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732302-99-7,MFCD18385007
Catalog No.:AA00FF6F

732302-99-7 | Givinostat Hydrochloride Hydrate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$65.00   $45.00
- +
5mg
≥98%
in stock  
$173.00   $121.00
- +
10mg
≥98%
in stock  
$315.00   $220.00
- +
50mg
≥95%
in stock  
$1,047.00   $733.00
- +
100mg
≥95%
in stock  
$1,631.00   $1,142.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00FF6F
Chemical Name:
Givinostat Hydrochloride Hydrate
CAS Number:
732302-99-7
Molecular Formula:
C24H30ClN3O5
Molecular Weight:
475.9651
MDL Number:
MFCD18385007
SMILES:
ONC(=O)c1ccc(cc1)NC(=O)OCc1ccc2c(c1)ccc(c2)C[NH+](CC)CC.O.[Cl-]
Properties
Computed Properties
 
Complexity:
575  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
9  

Literature

Title: Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay.

Journal: Annals of the rheumatic diseases 20120301

Title: The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet β cells in vivo and in vitro.

Journal: Molecular medicine (Cambridge, Mass.) 20110101

Title: Effects of the histone deacetylase inhibitor ITF2357 in autoinflammatory syndromes.

Journal: Molecular medicine (Cambridge, Mass.) 20110101

Title: ITF2357 interferes with apoptosis and inflammatory pathways in the HL-60 model: a gene expression study.

Journal: Anticancer research 20101101

Title: The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression on CD4(+) T-cells and monocytes and is superior to valproic acid for latent HIV-1 expression in vitro.

Journal: Journal of acquired immune deficiency syndromes (1999) 20100501

Title: Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice.

Journal: The Journal of clinical investigation 20080701

Title: Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice.

Journal: Gut 20080501

Title: Histone deacetylase inhibitors induce in human hepatoma HepG2 cells acetylation of p53 and histones in correlation with apoptotic effects.

Journal: International journal of oncology 20080101

Title: HDAC inhibitor treatment of hepatoma cells induces both TRAIL-independent apoptosis and restoration of sensitivity to TRAIL.

Journal: Hepatology (Baltimore, Md.) 20060301

Title: Apoptosis on hepatoma cells but not on primary hepatocytes by histone deacetylase inhibitors valproate and ITF2357.

Journal: Journal of hepatology 20050201

Title: Li S, et al. Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo. J Biol Chem. 2015 Jan 23;290(4):2368-78.

Title: Wang YG, et al. Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation. World J Gastroenterol. 2015 Jul 21;21(27):8326-39.

Title: Leoni F, et al. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med. 2005 Jan-Dec;11(1-12):1-15.

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