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71395-14-7,MFCD00941502
Catalog No.:AA00FBUS

71395-14-7 | Tocainide hydrochloride

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00FBUS
Chemical Name:
Tocainide hydrochloride
CAS Number:
71395-14-7
Molecular Formula:
C11H17ClN2O
Molecular Weight:
228.7185
MDL Number:
MFCD00941502
SMILES:
CC(C(=O)Nc1c(C)cccc1C)N.Cl
Properties
Computed Properties
 
Complexity:
196  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Searching for novel anti-myotonic agents: pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide.

Journal: Neuromuscular disorders : NMD 20120101

Title: The efficacy of anticonvulsants on orofacial pain: a systematic review.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20110501

Title: Non-antiepileptic drugs for trigeminal neuralgia.

Journal: The Cochrane database of systematic reviews 20110119

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Tocainide analogues binding to human serum albumin: a HPLAC and circular dichroism study.

Journal: Journal of pharmaceutical and biomedical analysis 20101010

Title: Effects of a new potent analog of tocainide on hNav1.7 sodium channels and in vivo neuropathic pain models.

Journal: Neuroscience 20100825

Title: 2D- and 3D-QSAR of tocainide and mexiletine analogues acting as Na(v)1.4 channel blockers.

Journal: European journal of medicinal chemistry 20090401

Title: Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents.

Journal: European journal of medicinal chemistry 20081101

Title: Preparation of two new liquid chromatographic chiral stationary phases based on diastereomeric chiral crown ethers incorporating two different chiral units and their applications.

Journal: Journal of chromatography. A 20080516

Title: Cyclic metabolites: chemical and biological considerations.

Journal: Current drug metabolism 20080201

Title: Non-antiepileptic drugs for trigeminal neuralgia.

Journal: The Cochrane database of systematic reviews 20060719

Title: Quantitative structure-pharmacokinetic relationships for drug clearance by using statistical learning methods.

Journal: Journal of molecular graphics & modelling 20060301

Title: Chiral separations on multichannel microfluidic chips.

Journal: Electrophoresis 20051201

Title: Systemic administration of local anesthetic agents to relieve neuropathic pain.

Journal: The Cochrane database of systematic reviews 20051019

Title: New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse.

Journal: Neuromuscular disorders : NMD 20040701

Title: Synthesis, structure and pharmacology of acyl-2,6-xylidines.

Journal: Acta poloniae pharmaceutica 20040101

Title: Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds.

Journal: Molecular pharmacology 20031001

Title: High-speed chiral separations on a microchip with UV detection.

Journal: Electrophoresis 20030901

Title: Enantiomeric separation of tocainide and its analogues on an optically active crown ether-based stationary phase by liquid chromatography.

Journal: Journal of chromatography. A 20030509

Title: A comparison of the antinociceptive effects of voltage-activated Na+ channel blockers in two rat models of neuropathic pain.

Journal: European journal of pharmacology 20030105

Title: Effect of acidity on the enantiomeric resolution of thyroxine and tocainide by HPLC on a (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid column.

Journal: Journal of biochemical and biophysical methods 20021231

Title: Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo.

Journal: British journal of pharmacology 20011201

Title: [Na channel myotonia].

Journal: Ryoikibetsu shokogun shirizu 20010101

Title: Pulmonary fibrosis associated with tocainide: report of a case with literature review.

Journal: The American review of respiratory disease 19900201

Title: Congestive heart failure induced by six of the newer antiarrhythmic drugs.

Journal: Journal of the American College of Cardiology 19891101

Title: Sinoatrial block due to tocainide.

Journal: American heart journal 19891001

Title: Tocainide-induced aplastic anemia.

Journal: DICP : the annals of pharmacotherapy 19890101

Title: Possible proarrhythmic effects of tocainide in dilated cardiomyopathy.

Journal: Pacing and clinical electrophysiology : PACE 19880701

Title: Effect on the seizure threshold in dogs of tocainide/lidocaine administration.

Journal: Annals of emergency medicine 19870701

Title: Tocainide-induced reversible agranulocytosis and anemia.

Journal: Archives of internal medicine 19870301

Title: Tocainide-induced granulomatous hepatitis.

Journal: JAMA 19860627

Title: Successful treatment with tocainide of recessive generalized congenital myotonia.

Journal: Annals of neurology 19860501

Title: Efficacy and safety of oral tocainide in refractory ventricular arrhythmia: a preliminary report on an open label study.

Journal: Angiology 19860401

Title: Aplastic anemia due to tocainide.

Journal: The New England journal of medicine 19860227

Title: A seizure induced by concurrent lidocaine-tocainide therapy--is it just a case of additive toxicity?

Journal: Drug intelligence & clinical pharmacy 19860101

Title: A sequential double blind cross-over trial of tocainide hydrochloride in tinnitus.

Journal: Clinical otolaryngology and allied sciences 19850401

Title: Exacerbation of ventricular tachycardia by tocainide.

Journal: Clinical cardiology 19850101

Title: Confusion and paranoia associated with oral tocainide.

Journal: Postgraduate medical journal 19850101

Title: [Analysis and toxicity of the anti-arrhythmia agent tocainide].

Journal: Beitrage zur gerichtlichen Medizin 19850101

Title: Paranoid psychoses induced by tocainide.

Journal: British medical journal (Clinical research ed.) 19840331

Title: Paranoid psychosis induced by tocainide.

Journal: British medical journal (Clinical research ed.) 19840225

Title: Heart failure and hepatitis in a patient taking tocainide.

Journal: International journal of cardiology 19840101

Title: Tocainide. A review of its pharmacological properties and therapeutic efficacy.

Journal: Drugs 19830801

Title: Antiarrhythmic effects of tocainide and lidocaine in dogs.

Journal: Acta pharmacologica et toxicologica 19830801

Title: Nodal bradycardia induced by tocainide.

Journal: Postgraduate medical journal 19830401

Title: Severe paranoia with concomitant tocainide and propranolol therapy.

Journal: Clinical pharmacy 19820101

Title: Tocainide-induced ventricular fibrillation.

Journal: American heart journal 19810401

Title: New drugs for treating cardiac arrhythmias.

Journal: Postgraduate medicine 19810101

Title: Open clinical studies at a referral center: chronic maintenance tocainide therapy in patients with recurrent sustained ventricular tachycardia refractory to conventional antiarrhythmic agents.

Journal: American heart journal 19801201

Title: Alpert JS, et al. Chemistry, pharmacology, antiarrhythmic efficacy and adverse effects of tocainide hydrochloride, an orally active structural analog of lidocaine. Pharmacotherapy. 1983 Nov-Dec;3(6):316-23.

Title: De Luca A,et al.Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds.Mol Pharmacol. 2003 Oct;64(4):932-45.

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