Title: The coffee diterpene kahweol suppresses the cell proliferation by inducing cyclin D1 proteasomal degradation via ERK1/2, JNK and GKS3β-dependent threonine-286 phosphorylation in human colorectal cancer cells.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20160901
Title: Optimization of the isolation and quantitation of kahweol and cafestol in green coffee oil.
Journal: Talanta 20131215
Title: Authentication of Italian Espresso coffee blends through the GC peak ratio between kahweol and 16-O-methylcafestol.
Journal: Food chemistry 20121201
Title: Microwave-assisted methanolysis of green coffee oil.
Journal: Food chemistry 20120915
Title: What is it about coffee? Research is showing benefits for everything from depression to liver disease. Is it just the caffeine?
Journal: Harvard health letter 20120101
Title: The coffee diterpene kahweol prevents osteoclastogenesis via impairment of NFATc1 expression and blocking of Erk phosphorylation.
Journal: Journal of pharmacological sciences 20120101
Title: Functional foods and nutraceuticals in the primary prevention of cardiovascular diseases.
Journal: Journal of nutrition and metabolism 20120101
Title: Natural diterpenes from coffee, cafestol and kahweol induce apoptosis through regulation of specificity protein 1 expression in human malignant pleural mesothelioma.
Journal: Journal of biomedical science 20120101
Title: Quantification of the Robusta fraction in a coffee blend via Raman spectroscopy: proof of principle.
Journal: Journal of agricultural and food chemistry 20110914
Title: Melatonin sensitizes Caki renal cancer cells to kahweol-induced apoptosis through CHOP-mediated up-regulation of PUMA.
Journal: Journal of pineal research 20110501
Title: Coffee and its consumption: benefits and risks.
Journal: Critical reviews in food science and nutrition 20110401
Title: Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal women.
Journal: Diabetes 20110101
Title: The Nrf2/ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease.
Journal: Parkinson's disease 20110101
Title: Coffee consumption and risk of cancers: a meta-analysis of cohort studies.
Journal: BMC cancer 20110101
Title: Cholesterol-raising diterpenes in types of coffee commonly consumed in Singapore, Indonesia and India and associations with blood lipids: a survey and cross sectional study.
Journal: Nutrition journal 20110101
Title: Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis.
Journal: Clinical and experimental gastroenterology 20110101
Title: Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene.
Journal: PloS one 20110101
Title: Effects of some common food constituents on cardiovascular disease.
Journal: ISRN cardiology 20110101
Title: Coffee induces expression of glucuronosyltransferases by the aryl hydrocarbon receptor and Nrf2 in liver and stomach.
Journal: Gastroenterology 20101101
Title: The role of epoxidation and electrophile-responsive element-regulated gene transcription in the potentially beneficial and harmful effects of the coffee components cafestol and kahweol.
Journal: The Journal of nutritional biochemistry 20100801
Title: Coffee and liver diseases.
Journal: Fitoterapia 20100701
Title: The coffee diterpene kahweol sensitizes TRAIL-induced apoptosis in renal carcinoma Caki cells through down-regulation of Bcl-2 and c-FLIP.
Journal: Chemico-biological interactions 20100607
Title: Evaluation of kahweol and cafestol in coffee tissues and roasted coffee by a new high-performance liquid chromatography methodology.
Journal: Journal of agricultural and food chemistry 20100113
Title: Acanthopanax koreanum fruit waste inhibits lipopolysaccharide-induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages.
Journal: Journal of biomedicine & biotechnology 20100101
Title: Nuclear factor-kappaB/signal transducers and activators of transcription-1-mediated inflammatory responses in lipopolysaccharide-activated macrophages are a major inhibitory target of kahweol, a coffee diterpene.
Journal: Biological & pharmaceutical bulletin 20100101
Title: In vivo induction of phase II detoxifying enzymes, glutathione transferase and quinone reductase by citrus triterpenoids.
Journal: BMC complementary and alternative medicine 20100101
Title: Differential reactivity of purified bioactive coffee furans, cafestol and kahweol, with acidic nitrite: product characterization and factors controlling nitrosation versus ring-opening pathways.
Journal: Chemical research in toxicology 20091201
Title: The coffee diterpene kahweol induces apoptosis in human leukemia U937 cells through down-regulation of Akt phosphorylation and activation of JNK.
Journal: Apoptosis : an international journal on programmed cell death 20091101
Title: Kahweol blocks STAT3 phosphorylation and induces apoptosis in human lung adenocarcinoma A549 cells.
Journal: Toxicology letters 20090522
Title: Does long-term coffee intake reduce type 2 diabetes mellitus risk?
Journal: Diabetology & metabolic syndrome 20090101
Title: Can coffee prevent caries?
Journal: Journal of conservative dentistry : JCD 20090101
Title: The multifaceted mechanisms for coffee's anti-tumorigenic effect on liver.
