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70967-97-4,MFCD00077161
Catalog No.:AA00FB3X

70967-97-4 | SUC-ALA-ALA-PRO-PHE-PNA

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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00FB3X
Chemical Name:
SUC-ALA-ALA-PRO-PHE-PNA
CAS Number:
70967-97-4
Molecular Formula:
C30H36N6O9
Molecular Weight:
624.6416
MDL Number:
MFCD00077161
SMILES:
O=C(N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N([C@H](C(=O)N)Cc1ccccc1)c1ccc(cc1)[N+](=O)[O-])C)C)CCC(=O)O
Properties
Computed Properties
 
Complexity:
1100  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
45  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
13  
XLogP3:
1.2  

Literature

Title: Modulation of the Binding Affinity of Polyzwitterion-Conjugated Protein by Ion-Specific Effects in Crowded Environments.

Journal: The journal of physical chemistry. B 20170803

Title: Purification, biochemical, and structural characterization of a novel fibrinolytic enzyme from Mucor subtilissimus UCP 1262.

Journal: Bioprocess and biosystems engineering 20170801

Title: SHG10 keratinolytic alkaline protease from Bacillus licheniformis SHG10 DSM 28096: Robust stability and unusual non-cumbersome purification.

Journal: Journal of basic microbiology 20161201

Title: Identification and characterization of a chymotrypsin-like serine protease from periodontal pathogen, Tannerella forsythia.

Journal: Microbial pathogenesis 20161101

Title: Enhancement of the catalytic efficiency and thermostability of Stenotrophomonas sp. keratinase KerSMD by domain exchange with KerSMF.

Journal: Microbial biotechnology 20160101

Title: PPIase is associated with the diversity of conotoxins from cone snail venom glands.

Journal: Biochimie 20150501

Title: Detergent-Stable Salt-Activated Proteinases from Virgibacillus halodenitrificans SK1-3-7 Isolated from Fish Sauce Fermentation.

Journal: Applied biochemistry and biotechnology 20150501

Title: The biotechnological potential of subtilisin-like fibrinolytic enzyme from a newly isolated Lactobacillus plantarum KSK-II in blood destaining and antimicrobials.

Journal: Biotechnology progress 20150101

Title: Overexpression of aprE2, a fibrinolytic enzyme gene from Bacillus subtilis CH3-5, in Escherichia coli and the properties of AprE2.

Journal: Journal of microbiology and biotechnology 20140701

Title: Molecular cloning and expression of a novel mesophilic alkaline protease from Bacillus sp. L010 in Escherichia coli.

Journal: Wei sheng wu xue bao = Acta microbiologica Sinica 20131104

Title: Redirecting catalysis from proteolysis to perhydrolysis in subtilisin Carlsberg.

Journal: Journal of biotechnology 20130910

Title: Purification and characterization of chymotrypsin from viscera of vermiculated sailfin catfish, Pterygoplichthys disjunctivus, Weber, 1991.

Journal: Fish physiology and biochemistry 20130401

Title: Characterization of a fibrinolytic enzyme secreted by Bacillus amyloliquefaciens CB1 and its gene cloning.

Journal: Journal of microbiology and biotechnology 20130101

Title: Bioactive hydrogels demonstrate mediated release of a chromophore by chymotrypsin.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20120530

Title: Gly or Ala substitutions for Pro(210)Thr(211)Asn(212) at the β8-β9 turn of subtilisin Carlsberg increase the catalytic rate and decrease thermostability.

Journal: Biochimica et biophysica acta 20120401

Title: Directed evolution improves the fibrinolytic activity of nattokinase from Bacillus natto.

Journal: FEMS microbiology letters 20111201

Title: A new tyrosine-specific chymotrypsin-like and angiotensin-degrading serine proteinase from Vipera lebetina snake venom.

Journal: Biochimie 20110201

Title: Purification and characterization of a novel fibrinolytic enzyme from fruiting bodies of Korean Cordyceps militaris.

Journal: Bioresource technology 20110201

Title: Gene expression and biochemical characterization of Azotobacter vinelandii cyclophilins and Protein Interaction Studies of the cytoplasmic isoform with dnaK and lpxH.

Journal: Journal of molecular microbiology and biotechnology 20110101

Title: Effects of serine protease inhibitors on growth and development and digestive serine proteinases of the Sunn pest, Eurygaster integriceps.

