Home Amines 71119-11-4
71119-11-4,MFCD00865898
Catalog No.:AA005NW5

71119-11-4 | 2-(3-((1-(1H-Indol-3-yl)-2-methylpropan-2-yl)amino)-2-hydroxypropoxy)benzonitrile

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1mg
98%
in stock  
$56.00   $39.00
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5mg
98%
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$166.00   $116.00
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10mg
98%
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$302.00   $211.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA005NW5
Chemical Name:
2-(3-((1-(1H-Indol-3-yl)-2-methylpropan-2-yl)amino)-2-hydroxypropoxy)benzonitrile
CAS Number:
71119-11-4
Molecular Formula:
C22H25N3O2
Molecular Weight:
363.4528
MDL Number:
MFCD00865898
SMILES:
N#Cc1ccccc1OCC(CNC(Cc1c[nH]c2c1cccc2)(C)C)O
Properties
Properties
 
Form:
Solid  
MP:
125-127°C  
Storage:
2-8℃;Keep in dry area;  

Computed Properties
 
Complexity:
515  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
1  
XLogP3:
3.3  

Literature

Title: Crystal structures of a stabilized β1-adrenoceptor bound to the biased agonists bucindolol and carvedilol.

Journal: Structure (London, England : 1993) 20120509

Title: β-blockers in stage B: a precursor of heart failure.

Journal: Heart failure clinics 20120401

Title: Combinatorial pharmacogenetic interactions of bucindolol and β1, α2C adrenergic receptor polymorphisms.

Journal: PloS one 20120101

Title: Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111201

Title: Which beta-blocker is most effective in heart failure?

Journal: Cardiovascular drugs and therapy 20100801

Title: An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure.

Journal: Circulation. Heart failure 20100101

Title: Pharmacogenetic effect of an endothelin-1 haplotype on response to bucindolol therapy in chronic heart failure.

Journal: Pharmacogenetics and genomics 20090101

Title: Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.

Journal: Journal of medicinal chemistry 20081009

Title: A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20060725

Title: Beta-adrenoceptor antagonists in elderly patients with chronic heart failure: therapeutic potential of third-generation agents.

Journal: Drugs & aging 20060101

Title: American Association for the Advancement of Science meeting. DNA tells story of heart drug failure.

Journal: Science (New York, N.Y.) 20050225

Title: Clinical trials update from the Heart Failure Society of America: EMOTE, HERB-CHF, BEST genetic sub-study and RHYTHM-ICD.

Journal: European journal of heart failure 20041201

Title: Effect of baseline or changes in adrenergic activity on clinical outcomes in the beta-blocker evaluation of survival trial.

Journal: Circulation 20040914

Title: Adverse effects of beta-blocker therapy for patients with heart failure: a quantitative overview of randomized trials.

Journal: Archives of internal medicine 20040712

Title: Beta blockers as anti-arrhythmic agents.

Journal: Heart failure reviews 20040401

Title: Myocardial contractile reserve by dobutamine stress echocardiography predicts improvement in ejection fraction with beta-blockade in patients with heart failure: the Beta-Blocker Evaluation of Survival Trial (BEST).

Journal: Circulation 20031111

Title: How should subgroup analyses affect clinical practice? Insights from the Metoprolol Succinate Controlled-Release/Extended-Release Randomized Intervention Trial in Heart Failure (MERIT-HF).

Journal: Cardiac electrophysiology review 20030901

Title: Failure of benefit and early hazard of bucindolol for Class IV heart failure.

Journal: Journal of cardiac failure 20030801

Title: Partial agonist activity of bucindolol is dependent on the activation state of the human beta1-adrenergic receptor.

Journal: Circulation 20030722

Title: Catecholamine release in human heart by bupropion.

Journal: European journal of pharmacology 20030425

Title: Beta-blockers in heart failure: how far have we progressed?

Journal: Postgraduate medicine 20021101

Title: [Treatment of heart failure: an update].

Journal: Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology 20020701

Title: Bucindolol displays intrinsic sympathomimetic activity in human myocardium.

Journal: Circulation 20020521

Title: Differential effects of bucindolol and carvedilol on noradenaline-induced hypertrophic response in ventricular cardiomyocytes of adult rats.

Journal: The Journal of pharmacology and experimental therapeutics 20020401

Title: Bucindolol exerts agonistic activity on the propranolol-insensitive state of beta1-adrenoceptors in human myocardium.

Journal: The Journal of pharmacology and experimental therapeutics 20020301

Title: Effects of beta-blocker therapy in severe chronic heart failure.

Journal: The New England journal of medicine 20010927

Title: [Role of beta-blockers in the treatment of chronic heart heart failure].

Journal: Orvosi hetilap 20010916

Title: Nebivolol, bucindolol, metoprolol and carvedilol are devoid of intrinsic sympathomimetic activity in human myocardium.

Journal: British journal of pharmacology 20010801

Title: [Effect of carvedilol on survival in severe chronic heart failure. A trial of the beta-blocker bucindolol in patient with advanced heart failure].

Journal: Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology 20010801

Title: Beta-blocker trials seem to be in conflict.

Journal: Circulation 20010612

Title: Bucindolol, a nonselective beta 1- and beta 2-adrenergic receptor antagonist, decreases beta-adrenergic receptor density in cultured embryonic chick cardiac myocyte membranes.

Journal: Journal of cardiovascular pharmacology 20010601

Title: Expanding indications for beta-blockers in heart failure.

Journal: The New England journal of medicine 20010531

Title: [Adrenergic beta inhibitors in heart insufficiency: which and when?].

Journal: Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20010301

Title: Receptor pharmacology of carvedilol in the human heart.

Journal: Journal of cardiovascular pharmacology 19920101

Title: Comparison of the haemodynamic effects of bucindolol, propranolol and pindolol in healthy volunteers.

Journal: British journal of clinical pharmacology 19851201

Title: Differential cardioprotective properties of the l- and d- enantiomers of bucindolol in a canine model of heart failure.

Journal: Archives internationales de pharmacodynamie et de therapie 19850501

Title: Beneficial effects of bucindolol in a canine model of pentobarbital-induced heart failure.

Journal: Archives internationales de pharmacodynamie et de therapie 19810301

Title: Liggett SB, et al. A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11288-93.

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