Title: Clinical, pharmacokinetic and pharmacodynamic evaluations of metronomic UFT and cyclophosphamide plus celecoxib in patients with advanced refractory gastrointestinal cancers.
Journal: Angiogenesis 20120601
Title: Time-dependent pharmacokinetics of 5-fluorouracil and association with treatment tolerability in the adjuvant setting of colorectal cancer.
Journal: Journal of clinical pharmacology 20120301
Title: Analysis of polymorphisms and haplotype structure of the human thymidylate synthase genetic region: a tool for pharmacogenetic studies.
Journal: PloS one 20120101
Title: Population pharmacokinetic analysis of 5-FU and 5-FDHU in colorectal cancer patients: search for biomarkers associated with gastro-intestinal toxicity.
Journal: Current topics in medicinal chemistry 20120101
Title: Determination of 5-fluorouracil and dihydrofluorouracil levels by using a liquid chromatography-tandem mass spectrometry method for evaluation of dihydropyrimidine dehydrogenase enzyme activity.
Journal: Cancer chemotherapy and pharmacology 20110801
Title: Matrix metalloproteinase-8 mediates the unfavorable systemic impact of local irradiation on pharmacokinetics of anti-cancer drug 5-Fluorouracil.
Journal: PloS one 20110101
Title: Tegafur/gimeracil/oteracil (S-1) approved for the treatment of advanced gastric cancer in adults when given in combination with cisplatin: a review comparing it with other fluoropyrimidine-based therapies.
Journal: OncoTargets and therapy 20110101
Title: Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines.
Journal: Cancer chemotherapy and pharmacology 20100801
Title: N(3)-o-toluyl-fluorouracil inhibits human hepatocellular carcinoma cell growth via sustained release of 5-FU.
Journal: Cancer chemotherapy and pharmacology 20100501
Title: A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma.
Journal: Biomedical chromatography : BMC 20100401
Title: Abdominal irradiation modulates 5-Fluorouracil pharmacokinetics.
Journal: Journal of translational medicine 20100101
Title: Predictors of survival and toxicity in patients on adjuvant therapy with 5-fluorouracil for colorectal cancer.
Journal: British journal of cancer 20090519
Title: Pharmacokinetic study of S-1.
Journal: International journal of clinical pharmacology and therapeutics 20090101
Title: A Stability-Indicating RP-HPLC Assay Method for 5-Fluorouracil.
Journal: Indian journal of pharmaceutical sciences 20090101
Title: 5-fluorouracil pharmacokinetics predicts disease-free survival in patients administered adjuvant chemotherapy for colorectal cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080501
Title: Improved chemical syntheses of 5,6-dihydro-5-fluorouracil.
Journal: The Journal of organic chemistry 20071026
Title: Alternative pharmacokinetics of S-1 components, 5-fluorouracil, dihydrofluorouracil and alpha-fluoro-beta-alanine after oral administration of S-1 following total gastrectomy.
Journal: Cancer science 20071001
Title: [Pro or con the phenotyping/genotyping of patients treated by 5-Fluorouracil to prevent adverse drug reactions?].
Journal: Therapie 20070101
Title: A pharmacokinetic-based test to prevent severe 5-fluorouracil toxicity.
Journal: Clinical pharmacology and therapeutics 20061001
Title: Sensitive MS/MS-liquid chromatography assay for simultaneous determination of tegafur, 5-fluorouracil and 5-fluorodihydrouracil in plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050925
Title: Overexpression of neuropilin-1 promotes constitutive MAPK signalling and chemoresistance in pancreatic cancer cells.
Journal: British journal of cancer 20050725
Title: Improved analysis of 5-Fluorouracil and 5,6-dihydro-5-Fluorouracil by HPLC with diode array detection for determination of cellular dihydropyrimidine dehydrogenase activity and pharmacokinetic profiling.
Journal: Therapeutic drug monitoring 20050601
Title: 5-Fluorouracil catabolism to 5-fluoro-5,6-dihydrouracil is reduced by acute liver impairment in mice.
Journal: Toxicology and applied pharmacology 20050301
Title: A simple and sensitive fully validated HPLC-UV method for the determination of 5-fluorouracil and its metabolite 5,6-dihydrofluorouracil in plasma.
Journal: Therapeutic drug monitoring 20050201
Title: Feasibility of measuring 5-fluorouracil catabolic potential by oral loading.
Journal: The Journal of international medical research 20050101
Title: Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
Journal: Anti-cancer drugs 20041101
Title: Simple determination of capecitabine and its metabolites by liquid chromatography with ultraviolet detection in a single injection.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040925
Title: Plasma concentrations of 5-fluorouracil and its metabolites in colon cancer patients.
Journal: Pharmacological research 20040801
Title: [Assay method for uracil, dihydrouracil, 5-fluorouracil and 5-fluoro-5, 6-dihydrouracil by high-performance liquid chromatography].
Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20040301
Title: Correlation between 5-fluorouracil metabolism and treatment response in two variants of C26 murine colon carcinoma.
Journal: British journal of cancer 20030818
Title: Extensive hepatic replacement due to liver metastases has no effect on 5-fluorouracil pharmacokinetics.
Journal: Cancer chemotherapy and pharmacology 20030201
Title: Limited sampling model for the analysis of 5-fluorouracil pharmacokinetics in adjuvant chemotherapy for colorectal cancer.
Journal: Clinical pharmacology and therapeutics 20021201
Title: Severe 5-fluorouracil toxicity associated with a marked alteration of pharmacokinetics of 5-fluorouracil and its catabolite 5-fluoro-5,6-dihydrouracil: a case report.
Journal: European journal of clinical pharmacology 20021201
Title: Relationship between plasma concentrations of 5-fluorouracil and 5-fluoro-5,6-dihydrouracil and toxicity of 5-fluorouracil infusions in cancer patients.
Journal: Therapeutic drug monitoring 20021001
Title: Simultaneous HPLC determination of 5-fluorouracil and its metabolites in plasma of cancer patients.
Journal: Biomedical chromatography : BMC 20021001
Title: Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene.
Journal: British journal of cancer 20020408
Title: Prognostic significance of dihydropyrimidine dehydrogenase expression in breast cancer.
Journal: British journal of cancer 20020121
Title: Synthesis and evaluation of N-acyl-2-(5-fluorouracil-1-yl)-D,L-glycine as a colon-specific prodrug of 5-fluorouracil.
Journal: Journal of pharmaceutical sciences 20011101
Title: High-performance liquid chromatographic assay with ultraviolet detection for quantification of dihydrofluorouracil in human lymphocytes: application to measurement of dihydropyrimidine dehydrogenase activity.
Journal: Journal of chromatography. B, Biomedical sciences and applications 20011025
Title: Relationship between 5-fluorouracil disposition, toxicity and dihydropyrimidine dehydrogenase activity in cancer patients.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20010901
