Home Iodos 70-78-0
70-78-0,MFCD00002608
Catalog No.:AA00317H

70-78-0 | 3-Iodo-L-tyrosine

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1mg
98%
in stock  
$6.00   $4.00
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50mg
98%
in stock  
$17.00   $12.00
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1g
98%
in stock  
$21.00   $15.00
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5g
98%
in stock  
$74.00   $52.00
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10g
98%
in stock  
$90.00   $63.00
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25g
98%
in stock  
$222.00   $156.00
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100g
98%
in stock  
$801.00   $561.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00317H
Chemical Name:
3-Iodo-L-tyrosine
CAS Number:
70-78-0
Molecular Formula:
C9H10INO3
Molecular Weight:
307.0851
MDL Number:
MFCD00002608
SMILES:
OC(=O)[C@H](Cc1ccc(c(c1)I)O)N
Properties
Properties
 
BP:
391°C at 760 mmHg  
Form:
Solid  
MP:
210 °C (dec.)(lit.)  
Solubility:
dilute aqueous acid: soluble  
Stability:
Light Sensitive  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
212  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
-1.1  

Literature

Title: Speciation of the bio-available iodine and bromine forms in edible seaweed by high performance liquid chromatography hyphenated with inductively coupled plasma-mass spectrometry.

Journal: Analytica chimica acta 20121001

Title: The involvement of noradrenergic mechanisms in the suppressive effects of diazepam on the hypothalamic-pituitary-adrenal axis activity in female rats.

Journal: Croatian medical journal 20120601

Title: Dopamine modulates metabolic rate and temperature sensitivity in Drosophila melanogaster.

Journal: PloS one 20120101

Title: Dopamine modulates the rest period length without perturbation of its power law distribution in Drosophila melanogaster.

Journal: PloS one 20120101

Title: Effects of halogenation on tyrosine phosphorylation and peptide binding to the SRC homology 2 domain of lymphocyte-specific protein tyrosine kinase.

Journal: Biological & pharmaceutical bulletin 20120101

Title: Multiple tyrosine metabolites are GPR35 agonists.

Journal: Scientific reports 20120101

Title: Ih current is necessary to maintain normal dopamine fluctuations and sleep consolidation in Drosophila.

Journal: PloS one 20120101

Title: Catecholamines up integrates dopamine synthesis and synaptic trafficking.

Journal: Journal of neurochemistry 20111201

Title: Dissecting cell signaling pathways with genetically encoded 3-iodo-L-tyrosine.

Journal: Chembiochem : a European journal of chemical biology 20110211

Title: Synthesis and characterization of 3-[131I]iodo-L-tyrosine grafted Fe3O4@SiO2 nanocomposite for single photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI).

Journal: Journal of nanoscience and nanotechnology 20110201

Title: Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships.

Journal: Bioorganic & medicinal chemistry 20101101

Title: Early temporal effects of three thyroid hormone synthesis inhibitors in Xenopus laevis.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20100601

Title: Genetic encoding of non-natural amino acids in Drosophila melanogaster Schneider 2 cells.

Journal: Protein science : a publication of the Protein Society 20100301

Title: A pair of dopamine neurons target the D1-like dopamine receptor DopR in the central complex to promote ethanol-stimulated locomotion in Drosophila.

Journal: PloS one 20100101

Title: Dietary modulation of Drosophila sleep-wake behaviour.

Journal: PloS one 20100101

Title: Structural Aspects of Phenylalanylation and Quality Control in Three Major Forms of Phenylalanyl-tRNA Synthetase.

Journal: Journal of amino acids 20100101

Title: Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells.

Journal: Toxicology and applied pharmacology 20091115

Title: A mammalian reductive deiodinase has broad power to dehalogenate chlorinated and brominated substrates.

Journal: Journal of the American Chemical Society 20091014

Title: Ancient tRNA synthetase meets modern structural biology.

Journal: Structure (London, England : 1993) 20090311

Title: Genetic encoding of 3-iodo-L-tyrosine in Escherichia coli for single-wavelength anomalous dispersion phasing in protein crystallography.

