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719277-26-6,MFCD00624584
Catalog No.:AA0061D2

719277-26-6 | Tg-003

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Purity
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5mg
≥98%(HPLC)
in stock  
$268.00   $188.00
- +
10mg
98%
in stock  
$274.00   $192.00
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50mg
98%
in stock  
$824.00   $577.00
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100mg
≥98%(HPLC)
in stock  
$1,340.00   $938.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0061D2
Chemical Name:
Tg-003
CAS Number:
719277-26-6
Molecular Formula:
C13H15NO2S
Molecular Weight:
249.3287
MDL Number:
MFCD00624584
SMILES:
COc1ccc2c(c1)n(CC)/c(=C/C(=O)C)/s2
Properties
Properties
 
Form:
Solid  
MP:
132-132.5℃  

Computed Properties
 
Complexity:
329  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
3  
XLogP3:
2.6  

Literature

Title: Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors.

Journal: Molecular pain 20140101

Title: Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315.

Journal: Bioorganic & medicinal chemistry letters 20130615

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.

Journal: Journal of medicinal chemistry 20121108

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.

Journal: Journal of medicinal chemistry 20110623

Title: Lipopolysaccharide signaling without a nucleus: kinase cascades stimulate platelet shedding of proinflammatory IL-1β-rich microparticles.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20110501

Title: Chemical treatment enhances skipping of a mutated exon in the dystrophin gene.

Journal: Nature communications 20110501

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Superoxide dismutase is regulated by LAMMER kinase in Drosophila and human cells.

Journal: Free radical biology & medicine 20090315

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Manipulation of alternative splicing by a newly developed inhibitor of Clks.

Journal: The Journal of biological chemistry 20040604

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Muraki M, et al. Manipulation of alternative splicing by a newly developed inhibitor of Clks. J Biol Chem. 2004 Jun 4;279(23):24246-54.

Title: Marcel V, et al. Modulation of p53β and p53γ expression by regulating the alternative splicing of TP53 gene modifies cellular response. Cell Death Differ. 2014 Sep;21(9):1377-87.

Title: Kurihara T, et al. Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors. Mol Pain. 2014 Mar 10;10:17.

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