Home Amines 7240-37-1
7240-37-1,MFCD00077295
Catalog No.:AA0065ZB

7240-37-1 | 7-Aminoactinomycin d

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1mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0065ZB
Chemical Name:
7-Aminoactinomycin d
CAS Number:
7240-37-1
Molecular Formula:
C62H87N13O16
Molecular Weight:
1270.4317
MDL Number:
MFCD00077295
SMILES:
O=C1N[C@H](C(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)CC(=O)N(C(C(=O)O[C@@H]([C@@H]1NC(=O)c1c2nc3c(cc(c(c3oc2c(c(=O)c1N)C)C)N)C(=O)N[C@H]1[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C(=O)[C@H]2N(C(=O)[C@H](NC1=O)C(C)C)CCC2)C)C)C(C)C)C
NSC Number:
239759
Properties
Properties
 
BP:
1400.8°C at 760 mmHg  
Form:
Solid  
MP:
252~253℃  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
3070  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
91  
Hydrogen Bond Acceptor Count:
19  
Hydrogen Bond Donor Count:
6  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
10  
XLogP3:
3.1  

Literature

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Title: Flow cytometry assessment of apoptotic CD34+ cells by annexin V labeling may improve prediction of cord blood potency for engraftment.

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Journal: Asian journal of andrology 20100701

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Title: Oral malodorous compound triggers mitochondrial-dependent apoptosis and causes genomic DNA damage in human gingival epithelial cells.

Journal: Journal of periodontal research 20100201

Title: Comparison between propidium iodide and 7-amino-actinomycin-D for viability assessment during flow cytometric analyses of the human sperm acrosome.

Journal: Andrologia 20100201

Title: Sca-1 expression pattern in the mouse limbal epithelium and its association with cell cycle.

Journal: Journal of stem cells 20100101

Title: 7-Amino actinomycin D bound to single-stranded hairpin DNA enhanced by loop sequence-dependent luminescent Eu(3+) and Tb(3+) binding.

Journal: Journal of inorganic biochemistry 20091201

Title: Spatiotemporal organization of AT- and GC-rich DNA and their association with transition proteins TP1 and TP2 in rat condensing spermatids.

Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20091001

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Journal: Analytical chemistry 20090815

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Journal: Neurosurgery 20090601

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Journal: Journal of immunological methods 20090531

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Journal: Annals of neurology 20090501

Title: DNA hairpins containing the cytidine analog pyrrolo-dC: structural, thermodynamic, and spectroscopic studies.

Journal: Biophysical journal 20090304

Title: 7-Aminoactinomycin binding to DNA sequences lacking GpC sites: a thermodynamic and kinetic study.

Journal: Biochemistry 20090113

Title: Isoflavone genistein protects human vascular endothelial cells against tumor necrosis factor-alpha-induced apoptosis through the p38beta mitogen-activated protein kinase.

Journal: Apoptosis : an international journal on programmed cell death 20090101

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Journal: Scandinavian journal of clinical and laboratory investigation 20090101

Title: The phytostilbene resveratrol induces apoptosis in INS-1E rat insulinoma cells.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20090101

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Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20090101

Title: Nicotine inhibits apoptosis and stimulates proliferation in aortic smooth muscle cells through a functional nicotinic acetylcholine receptor.

Journal: The Journal of surgical research 20081201

Title: High percentage of apoptotic spermatozoa in ejaculates from men with chronic genital tract inflammation.

Journal: Andrologia 20081001

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Journal: Cancer letters 20080928

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Journal: Journal of medical virology 20080401

Title: Proliferation and interleukin 5 production by CD8hi CD57+ T cells.

Journal: European journal of immunology 20080401

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Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20080201

Title: [Caffeine clusters as transmitters of actinomycin antibiotics to DNA in solutions].

Journal: Bioorganicheskaia khimiia 20080101

Title: In vivo and in vitro methods for studying apoptotic cell engulfment in Drosophila.

Journal: Methods in enzymology 20080101

Title: [7-aminoactinomycin as a fluorescent probe for DNA unwinding and denaturation].

Journal: Bioorganicheskaia khimiia 20080101

Title: Bortezomib induces apoptosis in T-cell prolymphocytic leukemia (T-PLL).

Journal: Leukemia & lymphoma 20071101

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Journal: Journal of immunological methods 20070831

Title: A rapid method to measure beta-amyloid induced neurotoxicity in vitro.

Journal: Journal of neuroscience methods 20070330

Title: A new multiparameter flow cytometric method for human semen analysis.

Journal: Human reproduction (Oxford, England) 20070201

Title: Exposure to mixtures of endosulfan and zineb induces apoptotic and necrotic cell death in SH-SY5Y neuroblastoma cells, in vitro.

Journal: Journal of applied toxicology : JAT 20070101

Title: HIV Tat protein increases Bcl-2 expression in monocytes which inhibits monocyte apoptosis induced by tumor necrosis factor-alpha-related apoptosis-induced ligand.

Journal: Intervirology 20070101

Title: Live-cell assay for detection of apoptosis by dual-laser flow cytometry using Hoechst 33342 and 7-amino-actinomycin D.

Journal: Nature protocols 20070101

Title: Decrease in CD93 (C1qRp) expression in a human monocyte-like cell line (U937) treated with various apoptosis-inducing chemical substances.

Journal: Microbiology and immunology 20070101

Title: A rapid method for the quantification of mouse hippocampal neurogenesis in vivo by flow cytometry. Validation with conventional and enhanced immunohistochemical methods.