Journal: Journal of insect science (Online) 20110101

Title: Conformational preferences of X-Pro sequences: Ala-Pro and Aib-Pro motifs.

Journal: The journal of physical chemistry. B 20101111

Title: Purification and characterization of a novel anticoagulant and fibrinolytic enzyme produced by endophytic bacterium Paenibacillus polymyxa EJS-3.

Journal: Thrombosis research 20101101

Title: Serine protease-mediated host invasion by the parasitic nematode Steinernema carpocapsae.

Journal: The Journal of biological chemistry 20101001

Title: Capillary electrophoresis of the proteolytic activity of the stratum corneum obtained by tape stripping.

Journal: Electrophoresis 20101001

Title: Enhancement of the thermostability and the catalytic efficiency of Bacillus pumilus CBS protease by site-directed mutagenesis.

Journal: Biochimie 20100401

Title: An apoptosis-inducing serine protease secreted by the entomopathogenic nematode Steinernema carpocapsae.

Journal: International journal for parasitology 20091001

Title: Molecular and biochemical characterization of an extracellular serine-protease from Vibrio metschnikovii J1.

Journal: Journal of industrial microbiology & biotechnology 20090701

Title: Cloning and overexpression of a thermostable signal peptide peptidase (SppA) from Thermoplasma volcanium GSS1 in E. coli.

Journal: Biotechnology journal 20090701

Title: Functional characterization of the trigger factor protein PceT of tetrachloroethene-dechlorinating Desulfitobacterium hafniense Y51.

Journal: Applied microbiology and biotechnology 20090601

Title: Role of surfactant on the proteolysis of aqueous bovine serum albumin.

Journal: Biotechnology and bioengineering 20090401

Title: Purification and characterization of keratinase from recombinant Pichia and Bacillus strains.

Journal: Protein expression and purification 20090301

Title: Studies on alkaline serine protease produced by Bacillus clausii GMBE 22.

Journal: Preparative biochemistry & biotechnology 20090101

Title: Purification and cloning of an extracellular serine protease from the nematode-trapping fungus Monacrosporium cystosporium.

Journal: Journal of microbiology and biotechnology 20080501

Title: Preparation, characterization and refolding in vitro of a recombinant human cyclophilin A mutant: effect of a single Pro/Ser substitution on cyclophilin A structure and properties.

Journal: Biotechnology progress 20080101

Title: Nattokinase-promoted tissue plasminogen activator release from human cells.

Journal: Pathophysiology of haemostasis and thrombosis 20080101

Title: Functional expression of the keratinolytic serine protease gene sfp2 from Streptomyces fradiae var. k11 in Pichia pastoris.

Journal: Protein expression and purification 20070701

Title: Purification and characterization of a neutral serine protease with nematicidal activity from Hirsutella rhossiliensis.

Journal: Mycopathologia 20070301

Title: Influence of modulated structural dynamics on the kinetics of alpha-chymotrypsin catalysis. Insights through chemical glycosylation, molecular dynamics and domain motion analysis.

Journal: The FEBS journal 20061201

Title: Purification and characterization of a fibrinolytic subtilisin-like protease of Bacillus subtilis TP-6 from an Indonesian fermented soybean, Tempeh.

Journal: Journal of industrial microbiology & biotechnology 20060601

Title: Partial purification and characterization of a 37 kDa extracellular proteinase from Trichophyton vanbreuseghemii.

Journal: Mycopathologia 20060601

Title: In vitro enzymatic stability of dendritic peptides.

Journal: Journal of biomedical materials research. Part A 20060201

Title: The streptococcal lipoprotein rotamase A (SlrA) is a functional peptidyl-prolyl isomerase involved in pneumococcal colonization.

Journal: The Journal of biological chemistry 20060113

Title: Characterization of a recombinantly expressed proteinase K-like enzyme from a psychrotrophic Serratia sp.

Journal: The FEBS journal 20060101

Title: Purification and characterization of a serine alkaline protease from Bacillus clausii GMBAE 42.

Journal: Journal of industrial microbiology & biotechnology 20050801

Title: Similarities and specificities of fungal keratinolytic proteases: comparison of keratinases of Paecilomyces marquandii and Doratomyces microsporus to some known proteases.

Journal: Applied and environmental microbiology 20050701

Title: Ionisations within a subtilisin-glyoxal inhibitor complex.

Journal: Biochimica et biophysica acta 20050520

Title: Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells.

Journal: Chemistry & biology 20050501

Title: Purification and characterization of a novel fibrinolytic enzyme from Rhizopus chinensis 12.

