+1 858-523-8231
Login | Register
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
Home Quinolines 6890-08-0
6890-08-0,MFCD00835191
Catalog No.:AA00FDCH

6890-08-0 | 2-Hydroxyisoquinoline-1,3(2H,4H)-dione

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
98%
in stock  
$674.00   $472.00
- +
1g
98%
in stock  
$1,838.00   $1,287.00
- +
5g
98%
in stock  
$6,191.00   $4,334.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00FDCH
Chemical Name:
2-Hydroxyisoquinoline-1,3(2H,4H)-dione
CAS Number:
6890-08-0
Molecular Formula:
C9H7NO3
Molecular Weight:
177.1568
MDL Number:
MFCD00835191
SMILES:
O=C1Cc2ccccc2C(=O)N1O
Properties
Computed Properties
 
Complexity:
251  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
XLogP3:
0.3  

Downstream Synthesis Route

[1]JournalofMedicinalChemistry,2008,vol.51,p.7717-7730

[2]JournaloftheChemicalSociety,1955,p.3518

[3]Patent:US2016/90639,2016,A1.Locationinpatent:Paragraph0163

[1]JournaloftheChemicalSociety,1955,p.3518

6890-08-0   
C9H6NO3(1-)*Na(1+) 

[1]JournalofMedicinalChemistry,2011,vol.54,p.1812-1824

[1]JournalofMedicinalChemistry,2011,vol.54,p.1812-1824

Literature

Title: 2-Hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs), novel inhibitors of HIV integrase with a high barrier to resistance.

Journal: ACS chemical biology 20130101

Title: Identification of influenza endonuclease inhibitors using a novel fluorescence polarization assay.

Journal: ACS chemical biology 20120316

Title: Magnesium chelating 2-hydroxyisoquinoline-1,3(2H,4H)-diones, as inhibitors of HIV-1 integrase and/or the HIV-1 reverse transcriptase ribonuclease H domain: discovery of a novel selective inhibitor of the ribonuclease H function.

Journal: Journal of medicinal chemistry 20110324

Title: 2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4.

Journal: European journal of medicinal chemistry 20110201

Title: Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold.

Journal: Bioorganic & medicinal chemistry letters 20101115

Title: Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain.

Journal: Journal of medicinal chemistry 20081225

Title: Substrate-dependent inhibition or stimulation of HIV RNase H activity by non-nucleoside reverse transcriptase inhibitors (NNRTIs).

Journal: Biochemical and biophysical research communications 20070112

Title: Activity of the isolated HIV RNase H domain and specific inhibition by N-hydroxyimides.

Journal: Biochemical and biophysical research communications 20040430

Title: Use of a pharmacophore model to discover a new class of influenza endonuclease inhibitors.

Journal: Journal of medicinal chemistry 20030327

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 6890-08-0
4456-77-3

4456-77-3

 4494-53-5

4494-53-5

 5488-36-8

5488-36-8

 18630-94-9

18630-94-9

 1092802-01-1

1092802-01-1
Building Blocks
More >
Tags:6890-08-0 Molecular Formula|6890-08-0 MDL|6890-08-0 SMILES|6890-08-0 2-Hydroxyisoquinoline-1,3(2H,4H)-dione