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70356-03-5,MFCD00151471
Catalog No.:AA005JSE

70356-03-5 | Cefaclor monohydrate

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Purity
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1g
98%(HPLC)
in stock  
$27.00   $19.00
- +
5g
98%
in stock  
$79.00   $55.00
- +
10g
98%
in stock  
$128.00   $90.00
- +
25g
98%
in stock  
$220.00   $154.00
- +
100g
98%
in stock  
$510.00   $357.00
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500g
98%(HPLC)
in stock  
$2,178.00   $1,525.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA005JSE
Chemical Name:
Cefaclor monohydrate
CAS Number:
70356-03-5
Molecular Formula:
C15H16ClN3O5S
Molecular Weight:
385.8226
MDL Number:
MFCD00151471
SMILES:
N[C@H](c1ccccc1)C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)O)Cl.O
Properties
Properties
 
BP:
713.4 °C at 760 mmHg  
Form:
Solid  
MP:
>180°C (dec.)  
Storage:
Light sensitive;Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
606  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
4  

Literature

Title: Drug interaction studies reveal that simotinib upregulates intestinal absorption by increasing the paracellular permeability of intestinal epithelial cells.

Journal: Drug metabolism and pharmacokinetics 20140101

Title: Direct effect of intracanal medicaments on survival of stem cells of the apical papilla.

Journal: Journal of endodontics 20121001

Title: Two plate-based colorimetric assays for screening α-amino acid ester hydrolase with high synthesis/hydrolysis ratio.

Journal: Enzyme and microbial technology 20120715

Title: [5 days Cefaclor vs. 10 days amoxicillin/clavulanate in the treatment of childhood streptococcal pharyngitis. Data from a randomized clinical trial].

Journal: Minerva pediatrica 20120601

Title: Bioequivalence studies of 2 oral cefaclor capsule formulations in chinese healthy subjects.

Journal: Arzneimittel-Forschung 20120301

Title: Synthesis, spectral and antibacterial sudies of copper(II) tetraaza macrocyclic complexes.

Journal: International journal of molecular sciences 20120101

Title: Evaluation of cefaclor oral suspensions stability using reversed phase high performance liquid chromatography and antimicrobial diffusion methods.

Journal: Pakistan journal of pharmaceutical sciences 20110701

Title: Evaluation of disk diffusion methods to detect low-level β-lactamase-negative ampicillin-resistant Haemophilus influenzae.

Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20110601

Title: Protein hydrolysate-induced cholecystokinin secretion from enteroendocrine cells is indirectly mediated by the intestinal oligopeptide transporter PepT1.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20110501

Title: Study on the binding behavior of bovine serum albumin with cephalosporin analogues by chemiluminescence method.

Journal: Talanta 20101215

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Pretreatment of plasma samples by a novel hollow fiber centrifugal ultrafiltrate device for the determination of cefaclor concentrations in human plasma.

Journal: Journal of chromatography. A 20101029

Title: [A simple disk diffusion test to identify beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae--application of cephalexin, cefsulodin and cefaclor disks].

Journal: Rinsho byori. The Japanese journal of clinical pathology 20101001

Title: Cefaclor: serum sickness.

Journal: Prescrire international 20100401

Title: In vitro antimicrobial activity of cefditoren and other oral antibiotics against Streptococcus pneumoniae, isolated from children with community acquired respiratory tract infections.

Journal: The Japanese journal of antibiotics 20100201

Title: Effects of cefaclor on gastric emptying and cholecystokinin release in healthy humans.

Journal: Regulatory peptides 20100108

Title: Biodegradable microspheres based on gelatin-porcine mucin admixtures: in vitro and in vivo delivery studies.

Journal: Biological & pharmaceutical bulletin 20091001

Title: Cefaclor anaphylaxis in children.

Journal: Allergy 20090801

Title: Is continuous antibiotic prophylaxis in children with vesicoureteral reflux really ineffective in preventing pyelonephritis?

Journal: Pediatric nephrology (Berlin, Germany) 20090701

Title: Can cranberry juice be a substitute for cefaclor prophylaxis in children with vesicoureteral reflux?

Journal: Pediatrics international : official journal of the Japan Pediatric Society 20090601

Title: Case report: pulp revascularization of a necrotic, infected, immature, permanent tooth.

Journal: Pediatric dentistry 20090101

Title: Stability of the crystalline form of cefaclor monohydrate and its pharmaceutical preparations.

Journal: Acta poloniae pharmaceutica 20090101

Title: Frequency, microbial interactions, and antimicrobial susceptibility of Fusobacterium nucleatum and Fusobacterium necrophorum isolated from primary endodontic infections.

