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708275-58-5,MFCD17170315
Catalog No.:AA00FDQ0

708275-58-5 | JNJ-10397049

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$70.00   $49.00
- +
5mg
≥98%
in stock  
$240.00   $168.00
- +
10mg
≥98%
in stock  
$340.00   $238.00
- +
50mg
≥99%(HPLC)
in stock  
$1,418.00   $993.00
- +
  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00FDQ0
Chemical Name:
JNJ-10397049
CAS Number:
708275-58-5
Molecular Formula:
C19H20Br2N2O3
Molecular Weight:
484.1817
MDL Number:
MFCD17170315
SMILES:
O=C(Nc1ccc(cc1Br)Br)N[C@H]1COC(O[C@H]1c1ccccc1)(C)C
Properties
Computed Properties
 
Complexity:
485  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
4.1  

Literature

Title: Selective orexin receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20130901

Title: Effects of orexins A and B on expression of orexin receptors and progesterone release in luteal and granulosa ovarian cells.

Journal: Regulatory peptides 20121010

Title: Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement.

Journal: Psychopharmacology 20110501

Title: Functional magnetic resonance imaging reveals different neural substrates for the effects of orexin-1 and orexin-2 receptor antagonists.

Journal: PloS one 20110101

Title: Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle: effects of orexin receptor antagonists on gonadotropins and ovulation.

Journal: American journal of physiology. Endocrinology and metabolism 20071001

Title: Novel substituted 4-phenyl-[1,3]dioxanes: potent and selective orexin receptor 2 (OX(2)R) antagonists.

Journal: Bioorganic & medicinal chemistry letters 20040816

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