Journal: Applied microbiology and biotechnology 20050401

Title: Conversion of renin substrate tetradecapeptide to angiotensin II by rat MAB elastase-2.

Journal: Canadian journal of physiology and pharmacology 20041101

Title: X-ray structure of peptidyl-prolyl cis-trans isomerase A from Mycobacterium tuberculosis.

Journal: European journal of biochemistry 20041001

Title: [Correlations between chymase activity, levels of tryptase, and eotaxin in the sputum of patients with chronic obstructive pulmonary disease and their clinical implications].

Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20041001

Title: Accelerating whole-cell biocatalysis by reducing outer membrane permeability barrier.

Journal: Biotechnology and bioengineering 20040920

Title: Engineering a substrate-specific cold-adapted subtilisin.

Journal: Protein engineering, design & selection : PEDS 20040201

Title: Mechanistic origins of the substrate selectivity of serine proteases.

Journal: Biochemistry 20030325

Title: Purification and characterization of a fibrinolytic enzyme produced by Bacillus amyloliquefaciens DC-4 screened from douchi, a traditional Chinese soybean food.

Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20030101

Title: Structural and biological characterisation of the gut-associated cyclophilin B isoforms from Caenorhabditis elegans.

Journal: Journal of molecular biology 20020906

Title: Synthesis and evaluation of Glypsi(PO(2)R-N)Pro-containing pseudopeptides as novel inhibitors of the human cyclophilin hCyp-18.

Journal: Journal of medicinal chemistry 20020829

Title: NMR analysis of in vitro-synthesized proteins without purification: a high-throughput approach.

Journal: FEBS letters 20020731

Title: A strategy for in vivo screening of subtilisin E reaction specificity in E. coli periplasm.

Journal: Biotechnology and bioengineering 20020630

Title: Purification and properties of an alkaline proteinase of Fusarium culmorum.

Journal: European journal of biochemistry 20020201

Title: Kinetic characterization and inhibition of the rat MAB elastase-2, an angiotensin I-converting serine protease.

Journal: Canadian journal of physiology and pharmacology 20020101

Title: Generation of a broad esterolytic subtilisin using combined molecular evolution and periplasmic expression.

Journal: Protein engineering 20011101

Title: Biochemical and molecular characterization of serine proteases from larvae of Chrysomya bezziana, the Old World Screwworm fly.

Journal: Insect biochemistry and molecular biology 20011001

Title: Interaction of human cyclophilin hCyp-18 with short peptides suggests the existence of two functionally independent subsites.

Journal: FEBS letters 20010907

Title: Active subtilisin-like protease from a hyperthermophilic archaeon in a form with a putative prosequence.

Journal: Applied and environmental microbiology 20010601

Title: The outstanding biological stability of beta- and gamma-peptides toward proteolytic enzymes: an in vitro investigation with fifteen peptidases.

Journal: Chembiochem : a European journal of chemical biology 20010601

Title: Macromolecular chromogenic substrates for measuring proteinase activity.

Journal: Clinical chemistry 20010201

Title: Host hemolymph proteins and protein digestion in larval Habrobracon hebetor (Hymenoptera: braconidae).

Journal: Insect biochemistry and molecular biology 20001001

Title: Involvement of an extracellular protease in algicidal activity of the marine bacterium Pseudoalteromonas sp. strain A28.

Journal: Applied and environmental microbiology 20001001

Title: Potent fibrinolytic enzyme from a mutant of Bacillus subtilis IMR-NK1.

Journal: Journal of agricultural and food chemistry 20000801

Title: Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.

Journal: Journal of medicinal chemistry 20000504

Title: Identification and characterisation of the excreted/secreted serine proteases of larvae of the old world screwworm fly, Chrysomya bezziana.

Journal: International journal for parasitology 20000501

Title: Engineering subtilisin E for enhanced stability and activity in polar organic solvents.

Journal: Journal of biochemistry 20000401

Title: Biochemical and structural characterization of a divergent loop cyclophilin from Caenorhabditis elegans.

Journal: The Journal of biological chemistry 19991203

Title: A cold-adapted protease engineered by experimental evolution system.

Journal: Journal of biochemistry 19991001

Title: Biochemical analysis of mouse FKBP60, a novel member of the FKPB family.

Journal: Biochimica et biophysica acta 19990903

Title: Modeling of enzymatic reactions in vesicles: the case of alpha-chymotrypsin.