Journal: Structure (London, England : 1993) 20090311

Title: Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegeneration.

Journal: PloS one 20090101

Title: Molecular characterization of iodotyrosine dehalogenase deficiency in patients with hypothyroidism.

Journal: The Journal of clinical endocrinology and metabolism 20081201

Title: Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.

Journal: Journal of medicinal chemistry 20080724

Title: Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's disease.

Journal: Journal of neuroinflammation 20080101

Title: Interaction of dopamine, female pheromones, locomotion and sex behavior in Drosophila melanogaster.

Journal: Journal of insect physiology 20080101

Title: Drosophila dopamine synthesis pathway genes regulate tracheal morphogenesis.

Journal: Developmental biology 20070801

Title: Chiral discrimination of D- and L-amino acids using iodinated tyrosines as chiral references: effect of iodine substituent.

Journal: Journal of the American Society for Mass Spectrometry 20070801

Title: Nicotine promotes cell proliferation via alpha7-nicotinic acetylcholine receptor and catecholamine-synthesizing enzymes-mediated pathway in human colon adenocarcinoma HT-29 cells.

Journal: Toxicology and applied pharmacology 20070615

Title: Site-specific incorporation of non-natural amino acids into proteins in mammalian cells with an expanded genetic code.

Journal: Nature protocols 20060101

Title: Bioinorganic chemistry in thyroid gland: effect of antithyroid drugs on peroxidase-catalyzed oxidation and iodination reactions.

Journal: Bioinorganic chemistry and applications 20060101

Title: The diazo route to diazonamide A: studies on the tyrosine-derived fragment.

Journal: Organic & biomolecular chemistry 20051021

Title: Synthesis of the side chain cross-linked tyrosine oligomers dityrosine, trityrosine, and pulcherosine.

Journal: The Journal of organic chemistry 20050902

Title: Effects of dopamine on juvenile hormone metabolism and fitness in Drosophila virilis.

Journal: Journal of insect physiology 20050901

Title: Development of a validated HPLC method for the determination of iodotyrosines and iodothyronines in pharmaceuticals and biological samples using solid phase extraction.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050105

Title: Sensitized photooxidation of thyroidal hormones. Evidence for heavy atom effect on singlet molecular oxygen [O2(1Deltag)]-mediated photoreactions.

Journal: Photochemistry and photobiology 20050101

Title: Cause of mortality in insects under severe stress.

Journal: European journal of biochemistry 20030801

Title: Use of a boroxazolidone complex of 3-iodo-L-tyrosine for palladium-catalyzed cross-coupling.

Journal: The Journal of organic chemistry 20030221

Title: Aromatic amino acids and their derivatives as ligands for the isolation of aspartic proteinases.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020425

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Identification of protein-derived tyrosyl radical in the reaction of cytochrome c and hydrogen peroxide: characterization by ESR spin-trapping, HPLC and MS.

Journal: The Biochemical journal 20020415

Title: The effects of dopamine synthesis inhibitors and dopamine antagonists on regeneration in the hydra Hydra attenuata.

Journal: Neuroscience and behavioral physiology 20020101

Title: Changing the amino acid specificity of yeast tyrosyl-tRNA synthetase by genetic engineering.

Journal: Journal of biochemistry 20010901

Title: Update on intrathyroidal iodine metabolism.

Journal: Thyroid : official journal of the American Thyroid Association 20010501

Title: D K Ness, et al. Effects of 3-iodo-L-tyrosine, a tyrosine hydroxylase inhibitor, on eye pigmentation and biogenic amines in the planarian, Dugesia dorotocephala. Fundam Appl Toxicol. 1996 Apr;30(2):153-61.

Title: GOLDSTEIN M, et al. INHIBITION OF TYROSINE HYDROXYLASE BY 3-IODO-L-TYROSINE. Life Sci (1962). 1965 Jan;4:261-4.

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Tags:70-78-0 Molecular Formula|70-78-0 MDL|70-78-0 SMILES|70-78-0 3-Iodo-L-tyrosine