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72063-39-9,MFCD09754430
Catalog No.:AA00FBD9

72063-39-9 | Spinosin

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1mg
95%
in stock  
$13.00   $9.00
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5mg
95%
in stock  
$32.00   $22.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00FBD9
Chemical Name:
Spinosin
CAS Number:
72063-39-9
Molecular Formula:
C28H32O15
Molecular Weight:
608.5447
MDL Number:
MFCD09754430
SMILES:
OC[C@H]1O[C@H]([C@@H]([C@H]([C@@H]1O)O)O[C@@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O)c1c(OC)cc2c(c1O)c(=O)cc(o2)c1ccc(cc1)O
Properties
Computed Properties
 
Complexity:
987  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
10  
Heavy Atom Count:
43  
Hydrogen Bond Acceptor Count:
15  
Hydrogen Bond Donor Count:
9  
Rotatable Bond Count:
7  
XLogP3:
-1.1  

Literature

Title: A UFLC-MS/MS method for simultaneous quantitation of spinosin, mangiferin and ferulic acid in rat plasma: application to a comparative pharmacokinetic study in normal and insomnic rats.

Journal: Journal of mass spectrometry : JMS 20121001

Title: In vivo microdialysis with LC-MS for analysis of spinosin and its interaction with cyclosporin A in rat brain, blood and bile.

Journal: Journal of pharmaceutical and biomedical analysis 20120305

Title: Augmentative effect of spinosin on pentobarbital-induced loss of righting reflex in mice associated with presynaptic 5-HT1A receptor.

Journal: The Journal of pharmacy and pharmacology 20120201

Title: Two new flavonoid glycosides from Semen Ziziphi Spinosae.

Journal: Journal of Asian natural products research 20120101

Title: A novel spinosin derivative from Semen Ziziphi Spinosae.

Journal: Journal of Asian natural products research 20111201

Title: Potentiating effect of spinosin, a C-glycoside flavonoid of Semen Ziziphi spinosae, on pentobarbital-induced sleep may be related to postsynaptic 5-HT(1A) receptors.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20100501

Title: [Metabolism and excretion of total flavonoids of Semen Ziziphi Spinosae in rat urine and feces].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090201

Title: Quantitative determination of spinosin in rat plasma by liquid chromatography-tandem mass spectrometry method.

Journal: Journal of pharmaceutical and biomedical analysis 20081201

Title: Spinosin, a C-glycoside flavonoid from semen Zizhiphi Spinozae, potentiated pentobarbital-induced sleep via the serotonergic system.

Journal: Pharmacology, biochemistry, and behavior 20080901

Title: Megastigmane and flavone glycosides from Strophioblachia fimbricalyx Boerl.

Journal: Journal of natural medicines 20080101

Title: Pharmacokinetics and tissue distribution of spinosin after intravenous administration in rats.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070801

Title: Pharmacokinetic study on spinosin in rat plasma after oral administration of suanzaoren extract at a single dose.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20030601

Title: Determination of spinosin in rat plasma by reversed-phase high-performance chromatography after oral administration of Suanzaoren decoction.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030425

Title: Jung IH, et al. Ameliorating effect of spinosin, a C-glycoside flavonoid, on scopolamine-induced memory impairment in mice. Pharmacol Biochem Behav. 2014 May;120:88-94.

Title: Xu F, et al. Neuroprotective Effects of Spinosin on Recovery of Learning and Memory in a Mouse Model of Alzheimer's Disease. Biomol Ther (Seoul). 2019 Jan 1;27(1):71-77.

Title: Zhang X, et al. Spinosin Inhibits Aβ1-42 Production and Aggregation via Activating Nrf2/HO-1 Pathway. Biomol Ther (Seoul). 2019 Dec 3.

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