Journal: Biotechnology and bioengineering 19990105

Title: Directed evolution converts subtilisin E into a functional equivalent of thermitase.

Journal: Protein engineering 19990101

Title: Conformationally changed cytochrome c-mediated fusion of enzyme- and substrate-containing liposomes.

Journal: Biotechnology progress 19990101

Title: Purification and characterization of a 315 kDa keratinolytic subtilisin-like serine protease from Microsporum canis and evidence of its secretion in naturally infected cats.

Journal: Medical mycology 19981201

Title: [Reliability of extracellular protease and lipase activities of Beauveria bassiana isolates used as their virulence indices].

Journal: Wei sheng wu xue bao = Acta microbiologica Sinica 19981201

Title: Detailed characterization of a cyclophilin from the human malaria parasite Plasmodium falciparum.

Journal: The Biochemical journal 19980901

Title: The third serine proteinase with chymotrypsin specificity isolated from Atlantic cod (Gadus morhua) is a type-II elastase.

Journal: European journal of biochemistry 19980801

Title: A relationship between proteinase activity and clinical parameters in the treatment of periodontal disease.

Journal: Journal of clinical periodontology 19980701

Title: Antibody catalysis of peptidyl-prolyl cis-trans isomerization in the folding of RNase T1.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19980623

Title: Engineering of a cold-adapted protease by sequential random mutagenesis and a screening system.

Journal: Applied and environmental microbiology 19980201

Title: Biochemical and genetic characterization of an FK506-sensitive peptidyl prolyl cis-trans isomerase from a thermophilic archaeon, Methanococcus thermolithotrophicus.

Journal: Journal of bacteriology 19980101

Title: Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism.

Journal: Science (New York, N.Y.) 19971212

Title: Cyclophilin A complexed with a fragment of HIV-1 gag protein: insights into HIV-1 infectious activity.

Journal: Structure (London, England : 1993) 19970115

Title: Crystal structure implies that cyclophilin predominantly catalyzes the trans to cis isomerization.

Journal: Biochemistry 19960611

Title: Mechanistic implication of crystal structures of the cyclophilin-dipeptide complexes.

Journal: Biochemistry 19960611

Title: Schistosoma mansoni: evidence for a 28-kDa membrane-anchored protease on schistosomula.

Journal: Experimental parasitology 19960601

Title: A 33 kDa serine proteinase from Scedosporium apiospermum.

Journal: The Biochemical journal 19960401

Title: Directed evolution of subtilisin E in Bacillus subtilis to enhance total activity in aqueous dimethylformamide.

Journal: Protein engineering 19960101

Title: Molecular cloning, DNA sequence analysis, and biochemical characterization of a novel 65-kDa FK506-binding protein (FKBP65).

Journal: The Journal of biological chemistry 19951208

Title: Purification and properties of an alkaline protease from alkalophilic Bacillus sp. KSM-K16.

Journal: Applied microbiology and biotechnology 19950701

Title: Purification, characterization and cDNA sequence of an alkaline chymotrypsin from the midgut of Manduca sexta.

Journal: Insect biochemistry and molecular biology 19950701

Title: Regulation of the activity of human chymase during storage and release from mast cells: the contributions of inorganic cations, pH, heparin and histamine.

Journal: Biochimica et biophysica acta 19950620

Title: Cleavage specificity of cucumisin, a plant serine protease.

Journal: Journal of biochemistry 19950501

Title: Biochemical and calmodulin binding properties of estrogen receptor binding cyclophilin expressed in Escherichia coli.

Journal: Biochemical and biophysical research communications 19950406

Title: Characterization of a collagenolytic serine proteinase from the Atlantic cod (Gadus morhua).

Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 19950401

Title: Yeast NPI46 encodes a novel prolyl cis-trans isomerase that is located in the nucleolus.

Journal: The Journal of cell biology 19940802

Title: The characterization of a cyclophilin-type peptidyl prolyl cis-trans-isomerase from the endoplasmic-reticulum lumen.

Journal: The Biochemical journal 19940615

Title: Improvement of a useful enzyme (subtilisin BPN') by an experimental evolution system.

Journal: Applied microbiology and biotechnology 19940401

Title: The N-terminal cyclophilin-homologous domain of a 150-kilodalton tumor recognition molecule exhibits both peptidylprolyl cis-trans-isomerase and chaperone activities.