Journal: Journal of neuroscience methods 20061015

Title: Prompt non-stacking binding of actinomycin D to hairpin oligonucleotide HP1 and slow redistribution from HP1 to DNA.

Journal: Journal of biochemistry 20060801

Title: Comparative quantification of umbilical cord blood CD34+ and CD34+ bright cells using the ProCount-BD and ISHAGE protocols.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20060701

Title: Comparison of immunophenotyping by slide-based cytometry and by flow cytometry.

Journal: Journal of immunological methods 20060420

Title: Quantitative measurement of nuclear translocation events using similarity analysis of multispectral cellular images obtained in flow.

Journal: Journal of immunological methods 20060420

Title: RNA interference in immune cells by use of osmotic delivery of siRNA.

Journal: Biochemical and biophysical research communications 20060310

Title: Simultaneous detection of antibody binding and cytotoxicity in flow cytometry crossmatch for renal transplantation.

Journal: Cytometry. Part B, Clinical cytometry 20060301

Title: Evaluation of the reactivity of apoptosis markers before and after cryopreservation in cord blood CD34(+) cells.

Journal: Stem cells and development 20060201

Title: Immunosuppression by morphine-induced lymphocyte apoptosis: is it a real issue?

Journal: Anesthesia and analgesia 20051001

Title: Crystal and solution structures of 7-amino-actinomycin D complexes with d(TTAGBrUT), d(TTAGTT) and d(TTTAGTTT).

Journal: Acta crystallographica. Section D, Biological crystallography 20050401

Title: Use of SYBR14, 7-amino-actinomycin D, and JC-1 in assessing sperm damage from rats with spinal cord injury.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20040901

Title: Characterization of YvcC (BmrA), a multidrug ABC transporter constitutively expressed in Bacillus subtilis.

Journal: Biochemistry 20040615

Title: Pesticide mixtures potentiate the toxicity in murine thymocytes.

Journal: Toxicology 20040315

Title: Retention of cellular properties of PBPCs following liquid storage and cryopreservation.

Journal: Transfusion 20040201

Title: The cell cycle related apoptotic susceptibility to arsenic trioxide is associated with the level of reactive oxygen species.

Journal: Cell research 20040201

Title: Multiparametric analysis of apoptosis by flow and image cytometry.

Journal: Methods in molecular biology (Clifton, N.J.) 20040101

Title: [Formation of DNA complexes with actinomycins in aqueous solutions and films].

Journal: Prikladnaia biokhimiia i mikrobiologiia 20040101

Title: [A study of interaction of 7-aminoactinomycin D with DNA by fluorescence correlation spectroscopy].

Journal: Biofizika 20040101

Title: Enthalpy/entropy compensation: influence of DNA flanking sequence on the binding of 7-amino actinomycin D to its primary binding site in short DNA duplexes.

Journal: Biochemistry 20031021

Title: Induction of apoptosis and/or necrosis following exposure to antitumour agents in a melanoma cell line, probably through modulation of Bcl-2 family proteins.

Journal: Melanoma research 20031001

Title: A flow cytometric method for enumeration of lymphocyte sub-populations in sample containing lysis-resistant red blood cells.

Journal: Immunology letters 20030501

Title: A nonsecreted variant of interleukin-4 is associated with apoptosis: implication for the T helper-2 polarization in HIV infection.

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Journal: International journal of radiation biology 20030301

Title: Flow cytometric quantification of apoptosis and proliferation in mixed lymphocyte culture.

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Title: Cryopreservation of umbilical cord blood: 2. Tolerance of CD34(+) cells to multimolar dimethyl sulphoxide and the effect of cooling rate on recovery after freezing and thawing.

Journal: Cryobiology 20030201

Title: Assessment of cell viability and apoptosis in human umbilical cord blood following storage.

Journal: Journal of hematotherapy & stem cell research 20030201

Title: Binding of actinomycin D to single-stranded DNA of sequence motifs d(TGTCT(n)G) and d(TGT(n)GTCT).

Journal: Biophysical journal 20030101

Title: Adherent cells generated during long-term culture of human umbilical cord blood CD34+ cells have characteristics of endothelial cells and beneficial effect on cord blood ex vivo expansion.

Journal: Stem cells (Dayton, Ohio) 20030101

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Journal: Methods in molecular medicine 20030101

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Journal: Thrombosis and haemostasis 20021201

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Title: Phagocytosis of apoptotic cells assessed by flow cytometry using 7-Aminoactinomycin D.

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Journal: Cytometry 20020801

Title: Multiparametric flow cytometric analysis of biochemical and functional events associated with apoptosis and oncosis using the 7-aminoactinomycin D assay.

Journal: Journal of immunological methods 20020701

Title: Five-color flow cytometric analysis of swine lymphocytes for detection of proliferation, apoptosis, viability, and phenotype.

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Journal: Molekuliarnaia biologiia 20020101

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Journal: Journal of neurology 20010801

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Title: The use of 7-amino-actinomycin D in the analysis of Candida albicans phagocytosis and opsonization.

Journal: Journal of immunological methods 20010701

Title: Influence of a transiently transfected gene on apoptosis, measurements guided by cotransfected GFP.

Journal: Journal of immunological methods 20010601

Title: Actinomycin D binds strongly to d(TGTCATTG), a single-stranded DNA devoid of GpC sites.

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Tags:7240-37-1 Molecular Formula|7240-37-1 MDL|7240-37-1 SMILES|7240-37-1 7-Aminoactinomycin d