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72873-74-6,MFCD00869367
Catalog No.:AA005E4Z

72873-74-6 | SKF-86002

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1mg
≥98%
in stock  
$52.00   $36.00
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5mg
≥98%
in stock  
$172.00   $120.00
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10mg
≥98%
in stock  
$319.00   $223.00
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25mg
≥98%
in stock  
$729.00   $510.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA005E4Z
Chemical Name:
SKF-86002
CAS Number:
72873-74-6
Molecular Formula:
C16H12FN3S
Molecular Weight:
297.3500
MDL Number:
MFCD00869367
SMILES:
Fc1ccc(cc1)c1nc2n(c1c1ccncc1)CCS2
Properties
Properties
 
BP:
476.1°C at 760 mmHg  
Form:
Solid  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
355  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
2  
XLogP3:
2.9  

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Expression of TNF-alpha and IL-6 in HMC-1 cells treated with bisphenol A is attenuated by plant-originating glycoprotein (75 kDa) by blocking p38 MAPK.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20100701

Title: Displacement assay for the detection of stabilizers of inactive kinase conformations.

Journal: Journal of medicinal chemistry 20100114

Title: Phytoglycoprotein (75 kDa) isolated from Cudrania tricuspidata Bureau inhibits expression of interleukin-4 in the presence of di (2-ethylhexyl) phthalate via modulation of p38 mitogen-activated protein kinase in primary-cultured mouse thymocytes.

Journal: Journal of applied toxicology : JAT 20090801

Title: p38 MAPK regulates ischemia-reperfusion-induced recruitment of leukocytes in the colon.

Journal: Surgery 20090301

Title: Hyperosmolarity-induced dilation and epithelial bioelectric responses of guinea pig trachea in vitro: role of kinase signaling.

Journal: The Journal of pharmacology and experimental therapeutics 20080701

Title: 6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA.

Journal: Journal of neurochemistry 20080301

Title: Activation of p38MAPK contributes to expanded polyglutamine-induced cytotoxicity.

Journal: PloS one 20080101

Title: Regulation of cardiotrophin-1 expression in mouse embryonic stem cells by HIF-1alpha and intracellular reactive oxygen species.

Journal: Journal of cell science 20060315

Title: Low density lipoproteins inhibit the Na+/H+ antiport in human platelets via activation of p38MAP kinase.

Journal: Biochemical and biophysical research communications 20060217

Title: Small molecular anti-cytokine agents.

Journal: Medicinal research reviews 20060101

Title: p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice.

Journal: American journal of physiology. Renal physiology 20050701

Title: Regulation of p38 phosphorylation and topoisomerase IIalpha expression in the B-cell lymphoma line Jiyoye by CD26/dipeptidyl peptidase IV is associated with enhanced in vitro and in vivo sensitivity to doxorubicin.

Journal: Cancer research 20050301

Title: Lipopolysaccharide: a p38 MAPK-dependent disrupter of neutrophil chemotaxis.

Journal: Microcirculation (New York, N.Y. : 1994) 20050101

Title: The discovery of novel chemotypes of p38 kinase inhibitors.

Journal: Current topics in medicinal chemistry 20050101

Title: A Biacore biosensor method for detailed kinetic binding analysis of small molecule inhibitors of p38alpha mitogen-activated protein kinase.

Journal: Analytical biochemistry 20040201

Title: Design and synthesis of 4-azaindoles as inhibitors of p38 MAP kinase.

Journal: Journal of medicinal chemistry 20031023

Title: Role of the p38 MAPK pathway in cisplatin-based therapy.

Journal: Oncogene 20030626

Title: p38 MAP kinase negatively regulates angiotensin II-mediated effects on cell cycle molecules in human coronary smooth muscle cells.

Journal: Biochemical and biophysical research communications 20030606

Title: P38 MAPK: critical molecule in thrombin-induced NF-kappa B-dependent leukocyte recruitment.

Journal: American journal of physiology. Heart and circulatory physiology 20030401

Title: Differential activation of the c-Jun N-terminal kinase pathway in arsenite-induced apoptosis and sensitization of chemically resistant compared to susceptible B-lymphoma cell lines.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20020701

Title: From imidazoles to pyrimidines: new inhibitors of cytokine release.

Journal: Journal of medicinal chemistry 20020620

Title: The effects of a cytokine suppressive anti-inflammatory drug on the output of prostaglandin E(2) and interleukin-1 beta from human fetal membranes.

Journal: Molecular human reproduction 20020301

Title: Role of p38 mitogen-activated protein kinase in chemokine-induced emigration and chemotaxis in vivo.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20011201

Title: Transcriptional cross-talk between Smad, ERK1/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-beta-induced aggrecan gene expression in chondrogenic ATDC5 cells.

Journal: The Journal of biological chemistry 20010427

Title: Inhibition of p38 MAP kinase as a therapeutic strategy.

Journal: Immunopharmacology 20000501

Title: Pyrimidinylimidazole inhibitors of CSBP/p38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes.

Journal: Bioorganic & medicinal chemistry letters 19981117

Title: p38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils.

Journal: The Journal of biological chemistry 19980403

Title: Regulation of prostaglandin H synthase 2 expression in human monocytes by the marine natural products manoalide and scalaradial. Novel effects independent of inhibition of lipid mediator production.

Journal: Biochemical pharmacology 19950928

Title: Effect of the beta-receptor blocking agent Visken on the action of coumarin.

Journal: International journal of clinical pharmacology and biopharmacy 19751201

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