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727-81-1,MFCD00274412
Catalog No.:AA00FA3B

727-81-1 | COENZYME Q1

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1mg
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$70.00   $49.00
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5mg
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10mg
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00FA3B
Chemical Name:
COENZYME Q1
CAS Number:
727-81-1
Molecular Formula:
C14H18O4
Molecular Weight:
250.2903
MDL Number:
MFCD00274412
SMILES:
COC1=C(OC)C(=O)C(=C(C1=O)CC=C(C)C)C
NSC Number:
268269
Properties
Computed Properties
 
Complexity:
474  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
4  
XLogP3:
2.8  

Literature

Title: Coenzyme Q(1) as a probe for mitochondrial complex I activity in the intact perfused hyperoxia-exposed wild-type and Nqo1-null mouse lung.

Journal: American journal of physiology. Lung cellular and molecular physiology 20120501

Title: Oral administration of coenzyme Q₁₀ reduces MPTP-induced loss of dopaminergic nerve terminals in the striatum in mice.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20120201

Title: Prerequisites for ubiquinone analogs to prevent mitochondrial permeability transition-induced cell death.

Journal: Journal of bioenergetics and biomembranes 20120201

Title: Vesiculation from Pseudomonas aeruginosa under SOS.

Journal: TheScientificWorldJournal 20120101

Title: Probing the mechanistic role of the long α-helix in subunit L of respiratory Complex I from Escherichia coli by site-directed mutagenesis.

Journal: Molecular microbiology 20111201

Title: Manipulating respiratory levels in Escherichia coli for aerobic formation of reduced chemical products.

Journal: Metabolic engineering 20111101

Title: Genetic evidence for NAD(P)H:quinone oxidoreductase 1-catalyzed quinone reduction on passage through the mouse pulmonary circulation.

Journal: American journal of physiology. Lung cellular and molecular physiology 20110501

Title: Reaction of the molybdenum- and copper-containing carbon monoxide dehydrogenase from Oligotropha carboxydovorans with quinones.

Journal: Biochemistry 20110322

Title: Effect of nitric oxide on mitochondrial activity of human synovial cells.

Journal: BMC musculoskeletal disorders 20110101

Title: NQO1-dependent redox cycling of idebenone: effects on cellular redox potential and energy levels.

Journal: PloS one 20110101

Title: Distribution of capillary transit times in isolated lungs of oxygen-tolerant rats.

Journal: Annals of biomedical engineering 20101101

Title: Old and new inhibitors of quinone reductase 2.

Journal: Chemico-biological interactions 20100730

Title: Purification and characterization of Put1p from Saccharomyces cerevisiae.

Journal: Archives of biochemistry and biophysics 20100615

Title: Photolabile ubiquinone analogues for identification and characterization of quinone binding sites in proteins.

Journal: Bioorganic & medicinal chemistry 20100515

Title: Loss of estrogen receptor beta decreases mitochondrial energetic potential and increases thrombogenicity of platelets in aged female mice.

Journal: Age (Dordrecht, Netherlands) 20100301

Title: Ubiquinone analogs: a mitochondrial permeability transition pore-dependent pathway to selective cell death.

Journal: PloS one 20100101

Title: Complex I-associated hydrogen peroxide production is decreased and electron transport chain enzyme activities are altered in n-3 enriched fat-1 mice.

Journal: PloS one 20100101

Title: Polymyxin B identified as an inhibitor of alternative NADH dehydrogenase and malate: quinone oxidoreductase from the Gram-positive bacterium Mycobacterium smegmatis.

Journal: Journal of biochemistry 20091001

Title: Properties of the thioredoxin fold superfamily are modulated by a single amino acid residue.

Journal: The Journal of biological chemistry 20090410

Title: Reduction of hydrophilic ubiquinones by the flavin in mitochondrial NADH:ubiquinone oxidoreductase (Complex I) and production of reactive oxygen species.

Journal: Biochemistry 20090310

Title: PGC-1-related coactivator modulates mitochondrial-nuclear crosstalk through endogenous nitric oxide in a cellular model of oncocytic thyroid tumours.

Journal: PloS one 20090101

Title: Platinum nanoparticles have an activity similar to mitochondrial NADH:ubiquinone oxidoreductase.

Journal: Colloids and surfaces. B, Biointerfaces 20081015

Title: Coenzyme Q1 redox metabolism during passage through the rat pulmonary circulation and the effect of hyperoxia.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20081001

Title: Activity of 1,4-benzoquinones against formosan subterranean termites (Coptotermes formosanus).