Journal: Journal of endodontics 20081201

Title: Decomposition and mineralization of cefaclor by ionizing radiation: kinetics and effects of the radical scavengers.

Journal: Chemosphere 20080501

Title: Comparative in vitro antimicrobial procedural efficacy for susceptibility of Staphylococcus aureus, Escherichia coil and Pseudomonas species to chloramphenicol, ciprofloxacin and cefaclor.

Journal: British journal of biomedical science 20080101

Title: Pharmacokinetic interaction between cefaclor and bromhexine in healthy Chinese volunteers.

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20071001

Title: A comparative study of capillary zone electrophoresis and pH-potentiometry for determination of dissociation constants.

Journal: Journal of pharmaceutical and biomedical analysis 20070903

Title: Gastrointestinal disorders in anaphylaxis.

Journal: Internal medicine (Tokyo, Japan) 20070101

Title: Study on the efficacy of cefaclor for the treatment of asymptomatic bacteriuria and lower urinary tract infections in pregnant women with a history of hypersensitivity to penicillin.

Journal: Clinical and experimental obstetrics & gynecology 20070101

Title: Pulp revascularization of a necrotic infected immature permanent tooth: case report and review of the literature.

Journal: Pediatric dentistry 20070101

Title: Immunomodulatory properties of cefaclor: in vivo effect on cytokine release and lymphoproliferative response in rats.

Journal: Journal of chemotherapy (Florence, Italy) 20061201

Title: [Management of acute pyelonephritis in patients older than 3 months: survey conducted in 39 paediatric emergency departments of the Ile de France Region in 2004].

Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20060301

Title: Different patterns of cytokines, ECP and immunoglobulin profiles at two adverse drug reactions in a patient.

Journal: Pediatrics international : official journal of the Japan Pediatric Society 20051201

Title: Evaluation of the clinical efficacy of Qingqiao capsule in treating patients with secretory otitis media.

Journal: Chinese journal of integrative medicine 20051201

Title: [Treatment of acute bacterial tonsillopharyngitis in pediatrics: a meta-analysis].

Journal: Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20051201

Title: Rapid elimination of cefaclor from the cerebrospinal fluid is mediated by a benzylpenicillin-sensitive mechanism distinct from organic anion transporter 3.

Journal: The Journal of pharmacology and experimental therapeutics 20050801

Title: Antibacterial activity of glass-ionomer cement containing antibiotics on caries lesion microorganisms.

Journal: American journal of dentistry 20050801

Title: Not all pustules are infective in nature: acute generalised exanthematous pustulosis causing pustular eruptions in an elderly woman.

Journal: Singapore medical journal 20050701

Title: Heterogeneity of the IgE response to allergenic determinants of cefaclor in serum samples from patients with cefaclor-induced anaphylaxis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20050601

Title: In vitro investigation of the indirect pathogenicity of beta-lactamase-producing microorganisms in the nasopharyngeal microflora.

Journal: International journal of pediatric otorhinolaryngology 20050401

Title: Comparative efficacy and safety evaluation of cefaclor vs amoxycillin + clavulanate in children with Acute Otitis Media (AOM).

Journal: Indian journal of pediatrics 20050301

Title: [Neonatale mastitis in a 4-week-old infant].

Journal: Klinische Padiatrie 20050101

Title: Ecthyma gangrenosum-like lesions in a healthy child after infection treated with antibiotics.

Journal: Pediatric dermatology 20050101

Title: Efficacy of prophylaxis in women with sex induced cystitis.

Journal: Clinical and experimental obstetrics & gynecology 20050101

Title: [Clinical efficacy and tolerability of short course therapy with cefaclor compared with long-term therapy for treatment of acute otitis media in children].

Journal: Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20041201

Title: [Comparison of pharmacokinetics/pharmacodynamics of cefdinir, cefpodoxime proxetil and cefaclor against common bacteria of community acquired infections].

Journal: Zhonghua yi xue za zhi 20041117

Title: [Comparative study on cefdinir and cefaclor in the treatment of patients with mild to moderate bacterial community acquired pneumonia].

Journal: Zhonghua yi xue za zhi 20041117

Title: Studies on the bioequivalence of second generation cephalosporins: cefaclor capsules and suspension.

Journal: Arzneimittel-Forschung 20040901

Title: Streptococcus pneumoniae in vitro development of resistance to amoxicillin/clavulanic acid, cefaclor, levofloxacin and azithromycin.

Journal: International journal of antimicrobial agents 20040801

Title: Reassessment of cefaclor breakpoints for Haemophilus influenzae.

