Home Other Building Blocks 693288-97-0
693288-97-0,MFCD12912405
Catalog No.:AA00FBWX

693288-97-0 | Ns 11394

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
98%
in stock  
$181.00   $127.00
- +
10mg
98%
in stock  
$286.00   $200.00
- +
25mg
98%
in stock  
$574.00   $402.00
- +
50mg
98%
in stock  
$747.00   $523.00
- +
100mg
98%
in stock  
$1,224.00   $857.00
- +
500mg
98% by HPLC
in stock  
$4,996.00   $3,498.00
- +
1000mg
98% by HPLC
in stock  
$7,957.00   $5,570.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00FBWX
Chemical Name:
Ns 11394
CAS Number:
693288-97-0
Molecular Formula:
C22H15ClN2O4
Molecular Weight:
406.8185
MDL Number:
MFCD12912405
SMILES:
Clc1ccc(c(c1)CN1C(=O)c2c(C1=O)cccc2)NC(=O)c1ccccc1O
Properties
Computed Properties
 
Complexity:
633  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
4.1  

Literature

Title: A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling.

Journal: Molecular pharmacology 20130401

Title: Effects of positive allosteric modulators on single-cell oscillatory Ca2+ signaling initiated by the type 5 metabotropic glutamate receptor.

Journal: Molecular pharmacology 20091201

Title: Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold.

Journal: Bioorganic & medicinal chemistry letters 20080715

Title: N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors.

Journal: Molecular pharmacology 20080301

Title: Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA.

Journal: Bioorganic & medicinal chemistry letters 20070301

Title: The effect of mGlu5 receptor positive allosteric modulators on signaling molecules in brain slices.

Journal: European journal of pharmacology 20060501

Title: Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia.

Journal: Current topics in medicinal chemistry 20060101

Title: Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes.

Journal: The Journal of pharmacology and experimental therapeutics 20051201

Title: A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models.

Journal: The Journal of pharmacology and experimental therapeutics 20050401

Title: Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.

Journal: Journal of medicinal chemistry 20041118

Title: A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain.

Journal: The Journal of pharmacology and experimental therapeutics 20040501

Title: Difference in mGluR5 interaction between positive allosteric modulators from two structural classes.

Journal: Annals of the New York Academy of Sciences 20031101

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