Journal: Journal of agricultural and food chemistry 20080611

Title: Reduction of ascorbate free radical by the plasma membrane of synaptic terminals from rat brain.

Journal: Archives of biochemistry and biophysics 20080115

Title: Oxidant-induced formation of a neutral flavosemiquinone in the Na+-translocating NADH:Quinone oxidoreductase (Na+-NQR) from Vibrio cholerae.

Journal: Biochimica et biophysica acta 20080101

Title: Functional role of coenzyme Q in the energy coupling of NADH-CoQ oxidoreductase (Complex I): stabilization of the semiquinone state with the application of inside-positive membrane potential to proteoliposomes.

Journal: BioFactors (Oxford, England) 20080101

Title: Mitochondrial production of reactive oxygen species: role of complex I and quinone analogues.

Journal: BioFactors (Oxford, England) 20080101

Title: Role of mitochondrial electron transport complex I in coenzyme Q1 reduction by intact pulmonary arterial endothelial cells and the effect of hyperoxia.

Journal: American journal of physiology. Lung cellular and molecular physiology 20070901

Title: Detergent-dependent kinetics of truncated Plasmodium falciparum dihydroorotate dehydrogenase.

Journal: The Journal of biological chemistry 20070427

Title: Theoretical study of the energetics of the reactions of triplet dioxygen with hydroquinone, semiquinone, and their protonated forms: relation to the mechanism of superoxide generation in the respiratory chain.

Journal: The journal of physical chemistry. B 20070405

Title: HQNO-sensitive NADH:quinone oxidoreductase of Bacillus cereus KCTC 3674.

Journal: Journal of biochemistry and molecular biology 20070131

Title: Inhibitory effect of coenzyme Q on eukaryotic DNA polymerase gamma and DNA topoisomerase II activities on the growth of a human cancer cell line.

Journal: Cancer science 20060801

Title: Coenzyme Q(1) depletes NAD(P)H and impairs recycling of ascorbate in astrocytes.

Journal: Brain research 20060317

Title: Inhibition of glycerophosphate-dependent H2O2 generation in brown fat mitochondria by idebenone.

Journal: Biochemical and biophysical research communications 20060106

Title: Sulfation and glucuronidation of phenols: implications in coenyzme Q metabolism.

Journal: Methods in enzymology 20050101

Title: Trichomonas hydrogenosomes contain the NADH dehydrogenase module of mitochondrial complex I.

Journal: Nature 20041202

Title: NADH-Ubiquinone oxidoreductase: substrate-dependent oxygen turnover to superoxide anion as a function of flavin mononucleotide.

Journal: Mitochondrion 20031001

Title: Coenzyme Q1-catalyzed luminol chemiluminescent assay for rapid antimicrobial susceptibility testing of Mycobacterium bovis.

Journal: Microbiology and immunology 20030101

Title: Cytoprotective and anticancer properties of coenzyme Q versus capsaicin.

Journal: BioFactors (Oxford, England) 20030101

Title: Hepatocyte metabolism of coenzyme Q1 (ubiquinone-5) to its sulfate conjugate decreases its antioxidant activity.

Journal: BioFactors (Oxford, England) 20030101

Title: CNS neurons express two distinct plasma membrane electron transport systems implicated in neuronal viability.

Journal: Journal of neurochemistry 20021101

Title: The second coenzyme Q1 binding site of bovine heart NADH: coenzyme Q oxidoreductase.

Journal: Journal of bioenergetics and biomembranes 20020401

Title: Coenzyme Q cytoprotective mechanisms for mitochondrial complex I cytopathies involves NAD(P)H: quinone oxidoreductase 1(NQO1).

Journal: Free radical research 20020401

Title: Interaction of purified NDH-1 from Escherichia coli with ubiquinone analogues.

Journal: Biochimica et biophysica acta 20020215

Title: Retention of heme in axial ligand mutants of succinate-ubiquinone xxidoreductase (complex II) from Escherichia coli.

Journal: The Journal of biological chemistry 20010601

Title: Moller IM, et al. Ubiquinone-1 Induces External Deamino-NADH Oxidation in Potato Tuber Mitochondria. Plant Physiol. 1996 Sep;112(1):75-78.

Title: R Fato, et al. Steady-state kinetics of the reduction of coenzyme Q analogs by complex I (NADH:ubiquinone oxidoreductase) in bovine heart mitochondria and submitochondrial particles. Biochemistry. 1996 Feb 27;35(8):2705-16.

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