Journal: Journal of chemotherapy (Florence, Italy) 20040801

Title: Reassessment of the cefaclor breakpoint for Streptococcus pneumoniae.

Journal: International journal of antimicrobial agents 20040401

Title: PK-PD modelling of the effect of cefaclor on four different bacterial strains.

Journal: International journal of antimicrobial agents 20040301

Title: Detection of penicillin-binding protein 2b gene alteration in Streptococcus mitis by polymerase chain reaction.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20040201

Title: [Cefaclor induced pemphigus vulgaris].

Journal: Minerva stomatologica 20040101

Title: Comparative effect of different types of food on the bioavailability of cefaclor extended release tablet.

Journal: European journal of drug metabolism and pharmacokinetics 20040101

Title: [Susceptibility of Branhamella catarrhalis to antibiotics].

Journal: Medycyna doswiadczalna i mikrobiologia 20040101

Title: Adverse skin and joint reactions associated with oral antibiotics in children: the role of cefaclor in serum sickness-like reactions.

Journal: Journal of paediatrics and child health 20031201

Title: Beta-lactam resistance in Streptococcus mitis isolated from saliva of healthy subjects.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20031201

Title: Microbiological analysis of infected root canals from symptomatic and asymptomatic teeth with periapical periodontitis and the antimicrobial susceptibility of some isolated anaerobic bacteria.

Journal: Oral microbiology and immunology 20031001

Title: Clarithromycin inhibits the development of dermatitis in NC/Nga mice.

Journal: Chemotherapy 20030901

Title: Modelling and analysing exchangeable binary data with random cluster sizes.

Journal: Statistics in medicine 20030815

Title: Cefaclor AF vs Clarithromycin in acute exacerbation of chronic bronchitis (B3M-PK-AJBG).

Journal: JPMA. The Journal of the Pakistan Medical Association 20030801

Title: Enhanced enzymatic synthesis of a semi-synthetic cephalosprin, cefaclor, with in situ product removal.

Journal: Biotechnology letters 20030701

Title: Antibiotic prophylaxis by low-dose cefaclor in children with vesicoureteral reflux.

Journal: Pediatric nephrology (Berlin, Germany) 20030501

Title: A comparative study of cefaclor vs amoxicillin/clavulanate in pediatric pharyngotonsillitis.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20030301

Title: Low plasma cefaclor levels in cystectomized bladder cancer patients with various types of urinary diversion.

Journal: European journal of clinical pharmacology 20030201

Title: Determination of cefaclor in human plasma by a sensitive and specific liquid chromatographic-tandem mass spectrometric method.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030125

Title: Sensitive determination of a beta-lactam antibiotic, cefaclor by liquid chromatography with chemiluminescence detection.

Journal: Journal of pharmaceutical and biomedical analysis 20030115

Title: Etiology of acute otitis media in childhood and evaluation of two different protocols of antibiotic therapy: 10 days cefaclor vs. 3 days azitromycin.

Journal: International journal of pediatric otorhinolaryngology 20030101

Title: A case of baboon syndrome associated with group a streptococcal infection.

Journal: The Journal of dermatology 20030101

Title: [Hypersensitivity reactions to beta-lactam antibiotics in childhood].

Journal: Allergologia et immunopathologia 20030101

Title: The effect of four different types of food on the bioavailability of cefaclor.

Journal: European journal of drug metabolism and pharmacokinetics 20030101

Title: An unusual abdominal mass in a renal transplant recipient.

Journal: Transplant infectious disease : an official journal of the Transplantation Society 20021201

Title: [Antibacterial activity of cefpodoxime against clinical isolates in 2000 and 2001].

Journal: The Japanese journal of antibiotics 20021201

Title: A case of purpuric drug eruption due to cefaclor.

Journal: International journal of antimicrobial agents 20021101

Title: Cefaclor induced serum sickness like reaction.

Journal: Indian journal of pediatrics 20021001

Title: An evaluation of cefaclor in Pakistani children with pharyngotonsillitis.

Journal: JPMA. The Journal of the Pakistan Medical Association 20021001

Title: [The influence of medicine to the expression of cell adhesion molecule in experimental otitis media with effusion].

Journal: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 20021001

Title: Effect of a short course of clarithromycin therapy on sputum production in patients with chronic airway hypersecretion.

Journal: Chest 20020701

Title: Comparative efficacy and safety of 5-day cefaclor and 10-day amoxycillin treatment of group A streptococcal pharyngitis in children.

Journal: International journal of antimicrobial agents 20020701

Title: [Microbiological and clinical studies of Haemophilus influenzae isolated at Kitakyushu Municipal Medical Center from 1996 through 1999].

