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71897-07-9,MFCD00270912
Catalog No.:AA005P50

71897-07-9 | 6,7-Dimethyl-2-phenylquinoxaline

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5mg
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10mg
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  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA005P50
Chemical Name:
6,7-Dimethyl-2-phenylquinoxaline
CAS Number:
71897-07-9
Molecular Formula:
C16H14N2
Molecular Weight:
234.2958
MDL Number:
MFCD00270912
SMILES:
Cc1cc2ncc(nc2cc1C)c1ccccc1
NSC Number:
380341
Properties
Properties
 
Form:
Solid  
MP:
127-129°C  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
272  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
3.6  

Literature

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Journal: Toxicology and applied pharmacology 20150615

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Inhibitory effects of resveratrol on PDGF-BB-induced retinal pigment epithelial cell migration via PDGFRβ, PI3K/Akt and MAPK pathways.

Journal: PloS one 20130101

Title: Platelet-derived growth factor receptor kinase inhibitor AG-1295 promotes osteoblast differentiation in MC3T3-E1 cells via the Erk pathway.

Journal: Bioscience trends 20120601

Title: N⁴-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation.

Journal: Bioorganic & medicinal chemistry 20120401

Title: HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers.

Journal: Cancer research 20111101

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: PDGF-β receptor and PKC have no effect on angiotensin II-induced JAK2 and STAT1 phosphorylation in vascular smooth muscle cells under high glucose condition.

Journal: Journal of receptor and signal transduction research 20111001

Title: The contribution of a 2-amino group on receptor tyrosine kinase inhibition and antiangiogenic activity in 4-anilinosubstituted pyrrolo[2,3-d]pyrimidines.

Journal: Bioorganic & medicinal chemistry letters 20100515

Title: Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors.

Journal: Bioorganic & medicinal chemistry 20091015

Title: FGF2 is crucial for the development of bovine luteal endothelial networks in vitro.

Journal: Reproduction (Cambridge, England) 20090901

Title: Bovine lactoferrin stimulates human corneal epithelial alkali wound healing in vitro.

Journal: Investigative ophthalmology & visual science 20090401

Title: BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3.

Journal: Blood 20090305

Title: Modulation of circadian rhythm of DNA synthesis in tumor cells by inhibiting platelet-derived growth factor signaling.

Journal: Journal of pharmacological sciences 20080801

Title: Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents.

Journal: Bioorganic & medicinal chemistry 20080515

Title: Potentiation by platelet-derived growth factor-BB of FGF-2-stimulated VEGF release in osteoblasts.

Journal: Journal of bone and mineral metabolism 20080101

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218

Title: Platelet-derived growth factors and receptors in the rat corpus luteum: localization and identification of an effect on luteogenesis.

Journal: Biology of reproduction 20070301

Title: Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones.

Journal: Bioorganic & medicinal chemistry 20070301

Title: Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase.

Journal: Journal of medicinal chemistry 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: The role of platelet-derived growth factor receptor in eotaxin signaling of eosinophils.

Journal: International archives of allergy and immunology 20060101

Title: Nicotinic and PDGF-receptor function are essential for nicotine-stimulated mitogenesis in human vascular smooth muscle cells.

Journal: Journal of cellular biochemistry 20051201

Title: Specific locations of hydrophilic amino acids in constructed transmembrane ligands of the platelet-derived growth factor beta receptor.

Journal: Journal of molecular biology 20050128

Title: Enforced expression of an Flt3 internal tandem duplication in human CD34+ cells confers properties of self-renewal and enhanced erythropoiesis.

Journal: Blood 20050101

Title: Signal transduction of c-Kit receptor tyrosine kinase in CHRF myeloid leukemia cells.

Journal: Journal of cancer research and clinical oncology 20041201

Title: Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD-transformed hematopoietic cells.

Journal: Blood 20040315

Title: Differential roles of WAVE1 and WAVE2 in dorsal and peripheral ruffle formation for fibroblast cell migration.

Journal: Developmental cell 20031001

Title: Signaling and distribution of NPR-Bi, the human splice form of the natriuretic peptide receptor type B.

Journal: American journal of physiology. Renal physiology 20030801

Title: Beta-platelet-derived growth factor receptor mediates motility and growth of Ewing's sarcoma cells.

Journal: Oncogene 20030417

Title: UVB-induced apoptosis in normal human keratinocytes: role of the erbB receptor family.

Journal: Experimental cell research 20030401

Title: PDGF and FGF2 regulate oligodendrocyte progenitor responses to demyelination.

Journal: Journal of neurobiology 20030215

Title: Platelet-derived growth factor up-regulates the expression of transcription factors NF-E2, GATA-1 and c-Fos in megakaryocytic cell lines.

Journal: Cytokine 20030121

Title: Platelet-derived growth factor receptor kinase inhibitor AG1295 and inhibition of experimental proliferative vitreoretinopathy.

Journal: Japanese journal of ophthalmology 20030101

Title: Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src.

Journal: The Journal of biological chemistry 20021122

Title: Inhibition of aortic allograft vasculopathy by local delivery of platelet-derived growth factor receptor tyrosine-kinase blocker AG-1295.

Journal: Transplantation 20021115

Title: Study of the drug release mechanism from tyrphostin AG-1295-loaded nanospheres by in situ and external sink methods.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20021030

Title: Inhibition of platelet-derived growth factor actions in the embryonic testis influences normal cord development and morphology.

Journal: Biology of reproduction 20020301

Title: Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase.

Journal: Journal of medicinal chemistry 20020227

Title: Formulation and delivery mode affect disposition and activity of tyrphostin-loaded nanoparticles in the rat carotid model.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20010901

Title: A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations.

Journal: Blood 20010801

Title: Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation.

Journal: Cancer research 19941201

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Tags:71897-07-9 Molecular Formula|71897-07-9 MDL|71897-07-9 SMILES|71897-07-9 6,7-Dimethyl-2-phenylquinoxaline