Title: Efficacy and safety of long-term use of hydroxyurea in young patients with essential thrombocythemia and a high risk of thrombosis.

Journal: Blood 20030501

Title: Treatment indications and choice of a platelet-lowering agent in essential thrombocythemia.

Journal: Current hematology reports 20030501

Title: Portal vein thrombosis after laparoscopy-assisted splenectomy and cholecystectomy.

Journal: Journal of pediatric surgery 20030401

Title: New approaches to the treatment of thrombocytosis.

Journal: Clinical advances in hematology & oncology : H&O 20030201

Title: Pilot study of pegylated interferon-alpha 2b in patients with essential thrombocythemia.

Journal: Cancer chemotherapy and pharmacology 20030101

Title: Indications for lowering platelet numbers in essential thrombocythemia.

Journal: Seminars in hematology 20030101

Title: Modern treatment strategies in polycythemia vera.

Journal: Seminars in hematology 20030101

Title: Treatment of essential thrombocythemia in childhood.

Journal: Pediatric hematology and oncology 20030101

Title: Essential thrombocytosis: diagnostic and treatment dilemmas.

Journal: The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society 20030101

Title: Associated thrombophilic defects in essential thrombocythaemia: their relationship with clinical manifestations.

Journal: Thrombosis research 20030101

Title: Essential thrombocythemia (ET): moving from palliation to cure.

Journal: Hematology (Amsterdam, Netherlands) 20021201

Title: [Anagrelide-induced changes of megakaryopoiesis during therapy of chronic myeloproliferative disorders with thrombocythemia].

Journal: Der Pathologe 20021101

Title: Comparison of the pharmacological mechanisms involved in the platelet lowering actions of anagrelide and hydroxyurea: a review.

Journal: Platelets 20021101

Title: Hematologic aspects of liver transplantation for Budd-Chiari syndrome with special reference to myeloproliferative disorders.

Journal: Transplantation 20021027

Title: What is the standard treatment in essential thrombocythemia.

Journal: International journal of hematology 20020801

Title: Is the platelet lowering activity of anagrelide mediated by its major metabolite 2-amino-5,6-dichloro-3,4-dihydroquinazoline (RL603)?

Journal: Experimental hematology 20020701

Title: Therapeutic options for essential thrombocythemia and polycythemia vera.

Journal: Seminars in oncology 20020601

Title: Other secondary sequelae of treatments for myeloproliferative disorders.

Journal: Seminars in oncology 20020601

Title: Cost-effectiveness considerations in the treatment of essential thrombocythemia.

Journal: Seminars in oncology 20020601

Title: Variation of PDGF, TGFbeta, and bFGF levels in essential thrombocythemia patients treated with anagrelide.

Journal: American journal of hematology 20020601

Title: Essential thrombocythemia: diagnosis and treatment, with special emphasis on the use of anagrelide.

Journal: Hematology (Amsterdam, Netherlands) 20020601

Title: Effects of anagrelide on in vivo megakaryocyte proliferation and maturation in essential thrombocythemia.

Journal: Blood 20020301

Title: The diagnosis and management of polycythemia vera in the era since the Polycythemia Vera Study Group: a survey of American Society of Hematology members' practice patterns.

Journal: Blood 20020215

Title: Chronic myeloid leukaemia with marked thrombocytosis in a patient with thalassaemia major: complete haematological remission under the combination of hydroxyurea and anagrelide.

Journal: British journal of haematology 20020101

Title: Anagrelide-induced erectile dysfunction.

Journal: The Annals of pharmacotherapy 20020101

Title: [Treatment of essential thrombocythemia with anagrelide: a ten-year experience].

Journal: Medicina 20020101

Title: [Hydroxyurea-induced leg ulcers in patients with chronic myeloproliferative disorders].

Journal: Ugeskrift for laeger 20011203

Title: Anagrelide metabolite induces thrombocytopenia in mice by inhibiting megakaryocyte maturation without inducing platelet aggregation.

Journal: Experimental hematology 20011201

Title: Unexplained pulmonary hypertension in chronic myeloproliferative disorders.

Journal: Chest 20010901

Title: Diagnosis and treatment of thrombocythemia in myeloproliferative disorders.

Journal: Oncology (Williston Park, N.Y.) 20010801

Title: [How should patients with essential thrombocythemia be treated?].

Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology 20010601

Title: [Anagrelide in primary thrombocythemia].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20010510

Title: Hydroxyurea and periodicity in myeloproliferative disease.

Journal: European journal of haematology 20010501

Title: [The chronic Philadelphia chromosome-negative myeloproliferative syndrome II. Clinical findings, diagnostics and treatment].

Journal: Ugeskrift for laeger 20010430

Title: Prognostic factors and current practice in treatment of myelofibrosis with myeloid metaplasia: an update anno 2000.

Journal: Pathologie-biologie 20010301

Title: Management of patients with essential thrombocythemia: current concepts and perspectives.

Journal: Pathologie-biologie 20010301

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