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712313-35-4
Catalog No.:AA00FBG3

712313-35-4 | HAMI3379

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  • Technical Information
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Technical Information
Catalog Number:
AA00FBG3
Chemical Name:
HAMI3379
CAS Number:
712313-35-4
Molecular Formula:
C34H45NO8
Molecular Weight:
595.7230
SMILES:
OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOC1CCCCC1)C(=O)O
Properties
Computed Properties
 
Complexity:
853  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
43  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
16  
Undefined Atom Stereocenter Count:
2  
XLogP3:
6.2  

Literature

Title: Intracerebroventricular injection of HAMI 3379, a selective cysteinyl leukotriene receptor 2 antagonist, protects against acute brain injury after focal cerebral ischemia in rats.

Journal: Brain research 20121112

Title: Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor.

Journal: British journal of pharmacology 20100501

Title: Wunder F, et al. Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor. Br J Pharmacol. 2010 May;160(2):399-409.

Title: Zhang XY, et al. HAMI 3379, a CysLT2 receptor antagonist, attenuates ischemia-like neuronal injury by inhibiting microglial activation. J Pharmacol Exp Ther. 2013 Aug;346(2):328-41.

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