Journal: Biochemistry 19940222

Title: Purification and characterization of a strong fibrinolytic enzyme (nattokinase) in the vegetable cheese natto, a popular soybean fermented food in Japan.

Journal: Biochemical and biophysical research communications 19931230

Title: Thrombospondin 1 is a tight-binding competitive inhibitor of neutrophil cathepsin G. Determination of the kinetic mechanism of inhibition and localization of cathepsin G binding to the thrombospondin 1 type 3 repeats.

Journal: The Journal of biological chemistry 19931015

Title: Protease 'Clipsin' extract activity reflects demographic characteristics of human brain.

Journal: Neuroscience letters 19920831

Title: Purification and characterization of a fibrinogenolytic serine proteinase from Aspergillus fumigatus culture filtrate.

Journal: FEBS letters 19920810

Title: Protein engineering of the high-alkaline serine protease PB92 from Bacillus alcalophilus: functional and structural consequences of mutation at the S4 substrate binding pocket.

Journal: Protein engineering 19920701

Title: Random mutagenesis to enhance the activity of subtilisin in organic solvents: Characterization of Q103R subtilisin E.

Journal: Biotechnology and bioengineering 19920315

Title: Neisseria meningitidis encodes an FK506-inhibitable rotamase.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19920215

Title: Purification and characterization of two chymotrypsin-like proteases from the pyloric caeca of rainbow trout (Oncorhynchus mykiss).

Journal: Comparative biochemistry and physiology. B, Comparative biochemistry 19920101

Title: The murine epsilon receptor modulating protein: a novel serine protease which modulates CD23 binding of IgE.

Journal: Cellular immunology 19911001

Title: Metallo-proteinase from the seedlings of kale (Brassica oleracea L. var. sabellica): : Preparation, partial characterization and substrate specificity.

Journal: Planta 19911001

Title: Substrate effects on the enzymatic activity of alpha-chymotrypsin in reverse micelles.

Journal: Biochemical and biophysical research communications 19910815

Title: Free energy perturbation calculations on binding and catalysis after mutating threonine 220 in subtilisin.

Journal: The Journal of biological chemistry 19910625

Title: Possible coupling of chemical to structural dynamics in subtilisin BPN' catalyzed hydrolysis.

Journal: Biophysical chemistry 19910101

Title: Determination of proteolytic enzymes by flow-injection analysis.

Journal: Analytical biochemistry 19910101

Title: Serine proteinase from Cucurbita ficifolia seed; purification, properties, substrate specificity and action on native squash trypsin inhibitor (CMTI I).

Journal: Biological chemistry Hoppe-Seyler 19900901

Title: The detection of proline isomerase activity in FK506-binding protein by two-dimensional 1H NMR exchange spectroscopy.

Journal: Biochemical and biophysical research communications 19900831

Title: Peptidyl-prolyl cis-trans-isomerase from Escherichia coli: a periplasmic homolog of cyclophilin that is not inhibited by cyclosporin A.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19900601

Title: Alternate substrate inhibitors of an alpha-chymotrypsin: enantioselective interaction of aryl-substituted enol lactones.

Journal: Biochemistry 19900508

Title: Clipsin, a chymotrypsin-like protease in rat brain which is irreversibly inhibited by alpha-1-antichymotrypsin.

Journal: The Journal of biological chemistry 19900305

Title: Cloning, expression, and purification of human cyclophilin in Escherichia coli and assessment of the catalytic role of cysteines by site-directed mutagenesis.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19900301

Title: Functional interaction among catalytic residues in subtilisin BPN'.

Journal: Proteins 19900101

Title: Purification and characterization of a 27,000-Mr extracellular proteinase from Trichophyton rubrum.

Journal: Infection and immunity 19891001

Title: Slow-binding inhibition of chymotrypsin and cathepsin G by the peptide aldehyde chymostatin.

Journal: Biochemistry 19870505

Title: Identification and characterization of eight porcine pancreatic proteinases, carboxypeptidase A and amylase after electrophoretic separation using specific substrates.

Journal: The International journal of biochemistry 19870101

Title: Lysosomal elastase and cathepsin G in beige mice. Neutrophils of beige (Chediak-Higashi) mice selectively lack lysosomal elastase and cathepsin G.

Journal: The Journal of experimental medicine 19860301

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Tags:70967-97-4 Molecular Formula|70967-97-4 MDL|70967-97-4 SMILES|70967-97-4 SUC-ALA-ALA-PRO-PHE-PNA