Journal: Medical hypotheses 20081101
Title: Cancer is a preventable disease that requires major lifestyle changes.
Journal: Pharmaceutical research 20080901
Title: The coffee diterpene kahweol induces heme oxygenase-1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6-hydroxydopamine-derived oxidative stress.
Journal: FEBS letters 20080723
Title: A perception on health benefits of coffee.
Journal: Critical reviews in food science and nutrition 20080501
Title: Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080401
Title: Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein.
Journal: Toxicology and applied pharmacology 20080201
Title: Hepatoprotective and antioxidant effects of the coffee diterpenes kahweol and cafestol on carbon tetrachloride-induced liver damage in mice.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20071101
Title: Protective effects of kahweol and cafestol against hydrogen peroxide-induced oxidative stress and DNA damage.
Journal: Toxicology letters 20070910
Title: Coffee consumption protects human lymphocytes against oxidative and 3-amino-1-methyl-5H-pyrido[4,3-b]indole acetate (Trp-P-2) induced DNA-damage: results of an experimental study with human volunteers.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070801
Title: Reduction in antioxidant defenses may contribute to ochratoxin A toxicity and carcinogenicity.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070301
Title: Coffee and cardiovascular disease: in vitro, cellular, animal, and human studies.
Journal: Pharmacological research 20070301
Title: [Negligible amounts of cholesterol-raising diterpenes in coffee made with coffee pads in comparison with unfiltered coffee].
Journal: Nederlands tijdschrift voor geneeskunde 20061230
Title: The coffee diterpene kahweol inhibits tumor necrosis factor-alpha-induced expression of cell adhesion molecules in human endothelial cells.
Journal: Toxicology and applied pharmacology 20061215
Title: Coffee and health: a review of recent human research.
Journal: Critical reviews in food science and nutrition 20060101
Title: Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice.
Journal: BMC complementary and alternative medicine 20060101
Title: Inhibitory effect of the coffee diterpene kahweol on carrageenan-induced inflammation in rats.
Journal: BioFactors (Oxford, England) 20060101
Title: Coffee consumption induces GSTP in plasma and protects lymphocytes against (+/-)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide induced DNA-damage: results of controlled human intervention trials.
Journal: Mutation research 20051211
Title: Chemical discrimination of arabica and robusta coffees by Fourier transform Raman spectroscopy.
Journal: Journal of agricultural and food chemistry 20050615
Title: Coffee diterpenes prevent the genotoxic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and N-nitrosodimethylamine in a human derived liver cell line (HepG2).
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20050301
Title: Coffee consumption and human health--beneficial or detrimental?--Mechanisms for effects of coffee consumption on different risk factors for cardiovascular disease and type 2 diabetes mellitus.
Journal: Molecular nutrition & food research 20050301
Title: Modification of N-acetyltransferases and glutathione S-transferases by coffee components: possible relevance for cancer risk.
Journal: Methods in enzymology 20050101
Title: The coffee diterpene kahweol suppress the inducible nitric oxide synthase expression in macrophages.
Journal: Cancer letters 20040930
Title: Suppressive effects of the kahweol and cafestol on cyclooxygenase-2 expression in macrophages.
Journal: FEBS letters 20040702
Title: Coffee bean extracts rich and poor in kahweol both give rise to elevation of liver enzymes in healthy volunteers.
Journal: Nutrition journal 20040101
Title: Potential chemoprotective effects of the coffee components kahweol and cafestol palmitates via modification of hepatic N-acetyltransferase and glutathione S-transferase activities.
Journal: Environmental and molecular mutagenesis 20040101
Title: Coffee diterpenes prevent benzo[a]pyrene genotoxicity in rat and human culture systems.
Journal: Biochemical and biophysical research communications 20030627
Title: Coffee and its chemopreventive components Kahweol and Cafestol increase the activity of O6-methylguanine-DNA methyltransferase in rat liver--comparison with phase II xenobiotic metabolism.
Journal: Mutation research 20030128
Title: Enhancement of glutathione and g-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2.
Journal: Nutrition and cancer 20030101
Title: Reproducibility of the serum lipid response to coffee oil in healthy volunteers.
Journal: Nutrition journal 20030101
Title: Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20020801
Title: Enhancement of the chemoprotective enzymes glucuronosyl transferase and glutathione transferase in specific organs of the rat by the coffee components kahweol and cafestol.
Journal: Archives of toxicology 20020501
Title: The coffee components kahweol and cafestol induce gamma-glutamylcysteine synthetase, the rate limiting enzyme of chemoprotective glutathione synthesis, in several organs of the rat.
Journal: Archives of toxicology 20020101
Title: Protective effects of coffee diterpenes against aflatoxin B1-induced genotoxicity: mechanisms in rat and human cells.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20010601
Title: Elevation of glutathione levels by coffee components and its potential mechanisms.
Journal: Advances in experimental medicine and biology 20010101
Title: The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism.
Journal: Carcinogenesis 19980801
