Title: Design and stereoselective synthesis of a C-aryl furanoside as a conformationally constrained CHIR-090 analogue.
Journal: Carbohydrate research 20121001
Title: Potent inhibitors of LpxC for the treatment of Gram-negative infections.
Journal: Journal of medicinal chemistry 20120126
Title: Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold.
Journal: Bioorganic & medicinal chemistry 20110115
Title: Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis.
Journal: Current pharmaceutical biotechnology 20080201
Title: A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin.
Journal: Biochemistry 20051220
Title: Barb AW, et al. Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli. Biochemistry. 2007 Mar 27;46(12):3793-802.
Title: Barb AW, et al. Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18433-8.
Title: Tan JH, et al. In Vitro and In Vivo Efficacy of an LpxC Inhibitor, CHIR-090, Alone or Combined with Colistin against Pseudomonas aeruginosa Biofilm. Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e02223-16.