Journal: The Japanese journal of antibiotics 20020601

Title: Serum sickness-like reactions.

Journal: Cutis 20020501

Title: [Urinary antimicrobial prophylaxis].

Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20020501

Title: Comparative target site pharmacokinetics of immediate- and modified-release formulations of cefaclor in humans.

Journal: Journal of clinical pharmacology 20020401

Title: Comparative study of cefaclor AF vs. cefuroxime axetil in acute exacerbations of chronic bronchitis.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20020101

Title: Foreign drug firm pleads guilty to felony charges.

Journal: FDA consumer 20020101

Title: Determination of antimicrobial activity of Cefaclor on common respiratory tract pathogens in Pakistan.

Journal: JPMA. The Journal of the Pakistan Medical Association 20020101

Title: Desirable and undesirable immunotropic effects of antibiotics: immunomodulating properties of cefaclor.

Journal: Journal of chemotherapy (Florence, Italy) 20011201

Title: [Activity of different antimicrobial agents against penicillin-resistant Streptococcus pneumoniae].

Journal: Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20011201

Title: Short-course therapy with cefaclor for treatment of streptococcal pharyngotonsillitis.

Journal: International journal of antimicrobial agents 20011001

Title: Novel mechanism of hydrolysis of therapeutic beta-lactams by Stenotrophomonas maltophilia L1 metallo-beta-lactamase.

Journal: The Journal of biological chemistry 20010907

Title: Penetration of cefaclor into the interstitial space fluid of skeletal muscle and lung tissue in rats.

Journal: Pharmaceutical research 20010901

Title: Evaluation of oral antimicrobial agent levels in tooth extraction sites.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20010601

Title: Serum sickness-like reaction to cefaclor.

Journal: Journal of paediatrics and child health 20010601

Title: Recurrent temporal petrositis.

Journal: The Journal of laryngology and otology 20010401

Title: Bioequivalence evaluation of two brands of cefaclor 500 mg capsules: quantification of cefaclor using solid phase extraction technique.

Journal: Journal of clinical pharmacy and therapeutics 20010401

Title: Tests for 2 x K contingency tables with clustered ordered categorical data.

Journal: Statistics in medicine 20010315

Title: The near fatal lick.

Journal: Australian family physician 20010101

Title: A comparative study of cefaclor vs. amoxicillin/clavulanate in tonsillopharyngitis.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20010101

Title: Clinical and pro-host effects of cefaclor in prophylaxis of recurrent otitis media in HIV-infected children.

Journal: The Journal of international medical research 20010101

Title: Oral pharmacokinetics of cefaclor in Mexican subjects.

Journal: Proceedings of the Western Pharmacology Society 20010101

Title: Hypersensitivity myocarditis caused by an allergic reaction to cefaclor.

Journal: The Journal of pediatrics 19980101

Title: beta-Lactam drug allergens: fine structural recognition patterns of cephalosporin-reactive IgE antibodies.

Journal: Journal of molecular recognition : JMR 19960101

Title: Clarithromycin versus cefaclor in lower respiratory tract infections. The Canadian Bronchitis Study Group.

Journal: Clinical and investigative medicine. Medecine clinique et experimentale 19950401

Title: Serum sickness-like syndrome associated with cefaclor therapy.

Journal: Allergy 19920801

Title: Loracarbef (LY163892) versus cefaclor in the treatment of bacterial skin and skin-structure infections in an adult population.

Journal: The American journal of medicine 19920622

Title: Loracarbef (LY163892) versus cefaclor and norfloxacin in the treatment of uncomplicated pyelonephritis.

Journal: The American journal of medicine 19920622

Title: Serum sickness-like reactions from cefaclor in children.

Journal: Journal of the American Academy of Dermatology 19911101

Title: Double-blind comparison of cefixime and cefaclor in the treatment of acute otitis media in children.

Journal: Scandinavian journal of infectious diseases 19910101

Title: Acute interstitial nephritis and non-oliguric renal failure after cefaclor treatment.

Journal: Klinische Wochenschrift 19860317

Title: Cholestatic jaundice and hematuria due to hypersensitivity to cefaclor in a child.

Journal: Journal of toxicology. Clinical toxicology 19830301

Title: Chambers HF, et al. Characterization of penicillin-binding protein 2 of Staphylococcus aureus: deacylation reaction and identification of two penicillin-binding peptides. Antimicrob Agents Chemother. 1992 Mar;36(3):656-61.

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Tags:70356-03-5 Molecular Formula|70356-03-5 MDL|70356-03-5 SMILES|70356-03-5 Cefaclor monohydrate